EKS-GOG-00342

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00342

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	451.2	1.3E-135	127	385	259

Status

Unreviewed

Ensembl Protein

ENSGGOP00000019940

UniProt Accession

G3R096;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK2

Gene Synonyms/Alias

TNK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000008767	ENSGGOP00000008577	ENSGGOT00000008812
ENSGGOG00000008767	ENSGGOP00000019940	ENSGGOT00000023635

Organism

Gorilla gorilla

Functional Description

Protein Length

1032

Protein Sequence
(FASTA)

MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRKALC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK TSPAPGGPAG EGPLQSLTCL 120

IGEKDLRLLE KLGDGSFGVV RRGEWDAPSG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 180

MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 240

GYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 300

SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 360

YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 420

ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 480

RIDELYLGNP MDPPDLLSVE LSTSRRPQHL GGVKREPPPR PPQPAFFTQK PTYDPVSEDQ 540

DPLSSDFKRL GLRKPGLPRG LWLAKPSARV PGTKASRGSG AEVTLIDFGE EPVVPALRPC 600

APSLAQLAMD ACSLLDETPP QSPTRALPRP LHPTPVVDWD ARPLPPPPAY DDVAQDEDDF 660

EICSINSTLV GAGVPAGPSQ GQTNYAFVPE QARPPPPLED NLFLPPQGGG KPPSSAQTAE 720

IFQALQQECM RQLQAPAGSP APSPSPGGDD KPQVPPRVPI PPRPTRPHVQ LSPAPLGEEE 780

TGRWPGPASP PRVPPREPLS PQGSRTPSPL VPPGSSPLPP RLSSSPGKIM PTTQSFASDP 840

KYATPQVIQA PGPRAGPCIL PIVRDGKKVS STHYYLLPER PSYLERYQRF LREAQSPEEP 900

VRPMPQAALD PKANFSTNNS NPGARPPPPR ATARLPQRGC PGDGPEAGRP GDKIQMLQAM 960

VHGVTTEECQ AALQCHGWSV QRAAQYLKVE QLFGLGLRPR GECHKVLEMF DWNLEQAGCH 1020

LLGSWGPAHH KR 1032

Nucleotide Sequence
(FASTA)

