EKS-GOG-00436

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00436

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	428.5	1.3E-128	1	230	230

Status

Unreviewed

Ensembl Protein

ENSGGOP00000009387

UniProt Accession

G3SI75;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA

Gene Synonyms/Alias

CDC42BPA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000009605	ENSGGOP00000009387	ENSGGOT00000009651
ENSGGOG00000009605	ENSGGOP00000027815	ENSGGOT00000031221

Organism

Gorilla gorilla

Functional Description

Protein Length

1480

Protein Sequence
(FASTA)

LKRSETACFR EERDVLVNGD NKWITTLHYA FQDDNNLYLV MDYYVGGDLL TLLSKFEDRL 60

PEDMARFYLA EMVIAIDSVH QLHYVHRDIK PDNILMDMNG HIRLADFGSC LKLMEDGTVQ 120

SSVAVGTPDY ISPEILQAME DGKGRYGPEC DWWSLGVCMY EMLYGETPFY AESLVETYGK 180

IMNHKERFQF PAQVTDVSEN AKDLIRRLIC SREHRLGQNG IEDFKKHPFF SGIDWDNIRN 240

CEAPYIPEVS SPTDTSNFDV DDDCLKNSET MPPPTHTAFS GHHLPFVGFT YTSSCVLSDR 300

SCLRVTAGPT SLDLDVNVQR TLDNNLATEA YERRIKRLEQ EKLELSRKLQ ESTQTVQALQ 360

YSTVDGPLTA SKDLEIKNLK EEIEKLRKQV TESSHLEQQL EEANAVRQEL DDAFRQIKAY 420

EKQIKTLQQE REDLNKELVQ ASERLKNQSK ELKDAHCQRK LAMQEFMEIN ERLTELHTQK 480

QKLARHVRDK EEEVDLVMQK VESLRQELRR TERAKKELEV HTEALAAEAS KDRKLREQSE 540

HYSKQLENEL EGLKQKQISY SPGVCSIEHQ QEITKLKTDL EKKSIFYEEE LSKREGIHAN 600

EIKNLKKELH DSEGQQLALN KEIMILKDKL EKTRRESQSE REEFESGFKQ QYEREKVLLT 660

EENKKLTSEL DKLTTLYENL SIHNQQLEEE VKDLADKKES VAHWEAQITE IIQWVSDEKD 720

ARGYLQALAS KMTEELEALR NSSLGTRATD MPWKMRRFAK LDMSARLELQ SALDAEIRAK 780

QAIQEELNKV KASNIITECK LKDSEKKNLE LLSEIEQLIK DTEELRSEKG IEHQDSQHSF 840

LAFLNTPTDA LDQFETVDST PLSVHTPTLR KKGCPGSTGF PPKRKTHQFF VKSFTTPTKC 900

HQCTSLMVGL IRQGCSCEVC GFSCHITCVN KAPTTCPVPP EQTKGPLGID PQKGIGTAYE 960

GHVRIPKPAG VKKGWQRALA IVCDFKLFLY DIAEGKASQP SVVISQVIDM RDEEFSVSSV 1020

LASDVIHASR KDIPCIFRVT ASQLSASNNK CSILMLADTE NEKNKWVGVL SELHKILKKN 1080

KFRDRSVYVP KEAYDSTLPL IKTTQAAAII DHERIALGNE EGLFVVHVTK DEIIRVGDNK 1140

KIHQIELIPN DQLVAVISGR NRHVRLFPMS ALDGRETDFY KLSETKGCQT ITSGKVRHGA 1200

LTCLCVAMKR QVLCYELFQS KTRHRKFKEI QVPYNVQWMA IFSEQLCVGF QSGFLRYPLN 1260

GEGNPYSMLH SNDHTLSFIA HQPMDAICAV EISSKEYLLC FNSIGIYTDC QGRRSRQQEL 1320

MWPANPSSCC YNAPYLSVYS ENAVDIFDVN SMEWIQTLPL KKVRPLNNEG SLNLLGLETI 1380

RLIYFKNKMA EGDELVVPET SDNSRKQMVR NINNKRRYSF RVPEEERMQQ RREMLRDPEM 1440

RNKLISNPTN FNHIAHMGPG DGIQILKDLP MTSVKSQTNQ 1480

Nucleotide Sequence
(FASTA)

