EKS-GOG-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	363.3	1.1E-108	67	328	262

Status

Unreviewed

Ensembl Protein

ENSGGOP00000009763

UniProt Accession

G3R3D8;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000009999	ENSGGOP00000027197	ENSGGOT00000025639
ENSGGOG00000009999	ENSGGOP00000009763	ENSGGOT00000010042

Organism

Gorilla gorilla

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PELSPASTGA LSSLTPCVRR PVGHYEEVEL TETSVNLGPE 60

RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLSSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLALPP YLTPDARDLV 300

KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH MNWDDLLAWR VDPPFRPCLQ SEEDVSQFDT 360

RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRA 420

PISPLKFSPF EGFRPSPSLP EPTELPLPPL LPPPPPSTTA PLPIRPPLGT KKSKRGRGRP 480

GR 482

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGATTT GGATTTGGAG ACGGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

CCAGAACTCA GCCCCGCGAG CACTGGAGCC TTGTCCTCAT TAACTCCTTG TGTCCGTAGG 120

CCTGTGGGAC ACTATGAAGA GGTGGAGCTG ACTGAGACCA GCGTGAACCT TGGCCCAGAG 180

CGCATCGGGC CCCACTGCTT TGAGCTGCTG CGTGTGCTGG GCAAGGGGGG CTATGGCAAG 240

GTGTTCCAGG TGCGAAAGGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 300

CTAAGGAAGG CCAAAATTGT GCGCAACGCC AAGGACACAG CACACACACG GGCTGAGCGG 360

AACATTCTAG AGTCAGTGAA GCACCCCTTT ATTGTGGAAC TGGCCTATGC CTTCCAGACT 420

GGTGGCAAAC TCTATCTCAT CCTTGAGTGC CTCAGTGGTG GCGAGCTCTT CACGCATCTG 480

GAGCGAGAGG GCATCTTCCT GGAAGATACG GCCTGCTTCT ACCTGGCTGA GATCACGCTG 540

GCCCTGGGCC ATCTCCACTC CCAGGGCATC ATCTACCGGG ACCTCAAGCC TGAGAACATC 600

ATGCTCAGCA GCCAGGGCCA CATCAAACTG ACCGACTTTG GACTCTGCAA GGAGTCGATC 660

CATGAGGGCG CCGTCACTCA CACCTTCTGC GGCACCATTG AGTACATGGC CCCTGAGATT 720

CTGGTGCGCA GTGGCCACAA CCGGGCTGTG GACTGGTGGA GCCTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC GCCCTTCACC GCAGAGAACC GGAAGAAAAC CATGGATAAG 840

ATCATCAAGG GCAAGCTGGC GCTGCCCCCC TACCTCACCC CAGATGCCCG GGACCTTGTC 900

AAAAAGTTTC TGAAACGGAA TCCCAGCCAG CGGATTGGGG GTGGCCCAGG GGATGCTGCT 960

GATGTGCAGA GACATCCCTT TTTCCGGCAC ATGAATTGGG ACGACCTTCT CGCCTGGCGT 1020

GTGGACCCCC CTTTCAGGCC CTGTCTGCAG TCAGAGGAGG ACGTGAGCCA GTTTGATACC 1080

CGCTTCACAC GGCAGACGCC GGTGGACAGT CCTGATGACA CAGCCCTCAG CGAGAGTGCC 1140

AACCAGGCCT TCCTGGGCTT CACATACGTG GCGCCGTCTG TCCTGGACAG CATCAAGGAG 1200

GGCTTCTCCT TCCAGCCCAA GCTGCGCTCA CCCAGGCGCC TCAACAGTAG CCCCCGGGCC 1260

CCCATCAGCC CCCTCAAGTT CTCCCCTTTT GAGGGGTTTC GGCCCAGCCC CAGCCTGCCG 1320

GAGCCCACGG AGCTACCTCT ACCTCCACTC CTGCCACCGC CGCCGCCCTC GACCACCGCC 1380

CCTCTCCCCA TCCGTCCCCC CTTAGGGACC AAGAAGTCCA AGAGGGGCCG TGGGCGTCCA 1440

GGGCGCTAG 1449

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTRAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dlvk

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LALPPY--LTPDARDLVK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL ALPPYLTPDA RDLVKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013