EKS-GOG-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	558.5	2.6E-168	501	777	277

Status

Unreviewed

Ensembl Protein

ENSGGOP00000008150

UniProt Accession

G3QZ51;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000008336	ENSGGOP00000008150	ENSGGOT00000008376

Organism

Gorilla gorilla

Functional Description

Protein Length

841

Protein Sequence
(FASTA)

MGLTSTWRYG RGPGIGTVTM VSWGRFICLV VVTMATLSLA RPSFSLVEDT TLEPEEPPTK 60

YQISQPEVYV AAPGESLEVR CLLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD 120

SGLYACTASR TVDSETWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNNK RAPYWTNTEK 180

MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240

VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300

SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EADAGEYICK 360

VSNYIGQANQ SAWLTVLPKQ QAPGREKEIT ASPDYLEIAI YCIGVFLIAC MVVTVILCRM 420

KNTTKKPDFS SQPAVHKLTK RIPLRRQVTV SAESSSSMNS NTPLVRITTR LSSTADTPML 480

AGVSEYELPE DPKWEFPRDK LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK 540

DDATEKDLSD LVSEMEMMKM IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR 600

PPGMEYSYDI NRVPEEQMTF KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM 660

KIADFGLARD INNIDYYKKT TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG 720

GSPYPGIPVE ELFKLLKEGH RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDLDRI 780

LTLTTNEEYL DLSQPLEQYS PSYPDTRSSC SSGDDSVFSP DPMPYEPCLP QYPHINGSVK 840

T 841

Nucleotide Sequence
(FASTA)