CTTAAAAGAT CAGAAACAGC ATGTTTTCGT GAAGAAAGGG ATGTATTAGT GAATGGAGAC 60

AATAAATGGA TTACAACCTT GCACTATGCT TTCCAGGATG ACAATAACTT ATACCTGGTT 120

ATGGATTATT ATGTTGGTGG GGATTTGCTT ACTCTACTCA GCAAATTTGA AGATAGATTG 180

CCTGAAGATA TGGCTCGATT TTACTTGGCT GAGATGGTGA TAGCAATTGA CTCAGTTCAT 240

CAGCTACACT ATGTACACAG AGACATTAAA CCTGACAATA TACTGATGGA TATGAATGGA 300

CATATTCGGT TAGCAGATTT TGGTTCTTGT CTGAAGCTGA TGGAAGATGG AACGGTTCAG 360

TCCTCAGTGG CTGTAGGAAC TCCAGATTAT ATCTCTCCTG AAATCCTTCA AGCCATGGAA 420

GATGGAAAAG GGAGATATGG ACCTGAATGT GACTGGTGGT CTTTGGGGGT CTGTATGTAT 480

GAAATGCTTT ATGGAGAAAC ACCATTTTAT GCAGAATCTC TGGTGGAGAC ATACGGAAAA 540

ATCATGAATC ACAAAGAGAG GTTTCAGTTT CCAGCCCAAG TGACTGATGT GTCTGAAAAT 600

GCTAAGGATC TTATTCGAAG GCTCATTTGT AGCAGAGAAC ATCGACTTGG TCAAAATGGA 660

ATAGAAGACT TTAAGAAACA CCCATTTTTC AGTGGAATTG ATTGGGATAA TATTCGGAAC 720

TGTGAAGCAC CTTATATTCC AGAAGTTAGT AGCCCAACAG ATACATCGAA TTTTGATGTA 780

GATGATGATT GTTTAAAAAA TTCTGAAACG ATGCCCCCAC CAACACATAC TGCATTTTCT 840

GGCCACCATC TGCCATTTGT TGGTTTTACA TATACTAGTA GCTGTGTACT TTCTGATCGG 900

AGCTGTTTAA GAGTTACGGC TGGTCCCACC TCACTGGATC TTGATGTTAA TGTTCAGAGG 960

ACTCTAGACA ACAACTTAGC AACTGAAGCT TATGAAAGAA GAATTAAGCG CCTTGAGCAA 1020

GAAAAACTTG AACTCAGTAG AAAACTTCAA GAGTCAACAC AGACTGTCCA AGCTCTGCAG 1080

TATTCAACTG TTGATGGCCC ACTAACAGCA AGCAAAGATT TAGAAATAAA AAACTTAAAA 1140

GAAGAAATTG AAAAACTAAG AAAACAAGTA ACAGAATCAA GTCATTTGGA ACAGCAACTT 1200

GAAGAAGCTA ATGCTGTGAG GCAAGAACTA GATGATGCTT TTAGACAAAT CAAGGCTTAT 1260

GAAAAACAAA TCAAAACATT ACAACAAGAA AGAGAAGATC TAAATAAGGA ACTAGTCCAG 1320

GCTAGTGAGC GATTAAAAAA CCAATCCAAA GAGCTGAAAG ACGCACACTG TCAGAGGAAA 1380

CTGGCCATGC AGGAATTCAT GGAGATCAAT GAGCGGCTAA CAGAATTGCA CACCCAAAAA 1440

CAGAAACTTG CTCGCCATGT CCGAGATAAG GAAGAAGAGG TGGACCTGGT GATGCAAAAA 1500

GTTGAAAGCT TAAGGCAAGA ACTGCGCAGA ACAGAAAGAG CCAAAAAAGA GCTGGAAGTT 1560

CATACAGAAG CTCTAGCTGC TGAAGCATCT AAAGACAGGA AGCTACGTGA ACAGAGTGAG 1620

CACTATTCTA AGCAACTGGA AAATGAATTG GAGGGACTGA AGCAAAAACA AATCAGTTAC 1680

TCACCAGGAG TATGCAGCAT AGAACATCAG CAAGAGATAA CCAAACTAAA GACTGATTTG 1740

GAAAAGAAAA GTATCTTTTA TGAAGAAGAA TTATCTAAAA GAGAAGGAAT ACATGCAAAT 1800

GAAATAAAGA ATCTTAAGAA AGAACTGCAT GATTCAGAAG GTCAGCAACT TGCTCTCAAC 1860

AAAGAAATTA TGATTTTAAA AGACAAATTG GAAAAAACCA GAAGAGAAAG TCAAAGTGAA 1920

AGGGAGGAAT TTGAAAGTGG GTTCAAACAA CAGTATGAAC GAGAAAAAGT GTTGTTAACT 1980

GAAGAAAATA AAAAGCTGAC GAGTGAACTT GATAAGCTTA CTACTTTGTA TGAGAACTTA 2040

