EKS-GOG-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	472.4	3.2E-142	195	440	246

Status

Unreviewed

Ensembl Protein

ENSGGOP00000010878

UniProt Accession

G3R6C9;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000011152	ENSGGOP00000010878	ENSGGOT00000011200

Organism

Gorilla gorilla

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60

PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 180

DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240

TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300

AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360

KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420

NCWHLDAAMR PSFLQLREQL EHIKTHELHL 450

Nucleotide Sequence
(FASTA)

ATGTCAGCAA TACAGGCCGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60

CACGGCACTG CCGAGCAGGA CCTGCCCTTC TGCAAAGGAG ACGTGCTCAC CATTGTGGCC 120

GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAGG TGGGCCGTGA GGGCATCATC 180

CCAGCCAACT ACGTCCAGAA GCGGGAGGGC GTGAAGGCGG GTACCAAACT CAGCCTCATG 240

CCTTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCTGAGC GGCTTCTGTA CCCGCCGGAG 300

ACAGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GAGACTACAC GCTGTGCGTG 360

AGCTGCGACG GCAAGGTGGA GCACTACCGC ATCATGTACC ATGCCAGCAA GCTCAGCATC 420

GACGAGGAGG TGTACTTTGA GAACCTCATG CAGCTGGTGG AGCACTACAC CTCAGACGCA 480

GATGGACTCT GTACGCGCCT CATTAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAG 540

GATGAGTTCT ACCGCAGCGG CTGGGCCCTG AACATGAAGG AGCTGAAGCT GCTGCAGACC 600

ATCGGGAAGG GGGAGTTCGG AGACGTGATG CTGGGCGATT ACCGAGGGAA CAAAGTCGCT 660

GTCAAGTGCA TTAAGAACGA CGCCACTGCC CAGGCCTTCC TGGCTGAAGC CTCAGTCATG 720

ACGCAACTGC GGCATAGCAA CCTCGTGCAG CTCCTGGGCG TGATCGTGGA GGAGAAGGGC 780

GGGCTCTACA TCGTCACTGA GTACATGGCC AAGGGGAGCC TCGTGGACTA CCTGCGGTCT 840

CGGGGTCGGT CAGTGCTGGG CGGAGACTGT CTCCTCAAGT TCTCGCTAGA TGTCTGCGAG 900

GCCATGGAAT ACCTGGAGGG CAACAATTTC GTGCATCGAG ACCTGGCTGC CCGCAATGTG 960

CTGGTGTCTG AGGACAACGT GGCCAAGGTC AGCGACTTTG GTCTCACCAA GGAGGCGTCC 1020

AGCACCCAGG ACACGGGCAA GCTGCCAGTC AAGTGGACAG CCCCTGAGGC CCTGAGAGAG 1080

AAGAAATTCT CCACTAAGTC TGACGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAC 1140

TCCTTTGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAG 1200

AAGGGCTACA AGATGGATGC CCCCGACGGC TGCCCGCCCG CAGTCTATGA GGTCATGAAG 1260

AACTGCTGGC ACCTGGATGC CGCCATGCGG CCCTCCTTCC TACAGCTCCG AGAGCAGCTT 1320

GAGCACATCA AAACCCACGA GCTGCACCTG TGA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv

Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 255   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  314

         *****99*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi

Q: 315   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf

Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFL  434

         ************************************************************

S: 240   klkekl  245

         +l+e+l

Q: 435   QLREQL  440

         ***997

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60

IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120

LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAAMRPSFL 240

QLREQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013