EKS-GOG-00458

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00458

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	377.6	4.7E-113	14	304	291

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007733

UniProt Accession

G3QY13;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000007904	ENSGGOP00000007733	ENSGGOT00000007940

Organism

Gorilla gorilla

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MCTAVDPRIV RRYLLRRQLG QGAYGIVWKA VDRRTGEVVA IKKIFDAFRD KTDAQRTFRE 60

ITLLQEFGDH PNIISLLDVI RAENDRDIYL VFEFMDTDLN AVIRKGGLLQ DVHVRSIFYQ 120

LLRATRFLHS GHVVHRDQKP SNVLLDANCT VKLCDFGLAR SLGDLPEGPE DQAVTEYVAT 180

RWYRAPEVLL SSHRYTLGVD MWSLGCILGE MLRGRPLFPG TSTLHQLELI LETIPPPSEE 240

DLLALGSGCR ASVLHHLGSR PRQTLDALLP PDTSPEALDL LRRLLVFAPD KRLSATQALQ 300

HPYVQRFHCP SDEWAREADV RLRAHEGVQL SVPEYRSRVY QMILEYGGSS GTSREKGPEG 360

VSPSQAHMHK PRADPQLPSR TSVQGPRPRP QSSPGHDPAE HESPHAAKNV PRQNSAPLLQ 420

TALLGNGERP PGAKEAPPLT LSLVKPSGRG AAPSLTSQAA AQVANQALIR GDWNRGGGVR 480

VASAQQVPPR LPPEARPGRR MFSTSALQGA QGGARALLGG YSQAYGTICH SALGHLPLLE 540

GHHV 544

Nucleotide Sequence
(FASTA)

ATGTGCACCG CAGTGGACCC TCGCATTGTC CGGAGATACC TACTCAGGCG GCAGCTCGGG 60

CAGGGAGCCT ATGGCATTGT GTGGAAGGCA GTGGACCGGA GGACTGGTGA GGTCGTGGCC 120

ATCAAGAAAA TCTTTGATGC TTTTAGGGAT AAGACAGATG CCCAGAGAAC ATTCCGGGAA 180

ATCACGCTCC TCCAGGAGTT TGGGGACCAT CCCAACATCA TCAGCCTCCT TGACGTGATC 240

CGGGCAGAGA ACGACAGGGA CATTTACCTG GTGTTTGAGT TTATGGACAC TGACCTGAAC 300

GCAGTCATCC GGAAGGGCGG CCTGCTGCAG GACGTCCACG TGCGCTCCAT CTTCTACCAG 360

CTCCTGCGGG CCACCCGGTT CCTCCACTCG GGGCACGTTG TGCACCGGGA CCAGAAGCCG 420

TCCAATGTGC TCCTGGATGC CAACTGCACA GTGAAGCTGT GTGACTTTGG CCTGGCCCGC 480

TCCCTGGGCG ACCTCCCCGA GGGGCCTGAG GACCAGGCCG TGACAGAGTA CGTGGCCACA 540

CGCTGGTACC GAGCACCGGA GGTGCTGCTC TCTTCACACC GATACACCCT TGGGGTGGAC 600

ATGTGGAGTC TGGGTTGTAT CCTGGGGGAG ATGCTGCGGG GGAGACCCCT GTTCCCGGGC 660

ACGTCCACCC TCCACCAGCT GGAGCTGATC CTGGAGACCA TCCCACCGCC ATCTGAGGAG 720

GACCTCCTGG CTCTCGGCTC AGGCTGCCGT GCCTCTGTAC TGCACCACCT GGGGTCCCGG 780

CCACGACAGA CGCTGGATGC CCTCCTACCG CCAGACACCT CCCCAGAGGC CTTGGACCTC 840

CTTAGGCGAC TCCTGGTGTT CGCCCCGGAC AAGCGGTTAA GCGCGACCCA GGCACTGCAG 900

CACCCCTACG TGCAGAGGTT CCACTGCCCC AGCGACGAGT GGGCACGAGA GGCAGATGTG 960

CGGCTCCGGG CACACGAAGG GGTCCAGCTC TCTGTGCCTG AGTACCGTAG CCGCGTCTAT 1020

CAGATGATCC TGGAGTATGG AGGCAGCAGC GGCACCTCGA GAGAGAAGGG CCCGGAGGGT 1080

GTCTCCCCAA GCCAGGCACA CATGCACAAA CCCAGAGCCG ACCCTCAGCT GCCTTCTAGG 1140

ACATCTGTGC AGGGTCCCAG ACCCAGGCCC CAGAGCAGCC CAGGCCATGA CCCCGCCGAG 1200

CACGAGTCCC CCCATGCAGC CAAGAACGTT CCCAGGCAGA ACTCTGCTCC CCTGCTCCAA 1260

ACTGCACTCC TAGGGAATGG GGAAAGGCCC CCTGGGGCAA AGGAAGCGCC CCCCTTGACA 1320

CTCTCGCTGG TGAAGCCAAG CGGGAGGGGA GCTGCGCCCT CCCTGACCTC CCAGGCTGCG 1380

GCTCAGGTGG CCAACCAGGC CCTGATCCGG GGTGACTGGA ACCGGGGCGG TGGGGTGAGG 1440

GTGGCCAGCG CACAACAGGT CCCTCCCCGG CTTCCTCCGG AGGCCCGGCC CGGCCGGAGG 1500

ATGTTCAGCA CCTCTGCCTT GCAGGGTGCC CAGGGGGGTG CCAGGGCTTT GCTTGGAGGC 1560

TACTCCCAAG CCTACGGGAC TATCTGCCAC TCGGCACTGG GCCACCTGCC CCTGCTGGAG 1620

GGGCACCATG TGTGA 1635

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE++ll+e+ +h+Ni

Q: 14    LLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFgDHPNI  73

         56799*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i+lldv+++e+     +d+Ylv+e+m+tdL++vi++   l+d h+++++yq+lr++++lH

Q: 74    ISLLDVIRAEN----DRDIYLVFEFMDTDLNAVIRKGgLLQDVHVRSIFYQLLRATRFLH  129

         ********999....9********************999*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         s +v+HrD+KPsN+l++++c++k++dFGlars  +  e      +teyvatrwYraPe+l

Q: 130   SGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPedqaVTEYVATRWYRAPEVL  189

         ********************************766554444566****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls+++yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+ile+++ psee+l ++ s +

Q: 190   LSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGC  249

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

          ++++++l +++++++++l+p  +s+ealdLl++lLv++pdkR+s+++aL+hpY+

Q: 250   RASVLHHLGSRPRQTLDALLPPdTSPEALDLLRRLLVFAPDKRLSATQALQHPYV  304

         *******************986599*****************************7

Domain Sequence
(FASTA)

LLRRQLGQGA YGIVWKAVDR RTGEVVAIKK IFDAFRDKTD AQRTFREITL LQEFGDHPNI 60

ISLLDVIRAE NDRDIYLVFE FMDTDLNAVI RKGGLLQDVH VRSIFYQLLR ATRFLHSGHV 120

VHRDQKPSNV LLDANCTVKL CDFGLARSLG DLPEGPEDQA VTEYVATRWY RAPEVLLSSH 180

RYTLGVDMWS LGCILGEMLR GRPLFPGTST LHQLELILET IPPPSEEDLL ALGSGCRASV 240

LHHLGSRPRQ TLDALLPPDT SPEALDLLRR LLVFAPDKRL SATQALQHPY V 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013