ATGGGATTAA CGTCCACATG GAGATATGGA AGAGGACCGG GGATTGGTAC CGTAACCATG 60

GTCAGCTGGG GTCGGTTCAT CTGCCTGGTC GTGGTCACCA TGGCAACCTT GTCCCTGGCC 120

CGGCCCTCCT TCAGTTTAGT TGAGGATACC ACATTAGAGC CAGAAGAGCC ACCAACCAAA 180

TACCAAATCT CTCAACCAGA AGTGTACGTG GCTGCACCAG GGGAGTCGCT AGAGGTGCGC 240

TGCCTGTTGA AAGATGCCGC CGTGATCAGT TGGACTAAGG ATGGGGTGCA CTTGGGGCCC 300

AACAATAGGA CAGTGCTTAT TGGGGAGTAC TTGCAGATAA AGGGCGCCAC GCCTAGAGAC 360

TCCGGCCTCT ATGCTTGTAC TGCCAGTAGG ACTGTAGACA GTGAAACTTG GTACTTCATG 420

GTGAATGTCA CAGATGCTAT CTCATCCGGA GATGATGAGG ATGACACCGA TGGTGCGGAA 480

GATTTTGTCA GTGAGAACAG TAACAACAAG AGAGCACCAT ACTGGACCAA CACAGAAAAG 540

ATGGAAAAGC GGCTCCATGC TGTGCCTGCG GCCAACACTG TCAAGTTTCG CTGCCCAGCC 600

GGGGGGAACC CAACGCCAAC CATGCGGTGG CTGAAAAACG GGAAGGAGTT TAAGCAGGAG 660

CATCGCATTG GAGGCTACAA GGTACGAAAC CAGCACTGGA GCCTCATTAT GGAAAGCGTG 720

GTCCCATCTG ACAAGGGAAA TTATACCTGT GTGGTGGAGA ATGAATACGG GTCCATCAAT 780

CACACGTACC ACCTGGATGT TGTGGAGCGA TCGCCTCACC GGCCCATCCT CCAAGCCGGA 840

CTGCCGGCAA ATGCCTCCAC AGTGGTCGGA GGAGACGTAG AGTTTGTCTG CAAGGTTTAC 900

AGTGATGCCC AGCCCCACAT CCAGTGGATC AAGCACGTGG AAAAGAACGG CAGTAAATAC 960

GGGCCCGACG GGCTGCCCTA CCTCAAGGTT CTCAAGCACT CGGGGATAAA TAGTTCCAAT 1020

GCAGAAGTGC TGGCTCTGTT CAATGTGACC GAGGCGGATG CTGGGGAATA TATATGTAAG 1080

GTCTCCAATT ATATAGGGCA GGCCAACCAG TCTGCCTGGC TCACTGTCCT GCCAAAACAG 1140

CAAGCACCTG GAAGAGAAAA GGAGATTACA GCTTCCCCAG ACTACCTGGA GATAGCCATT 1200

TACTGCATAG GGGTCTTCTT AATCGCCTGT ATGGTGGTAA CAGTCATCCT GTGCCGAATG 1260

AAGAACACGA CCAAGAAGCC AGACTTCAGC AGTCAGCCGG CTGTGCACAA GCTGACCAAA 1320

CGTATCCCTC TGCGGAGACA GGTAACAGTT TCGGCTGAGT CCAGCTCCTC CATGAACTCC 1380

AACACCCCAC TGGTGAGGAT AACAACACGC CTCTCTTCAA CGGCAGACAC CCCCATGCTG 1440

GCAGGGGTCT CCGAGTATGA ACTTCCAGAG GACCCAAAAT GGGAGTTTCC AAGAGATAAG 1500

CTGACACTGG GCAAGCCCCT GGGAGAAGGT TGCTTTGGGC AAGTGGTCAT GGCGGAAGCA 1560

GTGGGAATTG ACAAAGACAA GCCCAAGGAG GCGGTCACCG TGGCCGTGAA GATGTTGAAA 1620

GATGATGCCA CAGAGAAAGA CCTTTCTGAT CTGGTGTCAG AGATGGAGAT GATGAAGATG 1680

ATTGGGAAAC ACAAGAATAT CATAAATCTT CTTGGAGCCT GCACACAGGA TGGGCCTCTC 1740

TATGTCATAG TTGAGTATGC CTCTAAAGGC AACCTCCGAG AATACCTCCG AGCCCGGAGG 1800

CCACCCGGGA TGGAGTACTC CTATGACATT AACCGTGTTC CTGAGGAGCA GATGACCTTC 1860

AAGGACTTGG TGTCATGCAC CTACCAGCTG GCCAGAGGCA TGGAGTACTT GGCTTCCCAA 1920

AAATGTATTC ATCGAGATTT AGCAGCCAGA AATGTTTTGG TAACAGAAAA CAATGTGATG 1980

AAAATAGCAG ACTTCGGACT CGCCAGAGAT ATCAACAATA TAGACTATTA CAAAAAGACC 2040

ACCAATGGGC GGCTTCCAGT CAAGTGGATG GCTCCAGAAG CCCTGTTTGA TAGAGTATAC 2100

ACTCATCAGA GTGATGTCTG GTCCTTCGGG GTGTTAATGT GGGAGATCTT CACTTTAGGG 2160

GGCTCGCCCT ACCCAGGGAT TCCCGTGGAG GAACTTTTTA AGCTGCTGAA GGAAGGACAC 2220

AGAATGGATA AGCCAGCCAA CTGCACCAAC GAACTGTACA TGATGATGAG GGACTGTTGG 2280

CATGCAGTGC CCTCCCAGAG ACCAACATTC AAGCAGTTGG TAGAAGACTT GGATCGAATT 2340

CTCACTCTCA CAACCAATGA GGAATACTTG GACCTCAGCC AACCTCTCGA ACAGTATTCA 2400

CCTAGTTACC CTGACACAAG AAGTTCTTGT TCTTCAGGAG ATGATTCTGT TTTTTCTCCA 2460

GACCCCATGC CTTATGAACC ATGCCTTCCT CAGTATCCAC ACATAAACGG CAGTGTTAAA 2520

ACATGA 2526

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 501   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  560

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+

Q: 561   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  620

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt

Q: 621   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  680

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh

Q: 681   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  740

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 741   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  777

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120

KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013