EKS-GOG-00433

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00433

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	470.5	2.0E-141	76	338	263

Status

Unreviewed

Ensembl Protein

ENSGGOP00000019791

UniProt Accession

G3RVG1;

Protein Name

Protein Synonyms/Alias

Gene Name

ROCK1

Gene Synonyms/Alias

ROCK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000009574	ENSGGOP00000022771	ENSGGOT00000030938
ENSGGOG00000009574	ENSGGOP00000009363	ENSGGOT00000009627
ENSGGOG00000009574	ENSGGOP00000019791	ENSGGOT00000025826

Organism

Gorilla gorilla

Functional Description

Protein Length

1286

Protein Sequence
(FASTA)

MSTGDSFETR FEKIDNLLRD PKSEVNSDCL LDGLDALVYD LDFPALRKNK NIDNFLSRYK 60

DTINKIRDLR MKAEDYEVVK VIGRGAFGEV QLVRHKSTRK VYAMKLLSKF EMIKRSDSAF 120

FWEERDIMAF ANSPWVVQLF YAFQDDRYLY MVMEYMPGGD LVNLMSNYDV PEKWARFYTA 180

EVVLALDAIH SMGFIHRDVK PDNMLLDKSG HLKLADFGTC MKMNKEGMVR CDTAVGTPDY 240

ISPEVLKSQG GDGYYGRECD WWSVGVFLYE MLVGDTPFYA DSLVGTYSKI MNHKNSLTFP 300

DDNDISKEAK NLICAFLTDR EVRLGRNGVE EIKRHLFFKN DQWAWETLRD TVAPVVPDLS 360

SDIDTSNFDD LEEDKGEEET FPIPKAFVGN QLPFVGFTYY SNRRYLPSAN PNDNRTSSNA 420

DKSLLKQESL QKTIYKLEEQ LHNEMQLKDE MEQKCRTSNI KLDKIMKELD EEGNQRRNLE 480

STVSQIEKEK MLLQHRINEY QRKAEQENEK RRNVENEVST LKDQLEDLKK VSQNSQLANE 540

KLSQLQKQLE EANDLLRTES DTAVRLRKSH TEMSKSISQL ESLNRELQER NRILENSKSQ 600

TDKDYYQLQA ILEAERRDRG HDSEMVGKLI ARITSLQEEV KHLKHNLEKV EGERKEAQDM 660

LNHSEKEKNN LEIDLNYKLK SLQQRLEQEV NEHKVTKARL TDKHQSIEEA KSVAMCEMEK 720

KLKEEREARE KAENRVVQIE KQCSMLDVDL KQSQQKLEHL TGNKERMEDE VKNLTLQLEQ 780

ESNKRLLLQN ELKTQAFEAD NLKGLEKQMK QEINTLLEAK RLLEFELAQL TKQYRGNEGQ 840

MRELQDQLEA EQYFSTLYKT QVKELKEEIE EKNRENLKKI QELQNEKETL ATQLDLAETK 900

AESEQLARGL LEEQYFELTQ ESKKAASRNR QEITDKDHTV SRLEEANSML TKDIEILRRE 960

NEELTEKMKK AEEEYKLEKE EEISNLKAAF EKNINTERTL KTQAVNKLAE IMNRKDFKID 1020

RKKANTQDLR KKEKENRKLQ LELNQEREKF NQMVVKHQKE LNDMQAQLVE ECAHRNELQM 1080

QLASKESDIE QLRAKLLDLS DSTSVASFPS ADETDGNLPE SRIEGWLSVP NRGNIKRYGW 1140

KKQYVVVSSK KILFYNDEQD KEQSNPSMVL DIDKLFHVRP VTQGDVYRAE TEEIPKIFQI 1200

LYANEGECRK DVEMEPVQQA EKTNFQNHKG HEFIPTLYHF PANCDACAKP LWHVFKPPPA 1260

LECRRCHVKC HRDHLDKKED LICPCK 1286

Nucleotide Sequence
(FASTA)

