EKS-GOG-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph485.82.9E-146640897258
StatusUnreviewed
Ensembl ProteinENSGGOP00000019708
UniProt AccessionG3RV79;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA8
Gene Synonyms/Alias EPHA8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000010020ENSGGOP00000019708ENSGGOT00000030060
ENSGGOG00000010020ENSGGOP00000009786ENSGGOT00000010066
OrganismGorilla gorilla
Functional Description
Protein Length1010
Protein Sequence
(FASTA)
RGRARGCLPP ALWVVTAAAA AATCVSPAKP LLNLLDTSTI HGDWGWLTYP AHGWDSINEV 60
DESFQPIHTY QVCNVMSPNQ NNWLRTSWVP RDGARRVYAE IKFTLRDCNS MPGVLGTCKE 120
TFNLYYLESD RDLGASTQES QFLKIDTIAA DESFTGADLG VRRLKLNTEV RGVGPLSKRG 180
FYLAFQDIGA CLAILSLRIY YKKCPAMVRN LAAFSEAVTG ADSSSLVEVR GQCVRHSEER 240
DTPKMYCSAE GEWLVPIGKC VCSAGYEERR DACVACELGF YKSAPGDQLC ARCPPHSHSA 300
APAAQACHCD LSYYRAALDP PSSACTRPPS APVNLISSVN GTSVTLEWAP PLDPGGRSDI 360
TYNAVCRRCP WALSRCEACG SSTRFVPQQT SLVQASLLVA NLLAHMNYSF WIEAVNGVSD 420
LSPEPRRAAV VNITTNQAGL AAPAPSQVVV IRQERAGQTS VSLLWQEPEQ PNGIILEYEI 480
KYYEKDKEMQ SYSTLKAVTT RATISGLKPG TRYVFQVRAR TSAGCGRFSQ AMEVETGKPR 540
PRYDTRTIVW ICLTLITGLV VLLLLLICKK RHCGYSKAFQ DSDEEKMHYQ NGQAPPPVFL 600
PLHHPPGKLP EPQFYAEPHT YEEPGRAGRS FTREIEASRI HIEKIIGSGD SGEVCYGRLR 660
VPGQRDVPVA IKALKAGYTE RQRQDFLSEA SIMGQFDHPN IIRLEGVVTR GRLAMIVTEY 720
MENGSLDAFL RTHDGQFTIM QLVGMLRGVG AGMRYLSDLG YVHRDLAARN VLVDSNLVCK 780
VSDFGLSRVL EDDPDAAYTT TGGKIPIRWT APEAIAFRTF SSASDVWSFG VVMWEVLAYG 840
ERPYWNMTNR DVISSVEEGY RLPAPMGCPH ALHQLMLDCW HKDRAQRPRF SQIVSVLDAL 900
IRSPESLRAT ATVSRCPPPA FARSCFDLRG GSGGGGGLTV GDWLDSIRMG RYRDHFAAGG 960
YSSLGMVLRM NAQDVRALGI TLMGHQKKIL GSIQTMRAQL TSTQGPRRHL 1010
Nucleotide Sequence
(FASTA)
CGCGGCCGAG CCAGAGGGTG CCTGCCCCCT GCGCTCTGGG TCGTCACGGC CGCGGCGGCG 60
GCGGCTACCT GCGTGTCCCC CGCTAAGCCC CTCCTGAATT TGCTGGACAC ATCGACCATC 120
CACGGGGACT GGGGCTGGCT CACGTATCCG GCTCATGGGT GGGACTCCAT CAACGAGGTG 180
GACGAGTCCT TCCAGCCCAT CCACACGTAC CAGGTTTGCA ACGTTATGAG CCCCAACCAG 240
AACAACTGGC TGCGCACGAG CTGGGTCCCC CGAGACGGCG CCCGGCGCGT CTATGCTGAG 300
ATCAAGTTTA CCCTGCGCGA CTGCAACAGC ATGCCCGGTG TGCTGGGCAC CTGCAAGGAG 360
ACCTTCAACC TCTACTACCT GGAGTCGGAC CGCGACCTGG GGGCCAGCAC ACAAGAAAGC 420
CAGTTCCTCA AAATCGACAC CATTGCGGCC GACGAGAGCT TCACAGGTGC CGACCTTGGT 480
GTGCGGCGTC TCAAGCTCAA CACGGAGGTG CGCGGTGTGG GTCCCCTCAG CAAGCGCGGC 540
TTCTACCTGG CCTTCCAGGA CATAGGTGCC TGCCTGGCCA TCCTCTCTCT CCGCATCTAC 600
