EKS-GOG-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	498.2	5.9E-150	683	940	258

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007465

UniProt Accession

G3QXC5;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007623	ENSGGOP00000007465	ENSGGOT00000007666

Organism

Gorilla gorilla

Functional Description

Protein Length

1181

Protein Sequence
(FASTA)

VCQGTSNKLT QLGTFEDHFL SLQRMFNNCE VVLGNLEITY VQRNYDLSFL KTIQEVAGYV 60

LIALNTVERI PLENLQIIRG NMYYENSYAL AVLSNYDANK TGLKELPMRN LQEILHGAVR 120

FSNNPALCNV ESIQWRDIVS SDFLSNMSMD FQNHLGSCQK CDPSCPNGSC WGAGEENCQK 180

LTKIICAQQC SGRCRGKSPS DCCHNQCAAG CTGPRESDCL VCRKFRDEAT CKDTCPPLML 240

YNPTTYQMDV NPEGKYSFGA TCVKKCPRNY VVTDHGSCVR ACGADSYEME EDGVRKCKKC 300

EGPCRKVCNG IGIGEFKDTL SINATNIKHF KNCTSISGDL HILPVAFRGD SFTHTPPLDP 360

QELDILKTVK EITGFLLIQA WPENRTDLHA FENLEIIRGR TKQHGQFSLA VVSLNITSLG 420

LRSLKEISDG DVIISGNKNL CYANTINWKK LFGTSGQKTK IISNRGENSC KATGQVCHAL 480

CSPEGCWGPE PRDCVSCRNV SRGRECVDKC NILEGEPREF VENSECIQCH PECLPQAMNI 540

TCTGRGPDNC IQCAHYIDGP HCVKTCPAGV MGENNTLVWK YADAGHVCHL CHPNCTYGCT 600

GPGLEGCPTN GPKIPSIATG MVGALLLLLV VALGIGLFMR RRHIIRKRTL RRLLQERELV 660

EPLTPSGEAP NQALLRILKE TEFKKIKVLG SGAFGTVYKG LWIPEGEKVK IPVAIKELRE 720

ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPFGCLL DYVREHKDNI 780

GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY 840

HAEGGKVPIK WMALESILHR IYTHQSDVWS YGVTVWELMT FGSKPYDGIP ASEISSILEK 900

GERLPQPPIC TIDVYMIMVK CWMIDADSRP KFRELIIEFS KMARDPQRYL VIQGDERMHL 960

PSPTDSNFYR ALMDEEDMDD VVDADEYLIP QQGFFSSPST SRTPLLSSLS ATSNNSTVAC 1020

IDRNGLQSCP IKEDSFLQRY SSDPTGALTE DSIDDTFLPV PEYINQSVPK RPAGSVQNPV 1080

YHNQPLNPAP SRDPHYQDPH STAVGNPEYL NTVQPTCVNS TFDGPSHWAQ KGSHQISLDN 1140

PDYQQDFFPK EAKPNGIFKG STAENAEYLR VAPQSSEFIG A 1181

Nucleotide Sequence
(FASTA)

