EKS-GOG-00185

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00185

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CASK	542.0	2.9E-163	12	276	265

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007641

UniProt Accession

G3QXT0;

Protein Name

Protein Synonyms/Alias

Gene Name

CASK

Gene Synonyms/Alias

CASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007796	ENSGGOP00000018958	ENSGGOT00000029693
ENSGGOG00000007796	ENSGGOP00000007641	ENSGGOT00000007846

Organism

Gorilla gorilla

Functional Description

Protein Length

926

Protein Sequence
(FASTA)

MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS SPGLSTEDLK 60

REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC FEIVKRADAG FVYSEAVASH 120

YMRQILEALR YCHDNNIIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV 180

GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR 240

QWSHISESAK DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA 300

RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGN LSPLGAVSQV LDSLEEIHAL 360

TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN PPSDAVQRAK EVLEEISCYP 420

ENNDAKELKR ILTQPHFMAL LQTHDVVAHE VYSDEALRVT PPPTSPYLNG DSPESANGDM 480

DMENVTRVRL VQFQKNTDEP MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN 540

GISVANQTVE QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS 600

VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS KDDHNWWQGK 660

LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW FGKKKKQYKD KYLAKHNAVF 720

DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK 780

DEENGKNYYF VSHDQMMQDI SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ 840

ALKVLRTAEF APFVVFIAAP TITPGLNEDE SLQRLQKESD ILQRTYAHYF DLTIINNEID 900

ETIRHLEEAV ELVCTAPQWV PVSWVY 926

Nucleotide Sequence
(FASTA)

