EKS-GOG-00393
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00393
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR614.86.4E-185596953358
StatusUnreviewed
Ensembl ProteinENSGGOP00000010358
UniProt AccessionG3R4Z2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000010615ENSGGOP00000010358ENSGGOT00000010662
OrganismGorilla gorilla
Functional Description
Protein Length1092
Protein Sequence
(FASTA)
MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP 60
MSEEENSDVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTDEN ELEGRHIYIY 120
VPATDPDVAF VPLGMTDYLV IVEDDDSAII PCRTTDPETA VTLHNSEGVV PASYDSRQGF 180
NGTFTVGPYI CEATVKGKKF QTIPFNVYAL KATSELDLEM EALKTVYKSG ETIVVTCAVF 240
NNEVVDLQWT YPGEVKGKGI TMLEEIKIPS IKLVYTLTVP EATVKDSGDY ECAARQATRE 300
VKEMKKVTIS VHEKGFIEIK PTFSQLEAVN LHEVKHFVVE VRAYPPPRIS WLKNNLTLIE 360
NLTEITTDVE KIQEIRRYRS KLKLIRAKEE DSGHYTIVAQ NEDAVKSYTF ELLTQVPSSI 420
LDLVDDHHGS TGGQTVRCIA EGTPLPDIEW MICKDIKKCN NETSWTILAN NVSNIITEIH 480
PRDRSTVEGR VTFAKVEETI AVRCLAKNLL GAENRELKLV APTLRSELTV AAAVLVLLVI 540
VIISLIVLVV IWKQKPRYEI RWRVIESISP DGHEYIYVDP MQLPYDSRWE FPRDGLVLGR 600
VLGSGAFGKV VEGTAYGLSR SQPVMKVAVK MLKPTARSSE KQALMSELKI MTHLGPHLNI 660
VNLLGACTKS GPIYIITEYC FYGDLVNYLH KNRDSFLSHH PEKPKKELDI FGLNPADEST 720
RSYVILSFEN NGDYMDMKQA DTTQYVPMLE RKEVSKYSDI QRSLYDRPAS YKKKSMLDSE 780
VKNLLSDDNS EGLTLLDLLS FTYQVARGME FLASKNCVHR DLAARNVLLA QGKIVKICDF 840
GLARDIMHDS NYVSKGSTFL PVKWMAPESI FDNLYTTLSD VWSYGILLWE IFSLGGTPYP 900
GMMVDSTFYN KIKSGYRMAK PDHATSEVYE IMVKCWNSEP EKRPSFYHLS EIVENLLPGQ 960
YKKSYEKIHL DFLKSDHPAV ARMRVDSDNA YIGVTYKNEE DKLKDWEGGL DEQRLSADSG 1020
YIIPLPDIDP VPEEEDLGKR NRHSSQTSEE SAIETGSSSS TFIKREDETI EDIDMMDDIG 1080
IDSSDLVEDS FL 1092
Nucleotide Sequence
(FASTA)
ATGGGGACTT CCCATCCGGC GTTCCTGGTC TTAGGCTGTC TTCTCACAGG GCTGAGCCTA 60
ATCCTCTGCC AGCTTTCATT ACCCTCTATC CTTCCAAATG AAAATGAAAA GGTTGTGCAG 120
CTGAATTCAT CCTTTTCTCT GAGATGCTTT GGGGAGAGTG AAGTGAGCTG GCAGTACCCC 180
ATGTCTGAAG AAGAGAACTC CGATGTGGAA ATCAGAAATG AAGAAAACAA CAGTGGCCTT 240
TTTGTGACGG TCTTGGAAGT GAGCAGTGCC TCGGCGGCCC ACACAGGGTT GTACACTTGC 300
TATTACAACC ACACTCAGAC AGACGAGAAT GAGCTTGAAG GCAGGCACAT TTACATCTAT 360
GTGCCAGCCA CAGACCCAGA TGTAGCCTTT GTACCTCTAG GAATGACGGA TTATTTAGTC 420
ATCGTGGAGG ATGATGATTC TGCCATTATA CCTTGTCGCA CAACTGATCC CGAGACTGCT 480
GTAACCTTAC ACAACAGTGA GGGGGTGGTA CCTGCCTCCT ACGACAGCAG ACAGGGCTTT 540
