EKS-GOG-00397
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00397
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR576.13.9E-173574902329
StatusUnreviewed
Ensembl ProteinENSGGOP00000016943
UniProt AccessionG3R0P7;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000008936ENSGGOP00000008739ENSGGOT00000008978
ENSGGOG00000008936ENSGGOP00000016943ENSGGOT00000026868
OrganismGorilla gorilla
Functional Description
Protein Length951
Protein Sequence
(FASTA)
MGPGVLLLLL VATAWHGQGI PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL 60
YSDGSSSILR TNNATFQNTR TYRCTEPGDP LGGSATIHLY VKDPARPWNV LAQEVVVFED 120
QDALLPCLLT DPVLEAGVSL VRVRGRPLMR HTNYSFSPWH GFTIHKAKFI QSQDYQCSAL 180
MGGRKVMSIS IRLKVQKVIP GPPALTLVPA ELVRIQGEAA QIVCSASSVD VNFDVFLQHN 240
NTKLAIPQQS DFHNNRYQKV LTLNLDRVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY 300
LNLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY 360
RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTF INGSGTLLCA 420
ASGYPQPNVT WLQCSGHTDR CDEAQVLQVW DDPYPEVLSQ EPFHKVTVQS LLTVETLEHN 480
QTYECRAHNS VGSDSWAFRP TASSGAHTHP LDEFLFTPVV VACMSIMALY KYKQKPKYQV 540
RWKIIESYEG NSYTFIDPTQ LPYNEKWEFP RNNLQFGKTL GAGAFGKVVE ATAFGLGKED 600
AVLKVAVKML KSTAHADEKE ALMSELKIMS HLGQHENIVN LLGACTHGGP VLVITEYCCY 660
GDLLNFLRRK AEAMLGPSLS PGQDPEGGVD YKNIHLEKKY VRRDSGFSSQ GVDTYVEMRP 720
VSTSSNDSFS EQDLDKEDGR PLELRDLLHF SSQVAQGMAF LASKNCIHRD VAARNVLLTN 780
GHVAKIGDFG LARDIMNDSN YIVKGNARLP VKWMAPESIF DCVYTVQSDV WSYGILLWEI 840
FSLGLNPYPG ILVNSKFYKL VKDGYQMAQP AFAPKNIYSI MQACWALEPT HRPTFQQICS 900
FLQEQAQEDR RERDYTNLRE LEEESSSEHL TCCEQGDIAQ PLLQPNNYQF C 951
Nucleotide Sequence
(FASTA)
ATGGGCCCAG GAGTTCTGCT GCTCCTGCTG GTGGCCACAG CTTGGCATGG TCAGGGAATC 60
CCAGTGATAG AGCCCAGTGT CCCTGAGCTG GTCGTGAAGC CAGGAGCAAC GGTGACCTTG 120
CGATGTGTGG GCAACGGCAG CGTGGAATGG GATGGCCCCC CATCACCTCA CTGGACCCTG 180
TACTCTGATG GCTCCAGCAG CATCCTCCGC ACCAACAACG CTACCTTCCA AAACACGCGG 240
ACCTATCGCT GCACTGAGCC TGGAGACCCC CTGGGAGGCA GCGCCACCAT CCACCTCTAC 300
GTCAAAGACC CTGCCCGGCC CTGGAACGTG CTAGCACAGG AGGTGGTCGT GTTCGAGGAC 360
CAGGACGCAC TACTGCCCTG TCTGCTCACA GACCCGGTGC TGGAAGCAGG CGTCTCGCTG 420
GTGCGTGTGC GTGGCCGGCC CCTCATGCGC CACACCAACT ACTCCTTCTC GCCCTGGCAT 480
GGCTTCACCA TCCACAAGGC CAAGTTCATT CAGAGCCAGG ACTATCAATG CAGTGCCCTG 540
ATGGGTGGCA GGAAGGTGAT GTCCATCAGC ATCCGGCTGA AAGTGCAGAA AGTCATCCCA 600
GGGCCCCCAG CCTTGACACT GGTGCCTGCA GAGCTGGTGC GGATTCAAGG GGAGGCTGCC 660
CAGATCGTGT GCTCAGCCAG CAGCGTTGAT GTTAACTTTG ATGTCTTCCT CCAACACAAC 720
AACACCAAGC TCGCAATCCC TCAACAATCT GACTTTCATA ATAACCGTTA CCAAAAAGTT 780
CTGACCCTCA ACCTGGATCG AGTAGATTTC CAACATGCCG GCAACTACTC CTGCGTGGCC 840
AGCAACGTGC AGGGCAAGCA CTCCACCTCC ATGTTCTTCC GGGTGGTAGA GAGTGCCTAC 900
TTGAACTTGA GCTCTGAGCA GAACCTCATC CAGGAGGTGA CCGTGGGGGA GGGGCTCAAC 960
CTCAAAGTCA TGGTGGAGGC CTACCCAGGC CTGCAAGGTT TTAACTGGAC CTACCTGGGA 1020
CCCTTTTCTG ACCACCAGCC TGAGCCCAAG CTTGCTAATG CTACCACCAA GGACACATAC 1080
AGGCACACCT TCACCCTCTC TCTGCCCCGC CTGAAGCCCT CTGAGGCTGG CCGCTACTCC 1140
TTCCTGGCCA GAAACCCAGG AGGCTGGAGA GCTCTGACGT TTGAGCTCAC CCTTCGATAC 1200
CCCCCAGAGG TAAGCGTCAT ATGGACATTC ATCAACGGCT CTGGCACCCT TTTGTGTGCT 1260
GCCTCTGGGT ACCCCCAGCC CAACGTGACA TGGCTGCAGT GCAGTGGCCA CACTGATAGG 1320