GTTTGCCAAG GCACGAGTAA CAAGCTCACG CAGTTGGGCA CTTTTGAAGA TCATTTTCTC 60

AGCCTCCAGA GGATGTTCAA TAACTGTGAG GTGGTCCTTG GGAATTTGGA AATTACCTAT 120

GTGCAGAGGA ATTATGATCT TTCCTTCTTA AAGACCATCC AGGAGGTGGC TGGTTATGTC 180

CTCATTGCCC TCAACACAGT GGAGCGGATT CCTTTAGAAA ACCTGCAGAT CATCAGAGGA 240

AATATGTACT ACGAAAATTC CTACGCCTTA GCAGTCTTAT CTAACTATGA TGCAAATAAA 300

ACCGGACTGA AGGAGCTGCC CATGAGAAAT TTACAGGAAA TCCTGCATGG CGCCGTGCGG 360

TTCAGCAACA ACCCTGCCCT GTGCAACGTG GAGAGCATCC AGTGGCGGGA CATAGTCAGC 420

AGTGACTTTC TCAGCAACAT GTCGATGGAC TTCCAGAACC ACCTGGGCAG CTGCCAAAAG 480

TGTGATCCAA GCTGTCCCAA TGGGAGCTGC TGGGGTGCAG GAGAGGAGAA CTGCCAGAAA 540

CTGACCAAAA TCATCTGTGC CCAGCAGTGC TCCGGGCGCT GCCGTGGCAA GTCCCCCAGT 600

GACTGCTGCC ACAACCAGTG TGCCGCAGGC TGCACGGGCC CCCGGGAGAG CGACTGCCTG 660

GTCTGCCGCA AATTCCGAGA CGAAGCCACG TGCAAGGACA CCTGCCCCCC ACTCATGCTC 720

TACAACCCCA CCACGTACCA GATGGATGTG AACCCCGAGG GCAAATACAG CTTTGGTGCC 780

ACCTGCGTGA AGAAGTGTCC CCGTAATTAT GTGGTGACAG ATCACGGCTC GTGCGTCCGA 840

GCCTGTGGGG CCGACAGCTA TGAGATGGAG GAAGACGGCG TCCGCAAGTG TAAGAAGTGC 900

GAAGGGCCTT GCCGCAAAGT GTGTAACGGA ATAGGTATTG GTGAATTTAA AGACACACTC 960

TCCATAAATG CTACGAATAT TAAACACTTC AAAAACTGCA CCTCCATCAG TGGCGATCTC 1020

CACATCCTGC CGGTGGCATT TAGGGGTGAC TCCTTCACAC ATACTCCGCC TCTGGATCCA 1080

CAGGAACTGG ATATTCTGAA AACCGTAAAG GAAATCACAG GGTTTTTGCT GATTCAGGCT 1140

TGGCCTGAAA ACAGGACGGA CCTCCATGCT TTTGAGAACC TAGAAATCAT ACGCGGCAGG 1200

ACCAAGCAAC ATGGTCAGTT TTCTCTTGCG GTCGTCAGCC TGAACATAAC ATCCTTGGGA 1260

TTACGCTCCC TCAAGGAGAT AAGTGATGGA GATGTGATAA TTTCAGGAAA CAAAAATTTG 1320

TGCTATGCAA ATACAATAAA CTGGAAAAAA CTGTTTGGGA CCTCCGGTCA GAAAACCAAA 1380

ATTATAAGCA ACAGAGGTGA AAACAGCTGC AAGGCCACAG GCCAGGTCTG CCATGCCTTG 1440

TGCTCCCCCG AGGGCTGCTG GGGCCCGGAG CCCAGGGACT GCGTCTCTTG CCGGAATGTC 1500

AGCCGAGGCA GGGAATGCGT GGACAAGTGC AACATTCTGG AGGGCGAGCC AAGGGAGTTT 1560

GTGGAGAACT CTGAGTGCAT ACAGTGCCAC CCAGAGTGCC TGCCTCAGGC CATGAACATC 1620

ACCTGCACAG GACGGGGACC AGACAACTGT ATCCAGTGTG CCCACTACAT TGACGGCCCC 1680

CACTGCGTCA AGACCTGCCC GGCAGGAGTC ATGGGAGAAA ACAACACCCT GGTCTGGAAG 1740

TACGCAGATG CCGGCCATGT GTGCCACCTG TGCCATCCAA ACTGCACCTA CGGATGCACT 1800

GGGCCAGGTC TTGAAGGCTG TCCAACGAAT GGGCCTAAGA TCCCGTCCAT TGCCACTGGG 1860

ATGGTGGGGG CCCTCCTCTT GCTGCTGGTG GTGGCCCTGG GGATTGGCCT CTTCATGCGA 1920

AGGCGCCACA TCATTCGGAA GCGCACGCTG CGGAGGCTGC TGCAGGAGAG GGAGCTTGTG 1980

GAGCCTCTTA CACCCAGTGG AGAAGCTCCC AACCAAGCTC TCTTGAGGAT CTTGAAGGAA 2040

ACTGAATTCA AAAAGATCAA AGTGCTGGGC TCTGGCGCGT TCGGCACGGT GTATAAGGGA 2100