ATGCAGCCAG AGGAGGGCAC AGGCTGGCTG CTGGAGCTGC TGTCCGAGGT GCAGCTGCAA 60

CAGTACTTCC TGCGGCTCCG AGACGACCTC AACGTCACCC GCCTGTCCCA CTTTGAGTAC 120

GTCAAGAATG AGGACCTGGA GAAGATCGGC ATGGGCCGGC CTGGCCAGCG GCGGCTGTGG 180

GAGGCTGTGA AGAGGAGGAA GGCCTTGTGC AAACGCAAGT CGTGGATGAG TAAGGTGTTC 240

AGTGGAAAGC GACTGGAGGC TGAGTTCCCC CCTCATCACT CTCAGAGCAC CTTCCGGAAG 300

ACCTCGCCCG CCCCTGGGGG CCCAGCAGGG GAGGGGCCCC TGCAGAGCCT CACCTGCCTC 360

ATTGGGGAGA AGGACCTGCG CCTCCTGGAG AAGCTGGGCG ATGGTTCCTT TGGCGTGGTG 420

CGCAGGGGCG AGTGGGACGC GCCCTCAGGG AAGACGGTGA GTGTGGCTGT GAAGTGCCTG 480

AAGCCCGATG TCCTGAGCCA GCCAGAAGCC ATGGACGACT TCATCCGGGA GGTGAATGCC 540

ATGCACTCGC TCGACCACCG AAACCTCATC CGCCTCTACG GGGTGGTGCT CACGCCGCCC 600

ATGAAGATGG TGACAGAGCT GGCACCTCTG GGATCGTTGT TGGACCGGCT ACGTAAGCAC 660

CAGGGCCACT TCCTCCTGGG GACTCTGAGC CGCTATGCTG TGCAGGTGGC TGAGGGCATG 720

GGCTACCTGG AGTCCAAGCG CTTTATTCAC CGTGACCTGG CTGCCCGCAA TCTGCTGTTG 780

GCTACCCGCG ACCTGGTCAA GATCGGGGAC TTTGGGCTGA TGCGAGCACT ACCTCAGAAT 840

GACGACCATT ACGTCATGCA GGAACATCGC AAGGTGCCCT TCGCCTGGTG TGCCCCCGAG 900

AGCCTGAAGA CACGCACCTT CTCCCATGCC AGCGACACCT GGATGTTCGG GGTGACACTG 960

TGGGAAATGT TCACCTACGG CCAGGAGCCC TGGATCGGCC TCAACGGCAG TCAGATCCTG 1020

CATAAGATCG ACAAGGAGGG GGAGCGGCTG CCCCGGCCCG AGGACTGTCC CCAGGACATC 1080

TACAATGTCA TGGTCCAGTG CTGGGCTCAC AAGCCAGAGG ACAGACCCAC GTTTGTGGCC 1140

CTGCGGGACT TCCTGCTGGA GGCCCAGCCC ACAGACATGC GGGCCCTTCA GGACTTTGAG 1200

GAACCGGACA AGCTGCACAT CCAGATGAAT GATGTCATCA CCGTCATTGA GGGAAGGGCC 1260

GAGAACTACT GGTGGCGTGG GCAGAACACA CGGACGCTGT GTGTGGGGCC CTTCCCTCGC 1320

AACGTGGTGA CCTCTGTGGC CGGCCTGTCG GCCCAGGACA TCAGCCAGCC CCTGCAGAAC 1380

AGCTTCATCC ACACAGGGCA TGGCGACAGT GACCCCCGCC ACTGCTGGGG CTTCCCGGAC 1440

AGGATTGACG AACTGTATCT GGGAAACCCC ATGGACCCCC CCGACCTCCT GAGCGTGGAA 1500

CTGAGCACCT CCCGGCGCCC CCAGCATCTA GGAGGGGTGA AAAGGGAGCC TCCACCTCGC 1560

CCACCTCAGC CTGCCTTCTT CACTCAGAAA CCAACCTATG ACCCTGTGAG CGAGGACCAA 1620

GACCCCTTGT CCAGCGACTT CAAGAGGCTG GGCCTGCGGA AGCCAGGCCT GCCCCGAGGG 1680

CTGTGGCTGG CGAAGCCCTC GGCGCGGGTG CCGGGCACCA AGGCCAGCCG AGGCAGCGGG 1740

GCTGAGGTCA CGCTCATCGA CTTTGGTGAG GAGCCCGTGG TCCCGGCCCT ACGGCCCTGC 1800

GCGCCCTCCC TGGCGCAGCT GGCCATGGAC GCCTGCTCCC TGCTGGACGA GACCCCGCCT 1860

CAGAGCCCCA CGCGGGCACT GCCCCGGCCC CTGCACCCCA CGCCTGTGGT GGACTGGGAC 1920

GCACGCCCGC TGCCCCCCCC GCCCGCCTAT GACGACGTGG CCCAGGATGA GGATGACTTT 1980

GAGATCTGCT CCATCAACAG CACCCTCGTG GGCGCGGGGG TCCCTGCCGG GCCCAGCCAG 2040

GGCCAGACCA ACTACGCCTT TGTGCCTGAG CAGGCGCGGC CGCCTCCTCC CTTGGAGGAC 2100

AACCTGTTCC TGCCACCCCA GGGTGGGGGC AAGCCGCCCA GCTCCGCACA GACCGCAGAG 2160

ATCTTCCAGG CGCTGCAGCA GGAGTGCATG AGGCAACTGC AGGCTCCGGC CGGCTCCCCG 2220

GCCCCCTCTC CCAGCCCGGG GGGTGACGAC AAGCCCCAGG TGCCTCCTCG GGTACCCATC 2280

CCACCTCGGC CCACACGCCC CCACGTCCAG CTGTCTCCAG CCCCCTTGGG CGAGGAGGAG 2340

ACCGGCCGGT GGCCTGGACC TGCTTCCCCT CCCCGGGTGC CTCCGCGGGA GCCCCTGTCC 2400

CCTCAAGGCT CGAGGACACC CAGCCCCCTG GTACCACCTG GCAGCTCCCC GCTGCCACCC 2460

CGGCTCTCAA GCTCACCTGG GAAGATCATG CCCACCACCC AGAGCTTTGC CTCAGACCCC 2520

AAGTACGCCA CCCCCCAGGT GATCCAGGCC CCTGGCCCGC GGGCTGGTCC CTGCATCCTG 2580

CCCATCGTCC GGGATGGCAA GAAGGTCAGC AGCACCCACT ATTACTTGCT GCCCGAGCGA 2640

CCGTCCTACC TGGAGCGCTA CCAGCGCTTC CTGCGTGAGG CCCAGAGCCC CGAGGAGCCG 2700

GTGCGGCCGA TGCCCCAGGC TGCCTTGGAC CCCAAGGCCA ACTTCTCCAC CAACAACAGC 2760

AACCCAGGGG CCCGGCCACC ACCCCCGAGG GCCACTGCTC GGCTGCCACA GAGGGGCTGC 2820

CCTGGCGATG GGCCAGAGGC GGGCCGGCCA GGAGACAAGA TCCAGATGCT GCAGGCCATG 2880

GTGCATGGGG TGACCACAGA GGAGTGCCAG GCGGCCCTGC AGTGCCACGG CTGGAGCGTG 2940

CAGAGGGCTG CCCAGTATCT GAAGGTGGAG CAGCTCTTCG GGCTGGGTCT GCGGCCCAGA 3000

GGGGAGTGCC ACAAAGTGCT GGAGATGTTC GACTGGAACC TGGAGCAGGC CGGCTGCCAC 3060

CTTCTGGGCT CCTGGGGCCC TGCCCACCAC AAGCGCTGA 3099

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60

         +lleklG+Gsfgvv+rgeW+apsgk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h

Q: 127   RLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  186

         789****************************************99***************

S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120

         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle

Q: 187   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  244

         ***********************************9..9*********************

S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180

         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t

Q: 245   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  304

         ************************************************************

S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240

         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++

Q: 305   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVM  364

         ************************************************************

S: 241   lkcWakkpadrpkfsalkekl  261

         ++cWa+kp+drp+f+al+++l

Q: 365   VQCWAHKPEDRPTFVALRDFL  385

         ******************986

Domain Sequence
(FASTA)

RLLEKLGDGS FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60

RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120

RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180

FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDIYNVMVQ 240

CWAHKPEDRP TFVALRDFL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013