AGTATACACA ACCAGCAGTT AGAAGAAGAG GTTAAAGATC TAGCAGACAA GAAAGAATCA 2100

GTTGCACATT GGGAAGCCCA AATCACAGAA ATAATTCAGT GGGTCAGTGA TGAAAAGGAT 2160

GCACGAGGGT ATCTTCAGGC CTTAGCTTCT AAAATGACTG AAGAATTGGA GGCATTAAGA 2220

AATTCCAGCT TGGGTACACG AGCAACAGAT ATGCCTTGGA AAATGCGTCG TTTTGCGAAA 2280

CTGGATATGT CAGCTAGACT GGAGTTGCAG TCGGCTCTGG ATGCAGAAAT AAGAGCCAAA 2340

CAGGCCATCC AAGAAGAGTT GAATAAAGTT AAAGCATCTA ATATCATAAC AGAATGTAAA 2400

CTAAAAGATT CAGAGAAGAA GAACTTGGAA CTACTCTCAG AAATCGAACA GCTGATAAAG 2460

GACACTGAAG AGCTTAGATC TGAAAAGGGT ATAGAGCACC AAGACTCACA GCATTCTTTC 2520

TTGGCATTTT TGAATACGCC TACCGATGCT CTGGATCAAT TTGAAACTGT AGACTCCACT 2580

CCACTTTCAG TTCACACACC AACCTTAAGG AAAAAAGGAT GTCCTGGTTC AACTGGCTTT 2640

CCACCTAAGC GCAAGACTCA CCAGTTTTTT GTAAAATCTT TTACTACTCC TACCAAGTGT 2700

CATCAGTGTA CCTCCTTGAT GGTGGGTTTA ATAAGACAGG GCTGTTCATG TGAAGTGTGT 2760

GGATTCTCAT GCCATATAAC TTGTGTAAAC AAAGCTCCAA CAACTTGTCC AGTTCCTCCT 2820

GAACAGACAA AAGGTCCCCT GGGTATAGAC CCTCAGAAAG GAATAGGAAC AGCATATGAA 2880

GGTCATGTCA GGATTCCTAA GCCAGCTGGA GTGAAGAAAG GGTGGCAGAG AGCACTGGCT 2940

ATAGTGTGTG ACTTCAAACT CTTTCTGTAC GATATTGCTG AAGGAAAAGC ATCTCAGCCC 3000

AGTGTTGTCA TTAGTCAAGT GATTGACATG AGGGATGAAG AATTTTCTGT GAGTTCAGTC 3060

TTGGCTTCTG ATGTTATCCA TGCAAGTCGG AAAGATATAC CCTGTATATT TAGGGTCACA 3120

GCTTCCCAGC TCTCAGCATC TAATAACAAA TGTTCAATCC TGATGCTAGC AGACACTGAG 3180

AATGAGAAGA ATAAGTGGGT GGGAGTGCTG AGTGAATTGC ACAAGATTTT GAAGAAAAAC 3240

AAATTCAGAG ACCGCTCAGT CTATGTTCCC AAAGAGGCTT ATGACAGCAC TCTACCCCTC 3300

ATTAAAACAA CCCAGGCAGC CGCAATCATA GATCATGAAA GAATTGCTTT GGGAAACGAA 3360

GAAGGGTTAT TTGTTGTACA TGTCACCAAA GATGAAATTA TTAGAGTTGG TGACAATAAG 3420

AAGATTCATC AGATTGAACT CATTCCAAAT GATCAGCTTG TTGCTGTGAT CTCAGGACGA 3480

AATCGTCATG TACGACTTTT TCCTATGTCA GCATTGGATG GGCGAGAGAC CGATTTTTAC 3540

AAGCTGTCAG AAACTAAAGG GTGTCAAACC ATAACTTCTG GAAAGGTGCG CCATGGAGCT 3600

CTCACATGCC TGTGTGTGGC TATGAAAAGG CAGGTCCTCT GTTATGAGCT ATTTCAGAGC 3660

AAGACCCGTC ACAGAAAATT TAAGGAAATT CAAGTCCCAT ATAATGTCCA GTGGATGGCA 3720

ATCTTCAGTG AACAACTCTG TGTGGGATTC CAGTCAGGAT TTCTAAGATA CCCCTTGAAT 3780

GGAGAAGGAA ATCCATACAG TATGCTCCAT TCAAATGACC ATACACTATC ATTTATTGCA 3840

CATCAACCAA TGGATGCTAT CTGCGCAGTT GAGATCTCCA GTAAAGAATA TCTGCTGTGT 3900

TTTAACAGCA TTGGGATATA CACTGACTGC CAGGGCCGAA GATCTAGACA ACAGGAATTG 3960

ATGTGGCCAG CAAATCCTTC CTCTTGTTGT TACAATGCAC CATATCTCTC GGTGTACAGT 4020

