EKS-GOG-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	420.9	4.7E-126	1	307	307

Status

Unreviewed

Ensembl Protein

ENSGGOP00000011605

UniProt Accession

G3R8A1;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000011897	ENSGGOP00000011605	ENSGGOT00000011941

Organism

Gorilla gorilla

Functional Description

Protein Length

577

Protein Sequence
(FASTA)

VVKAYDRVEQ EWVAIKIIKN KKAFLNQAQI EVRLLELMNK HDTEMKYYIV HLKRHFMFRN 60

HLCLVFEMLS YNLYDLLRNT NFRGVSLNLT RKFAQQMCTA LLFLATPELS IIHCDLKPEN 120

ILLCNPKRSA IKIVDFGSSC QLGQRIYQYI QSRFYRSPEV LLGMPYDLAI DMWSLGCILV 180

EMHTGEPLFS GANEVDQMNK IVEVLGIPPA HILDQAPKAR KFFEKLPDGT WNLKKTKDGK 240

REYKPPGTRK LHNILGVETG GPGGRRAGES GHTVADYLKF KDLILRMLDY DPKTRIQPYY 300

ALQHSFFKKT ADEGTNTSNS VSTSPAMEQS QSSGTTSSTS SSSGGSSGTS NSGRARSDPT 360

HQHRHSGGHF TAAVQAMDCE THSPQVRQQF PAPLGWSGTE APTQVTVETH PVQETTFHVA 420

PQQNALHHHH GNSGQQALGN RTRPRVYNSP TNSSSTQDSM EVGHSHHSMT SLSSSTTSSS 480

TSSSSTGNQG NQAYQNRPVA ANTLDFGQNG AMDVNLTVYS NPRQETGIAG HPTYQFSANT 540

GPAHYMTEGH LTMRQGADRE ESPMTGVCVQ QSPVASS 577

Nucleotide Sequence
(FASTA)

