EKS-GOG-00364

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00364

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	386.8	5.4E-116	192	440	249

Status

Unreviewed

Ensembl Protein

ENSGGOP00000011037

UniProt Accession

G3R6S0;

Protein Name

Protein Synonyms/Alias

Gene Name

PTK6

Gene Synonyms/Alias

PTK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000011325	ENSGGOP00000011037	ENSGGOT00000011364

Organism

Gorilla gorilla

Functional Description

Protein Length

451

Protein Sequence
(FASTA)

MVSRDQTHLC PKYVGLWDFK SRTDEELSFR AGDVFHVARK EEQWWWATLL DEAGGAVAQG 60

YVPHNYLAER ETVESEPWFF GCISRSEAVR QLQAEGNAAG AFLIRVSEKP SADYVLSVRD 120

TQAVRHYKIW RRAGGRLHLN EAVSFLSLPE LVNYHRAQSL SHGLRLAAPC RKHEPEPLPH 180

WDDWERPREE FTLCRKLGSG YFGEVFEGLW KDRVQVAIKV ISRDNLLHQQ MLQSEIQAMK 240

KLRHKHILAL YAVVSVGDPV YIITELMAKG SLLELLRDSD EKVLPVSELL DIAWQVAEGM 300

CYLESQNYIH RDLAARNILV GENTLCKVGD FGLARLIKED VYLSHDHNIP YKWTAPEALS 360

RGHYSTKSDV WSFGILLHEM FSRGQVPYPG MSNHEAFLRV DAGYRMPCPL ECPPSVHKLM 420

LTCWCRDPEQ RPCFKALRER LSSFTSYENP T 451

Nucleotide Sequence
(FASTA)

ATGGTGTCCC GGGACCAGAC TCACCTGTGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 60

TCCCGGACGG ATGAGGAGCT GAGCTTCCGC GCGGGGGATG TCTTCCACGT GGCCAGGAAG 120

GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 180

TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 240

GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CAGCTGCAGG CCGAGGGCAA CGCCGCGGGC 300

GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 360

ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 420

GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 480

TCCCACGGCC TGCGGCTGGC CGCGCCCTGT CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 540

TGGGATGACT GGGAGAGGCC AAGGGAGGAG TTCACGCTCT GCAGAAAGCT GGGGTCCGGC 600

TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 660

ATTTCTCGAG ACAACCTCCT GCACCAGCAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG 720

AAGCTGCGGC ACAAACACAT CCTGGCGCTG TACGCCGTAG TGTCCGTGGG GGACCCCGTG 780

TACATCATCA CGGAGCTCAT GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGAT 840

GAGAAAGTCC TGCCCGTTTC GGAGCTGCTG GATATCGCCT GGCAGGTGGC TGAGGGCATG 900

TGTTACCTGG AGTCACAGAA TTACATCCAC CGGGACCTGG CCGCCAGGAA CATCCTCGTC 960

GGGGAAAACA CCCTCTGCAA AGTTGGGGAC TTCGGGTTAG CCAGGCTTAT CAAGGAGGAC 1020

GTGTACCTCT CCCATGACCA CAATATCCCC TACAAGTGGA CGGCCCCTGA AGCGCTCTCC 1080

CGAGGCCATT ACTCCACCAA ATCCGACGTC TGGTCCTTTG GGATTCTCCT GCATGAGATG 1140

TTCAGCAGGG GTCAGGTGCC CTACCCAGGC ATGTCCAACC ATGAGGCCTT CCTGAGGGTG 1200

GACGCCGGCT ACCGCATGCC CTGCCCTCTG GAGTGCCCGC CCAGCGTGCA CAAGCTGATG 1260

CTGACATGCT GGTGCAGGGA CCCCGAGCAG AGACCCTGCT TCAAGGCCCT GCGGGAGAGG 1320

CTCTCCAGCT TCACCAGCTA CGAGAACCCG ACCTGA 1356

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60

         +l++klG+G+fGev++g+wk++v+va+k++++++ l+++++++e+q++kklrh+++++ly

Q: 192   TLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNlLHQQMLQSEIQAMKKLRHKHILALY  251

         799******************************9778888999*****************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvs ++P+yi+telmakGsll++l+++++k l++++l+d+a+qvaeGm+yle++n+ihr

Q: 252   AVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHR  311

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dlaarn+lvge++++kv+dfGlarli++d y +++ +++P+kWtaPea++ g++++ksdv

Q: 312   DLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTAPEALSRGHYSTKSDV  370

         *******************************9876.99**********************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+e++++G+vPypGm+n+e++ +v++gyr+p+p ecp ++++l+l+cw +dpe+

Q: 371   WSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQ  430

         ************************************************************

S: 241   rPtfetlqev  250

         rP+f++l+e

Q: 431   RPCFKALRER  440

         *******986

Domain Sequence
(FASTA)

TLCRKLGSGY FGEVFEGLWK DRVQVAIKVI SRDNLLHQQM LQSEIQAMKK LRHKHILALY 60

AVVSVGDPVY IITELMAKGS LLELLRDSDE KVLPVSELLD IAWQVAEGMC YLESQNYIHR 120

DLAARNILVG ENTLCKVGDF GLARLIKEDV YLSHDHNIPY KWTAPEALSR GHYSTKSDVW 180

SFGILLHEMF SRGQVPYPGM SNHEAFLRVD AGYRMPCPLE CPPSVHKLML TCWCRDPEQR 240

PCFKALRER 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013