EKS-GOG-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	451.3	1.2E-135	272	521	250

Status

Unreviewed

Ensembl Protein

ENSGGOP00000007888

UniProt Accession

G3QYF5;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000008065	ENSGGOP00000007888	ENSGGOT00000008104

Organism

Gorilla gorilla

Functional Description

Protein Length

538

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTAGVTLFVA LYDYEARTED DLSFHKGEKF QILNSSEGDW 120

WEARSLTTGE TGYIPSNYVA PVDSIQAEEW YFGKLGRKDA ERQLLSFGNP RGTFLIRESE 180

TTKGAYSLSI RDWDDMKGDH VKHYKIRKLD NGGYYITTRA QFETLQQLVQ HYSERAAGLC 240

CRLVVPCHKG MPRLTDLSVK TKDVWEIPRE SLQLIKRLGN GQFGEVWMGT WNGNTKVAIK 300

TLKPGTMSPE SFLEEAQIMK KLKHDKLVQL YAVVSEEPIY IVTEYMNKGS LLDFLKDGEG 360

RALKLPNLVD MAAQVAAGMA YIERMNYIHR DLRSANILVG NGLICKIADF GLARLIEDNE 420

YTARQGAKFP IKWTAPEAAL YGRFTIKSDV WSFGILLTEL VTKGRVPYPG MNNREVLEQV 480

ERGYRMPCPQ DCPISLHELM IHCWKKDPEE RPTFEYLQSF LEDYFTATEP QYQPGENL 538

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACGGAGGA GAGGGACGGC 60

AGCCTGAACC AGAGCTCTGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 120

AGCTTCGGCG TGACCTCCAT CCCCAACTAC AACAACTTCC ATGCAGCCGG GGGCCAAGGA 180

CTCACCGTCT TTGGAGGTGT GAACTCTTCG TCTCATACGG GGACCTTGCG TACGAGAGGA 240

GGAACAGCAG GAGTGACACT CTTTGTGGCC CTTTATGACT ATGAAGCACG GACAGAAGAT 300

GACCTGAGTT TTCACAAAGG AGAAAAATTT CAAATATTGA ACAGCTCGGA AGGAGATTGG 360

TGGGAAGCCC GCTCCTTGAC AACTGGAGAG ACAGGTTACA TTCCCAGCAA TTATGTGGCT 420

CCAGTTGACT CTATCCAGGC AGAAGAGTGG TACTTTGGAA AACTTGGCCG AAAAGATGCT 480

GAGCGACAGC TATTGTCCTT TGGAAACCCA AGAGGTACCT TTCTTATCCG CGAGAGTGAA 540

ACCACCAAAG GTGCCTATTC ACTTTCCATC CGTGATTGGG ATGATATGAA AGGAGACCAT 600

GTCAAACATT ATAAAATTCG CAAACTTGAC AATGGTGGAT ACTACATTAC CACCCGGGCC 660

CAGTTTGAAA CACTTCAGCA GCTTGTACAA CATTACTCAG AGAGAGCTGC AGGTCTCTGC 720

TGCCGCCTAG TAGTTCCCTG TCACAAAGGG ATGCCAAGGC TTACCGATCT GTCTGTCAAA 780

ACCAAAGATG TCTGGGAAAT CCCTCGAGAA TCCCTGCAGT TGATCAAGAG ACTGGGAAAT 840

GGGCAGTTTG GGGAAGTATG GATGGGTACC TGGAATGGAA ACACAAAAGT AGCCATAAAG 900

ACTCTTAAAC CAGGCACAAT GTCCCCCGAA TCATTCCTTG AGGAAGCGCA GATCATGAAG 960

AAGCTGAAGC ACGACAAGCT GGTCCAGCTC TATGCAGTGG TGTCTGAGGA GCCCATCTAC 1020

ATCGTCACCG AGTATATGAA CAAAGGAAGT TTACTGGATT TCTTAAAAGA TGGAGAAGGA 1080

AGAGCTCTGA AATTACCAAA TCTTGTGGAC ATGGCAGCAC AGGTGGCTGC AGGAATGGCT 1140

TACATCGAGC GCATGAATTA TATCCATAGA GATCTGCGAT CAGCAAACAT TCTAGTGGGG 1200

AATGGACTCA TATGCAAGAT TGCTGACTTT GGATTGGCCC GATTGATCGA AGACAATGAG 1260

TACACAGCAA GACAAGGTGC AAAGTTCCCC ATCAAGTGGA CGGCCCCTGA GGCAGCCCTG 1320

TACGGGAGGT TCACAATCAA GTCTGACGTG TGGTCTTTTG GAATCTTACT CACAGAGCTG 1380

GTCACCAAAG GAAGAGTGCC ATACCCAGGC ATGAACAACC GGGAGGTGCT GGAGCAGGTG 1440

GAGCGAGGCT ACAGGATGCC CTGCCCGCAG GACTGCCCCA TCTCTCTGCA TGAGCTCATG 1500

ATCCACTGCT GGAAAAAGGA CCCTGAAGAA CGCCCCACTT TTGAGTACTT GCAGAGCTTC 1560

CTGGAAGACT ACTTTACCGC GACAGAGCCC CAGTACCAAC CTGGTGAAAA CCTGTAA 1617

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly

Q: 272   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  331

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 332   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  390

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 391   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  450

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee

Q: 451   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  510

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 511   RPTFEYLQSFL  521

         ********986

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013