EKS-GOG-00424

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00424

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	394.8	2.6E-118	9	271	263

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007528

UniProt Accession

G3QXI5;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007689	ENSGGOP00000007528	ENSGGOT00000007730

Organism

Gorilla gorilla

Functional Description

Protein Length

986

Protein Sequence
(FASTA)

MEVVGDFEYS KRDLVGHGAF AVVFRGRHRQ KTDWEVAIKS INKKNLSKSQ ILLGKEIKIL 60

KELQHENIVA LYDVQELPNS VFLVMEYCNG GDLADYLQAK GTLSEDTIRV FLHQIAAAMR 120

ILHSKGIIHR DLKPQNILLS YANRRKSSVS GIRIKIADFG FARYLHSNMM AATLCGSPMY 180

MAPEVIMSQH YDAKADLWSI GTVIYQCLVG KPPFQANSPQ DLRMFYEKNR SLMPSIPRET 240

SPYLANLLLG LLQRNQKDRM DFEAFFSHPF LEQGPVKKSC PVPVPMYSGS VSGSSCGSSP 300

SCRFASPPSL PDMQHIQEEN LSSPPLGPPN YLQVSKDSAS TSSKNSSCDT DDFVLVPHNI 360

SSDHSYDMPM GTAGRRASNE FLVCGGQCQP TVSPHSETAP IPVPTQIRNY QRIEQNLTST 420

ASSGTNVHGS PRSAVVRRSN TSPMGFLRPG SCSPVPADTA QTVGRRLSTG SSRPYSPSPL 480

VGTIPEQFSQ CCCGHPQGHD SRSRNSSGSP VPQAQSPQSL LSGARLQSAP TLTDIYQNKQ 540

KLRKQHSDPV CPSHTGAGYS YSPQPSRPGS LGTSPTKHLG SSPRSSDWFF KTPLPTIIGS 600

PTKTTAPFKI PKTQASSNLL ALVTRHGPAE EQSKDGNEPR ECAHCLLVQG SERQRAEQQS 660

KAVFGRSVST GKLSDQQGKT PICRHQGSTD SLNTERPMDI VGPSNSGGSL CAMSGRVCVG 720

SPPGPGFGSS PPGAEAAPSL RYVPYGASPP SLEGLITFEA PELPEETLME REHTDTLRHL 780

NVMLMFTECV LDLTAMRGGN PELCTSAVSL YQIQESVVVD QISQLSKDWG RVEQLVLYMK 840

AAQLLAASLH LAKAQIKSGK LSPSTAVKQV VKNLNERYKF CITMCKKLTE KLNRFFSDKQ 900

RFIDEINSVT AEKLIYNCAV EMVQSAALDE MFQQTEDIVY RYHKAALLLE GLSKILQDPA 960

DIENVHKYKC SIERRLSALC HSTATV 986

Nucleotide Sequence
(FASTA)

