EKS-GOG-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	384.0	4.9E-115	73	369	297

Status

Unreviewed

Ensembl Protein

ENSGGOP00000008637

UniProt Accession

G3R0F2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000008832	ENSGGOP00000008637	ENSGGOT00000008873

Organism

Gorilla gorilla

Functional Description

Protein Length

400

Protein Sequence
(FASTA)

MLARRKPVLP ALTINPTIAE GPSPTSEGAS EANLVDLQKK LEELELDEQQ KKRLEAFLTQ 60

KAKVGELKDD DFERISELGA GNGGVVTKVQ HRPSGLIMAR KLIHLEIKPA IRNQIIRELQ 120

VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEEIL GKVSIAVLRG 180

LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMAPERLQ 240

GTHYSVQSDI WSMGLSLVEL AVGRYPIPPP DAKELEAIFG RPVVDGEEGE PHSISPRPRP 300

PGRPVSGHGM DSRPAMAIFE LLDYIVNEPP PKLPNGVFTP DFQEFVNKCL IKNPAERADL 360

KMLTNHTFIK RSEVEEVDFA GWLCKTLRLN QPGTPTRTAV 400

Nucleotide Sequence
(FASTA)

ATGCTGGCCC GGAGGAAGCC GGTGCTGCCG GCGCTCACCA TCAACCCTAC CATCGCCGAG 60

GGCCCATCCC CTACCAGCGA GGGCGCCTCC GAGGCAAACC TGGTGGACCT GCAGAAGAAG 120

CTGGAGGAGC TGGAACTTGA CGAGCAGCAG AAGAAGCGGC TGGAAGCCTT TCTCACCCAG 180

AAAGCCAAGG TCGGTGAACT CAAAGACGAT GACTTCGAAA GGATCTCAGA GCTGGGCGCA 240

GGCAACGGCG GGGTGGTCAC CAAAGTCCAG CACAGACCCT CGGGCCTCAT CATGGCCAGG 300

AAGCTGATCC ACCTTGAGAT CAAGCCGGCC ATCCGGAACC AGATCATCCG CGAGCTGCAG 360

GTCCTGCACG AATGCAACTC GCCGTACATC GTGGGCTTCT ACGGGGCCTT CTACAGTGAC 420

GGGGAGATCA GCATCTGCAT GGAACACATG GATGGCGGCT CCCTGGACCA GGTGCTGAAA 480

GAGGCCAAGA GGATTCCCGA GGAGATCCTG GGGAAAGTCA GCATCGCGGT TCTCCGGGGC 540

TTGGCGTACC TCCGAGAGAA GCACCAGATC ATGCACCGAG ATGTGAAGCC CTCCAACATC 600

CTCGTGAACT CTAGAGGGGA GATCAAGCTG TGTGACTTCG GAGTGAGCGG CCAGCTCATC 660

GACTCCATGG CCAACTCCTT CGTGGGCACG CGCTCCTACA TGGCTCCGGA GCGGTTGCAG 720

GGCACACATT ACTCGGTGCA GTCGGACATC TGGAGCATGG GCCTGTCCCT GGTGGAGCTG 780

GCCGTCGGAA GGTACCCCAT CCCCCCGCCC GACGCCAAAG AGCTGGAGGC CATCTTTGGC 840

CGGCCCGTGG TCGACGGGGA AGAAGGAGAG CCTCACAGCA TCTCGCCTCG GCCGAGGCCC 900

CCCGGGCGCC CCGTCAGCGG TCACGGGATG GATAGCCGGC CCGCCATGGC CATCTTTGAA 960

CTCCTGGACT ATATTGTGAA CGAGCCGCCT CCTAAGCTGC CCAACGGTGT GTTCACCCCC 1020

GACTTCCAGG AGTTTGTCAA TAAATGCCTC ATCAAGAACC CAGCGGAGCG GGCGGACCTG 1080

AAGATGCTCA CAAACCACAC CTTCATCAAG CGGTCCGAGG TGGAAGAAGT GGATTTTGCC 1140

GGCTGGTTGT GTAAAACCCT GCGGCTGAAC CAGCCCGGCA CACCCACGCG CACCGCCGTG 1200

TGA 1203

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e+++elGaGnggvV+kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 73    ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  131

         789**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    +kripe++lgk+++av+++l+yl+ek

Q: 132   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEEILGKVSIAVLRGLAYLREK  187

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYmaPEr++g ++Ysv

Q: 188   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQG-THYSV  246

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lvela+gryp++++++

Q: 247   QSDIWSMGLSLVELAVGRYPIPPPDAkeleaifgrpvvdgeegephsisprprppgrpvs  306

         ************************999*********************************

S: 208   ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh  256

                    i+ell++ivne+ppklp+  f+++fqefv+kCl+k+++eR++lk+l++h

Q: 307   ghgmdsrpamaIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNH  366

         ************************************************************

S: 257   afi  259

+fi

Q: 367   TFI  369

*97

Domain Sequence
(FASTA)

ERISELGAGN GGVVTKVQHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMAPERLQGT HYSVQSDIWS 180

MGLSLVELAV GRYPIPPPDA KELEAIFGRP VVDGEEGEPH SISPRPRPPG RPVSGHGMDS 240

RPAMAIFELL DYIVNEPPPK LPNGVFTPDF QEFVNKCLIK NPAERADLKM LTNHTFI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013