GTTGTAAAGG CATATGATCG TGTGGAGCAA GAATGGGTTG CCATTAAAAT AATAAAGAAC 60

AAGAAGGCTT TTCTGAATCA AGCGCAGATA GAAGTGCGAC TTCTTGAGCT CATGAACAAA 120

CATGACACTG AAATGAAATA CTACATAGTG CATTTGAAAC GCCACTTTAT GTTTCGAAAC 180

CATCTCTGTT TAGTTTTTGA AATGCTGTCC TACAACCTCT ATGACTTGCT GAGAAACACC 240

AATTTCCGAG GGGTCTCTTT GAACCTAACA CGAAAGTTTG CGCAACAGAT GTGCACTGCA 300

CTGCTTTTCC TTGCGACTCC AGAACTTAGT ATCATTCACT GTGATCTAAA ACCTGAAAAT 360

ATCCTTCTTT GTAACCCCAA ACGCAGTGCA ATCAAGATAG TTGACTTTGG CAGTTCTTGT 420

CAGTTGGGGC AGAGGATATA CCAGTATATT CAGAGTCGCT TTTATCGGTC TCCAGAGGTG 480

CTACTGGGAA TGCCTTATGA CCTTGCCATT GATATGTGGT CCCTCGGGTG TATTTTGGTT 540

GAAATGCACA CTGGAGAACC TCTGTTCAGT GGTGCCAATG AGGTAGATCA GATGAATAAA 600

ATAGTAGAAG TTCTGGGTAT TCCACCTGCT CATATTCTTG ACCAAGCACC AAAAGCAAGA 660

AAGTTCTTTG AGAAGTTGCC AGATGGCACT TGGAACTTAA AGAAGACCAA AGATGGAAAA 720

CGGGAGTACA AACCGCCAGG AACCCGTAAA CTTCATAACA TTCTTGGAGT GGAAACAGGA 780

GGACCTGGTG GGCGTCGTGC TGGGGAGTCA GGTCATACGG TCGCTGACTA CTTGAAGTTC 840

AAAGACCTCA TTTTAAGGAT GCTTGATTAT GACCCCAAAA CTCGAATTCA ACCTTATTAT 900

GCTCTGCAGC ACAGTTTCTT CAAGAAAACA GCTGATGAAG GTACAAATAC AAGTAATAGT 960

GTATCTACAA GCCCCGCCAT GGAGCAGTCT CAGTCTTCGG GCACCACCTC CAGTACATCG 1020

TCAAGCTCAG GTGGCTCATC GGGGACAAGT AACAGTGGGA GAGCCCGGTC GGATCCGACG 1080

CACCAGCATC GGCACAGTGG CGGGCACTTC ACAGCTGCCG TGCAGGCCAT GGACTGCGAG 1140

ACACACAGTC CCCAGGTGCG TCAGCAATTT CCTGCTCCTC TTGGTTGGTC AGGCACTGAA 1200

GCTCCTACAC AGGTCACTGT TGAAACTCAT CCTGTTCAAG AAACAACCTT TCATGTAGCC 1260

CCTCAACAGA ATGCATTGCA TCATCACCAT GGTAACAGTG GACAACAAGC CTTGGGTAAC 1320

CGGACCAGGC CAAGGGTCTA CAATTCTCCA ACGAATAGCT CCTCTACCCA AGATTCTATG 1380

GAGGTTGGCC ACAGTCACCA CTCCATGACA TCCCTGTCTT CCTCAACGAC TTCTTCCTCG 1440

ACATCTTCCT CCTCTACTGG TAATCAAGGC AATCAGGCCT ACCAGAATCG CCCAGTGGCT 1500

GCTAATACCT TGGACTTTGG ACAGAATGGA GCTATGGACG TTAATTTGAC CGTCTACTCC 1560

AATCCCCGCC AAGAGACTGG CATAGCTGGA CATCCAACAT ACCAATTTTC TGCTAATACA 1620

GGTCCTGCAC ATTACATGAC TGAAGGACAT CTGACAATGA GGCAAGGGGC TGATAGAGAA 1680

GAGTCCCCCA TGACAGGAGT TTGTGTGCAA CAGAGTCCTG TAGCTAGCTC GTGA 1734

Domain Profile

S: 15    VvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeekynvvrllelfvfrn  74

         Vvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+ky++v+l+++f+frn

Q: 1     VVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRN  60

         8***********************************************************

S: 75    hlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk..elkiiHaDlKPeN  132

         hlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+  el+iiH+DlKPeN

Q: 61    HLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAtpELSIIHCDLKPEN  120

         ********************************************9999************

S: 133   illvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkydeaiDmWSlGcvl  192

         ill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++yd aiDmWSlGc+l

Q: 121   ILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCIL  179

         *************************.**********************************

S: 193   aElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkkeapkyilktk...  249

         +E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k  + ++ lk++

Q: 180   VEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTkdg  239

         ******************************************************999777

S: 250   ......ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.fkdllkrmleldpak  302

                ++rk +++l+v++ +     p+ +++ge+ ++++d+l fkdl+ rml++dp++

Q: 240   kreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkFKDLILRMLDYDPKT  294

         7777777777777777777776.....99*******************************

S: 303   Ritpkealkhpfv  315

         Ri+p++al+h+f+

Q: 295   RIQPYYALQHSFF  307

         ************7

Domain Sequence
(FASTA)

VVKAYDRVEQ EWVAIKIIKN KKAFLNQAQI EVRLLELMNK HDTEMKYYIV HLKRHFMFRN 60

HLCLVFEMLS YNLYDLLRNT NFRGVSLNLT RKFAQQMCTA LLFLATPELS IIHCDLKPEN 120

ILLCNPKRSA IKIVDFGSSC QLGQRIYQYI QSRFYRSPEV LLGMPYDLAI DMWSLGCILV 180

EMHTGEPLFS GANEVDQMNK IVEVLGIPPA HILDQAPKAR KFFEKLPDGT WNLKKTKDGK 240

REYKPPGTRK LHNILGVETG GPGGRRAGES GHTVADYLKF KDLILRMLDY DPKTRIQPYY 300

ALQHSFF 307

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>