ATGTCGACTG GGGACAGTTT TGAGACTCGA TTTGAAAAAA TCGACAACCT GCTGCGGGAT 60

CCCAAATCGG AAGTGAATTC GGATTGTTTG CTGGATGGAT TGGATGCTTT GGTATATGAT 120

TTGGATTTTC CTGCCTTAAG AAAAAACAAA AATATTGACA ACTTTTTAAG CAGATATAAA 180

GACACAATAA ATAAAATCAG AGATTTACGA ATGAAAGCTG AAGATTATGA AGTAGTGAAG 240

GTGATTGGTA GAGGTGCATT TGGAGAAGTT CAATTGGTAA GGCATAAATC CACCAGGAAG 300

GTATATGCTA TGAAGCTTCT CAGCAAATTT GAAATGATTA AGAGATCTGA TTCTGCTTTT 360

TTCTGGGAAG AAAGGGACAT CATGGCTTTT GCCAACAGTC CTTGGGTTGT TCAGCTTTTT 420

TATGCATTCC AAGATGATCG TTATCTCTAC ATGGTGATGG AATACATGCC TGGTGGAGAT 480

CTTGTAAACT TAATGAGCAA CTATGATGTG CCTGAAAAAT GGGCACGATT CTATACTGCA 540

GAAGTAGTTC TTGCATTGGA TGCAATCCAT TCCATGGGTT TTATTCACAG AGATGTGAAG 600

CCTGATAACA TGCTGCTGGA TAAATCTGGA CATTTGAAGT TAGCAGATTT TGGTACTTGT 660

ATGAAGATGA ATAAGGAAGG CATGGTACGA TGTGATACAG CAGTTGGAAC ACCTGATTAT 720

ATTTCCCCTG AAGTATTAAA ATCCCAAGGT GGTGATGGTT ATTATGGAAG AGAATGTGAC 780

TGGTGGTCGG TTGGGGTATT TTTATACGAA ATGCTTGTAG GTGATACACC TTTTTATGCA 840

GATTCTTTGG TTGGAACTTA CAGTAAAATT ATGAACCATA AAAATTCACT TACCTTTCCT 900

GATGATAATG ACATATCAAA AGAAGCAAAA AACCTTATTT GTGCCTTCCT TACTGACAGG 960

GAAGTGAGGT TAGGGCGAAA TGGTGTAGAA GAAATCAAAC GACATCTCTT CTTCAAAAAT 1020

GACCAGTGGG CTTGGGAAAC GCTCCGAGAC ACTGTAGCAC CAGTTGTACC CGATTTAAGT 1080

AGTGACATTG ATACTAGTAA TTTTGATGAC TTGGAAGAAG ATAAAGGAGA GGAAGAAACA 1140

TTCCCTATTC CTAAAGCTTT CGTTGGCAAT CAACTACCTT TTGTAGGATT TACATATTAT 1200

AGCAATCGTA GATACTTACC TTCAGCAAAT CCTAATGATA ACAGAACTAG CTCCAATGCA 1260

GATAAAAGCT TGTTAAAGCA GGAAAGTTTG CAAAAAACAA TCTATAAGCT GGAAGAACAG 1320

CTGCATAATG AAATGCAGTT AAAAGATGAA ATGGAGCAGA AGTGCAGAAC CTCAAACATA 1380

AAACTAGACA AGATAATGAA AGAATTGGAT GAAGAGGGAA ATCAAAGAAG AAATCTAGAA 1440

TCTACAGTGT CTCAGATTGA GAAGGAGAAA ATGTTGCTAC AGCATAGAAT TAATGAATAC 1500

CAAAGAAAAG CTGAACAGGA AAATGAGAAG AGAAGAAATG TAGAAAATGA AGTTTCTACA 1560

TTAAAGGATC AGTTGGAAGA CTTAAAGAAA GTCAGTCAGA ATTCACAGCT TGCTAATGAG 1620

AAGCTGTCCC AGTTACAAAA GCAGCTAGAA GAAGCCAATG ACTTACTTAG GACAGAATCG 1680

GACACAGCTG TAAGACTGAG GAAGAGTCAC ACAGAGATGA GCAAGTCAAT TAGTCAGTTA 1740

GAGTCCCTGA ACAGAGAGTT GCAAGAGAGA AATCGAATTT TAGAGAATTC TAAGTCACAA 1800

ACAGACAAAG ATTATTACCA GCTGCAAGCT ATATTAGAAG CTGAACGAAG AGACAGAGGT 1860

CATGATTCTG AGATGGTGGG AAAGTTGATA GCTCGAATTA CATCTTTACA AGAGGAGGTG 1920

AAGCATCTCA AACATAATCT CGAAAAAGTG GAAGGAGAAA GAAAAGAGGC TCAAGACATG 1980

CTTAATCACT CAGAAAAGGA AAAGAATAAT TTAGAGATAG ATTTAAACTA CAAACTTAAA 2040

TCATTACAAC AACGGTTAGA ACAAGAGGTA AATGAACACA AAGTAACCAA AGCTCGTTTA 2100

ACTGACAAAC ATCAATCTAT TGAAGAGGCA AAGTCTGTGG CAATGTGTGA GATGGAAAAA 2160

AAGCTGAAAG AAGAAAGAGA AGCTCGAGAG AAGGCTGAAA ATCGGGTTGT TCAGATTGAG 2220

AAACAGTGTT CCATGCTAGA CGTTGATCTG AAGCAATCTC AGCAGAAACT AGAACATTTG 2280

ACTGGAAATA AAGAAAGGAT GGAGGATGAA GTTAAGAATC TAACCCTGCA ACTGGAGCAG 2340

GAATCAAATA AGCGGCTGTT GTTACAAAAT GAATTGAAGA CTCAAGCATT TGAGGCAGAC 2400

AATTTAAAAG GTTTAGAAAA GCAGATGAAA CAGGAAATAA ATACTTTATT GGAAGCAAAG 2460

AGATTATTAG AATTTGAGTT AGCTCAGCTT ACGAAACAGT ATAGAGGAAA TGAAGGACAG 2520

ATGCGGGAGC TACAAGATCA GCTTGAAGCT GAGCAATATT TCTCGACACT TTATAAAACC 2580

CAGGTAAAGG AACTTAAAGA AGAAATTGAA GAAAAAAACA GAGAAAATTT AAAGAAAATA 2640

CAGGAACTAC AAAATGAAAA AGAAACTCTT GCTACTCAGT TGGATCTAGC AGAAACAAAA 2700

