EKS-GOG-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	497.7	8.7E-150	421	678	258

Status

Unreviewed

Ensembl Protein

ENSGGOP00000008643

UniProt Accession

G3R0F8;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA3

Gene Synonyms/Alias

RPS6KA3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000008837	ENSGGOP00000008643	ENSGGOT00000008879

Organism

Gorilla gorilla

Functional Description

Protein Length

739

Protein Sequence
(FASTA)

MPLAQLADPW QKMAVESPSD SAEVSAAGRP GPLLLLRLSQ QEEVSIKEIA ITHHVKEGHE 60

KADPSQFELL KVLGQGSFGK VFLVKKISGS DARQLYAMKV LKKATLKVRD RVRTKMERDI 120

LVEVNHPFIV KLHYAFQTEG KLYLILDFLR GGDLFTRLSK EVMFTEEDVK FYLAELALAL 180

DHLHSLGIIY RDLKPENILL DEEGHIKLTD FGLSKESIDH EKKAYSFCGT VEYMAPEVVN 240

RRGHTQSADW WSFGVLMFEM LTGTLPFQGK DRKETMTMIL KAKLGMPQFL SPEAQSLLRM 300

LFKRNPANRL GAGPDGVEEI KRHSFFSTID WNKLYRREIH PPFKPATGRP EDTFYFDPEF 360

TAKTPKDSPG IPPSANAHQL FRGFSFVAIT SDDESQAMQT VGVHSIVQQL HRNSIQFTDG 420

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 480

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 540

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 600

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 660

VDPHQRLTAA LVLRHPWIVH WDQLPQYQLN RQDAPHLVKG AMAATYSALN RNQSPVLEPV 720

GRSTLAQRRG IKKITSTAL 739

Nucleotide Sequence
(FASTA)

ATGCCGCTGG CGCAGCTGGC GGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCGTCCGAC 60

AGCGCTGAGG TGAGTGCAGC AGGGCGGCCG GGGCCGTTGC TCCTCTTACG TTTATCTCAA 120

CAGGAAGAAG TCAGTATCAA AGAAATTGCA ATCACACATC ATGTAAAGGA AGGACATGAA 180

AAGGCAGATC CTTCCCAGTT TGAACTTTTA AAAGTATTAG GGCAGGGATC ATTTGGAAAG 240

GTTTTCTTAG TTAAAAAAAT CTCAGGCTCT GATGCTAGGC AGCTTTATGC CATGAAGGTA 300

TTGAAGAAGG CCACACTGAA AGTTCGAGAC CGAGTTCGGA CAAAAATGGA ACGTGATATC 360

TTGGTAGAGG TTAATCATCC TTTTATTGTC AAGTTGCATT ATGCTTTTCA AACTGAAGGG 420

AAGTTGTATC TTATTTTGGA TTTTCTCAGG GGAGGAGATT TGTTTACACG TTTATCCAAA 480

GAGGTGATGT TCACAGAAGA AGATGTCAAA TTCTACTTGG CTGAACTTGC ACTTGCTTTA 540

GACCATCTAC ATAGCCTGGG AATAATTTAT AGAGACTTAA AACCAGAAAA TATACTTCTT 600

GATGAAGAAG GTCACATCAA GTTAACAGAT TTCGGCCTAA GTAAAGAGTC TATTGACCAT 660

GAAAAGAAGG CATATTCTTT TTGTGGAACT GTGGAGTATA TGGCTCCAGA AGTAGTTAAT 720

CGTCGAGGTC ATACTCAGAG TGCTGACTGG TGGTCTTTTG GTGTGTTAAT GTTTGAAATG 780

CTTACTGGTA CACTACCTTT CCAAGGAAAA GATCGAAAAG AAACAATGAC TATGATTCTT 840

AAAGCCAAAC TTGGAATGCC ACAGTTTTTG AGTCCTGAAG CCCAGAGTCT TTTACGAATG 900

CTTTTCAAGC GAAATCCTGC AAACAGATTA GGTGCAGGAC CAGATGGAGT TGAAGAAATT 960

AAAAGACATT CATTTTTCTC AACGATAGAC TGGAATAAAC TGTATAGAAG AGAAATTCAT 1020

CCGCCATTTA AACCTGCAAC GGGCAGGCCT GAAGATACAT TCTATTTTGA TCCTGAGTTT 1080

ACTGCAAAAA CTCCCAAAGA TTCACCTGGC ATTCCACCTA GTGCTAATGC ACATCAGCTT 1140

TTTCGGGGGT TTAGTTTTGT CGCTATTACC TCAGATGATG AAAGCCAAGC TATGCAGACA 1200

GTTGGTGTAC ATTCAATTGT TCAGCAGTTA CACAGGAACA GTATTCAGTT TACTGATGGA 1260

TATGAAGTAA AAGAAGATAT TGGAGTTGGC TCCTACTCTG TTTGCAAGAG ATGTATACAT 1320

AAAGCTACAA ACATGGAGTT TGCAGTGAAG ATTATTGATA AAAGCAAGAG AGACCCAACA 1380

GAAGAAATTG AAATTCTTCT TCGTTATGGA CAGCATCCAA ACATCATCAC TCTAAAGGAT 1440

GTATATGATG ATGGAAAATA TGTGTATGTA GTAACAGAAC TTATGAAAGG AGGTGAATTG 1500

CTGGATAAAA TTCTTAGACA AAAATTTTTC TCTGAACGAG AGGCCAGTGC TGTCCTGTTC 1560

ACTATAACTA AAACCGTTGA ATATCTTCAC GCACAAGGGG TGGTTCATAG AGACTTGAAA 1620

CCTAGCAACA TTCTTTATGT GGATGAATCT GGTAATCCGG AATCTATTCG AATTTGTGAT 1680

TTTGGCTTTG CAAAACAGCT GAGAGCGGAA AATGGTCTTC TCATGACTCC TTGTTACACT 1740

GCAAATTTTG TTGCACCAGA GGTTTTAAAA AGACAAGGCT ATGATGCTGC TTGTGATATA 1800

TGGAGTCTTG GTGTCCTACT CTATACAATG CTTACCGGTT ACACTCCATT TGCAAATGGT 1860

CCTGATGATA CACCAGAGGA AATATTGGCA CGAATAGGTA GCGGAAAATT CTCACTCAGT 1920

GGTGGTTACT GGAATTCTGT TTCAGACACA GCAAAGGACC TGGTGTCAAA GATGCTTCAT 1980

GTAGACCCTC ATCAGAGACT GACTGCTGCT CTTGTGCTCA GACATCCTTG GATCGTCCAC 2040

TGGGACCAAC TGCCGCAATA CCAACTAAAC AGACAGGATG CACCACATCT AGTAAAGGGT 2100

GCCATGGCAG CTACATATTC TGCTTTGAAC CGTAATCAGT CACCAGTTTT GGAACCAGTA 2160

GGCCGCTCTA CTCTTGCTCA GCGGAGAGGT ATTAAAAAAA TCACCTCAAC AGCCCTGTGA 2220

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd

Q: 421   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  480

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 481   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK  540

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 541   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  600

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+

Q: 601   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  660

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++ +l+h+w+

Q: 661   VDPHQRLTAALVLRHPWI  678

         *****************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240

VDPHQRLTAA LVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013