CTCTGGATCC CAGAAGGTGA GAAAGTTAAA ATTCCCGTCG CTATCAAGGA ATTAAGAGAA 2160

GCAACGTCTC CGAAAGCCAA CAAGGAAATC CTCGATGAAG CCTACGTGAT GGCCAGCGTG 2220

GACAACCCCC ACGTGTGCCG CCTGCTGGGC ATCTGCCTCA CCTCCACCGT GCAGCTCATC 2280

ACGCAGCTCA TGCCCTTCGG CTGCCTCCTG GACTATGTCC GGGAACACAA AGACAATATT 2340

GGCTCCCAGT ACCTGCTCAA CTGGTGTGTG CAGATCGCAA AGGGCATGAA CTACTTGGAG 2400

GACCGTCGCT TGGTGCACCG CGACCTGGCA GCCAGGAACG TACTGGTGAA AACACCGCAG 2460

CATGTCAAGA TCACAGATTT TGGGCTGGCC AAACTGCTGG GTGCAGAAGA GAAAGAATAC 2520

CATGCAGAAG GAGGCAAAGT GCCTATCAAG TGGATGGCAT TGGAATCAAT TTTACACAGA 2580

ATCTATACCC ACCAGAGTGA TGTCTGGAGC TACGGGGTGA CCGTTTGGGA GTTGATGACC 2640

TTTGGATCCA AGCCATATGA TGGAATCCCT GCCAGCGAGA TCTCCTCCAT CCTGGAGAAA 2700

GGAGAACGCC TCCCTCAGCC ACCCATATGT ACCATCGATG TCTACATGAT CATGGTCAAA 2760

TGCTGGATGA TAGACGCAGA TAGTCGCCCA AAGTTCCGTG AGTTGATCAT CGAATTCTCC 2820

AAAATGGCCC GAGACCCCCA GCGCTACCTT GTCATTCAGG GGGATGAAAG AATGCATTTG 2880

CCAAGCCCTA CAGACTCCAA CTTCTACCGT GCCCTGATGG ATGAAGAAGA CATGGACGAT 2940

GTGGTGGATG CCGACGAGTA CCTCATCCCA CAGCAGGGCT TCTTCAGCAG CCCCTCCACG 3000

TCACGGACTC CCCTCCTGAG CTCTCTGAGT GCAACCAGCA ACAATTCCAC TGTGGCTTGC 3060

ATTGATAGAA ATGGGCTGCA AAGCTGTCCC ATCAAGGAAG ATAGCTTCTT GCAGCGATAC 3120

AGCTCAGACC CCACAGGCGC CTTGACTGAG GACAGCATAG ACGACACCTT CCTCCCAGTG 3180

CCTGAATACA TAAACCAGTC CGTTCCCAAA AGGCCCGCTG GCTCTGTGCA GAATCCTGTC 3240

TATCACAATC AGCCTCTGAA CCCCGCACCC AGCAGAGACC CACACTACCA GGACCCCCAC 3300

AGCACTGCAG TGGGCAACCC CGAGTATCTC AACACTGTCC AGCCCACCTG TGTCAACAGC 3360

ACATTCGACG GCCCTTCCCA CTGGGCCCAG AAAGGCAGCC ACCAAATTAG CCTGGACAAC 3420

CCTGACTACC AGCAGGACTT CTTTCCCAAG GAAGCCAAGC CAAATGGCAT CTTTAAGGGC 3480

TCCACAGCTG AAAATGCAGA ATACCTAAGG GTCGCGCCAC AAAGCAGTGA ATTTATTGGA 3540

GCATGA 3546

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 683   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  742

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++

Q: 743   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  802

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 803   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  862

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 863   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  922

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 923   MIDADSRPKFRELIIEFS  940

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIIEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 3.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013