ATGGCCGACG ACGACGTGCT GTTCGAGGAT GTGTACGAGC TGTGCGAGGT GATCGGAAAG 60

GGTCCCTTCA GTGTTGTACG ACGATGTATC AACAGAGAAA CTGGGCAACA ATTTGCTGTA 120

AAAATTGTTG ATGTAGCCAA GTTCACATCA AGTCCAGGGT TAAGTACAGA AGATCTAAAG 180

CGGGAAGCCA GTATCTGTCA TATGCTGAAA CATCCACACA TTGTAGAGTT ATTGGAGACA 240

TATAGCTCAG ATGGAATGCT TTACATGGTT TTCGAATTTA TGGATGGAGC AGATCTGTGT 300

TTTGAAATCG TAAAGCGAGC TGACGCTGGT TTTGTGTACA GTGAAGCTGT AGCCAGCCAT 360

TATATGAGAC AGATACTGGA AGCTCTACGT TACTGCCATG ATAATAACAT AATTCACAGG 420

GATGTGAAGC CCCACTGTGT TCTCCTTGCC TCAAAAGAAA ACTCGGCACC TGTTAAACTT 480

GGAGGCTTTG GGGTAGCTAT TCAATTAGGG GAGTCTGGAC TTGTAGCTGG AGGACGTGTT 540

GGAACACCTC ATTTTATGGC ACCAGAAGTG GTCAAAAGAG AGCCTTACGG AAAGCCTGTA 600

GACGTCTGGG GGTGTGGTGT GATCCTTTTT ATCCTGCTCA GTGGTTGTTT GCCTTTTTAC 660

GGAACCAAGG AAAGATTGTT TGAAGGCATT ATTAAAGGAA AATATAAGAT GAATCCAAGG 720

CAGTGGAGCC ATATCTCTGA AAGTGCCAAA GACCTAGTAC GTCGCATGCT GATGCTGGAT 780

CCAGCTGAAA GGATCACTGT TTATGAAGCA CTGAATCACC CATGGCTTAA GGAGCGGGAT 840

CGTTACGCCT ACAAGATTCA TCTTCCAGAA ACAGTAGAGC AGCTGAGGAA ATTCAATGCA 900

AGGAGGAAAC TAAAGGGTGC AGTACTGGCC GCTGTGTCAA GTCACAAATT CAACTCATTC 960

TATGGGGATC CCCCTGAAGA GTTACCAGAT TTCTCCGAAG ACCCTACCTC CTCAGGTAAT 1020

TTGTCCCCCT TAGGAGCAGT CTCACAGGTG CTGGACAGCC TGGAAGAGAT TCATGCGCTT 1080

ACAGACTGCA GTGAAAAGGA CCTAGATTTT CTACACAGTG TTTTCCAGGA TCAGCATCTT 1140

CACACACTAC TAGATCTGTA TGACAAAATT AACACAAAGT CTTCACCACA AATCAGGAAT 1200

CCTCCAAGCG ATGCAGTACA GAGAGCCAAA GAGGTATTGG AAGAAATTTC ATGTTACCCT 1260

GAGAATAACG ACGCAAAGGA ACTAAAGCGT ATTTTAACAC AACCTCATTT CATGGCCTTA 1320

CTTCAGACTC ACGACGTAGT GGCACATGAA GTTTACAGTG ATGAAGCATT GAGGGTCACA 1380

CCTCCTCCCA CCTCTCCCTA TTTAAACGGC GATTCTCCAG AAAGTGCTAA CGGAGACATG 1440

GATATGGAGA ATGTGACCAG AGTTCGGCTG GTACAGTTCC AAAAGAACAC AGATGAACCA 1500

ATGGGAATCA CTTTAAAAAT GAATGAACTA AATCATTGTA TTGTTGCAAG AATTATGCAT 1560

GGTGGCATGA TTCACAGGCA AGGTACACTT CATGTTGGTG ATGAAATTCG AGAAATCAAT 1620

GGCATCAGTG TGGCTAACCA AACAGTGGAA CAACTGCAAA AAATGCTTAG GGAAATGCGG 1680

GGGAGTATTA CCTTCAAGAT TGTGCCAAGT TACCGCACTC AGTCTTCGTC CTGTGAGAGA 1740

GATTCCCCTT CCACTTCCAG ACAGTCCCCA GCTAATGGTC ATAGCAGCAC TAACAATTCT 1800

GTTTCGGACT TGCCATCAAC TACCCAACCA AAAGGACGAC AGATCTATGT AAGAGCACAA 1860

TTTGAATATG ATCCAGCCAA GGATGACCTC ATCCCCTGTA AAGAAGCTGG CATTCGATTC 1920

AGAGTTGGTG ACATCATCCA GATTATTAGT AAGGATGATC ATAATTGGTG GCAGGGTAAA 1980

CTGGAAAACT CCAAAAATGG AACTGCAGGT CTCATTCCTT CTCCTGAACT TCAGGAATGG 2040

CGAGTAGCTT GCATTGCCAT GGAGAAGACC AAACAGGAGC AGCAGGCCAG CTGTACTTGG 2100

TTTGGCAAGA AAAAGAAGCA GTACAAAGAT AAATATTTGG CAAAGCACAA TGCAGTGTTT 2160

GATCAATTAG ATCTTGTCAC ATATGAAGAA GTAGTAAAAC TGCCAGCATT CAAGAGGAAA 2220

ACACTAGTCT TATTAGGCGC ACATGGTGTT GGGAGAAGAC ACATAAAAAA CACTCTCATC 2280

ACAAAGCACC CAGACCGGTT TGCATACCCT ATTCCACATA CAACCAGACC TCCAAAGAAA 2340

GACGAAGAAA ATGGAAAGAA TTATTACTTT GTATCTCATG ACCAAATGAT GCAAGACATC 2400

TCTAATAACG AGTACTTGGA GTACGGCAGC CACGAGGATG CAATGTATGG GACAAAACTG 2460

GAGACCATCC GGAAGATCCA CGAGCAGGGG CTGATTGCAA TACTGGACGT GGAGCCTCAG 2520

GCACTGAAGG TCCTGAGAAC TGCAGAGTTT GCTCCTTTTG TTGTTTTCAT TGCTGCACCA 2580

ACTATTACTC CAGGTTTAAA TGAGGATGAA TCTCTTCAGC GTCTGCAGAA GGAGTCTGAC 2640

ATCTTACAGA GAACATATGC ACACTACTTC GATCTCACAA TTATCAACAA TGAAATTGAT 2700

GAGACAATCA GACATCTGGA GGAAGCTGTT GAGCTCGTGT GCACAGCCCC ACAGTGGGTC 2760

CCTGTCTCCT GGGTCTATTA G 2781

Domain Profile

S: 1     yelcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkh  60

         yelcevigkGpfsvvrr+i+re++q+favkivdvakftsspGlstedlkreasichmlkh

Q: 12    YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH  71

         89**********************************************************

S: 61    pyivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealry  120

         p+ivelletyss+gmly+vfefm+Gadlcfeivkra+aGfvyseavashymrqilealry

Q: 72    PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY  131

         ************************************************************

S: 121   chdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapev  180

         chdn+i+hrdv+phcvllask+nsapvklgGfGvaiql+e sglvagGrvG+phfmapev

Q: 132   CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGE-SGLVAGGRVGTPHFMAPEV  190

         ****************************************.*******************

S: 181   vkrerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesak  240

         vkre+ygk+vdvwg+Gv+lfillsG+lpf+G+kerlfe+iikgk+k+++r+ws+isesak

Q: 191   VKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAK  250

         ************************************************************

S: 241   dlvrrmlaadpakrisvkealnhewl  266

         dlvrrml++dpa+ri+v+ealnh+wl

Q: 251   DLVRRMLMLDPAERITVYEALNHPWL  276

         *************************7

Domain Sequence
(FASTA)

YELCEVIGKG PFSVVRRCIN RETGQQFAVK IVDVAKFTSS PGLSTEDLKR EASICHMLKH 60

PHIVELLETY SSDGMLYMVF EFMDGADLCF EIVKRADAGF VYSEAVASHY MRQILEALRY 120

CHDNNIIHRD VKPHCVLLAS KENSAPVKLG GFGVAIQLGE SGLVAGGRVG TPHFMAPEVV 180

KREPYGKPVD VWGCGVILFI LLSGCLPFYG TKERLFEGII KGKYKMNPRQ WSHISESAKD 240

LVRRMLMLDP AERITVYEAL NHPWL 265

Keyword

Complete proteome; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR008144	; Guanylate_kin.
IPR008145	; Guanylate_kin/L-typ_Ca_channel.
IPR020590	; Guanylate_kinase_CS.
IPR011009	; Kinase-like_dom.
IPR004172	; L27.
IPR014775	; L27_C.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR011511	; SH3_2.
IPR001452	; SH3_domain.

Pfam

PF00625	; Guanylate_kin; 1.
PF02828	; L27; 2.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.
PF07653	; SH3_2; 1.

SMARTs

SM00072	; GuKc; 1.
SM00569	; L27; 2.
SM00228	; PDZ; 1.
SM00220	; S_TKc; 1.
SM00326	; SH3; 1.

Prosites

PS00856	; GUANYLATE_KINASE_1; 1.
PS50052	; GUANYLATE_KINASE_2; 1.
PS51022	; L27; 2.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50002	; SH3; 1.

Prints

Created Date

20-Feb-2013