EKS-GOG-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Syk	488.9	3.4E-147	371	619	249

Status

Unreviewed

Ensembl Protein

ENSGGOP00000010128

UniProt Accession

G3R4D0;

Protein Name

Tyrosine-protein kinase

Protein Synonyms/Alias

Gene Name

SYK

Gene Synonyms/Alias

SYK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000010377	ENSGGOP00000010128	ENSGGOT00000010422

Organism

Gorilla gorilla

Functional Description

Protein Length

635

Protein Sequence
(FASTA)

MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK 60

AHHYTIEREL NGTYAIAGGR THASPADLCQ YHSQESDGLV CLLKKPFNRP QGVQPKTGPF 120

EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ 180

IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL 240

VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK 300

PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AAEKGPQREA LPMDTEVYES PYADPEEIRP 360

KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE 420

ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM 480

GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA 540

PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE 600

MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN 635

Nucleotide Sequence
(FASTA)

ATGGCCAGCA GCGGCATGGC TGACAGCGCC AACCACCTGC CCTTCTTTTT CGGCAACATC 60

ACCCGGGAGG AGGCAGAAGA TTACCTGGTC CAGGGGGGCA TGAGTGATGG GCTTTATTTG 120

CTGCGCCAGA GCCGCAACTA CTTGGGCGGC TTCGCCCTGT CCGTGGCCCA CGGGAGGAAG 180

GCACACCACT ACACCATCGA GCGGGAGCTG AATGGCACCT ACGCCATCGC CGGTGGCAGG 240

ACCCATGCCA GCCCCGCCGA CCTCTGCCAG TACCACTCCC AGGAGTCTGA TGGCCTGGTC 300

TGCCTCCTCA AGAAGCCCTT CAACCGGCCC CAAGGGGTGC AGCCCAAGAC TGGGCCCTTT 360

GAGGATTTGA AGGAAAACCT CATCAGGGAA TATGTGAAGC AGACATGGAA CCTGCAGGGT 420

CAGGCTCTGG AGCAGGCCAT CATCAGTCAG AAGCCTCAGC TGGAGAAGCT GATCGCTACC 480

ACAGCCCATG AAAAAATGCC TTGGTTCCAT GGAAAAATCT CTCGGGAAGA ATCTGAGCAA 540

ATTGTCCTGA TAGGATCAAA GACAAATGGA AAATTCCTGA TCCGAGCCAG AGACAACAAC 600

GGCTCCTACG CCCTGTGCCT GCTGCACGAA GGGAAGGTGC TGCACTATCG CATCGACAAA 660

GACAAGACAG GGAAGCTCTC CATCCCCGAG GGAAAGAAGT TCGACACGCT CTGGCAGCTA 720

GTCGAGCATT ATTCTTATAA AGCAGATGGT TTGTTAAGAG TTCTTACTGT CCCATGTCAA 780

AAAATCGGCA CACAGGGAAA TGTTAATTTT GGAGGCCGTC CACAACTTCC AGGTTCCCAT 840

CCTGCGACTT GGTCAGCGGG TGGAATAATC TCAAGAATCA AATCATACTC CTTCCCAAAG 900

CCTGGCCACA GAAAGTCCTC CCCTGCCCAA GGGAACCGGC AAGAGAGTAC TGTGTCATTC 960

AATCCGTATG AGCCAGAACT TGCACCCTGG GCTGCAGAAA AAGGCCCCCA GAGAGAAGCC 1020

CTACCCATGG ACACAGAGGT GTACGAGAGC CCCTACGCGG ACCCCGAGGA GATCAGGCCC 1080

AAGGAAGTTT ACCTGGACCG AAAGCTGCTG ACGCTGGAAG ACAAAGAACT GGGCTCTGGT 1140

AATTTTGGAA CTGTGAAAAA GGGCTACTAC CAAATGAAAA AAGTTGTGAA AACCGTGGCT 1200

GTGAAAATAC TGAAAAATGA GGCCAATGAC CCCGCTCTTA AAGATGAGTT ATTAGCAGAA 1260

GCAAATGTCA TGCAGCAGCT GGACAACCCG TACATCGTGC GCATGATCGG GATATGCGAG 1320

GCCGAGTCCT GGATGCTGGT TATGGAAATG GCAGAACTTG GTCCCCTCAA TAAGTATTTG 1380

CAGCAGAACA GACATGTCAA GGATAAGAAC ATCATAGAAC TGGTTCATCA GGTTTCCATG 1440

GGCATGAAGT ACTTGGAGGA GAGCAATTTT GTGCACAGAG ATCTGGCTGC AAGAAATGTG 1500

TTGCTAGTTA CCCAACATTA CGCCAAGATC AGTGATTTCG GACTTTCCAA AGCACTGCGT 1560

GCTGATGAAA ACTACTACAA GGCCCAGACC CATGGAAAGT GGCCTGTCAA GTGGTACGCT 1620

CCGGAATGCA TCAACTACTA CAAGTTCTCC AGCAAAAGCG ATGTCTGGAG CTTTGGAGTG 1680

TTGATGTGGG AAGCATTCTC CTATGGGCAG AAGCCATATC GAGGGATGAA AGGAAGTGAA 1740

GTCACCGCTA TGTTAGAGAA AGGAGAGCGG ATGGGGTGCC CTGCAGGGTG TCCAAGAGAG 1800

ATGTACGATC TCATGAATCT GTGCTGGACA TACGATGTGG AAAACAGGCC CGGATTCGCA 1860

GCAGTGGAAC TGCGGCTGCG CAATTACTAC TATGACGTGG TGAACTAA 1908

Domain Profile

S: 1     lvedkelGsGnfGsvkkGyyrmkkkrlevaikvlk.eadekadkdellreasvmqqldnk  59

         ++edkelGsGnfG+vkkGyy+mkk++++va+k+lk ea+++a kdell+ea+vmqqldn+

Q: 371   TLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKnEANDPALKDELLAEANVMQQLDNP  430

         589********************************99***********************

S: 60    yivrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleekn  119

         yivr+iGi++ae++mlvme+aelGpl+kyl+++r+ +k+kn++elvhqv+mGmkylee+n

Q: 431   YIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESN  489

         ***********************************.************************

S: 120   fvhrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkf  179

         fvhrdlaarnvllv++hyakisdfGlskalrade+yyka+++Gkwpvkwyapecin++kf

Q: 490   FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKF  549

         ************************************************************

S: 180   ssksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscw  239

         ssksdvwsfGv++weafsyGqkpy+++kgsev+a++ekGer++cpa+cp+e+y+lm+ cw

Q: 550   SSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCW  609

         ************************************************************

S: 240   kykvedrpdf  249

         +y+ve+rp+f

Q: 610   TYDVENRPGF  619

         *********9

Domain Sequence
(FASTA)

TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE ANVMQQLDNP 60

YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM GMKYLEESNF 120

VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA PECINYYKFS 180

SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE MYDLMNLCWT 240

YDVENRPGF 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR023420	; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR012234	; Tyr_kinase_non-rcpt_SYK/ZAP70.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 2.

SMARTs

SM00252	; SH2; 2.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 2.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013