AATGGGACCT TCACTGTAGG GCCCTATATC TGTGAGGCCA CCGTCAAAGG AAAGAAGTTC 600
CAGACCATCC CATTTAACGT TTATGCTTTA AAAGCAACAT CAGAGCTGGA TCTAGAAATG 660
GAAGCTCTTA AAACCGTGTA TAAGTCAGGG GAAACGATTG TGGTCACCTG TGCTGTTTTT 720
AACAATGAGG TGGTTGACCT TCAATGGACT TACCCTGGAG AAGTGAAAGG CAAAGGCATC 780
ACAATGCTGG AAGAAATCAA AATCCCATCC ATCAAATTGG TGTACACTTT GACGGTCCCC 840
GAGGCCACGG TGAAAGACAG TGGAGATTAC GAATGTGCTG CCCGCCAGGC TACCAGGGAG 900
GTCAAAGAAA TGAAGAAAGT CACTATTTCT GTCCATGAGA AAGGGTTCAT TGAAATCAAA 960
CCCACCTTCA GCCAGTTGGA AGCTGTCAAC CTGCATGAAG TCAAACATTT TGTTGTAGAG 1020
GTGCGGGCCT ACCCACCTCC TAGGATATCC TGGCTGAAAA ACAATCTGAC TCTGATTGAA 1080
AATCTCACTG AGATCACCAC TGATGTGGAA AAGATTCAGG AAATAAGAAG GTATCGAAGC 1140
AAATTAAAGC TGATCCGTGC TAAGGAAGAA GACAGTGGCC ATTATACTAT TGTAGCTCAA 1200
AATGAAGATG CTGTGAAGAG CTATACTTTT GAACTGTTAA CTCAAGTTCC TTCATCCATT 1260
CTGGACTTGG TCGATGATCA CCATGGCTCA ACTGGGGGAC AGACGGTGAG GTGCATAGCT 1320
GAAGGCACGC CGCTTCCTGA TATTGAGTGG ATGATATGCA AAGATATTAA GAAATGTAAT 1380
AATGAAACTT CCTGGACGAT TTTGGCCAAC AATGTCTCAA ACATCATCAC GGAGATCCAC 1440
CCCCGAGACA GGAGTACCGT GGAGGGCCGT GTGACTTTCG CCAAAGTGGA GGAGACCATC 1500
GCGGTGCGAT GCCTGGCTAA GAATCTCCTT GGAGCTGAGA ACCGAGAGCT GAAGCTGGTG 1560
GCTCCCACCC TGCGTTCTGA ACTCACGGTG GCTGCTGCAG TCCTGGTGCT GTTGGTGATT 1620
GTGATCATCT CACTTATTGT CCTGGTTGTC ATTTGGAAAC AGAAACCGAG GTATGAAATT 1680
CGCTGGAGGG TCATTGAATC AATCAGCCCG GATGGACATG AATATATTTA TGTGGACCCG 1740
ATGCAGCTGC CTTATGACTC AAGATGGGAG TTTCCAAGAG ATGGACTAGT GCTTGGTCGG 1800
GTCTTGGGGT CTGGAGCGTT TGGGAAGGTG GTTGAAGGAA CAGCCTATGG ATTAAGCCGG 1860
TCCCAACCTG TCATGAAAGT TGCAGTGAAG ATGCTAAAAC CCACGGCCAG ATCCAGTGAA 1920
AAACAAGCTC TCATGTCTGA ACTGAAGATA ATGACTCACC TGGGGCCACA TTTGAACATT 1980
GTAAACTTGC TGGGAGCCTG CACCAAGTCA GGCCCCATTT ACATCATCAC AGAGTACTGC 2040
TTCTATGGAG ATTTGGTCAA CTATTTGCAT AAGAATAGGG ATAGCTTCCT GAGCCACCAC 2100
CCAGAGAAGC CAAAGAAAGA GCTGGATATC TTTGGATTGA ACCCTGCTGA TGAAAGCACA 2160
CGGAGCTATG TTATTTTATC TTTTGAAAAC AATGGTGACT ACATGGACAT GAAGCAGGCT 2220
GATACTACAC AGTATGTCCC CATGCTAGAA AGGAAAGAGG TTTCTAAATA TTCCGACATC 2280
CAGAGATCAC TCTATGATCG TCCAGCCTCA TATAAGAAGA AATCTATGTT AGACTCAGAA 2340
GTCAAAAACC TCCTTTCAGA TGATAACTCA GAAGGCCTTA CTTTATTGGA TTTGTTGAGC 2400
TTCACCTATC AAGTTGCCCG AGGAATGGAG TTTTTGGCTT CAAAAAATTG TGTCCACCGT 2460
GATCTGGCTG CTCGCAACGT CCTCCTGGCA CAAGGAAAAA TCGTGAAGAT CTGTGACTTT 2520
GGCCTGGCCA GAGACATCAT GCATGATTCG AACTATGTGT CGAAAGGCAG TACCTTTCTG 2580