TATAAGAAGT GCCCTGCCAT GGTGCGCAAT CTGGCTGCCT TCTCAGAGGC AGTGACGGGG 660
GCCGACTCGT CCTCACTGGT GGAGGTGAGG GGCCAGTGCG TGCGGCACTC AGAGGAGCGG 720
GACACACCCA AGATGTACTG CAGCGCGGAG GGCGAGTGGC TCGTGCCCAT CGGCAAATGC 780
GTGTGCAGTG CCGGCTACGA GGAGCGGCGG GATGCCTGTG TGGCCTGTGA GCTGGGCTTC 840
TACAAGTCAG CCCCTGGGGA CCAGCTGTGC GCCCGCTGCC CTCCTCACAG CCACTCCGCA 900
GCTCCAGCCG CCCAAGCCTG CCACTGTGAC CTCAGCTACT ACCGCGCAGC CCTGGACCCG 960
CCATCCTCAG CCTGCACCCG GCCACCCTCG GCACCAGTGA ACCTGATCTC CAGTGTGAAT 1020
GGGACATCAG TGACTCTGGA GTGGGCCCCT CCCCTGGACC CAGGTGGCCG CAGTGACATC 1080
ACCTACAACG CCGTGTGCCG CCGCTGCCCC TGGGCACTGA GCCGCTGCGA GGCATGTGGG 1140
AGCAGCACCC GCTTTGTGCC CCAGCAGACA AGCCTGGTGC AGGCCAGCCT GCTGGTGGCC 1200
AACCTGCTGG CCCACATGAA CTACTCCTTC TGGATCGAGG CCGTCAATGG CGTGTCCGAC 1260
CTGAGCCCCG AGCCCCGCCG GGCCGCTGTG GTCAACATCA CCACGAACCA GGCAGGATTG 1320
GCCGCCCCAG CCCCGTCCCA GGTGGTGGTG ATCCGTCAAG AGCGGGCGGG GCAGACCAGC 1380
GTCTCGCTGC TGTGGCAGGA GCCCGAGCAG CCAAACGGCA TCATCCTGGA GTATGAGATC 1440
AAGTACTACG AGAAGGACAA GGAGATGCAG AGCTACTCCA CCCTCAAGGC CGTCACCACC 1500
AGAGCCACCA TCTCCGGCCT CAAGCCGGGC ACGCGCTACG TGTTCCAGGT CCGAGCCCGC 1560
ACCTCAGCAG GCTGTGGCCG CTTCAGCCAG GCCATGGAGG TGGAGACCGG GAAACCCCGG 1620
CCCCGCTATG ACACCAGGAC CATTGTCTGG ATCTGCCTGA CGCTCATCAC GGGCCTGGTG 1680
GTGCTTCTGC TCCTGCTCAT CTGCAAGAAG AGGCACTGTG GCTACAGCAA GGCCTTCCAG 1740
GACTCGGACG AGGAGAAGAT GCACTATCAG AATGGACAGG CACCCCCACC TGTCTTCCTG 1800
CCTCTGCATC ACCCCCCGGG AAAGCTCCCA GAGCCCCAGT TCTATGCGGA ACCCCACACC 1860
TACGAGGAGC CAGGCCGGGC GGGCCGCAGT TTCACTCGGG AGATCGAGGC CTCTAGGATC 1920
CACATCGAGA AAATCATCGG CTCTGGAGAC TCCGGGGAAG TCTGCTACGG GAGGCTGCGG 1980
GTGCCAGGGC AGCGGGATGT GCCCGTGGCC ATCAAGGCCC TCAAAGCCGG CTACACGGAA 2040
AGACAGAGGC AGGACTTCCT GAGCGAGGCA TCCATCATGG GGCAATTCGA CCATCCCAAC 2100
ATCATCCGCC TCGAGGGTGT CGTCACCCGT GGCCGCCTGG CAATGATCGT GACTGAGTAC 2160
ATGGAGAACG GCTCTCTGGA CGCCTTCCTG AGGACCCACG ACGGGCAGTT CACCATCATG 2220
CAGCTGGTGG GCATGCTGAG AGGAGTGGGT GCCGGCATGC GCTACCTCTC AGACCTGGGC 2280
TATGTCCACC GAGACCTGGC CGCCCGCAAC GTCCTGGTTG ACAGCAACCT GGTCTGCAAG 2340
GTGTCTGACT TCGGGCTCTC ACGGGTGCTG GAGGACGACC CGGATGCTGC CTACACCACC 2400
ACGGGCGGGA AGATCCCCAT CCGCTGGACG GCCCCAGAGG CCATCGCCTT CCGCACCTTC 2460
TCCTCAGCCA GCGACGTGTG GAGCTTCGGT GTGGTCATGT GGGAGGTGCT GGCCTATGGG 2520
GAGCGGCCCT ACTGGAACAT GACCAACCGG GATGTCATCA GCTCCGTGGA GGAGGGGTAC 2580