TGTGATGAGG CCCAAGTGCT GCAGGTCTGG GATGACCCAT ACCCTGAGGT CCTGAGCCAG 1380
GAGCCCTTCC ACAAGGTGAC TGTGCAGAGC CTGCTGACTG TTGAGACCTT AGAGCACAAC 1440
CAAACCTACG AGTGCAGGGC CCACAACAGC GTGGGGAGTG ACTCCTGGGC CTTCAGGCCC 1500
ACAGCATCCT CAGGAGCCCA CACGCATCCC CTGGATGAGT TCCTCTTCAC ACCAGTGGTG 1560
GTTGCCTGCA TGTCCATCAT GGCCTTGTAC AAGTATAAGC AGAAGCCCAA GTACCAGGTC 1620
CGCTGGAAGA TCATCGAGAG CTATGAGGGC AACAGTTATA CTTTCATCGA CCCCACGCAG 1680
CTGCCTTACA ACGAGAAGTG GGAGTTCCCC CGGAACAACC TGCAGTTTGG TAAGACCCTC 1740
GGAGCTGGAG CCTTTGGGAA GGTGGTGGAG GCCACGGCCT TTGGTCTGGG CAAGGAGGAT 1800
GCTGTCCTGA AGGTGGCTGT GAAGATGCTG AAGTCCACGG CCCATGCTGA TGAGAAGGAG 1860
GCCCTCATGT CCGAGCTGAA GATCATGAGC CACCTGGGCC AGCATGAGAA CATAGTCAAC 1920
CTTCTGGGAG CCTGTACCCA TGGAGGCCCT GTACTGGTCA TCACGGAGTA CTGTTGCTAT 1980
GGCGACCTGC TCAACTTTCT GCGAAGGAAG GCTGAGGCCA TGCTGGGACC CAGCCTGAGC 2040
CCCGGCCAGG ACCCCGAGGG AGGCGTCGAC TATAAGAACA TCCACCTCGA GAAGAAATAT 2100
GTCCGCAGGG ACAGTGGCTT CTCCAGCCAG GGTGTGGACA CCTATGTGGA GATGAGGCCT 2160
GTCTCCACTT CTTCAAATGA CTCCTTCTCT GAGCAAGACC TGGACAAGGA GGATGGACGG 2220
CCCCTGGAGC TCCGGGACCT GCTTCACTTC TCCAGCCAAG TAGCTCAGGG CATGGCCTTC 2280
CTCGCTTCCA AGAATTGCAT CCACCGGGAC GTGGCAGCGC GTAACGTGCT GTTGACCAAT 2340
GGTCATGTGG CCAAGATTGG GGACTTCGGG CTGGCTAGGG ACATCATGAA TGACTCCAAC 2400
TACATTGTCA AGGGCAATGC CCGCCTGCCT GTGAAGTGGA TGGCCCCAGA GAGCATCTTT 2460
GACTGTGTCT ACACGGTTCA GAGCGACGTC TGGTCCTATG GCATCCTCCT CTGGGAGATC 2520
TTCTCACTTG GGCTGAATCC CTACCCTGGC ATCCTGGTGA ACAGCAAGTT CTATAAACTG 2580
GTGAAGGATG GATACCAAAT GGCCCAGCCT GCATTTGCCC CAAAGAATAT ATACAGCATC 2640
ATGCAGGCCT GCTGGGCCTT GGAGCCCACC CACAGACCCA CCTTCCAGCA GATCTGCTCC 2700
TTCCTTCAGG AGCAGGCCCA AGAGGACAGG AGAGAGCGGG ACTATACCAA TCTGCGTGAG 2760
CTGGAGGAGG AGAGCTCTAG TGAGCACCTG ACCTGCTGCG AGCAAGGGGA TATCGCCCAG 2820
CCCTTGCTGC AGCCCAACAA CTATCAGTTC TGCTGA 2856
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 574   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  633
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  sl+  +++e  +d+k+
Q: 634   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKN  693
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s++d++++++            l++e
Q: 694   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSNDSFSEQD------------LDKE  737
         *999***********************....9999999999988............8899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 738   DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN  797
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 798   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  857
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q++++l
Q: 858   YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFL  902
         ******************************************986
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSLSPGQ DPEGGVDYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSNDSFSEQD LDKEDGRPLE LRDLLHFSSQ 180
VAQGMAFLAS KNCIHRDVAA RNVLLTNGHV AKIGDFGLAR DIMNDSNYIV KGNARLPVKW 240
MAPESIFDCV YTVQSDVWSY GILLWEIFSL GLNPYPGILV NSKFYKLVKD GYQMAQPAFA 300
PKNIYSIMQA CWALEPTHRP TFQQICSFL 329
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013