CCCGTGAAGT GGATGGCTCC TGAGAGCATC TTTGACAACC TCTACACCAC ACTGAGTGAT 2640
GTCTGGTCTT ACGGCATTCT GCTCTGGGAG ATCTTTTCCC TTGGTGGCAC CCCTTACCCC 2700
GGCATGATGG TGGATTCTAC TTTCTACAAT AAGATCAAGA GTGGGTACCG GATGGCCAAG 2760
CCTGACCACG CTACCAGTGA AGTCTACGAG ATCATGGTGA AATGCTGGAA CAGTGAGCCG 2820
GAGAAGAGAC CCTCCTTTTA CCACCTGAGT GAGATTGTGG AGAATCTGCT GCCTGGACAA 2880
TATAAAAAGA GTTATGAAAA AATTCACCTG GACTTCCTGA AGAGTGACCA TCCTGCTGTG 2940
GCACGCATGC GTGTGGACTC AGACAATGCA TACATTGGTG TCACCTACAA AAACGAGGAA 3000
GACAAGCTGA AGGACTGGGA GGGTGGTCTG GATGAGCAGA GACTGAGCGC TGACAGTGGC 3060
TACATCATTC CTCTGCCTGA CATTGACCCT GTCCCTGAGG AGGAGGACCT GGGCAAGAGG 3120
AACAGACACA GCTCGCAGAC CTCTGAAGAG AGTGCCATTG AGACGGGTTC CAGCAGTTCC 3180
ACCTTCATCA AGAGAGAGGA CGAGACCATT GAAGACATCG ACATGATGGA CGACATCGGC 3240
ATAGACTCTT CAGACCTGGT GGAAGACAGC TTCCTGTAA 3279
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG+vlGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 596   LVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  655
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sfl+++ ek   +++eld+++
Q: 656   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEK---PKKELDIFG  712
         *********************************************999...9999*****
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++y+d+k++                +sd+++s +d++as+k
Q: 713   LnPADESTRSYVILSFENNGDYMDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  772
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++evk+ l++++se+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 773   KKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  832
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 833   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  892
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim+kcw++epekrpsf++l+e+
Q: 893   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEI  952
         *********************************************************998
S: 344   l  344
         +
Q: 953   V  953
         6
Domain Sequence
(FASTA)
LVLGRVLGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FLSHHPEKPK KELDIFGLNP 120
ADESTRSYVI LSFENNGDYM DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEVKNLL SDDNSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG ILLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVKC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013