ATGGAGGTGG TGGGCGACTT CGAGTACAGC AAGAGGGATC TCGTGGGACA CGGGGCCTTC 60

GCCGTGGTCT TCCGGGGGCG GCACCGCCAG AAAACTGATT GGGAGGTAGC TATTAAAAGT 120

ATTAATAAAA AGAACTTGTC AAAATCACAA ATACTGCTTG GAAAGGAAAT TAAAATCTTA 180

AAGGAACTTC AGCATGAAAA TATTGTAGCA CTCTATGATG TTCAGGAATT ACCCAACTCT 240

GTCTTTTTGG TGATGGAGTA TTGCAATGGT GGAGACCTCG CAGATTATTT GCAAGCGAAA 300

GGGACTCTCA GTGAAGACAC TATCAGAGTG TTTCTGCATC AGATTGCTGC TGCCATGCGA 360

ATCCTGCACA GCAAAGGAAT CATCCATAGA GATCTCAAAC CACAGAACAT CTTGCTGTCC 420

TATGCCAATC GCAGAAAATC AAGTGTCAGT GGTATTCGCA TCAAAATAGC GGATTTTGGT 480

TTTGCTCGTT ACCTACATAG TAACATGATG GCTGCAACAC TGTGTGGATC CCCGATGTAC 540

ATGGCTCCTG AGGTTATTAT GTCTCAACAT TATGATGCTA AGGCTGACTT GTGGAGCATA 600

GGAACAGTGA TATACCAGTG CCTAGTTGGA AAACCACCTT TTCAGGCCAA TAGTCCTCAA 660

GACTTAAGGA TGTTTTATGA AAAAAACAGG AGCTTAATGC CTAGTATTCC CAGAGAAACA 720

TCACCTTATT TGGCTAATCT CCTTTTGGGT TTGCTTCAGA GAAACCAAAA AGATAGAATG 780

GACTTTGAAG CATTTTTTAG CCATCCTTTT CTTGAGCAAG GTCCAGTAAA AAAATCTTGC 840

CCAGTTCCAG TGCCCATGTA TTCTGGTTCT GTCTCGGGAA GCTCCTGTGG CAGCTCTCCA 900

TCTTGTCGTT TTGCTTCTCC ACCATCCCTT CCAGATATGC AGCATATTCA GGAAGAAAAC 960

TTATCTTCCC CACCATTGGG TCCTCCCAAC TATCTACAAG TTTCCAAAGA TTCTGCCAGT 1020

ACTAGTAGCA AGAACTCTTC TTGTGACACG GATGACTTTG TTTTGGTGCC ACACAACATC 1080

TCGTCAGACC ACTCATATGA TATGCCAATG GGGACTGCTG GCAGACGTGC TTCAAATGAA 1140

TTCTTGGTGT GTGGAGGGCA GTGTCAGCCT ACTGTGTCAC CTCACAGCGA AACAGCACCA 1200

ATTCCAGTTC CTACTCAAAT AAGGAATTAT CAGCGCATAG AGCAGAATCT TACATCTACT 1260

GCCAGCTCAG GCACAAATGT ACATGGTTCT CCAAGATCTG CAGTGGTACG AAGGTCCAAC 1320

ACCAGCCCCA TGGGCTTCCT CCGGCCGGGA TCATGCTCCC CAGTACCAGC AGACACAGCA 1380

CAGACAGTTG GACGAAGGCT CTCCACTGGG TCTTCTAGGC CTTACTCACC TTCCCCTTTG 1440

GTTGGTACCA TTCCTGAGCA ATTCAGTCAG TGCTGCTGTG GGCATCCTCA GGGCCATGAC 1500

TCCAGGAGTA GAAACTCCTC AGGTTCTCCA GTGCCACAAG CTCAGTCCCC ACAGTCTCTC 1560

TTATCGGGTG CTAGACTGCA GAGCGCCCCC ACCCTCACTG ACATCTATCA GAACAAGCAG 1620

AAGCTCAGAA AACAGCACTC TGACCCCGTG TGCCCATCCC ATACTGGGGC TGGGTACAGC 1680

TACTCACCTC AGCCCAGTCG GCCTGGCAGC CTTGGAACTT CTCCCACCAA GCACTTGGGG 1740

TCCTCTCCAC GGAGTTCTGA CTGGTTCTTT AAAACTCCTT TGCCAACAAT CATTGGCTCT 1800

CCTACTAAGA CCACAGCTCC TTTCAAAATC CCTAAAACTC AAGCATCTTC CAACCTGTTA 1860

GCCTTGGTTA CTCGTCATGG GCCTGCTGAA GAACAGTCCA AAGATGGGAA TGAGCCACGG 1920

GAATGTGCCC ATTGCCTCTT AGTGCAAGGA AGTGAGAGGC AGCGGGCCGA GCAGCAGAGC 1980

AAGGCAGTGT TTGGCAGATC TGTCAGTACT GGGAAGTTAT CAGATCAACA AGGAAAGACT 2040

CCTATATGTC GACATCAGGG CAGCACAGAC AGTTTAAATA CAGAACGACC AATGGATATA 2100

GTGGGGCCCA GCAACTCCGG GGGCTCTCTT TGTGCCATGA GTGGCCGCGT GTGCGTGGGG 2160

TCCCCGCCTG GCCCAGGCTT CGGCTCTTCC CCTCCAGGAG CAGAGGCAGC TCCCAGCCTG 2220

AGATACGTGC CTTACGGTGC TTCACCCCCC AGCCTAGAGG GGCTCATCAC CTTTGAAGCC 2280

CCTGAACTGC CGGAGGAGAC GCTGATGGAG CGGGAACACA CAGACACCTT ACGCCATCTG 2340

AATGTGATGC TGATGTTCAC TGAGTGTGTG CTGGACCTGA CAGCCATGAG GGGAGGAAAC 2400

CCTGAGCTGT GCACATCTGC TGTGTCCTTG TACCAGATCC AGGAGAGTGT GGTGGTGGAC 2460

CAGATCAGTC AGCTGAGCAA AGACTGGGGG CGGGTGGAGC AGCTGGTGTT GTACATGAAA 2520

GCAGCACAGC TGCTTGCGGC TTCTCTGCAT CTTGCCAAAG CCCAGATCAA GTCCGGGAAA 2580

CTGAGCCCAT CCACAGCTGT GAAACAAGTT GTCAAGAATC TGAACGAACG ATATAAATTC 2640

TGCATCACCA TGTGCAAGAA ACTTACAGAA AAGCTGAATC GATTCTTCTC TGACAAACAG 2700

AGGTTTATTG ATGAAATCAA CAGTGTGACT GCAGAGAAAC TCATCTATAA TTGTGCTGTA 2760

GAAATGGTTC AGTCTGCAGC CCTGGATGAG ATGTTTCAGC AGACCGAAGA TATTGTTTAT 2820

CGCTATCATA AGGCAGCCCT TCTTTTGGAA GGCCTAAGTA AGATTCTACA GGACCCTGCA 2880

GATATTGAAA ATGTACATAA ATATAAATGT AGTATTGAGA GAAGACTGTC GGCGCTCTGC 2940

CATAGCACTG CAACCGTGTG A 2961

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ +G+G+favv++gr+r+kt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 9     YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  68

         8899********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e  ++v+lvmeyc+ggdLa++l++k++Lsedt+r+fl+q+a+a+++Lhsk+i+

Q: 69    VALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGII  128

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 129   HRDLKPQNILLSYANRRKsSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  188

         ***************99989****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l+p+ip+e+s+ l++ll

Q: 189   QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLL  248

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++fe +f+hpfl

Q: 249   LGLLQRNQKDRMDFEAFFSHPFL  271

         *********************96

Domain Sequence
(FASTA)

YSKRDLVGHG AFAVVFRGRH RQKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQELP NSVFLVMEYC NGGDLADYLQ AKGTLSEDTI RVFLHQIAAA MRILHSKGII 120

HRDLKPQNIL LSYANRRKSS VSGIRIKIAD FGFARYLHSN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTVIYQCL VGKPPFQANS PQDLRMFYEK NRSLMPSIPR ETSPYLANLL 240

LGLLQRNQKD RMDFEAFFSH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013