EKS-GOG-00366

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00366

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	311.8	4.1E-93	237	421	185

Status

Unreviewed

Ensembl Protein

ENSGGOP00000018321

UniProt Accession

G3QWW0;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007437	ENSGGOP00000007283	ENSGGOT00000007475
ENSGGOG00000007437	ENSGGOP00000018321	ENSGGOT00000026168

Organism

Gorilla gorilla

Functional Description

Protein Length

438

Protein Sequence
(FASTA)

VALYDYESRT ETDLSFKKGE RLQIVNNTEG DWWLAHSLST GQTGYIPSNY VAPSDSIQAE 60

EWYFGKITRR ESERLLLNAE NPRGTFLVRE SETTKGAYCL SVSDFDNAKG LNVKHYKIRK 120

LDSGGFYITS RTQFNSLQQL VAYYSKHADG LCHRLTTVCP TSKPQTQGLA KDAWEIPRES 180

LRLEVKLGQG CFGEVWMGMG PRSHIKGTSR PAGTRTWIKH AGLECSFPQS PTVRKADSSA 240

VIFKLISPGS LLDFLKGETG KYLRLPQLVD MAAQIASGMA YVERMNYVHR DLRAANILVG 300

ENLVCKVADF GLARLIEDNE YTARQGAKFP IKWTAPEAAL YGRFTIKSDV WSFGILLTEL 360

TTKGRVPYPG MVNREVLDQV ERGYRMPCPP ECPESLHDLM CQCWRKEPEE RPTFEYLQAF 420

LEDYFTSTEP QYQPGENL 438

Nucleotide Sequence
(FASTA)

GTGGCCCTCT ATGACTATGA GTCTAGGACG GAGACAGACC TGTCCTTCAA GAAAGGCGAG 60

CGGCTCCAGA TTGTCAACAA CACAGAGGGA GACTGGTGGC TGGCCCACTC GCTCAGCACA 120

GGACAGACAG GCTACATCCC CAGCAACTAC GTGGCGCCCT CCGACTCCAT CCAGGCCGAG 180

GAGTGGTATT TTGGCAAGAT CACCAGACGG GAGTCAGAGC GGTTACTGCT CAATGCGGAG 240

AACCCGAGAG GGACCTTCCT CGTGCGAGAA AGTGAGACCA CGAAAGGTGC CTACTGCCTC 300

TCAGTGTCTG ACTTCGACAA TGCCAAGGGC CTCAACGTGA AGCACTACAA GATCCGCAAG 360

CTGGACAGCG GCGGCTTCTA CATCACCTCC CGCACCCAGT TCAACAGCCT GCAGCAGCTG 420

GTGGCCTACT ACTCCAAACA CGCCGATGGC CTGTGCCACC GCCTCACCAC CGTGTGTCCC 480

ACGTCCAAGC CGCAGACTCA GGGCCTGGCC AAGGATGCCT GGGAGATCCC TCGGGAGTCG 540

CTGCGGCTGG AGGTCAAGCT GGGCCAGGGC TGCTTTGGCG AGGTGTGGAT GGGAATGGGC 600

CCAAGGTCAC ACATCAAAGG AACCTCCAGG CCCGCTGGGA CAAGAACCTG GATTAAACAT 660

GCTGGTCTAG AATGCAGCTT CCCCCAGAGC CCCACAGTTA GAAAAGCAGA TAGTAGTGCA 720

GTAATTTTTA AACTAATTAG CCCAGGGAGT TTGCTGGACT TTCTCAAGGG GGAGACAGGC 780

AAGTACCTGC GGCTGCCTCA GCTGGTGGAC ATGGCTGCTC AGATCGCCTC AGGCATGGCG 840

TACGTGGAGC GGATGAACTA TGTCCACCGG GACCTTCGTG CAGCCAACAT CCTGGTGGGA 900

GAGAACCTGG TGTGCAAAGT GGCCGACTTT GGGCTGGCTC GGCTCATTGA AGACAATGAG 960

TACACGGCGC GGCAAGGTGC CAAATTCCCC ATCAAGTGGA CGGCTCCGGA AGCTGCCCTC 1020

TATGGCCGCT TCACCATCAA GTCGGACGTG TGGTCCTTCG GGATCCTGCT GACTGAGCTC 1080

ACCACAAAGG GACGGGTGCC CTACCCTGGG ATGGTGAACC GCGAGGTGCT GGACCAGGTG 1140

GAGCGGGGCT ACCGGATGCC CTGCCCGCCG GAGTGTCCCG AGTCCCTGCA CGACCTCATG 1200

TGCCAGTGCT GGCGGAAGGA GCCTGAGGAG CGGCCCACCT TCGAGTACCT GCAGGCCTTC 1260

CTGGAGGACT ACTTCACGTC CACGGAGCCC CAGTACCAGC CCGGGGAGAA CCTCTAG 1317

Domain Profile

S: 67    ePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdlaarn  126

         +   ++  l++ Gslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hrdl+a+n

Q: 237   DSSAVIFKLISPGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAAN  296

         556688999***************************************************

S: 127   vlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWsfGil  186

         +lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdvWsfGil

Q: 297   ILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL  356

         ************************************************************

S: 187   lteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerPtfet  246

         lte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+peerPtfe+

Q: 357   LTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEY  416

         ************************************************************

S: 247   lqevl  251

         lq++l

Q: 417   LQAFL  421

         *9876

Domain Sequence
(FASTA)

DSSAVIFKLI SPGSLLDFLK GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN 60

ILVGENLVCK VADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL 120

LTELTTKGRV PYPGMVNREV LDQVERGYRM PCPPECPESL HDLMCQCWRK EPEERPTFEY 180

LQAFL 185

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013