GAAAATGCAG TTGATATCTT TGATGTGAAC TCCATGGAAT GGATTCAGAC TCTTCCTCTC 4080

AAAAAGGTTC GACCCTTAAA CAATGAAGGA TCATTAAATC TTTTAGGGTT GGAGACCATT 4140

AGATTAATAT ATTTCAAAAA TAAGATGGCA GAAGGGGACG AACTGGTAGT TCCTGAAACA 4200

TCAGATAATA GTCGGAAACA AATGGTTAGA AACATTAACA ATAAGCGGCG TTATTCCTTC 4260

AGAGTCCCAG AAGAGGAAAG GATGCAGCAG AGGAGGGAAA TGCTACGAGA TCCAGAAATG 4320

AGAAATAAAT TAATTTCTAA TCCAACTAAT TTTAATCACA TAGCACACAT GGGTCCTGGA 4380

GATGGAATAC AGATCCTGAA AGATCTGCCC ATGACATCTG TCAAAAGCCA AACAAATCAG 4440

Domain Profile

S: 38    lkraesaffreerdvlvkadsewivqlqyafqdekylylvmeylvGGdlltllskyedkl  97

         lkr+e+a+freerdvlv++d++wi++l+yafqd+++lylvm+y+vGGdlltllsk+ed+l

Q: 1     LKRSETACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRL  60

         69**********************************************************

S: 98    peelarfylaelvlaldsvhelgyvhrdikpdnilldksGhikladfGsclklnedgtvk  157

         pe++arfylae+v+a+dsvh+l+yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+

Q: 61    PEDMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQ  120

         ************************************************************

S: 158   ssvavGtpdyispevlkaleegkgeygkecdwwslGvilyellvgetpfyaeslvetysk  217

         ssvavGtpdyispe+l+a+e+gkg+yg+ecdwwslGv++ye+l+getpfyaeslvety+k

Q: 121   SSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGK  180

         ************************************************************

S: 218   ilnhkeslkfpede.kvseeakdlikklltsreerlgregiedlkkhpff  266

         i+nhke+++fp+++ +vse+akdli++l++sre+rlg++gied+kkhpff

Q: 181   IMNHKERFQFPAQVtDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFF  230

         *************99**********************************9

Domain Sequence
(FASTA)

LKRSETACFR EERDVLVNGD NKWITTLHYA FQDDNNLYLV MDYYVGGDLL TLLSKFEDRL 60

PEDMARFYLA EMVIAIDSVH QLHYVHRDIK PDNILMDMNG HIRLADFGSC LKLMEDGTVQ 120

SSVAVGTPDY ISPEILQAME DGKGRYGPEC DWWSLGVCMY EMLYGETPFY AESLVETYGK 180

IMNHKERFQF PAQVTDVSEN AKDLIRRLIC SREHRLGQNG IEDFKKHPFF 230

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005615	; C:extracellular space
GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.
IPR014760	; Serum_albumin_N.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 2.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS51438	; ALBUMIN_2; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 2.
PS50003	; PH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013