GCTGAGTCTG AGCAGTTGGC GCGAGGCCTT CTGGAAGAAC AGTATTTTGA ATTGACGCAA 2760

GAAAGCAAGA AAGCTGCTTC AAGAAATAGA CAAGAGATTA CAGATAAAGA TCACACTGTT 2820

AGTCGGCTTG AAGAAGCAAA CAGCATGCTA ACCAAAGATA TTGAAATATT AAGAAGAGAG 2880

AATGAAGAGC TAACAGAGAA AATGAAGAAG GCAGAGGAAG AATATAAACT GGAGAAGGAG 2940

GAGGAGATCA GTAATCTTAA GGCTGCCTTT GAAAAGAATA TCAACACTGA ACGAACCCTT 3000

AAAACACAGG CTGTTAACAA GTTGGCAGAA ATAATGAATC GAAAAGATTT TAAAATTGAT 3060

AGAAAGAAAG CTAATACACA AGATTTGAGA AAGAAAGAAA AGGAAAATCG AAAGCTGCAA 3120

CTGGAACTCA ACCAAGAAAG AGAGAAATTC AACCAGATGG TAGTGAAACA TCAGAAGGAA 3180

CTGAATGACA TGCAAGCGCA ATTGGTAGAA GAATGTGCAC ATAGGAATGA GCTTCAGATG 3240

CAGTTGGCCA GCAAAGAGAG TGATATTGAG CAATTGCGTG CTAAACTTTT GGACCTCTCG 3300

GATTCTACAA GTGTTGCTAG TTTTCCTAGT GCTGATGAAA CTGATGGTAA CCTCCCAGAG 3360

TCAAGAATTG AAGGTTGGCT TTCAGTACCA AATAGAGGAA ATATCAAACG ATATGGCTGG 3420

AAGAAACAGT ATGTTGTGGT AAGCAGCAAA AAAATTTTGT TCTATAATGA CGAACAAGAT 3480

AAGGAGCAAT CCAATCCATC TATGGTATTA GACATAGATA AACTGTTTCA CGTTAGACCT 3540

GTAACCCAAG GAGATGTGTA TAGAGCTGAA ACTGAAGAAA TTCCTAAAAT ATTCCAGATA 3600

CTATATGCAA ATGAAGGTGA ATGTAGAAAA GATGTAGAGA TGGAACCAGT ACAACAAGCT 3660

GAAAAAACTA ATTTCCAAAA TCACAAAGGC CATGAGTTTA TCCCTACACT CTACCACTTT 3720

CCTGCCAATT GTGATGCCTG TGCCAAACCT CTCTGGCATG TTTTTAAGCC ACCCCCTGCC 3780

CTAGAGTGTC GAAGATGCCA CGTTAAGTGC CACAGAGATC ACTTAGATAA GAAAGAGGAC 3840

TTAATTTGTC CATGTAAA 3858

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         +e++kviGrGafgev++vr+k+t+kvyamk+l+k+e++kr++saff+eerd++++a+s+w

Q: 76    YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         +vql+yafqd++yly+vmey++GGdl++l+s+y+  +pe++arfy+ae+vlald++h++g

Q: 136   VVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMG  193

         **********************************..9***********************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         ++hrd+kpdn+lldksGh+kladfG+c+k+n++g+v++++avGtpdyispevlk+++ g+

Q: 194   FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQG-GD  252

         ********************************************************9.**

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240

         g+yg+ecdwws+Gv+lye+lvg+tpfya+slv tyski+nhk+sl+fp+d+++s+eak+l

Q: 253   GYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNL  312

         ************************************************************

S: 241   ikklltsreerlgregiedlkkhpff  266

         i+++lt+re rlgr+g+e++k+h ff

Q: 313   ICAFLTDREVRLGRNGVEEIKRHLFF  338

         *************************9

Domain Sequence
(FASTA)

YEVVKVIGRG AFGEVQLVRH KSTRKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60

VVQLFYAFQD DRYLYMVMEY MPGGDLVNLM SNYDVPEKWA RFYTAEVVLA LDAIHSMGFI 120

HRDVKPDNML LDKSGHLKLA DFGTCMKMNK EGMVRCDTAV GTPDYISPEV LKSQGGDGYY 180

GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA 240

FLTDREVRLG RNGVEEIKRH LFF 263

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000910	; P:cytokinesis
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020684	; Rho-assoc_coiled-coil_kin.
IPR015008	; Rho-bd.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 1.
PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF08912	; Rho_Binding; 1.

SMARTs

SM00109	; C1; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013