CGCCTGCCCG CACCCATGGG CTGCCCCCAC GCCCTGCACC AGCTCATGCT CGACTGTTGG 2640
CACAAGGACC GGGCGCAGCG GCCTCGCTTC TCCCAGATTG TCAGTGTCCT CGATGCGCTC 2700
ATCCGCAGCC CTGAGAGTCT CAGGGCCACC GCCACTGTCA GCAGGTGCCC ACCCCCTGCC 2760
TTCGCCCGGA GCTGCTTTGA CCTCCGAGGG GGCAGCGGTG GCGGTGGGGG CCTCACCGTG 2820
GGGGACTGGC TGGACTCCAT CCGCATGGGC CGGTACCGAG ACCACTTCGC TGCGGGCGGC 2880
TACTCCTCTC TGGGCATGGT GCTACGCATG AACGCCCAGG ACGTGCGCGC CCTGGGCATC 2940
ACCCTCATGG GCCACCAGAA GAAGATCCTG GGCAGCATTC AGACCATGCG GGCCCAGCTG 3000
ACCAGCACCC AGGGGCCCCG CCGGCACCTC TGA 3033
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++iek+iG+G+ Gevc Grl++pg+r+++vaik+lkag+te+qr+dflseasi+Gqfdhp
Q: 640   IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRQDFLSEASIMGQFDHP  699
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvt+++  mivteymeng+ld+flr++dgqft++qlvgmlrG+++gm+ylsd+
Q: 700   NIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDL  759
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarn+lv+snlvckvsdfGlsrvledd++aaytt+ggkipirwtapeaia+r+
Q: 760   GYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRT  819
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         f+sasdvws+G+v+wevl+yGerpyw+m+n+dvi+++eegyrlp+pm+cp+al+qlmldc
Q: 820   FSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDC  879
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         w+kdra+rp+f+qivs+l
Q: 880   WHKDRAQRPRFSQIVSVL  897
         ***************985
Domain Sequence
(FASTA)
IHIEKIIGSG DSGEVCYGRL RVPGQRDVPV AIKALKAGYT ERQRQDFLSE ASIMGQFDHP 60
NIIRLEGVVT RGRLAMIVTE YMENGSLDAF LRTHDGQFTI MQLVGMLRGV GAGMRYLSDL 120
GYVHRDLAAR NVLVDSNLVC KVSDFGLSRV LEDDPDAAYT TTGGKIPIRW TAPEAIAFRT 180
FSSASDVWSF GVVMWEVLAY GERPYWNMTN RDVISSVEEG YRLPAPMGCP HALHQLMLDC 240
WHKDRAQRPR FSQIVSVL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00010
EKS-ANC-00008
EKS-BOT-00009
EKS-CAJ-00010
EKS-CAF-00011
EKS-CAP-00008
EKS-DAR-00014
EKS-EQC-00011
EKS-FEC-00008
EKS-GAG-00009
EKS-GAA-00013
EKS-HOS-00010
EKS-ICT-00010
EKS-LOA-00011
EKS-MAM-00008
EKS-MEG-00008
EKS-MOD-00010
EKS-MUM-00011
EKS-MUP-00011
EKS-MYL-00012
EKS-NOL-00010
EKS-OCP-00001
EKS-ORN-00013
EKS-ORC-00010
EKS-ORL-00016
EKS-OTG-00011
EKS-PAT-00013
EKS-PES-00012
EKS-POA-00007
EKS-RAN-00010
EKS-SAH-00010
EKS-SUS-00008
EKS-TAG-00007
EKS-XIM-00014
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR020691; EphrinA_rcpt8.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013