EKS-GOG-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	402.9	7.6E-121	45	329	285

Status

Unreviewed

Ensembl Protein

ENSGGOP00000027018

UniProt Accession

G3R8S2;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000012084	ENSGGOP00000011790	ENSGGOT00000012131
ENSGGOG00000012084	ENSGGOP00000027018	ENSGGOT00000033252

Organism

Gorilla gorilla

Functional Description

Protein Length

420

Protein Sequence
(FASTA)

YISSYLLEMG SSEPLPIADG DRRRKKKRRA QATDSLPGKF EDMYKLTSEL LGEGAYAKVQ 60

GAVSLQNGKE YAVKIIEKQA GHSRSRVFRE VETLYQCQGN KNILELIEFF EDDTRFYLVF 120

EKLQGGSILA HIQKQKHFNE REASRVVRDV AAALDFLHTK GIAHRDLKPE NILCESPEKV 180

SPVKICDFDL GSGMKLNNSC TPITTPELTT PCGSAEYMAP EVVEVFTDQA TFYDKRCDLW 240

SLGVVLYIML SGYPPFVGHC GADCGWDRGE VCRVCQNKLF ESIQEGKYEF PDKDWAHISS 300

EAKDLISKLL VRDAKQRLSA AQVLQHPWVQ GQAPEKGLPT PQVLQRNSST MDLTLFAAEA 360

IALNRQLSQH EENELAEEPE ALADGLCSMK LSPPCKSRLA RRRALAQAGR GEDRSPPTAL 420

Nucleotide Sequence
(FASTA)

TACATCTCCT CTTATCTCCT AGAGATGGGC AGTAGCGAAC CCCTTCCCAT CGCAGATGGT 60

GACAGGAGGA GGAAGAAGAA GCGGAGGGCC CAGGCCACTG ACTCCTTGCC AGGAAAGTTT 120

GAAGATATGT ACAAGCTGAC CTCTGAATTG CTTGGAGAGG GAGCCTATGC CAAAGTTCAA 180

GGTGCCGTGA GCCTACAGAA TGGCAAAGAG TATGCCGTCA AAATCATCGA GAAACAAGCA 240

GGGCACAGTC GGAGTAGGGT GTTTCGAGAG GTGGAGACGC TGTATCAGTG TCAGGGAAAC 300

AAGAACATTT TGGAGCTGAT TGAGTTCTTT GAAGATGACA CAAGGTTTTA CTTGGTCTTT 360

GAGAAATTGC AAGGAGGTTC CATCTTAGCC CACATCCAGA AGCAAAAGCA CTTCAATGAG 420

CGAGAAGCCA GCCGAGTGGT GCGGGACGTT GCTGCTGCCC TTGACTTCCT GCATACCAAA 480

GGCATTGCTC ATCGTGATCT GAAACCAGAA AATATATTGT GTGAATCTCC AGAAAAGGTG 540

TCTCCAGTGA AAATCTGTGA CTTTGACTTG GGCAGTGGGA TGAAACTGAA CAACTCCTGT 600

ACCCCCATAA CCACACCAGA GCTGACCACC CCATGTGGCT CTGCAGAATA CATGGCCCCT 660

GAGGTAGTGG AGGTCTTCAC GGACCAGGCC ACATTCTACG ACAAGCGCTG TGACCTGTGG 720

AGCCTGGGCG TGGTCCTCTA CATCATGCTG AGTGGCTACC CGCCCTTCGT GGGTCACTGC 780

GGGGCCGACT GTGGCTGGGA CCGGGGCGAG GTCTGCAGGG TGTGCCAGAA CAAGCTGTTT 840

GAAAGCATCC AGGAAGGCAA GTATGAGTTT CCTGACAAGG ACTGGGCACA CATCTCCAGT 900

GAGGCCAAAG ACCTCATCTC CAAGCTCCTG GTGCGAGATG CAAAGCAGAG ACTTAGCGCC 960

GCCCAAGTTC TGCAGCACCC ATGGGTGCAG GGGCAAGCTC CAGAAAAGGG ACTCCCCACG 1020

CCGCAAGTCC TCCAGAGGAA CAGCAGCACA ATGGACCTGA CGCTCTTCGC AGCTGAGGCC 1080

ATCGCCCTTA ACCGCCAGCT ATCTCAGCAC GAAGAGAACG AACTAGCAGA GGAGCCAGAG 1140

GCACTAGCTG ATGGCCTCTG CTCCATGAAG CTTTCCCCTC CCTGCAAGTC ACGCCTGGCC 1200

CGGAGACGGG CCCTGGCCCA GGCAGGCCGT GGTGAAGACA GGAGCCCGCC CACAGCACTC 1260

TGA 1263

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+e+lGeG+++kv+ +v+ ++g++ya+ki+     ++r++v+reve+++q++g+kni+

Q: 45    KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIekqagHSRSRVFREVETLYQCQGNKNIL  104

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli++fe    d++r++lv+ekl+GG++l++iq++k+f+e+eas+vv+d+a+al+flh+k

Q: 105   ELIEFFE----DDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK  160

         *******....*************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaP  167

         +iahrDlkpen+L+es+ek++pvk+cDf+l+++++ +        +el+tpc++aey+aP

Q: 161   GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNnsctpittPELTTPCGSAEYMAP  220

         *********************************943346899999***************

S: 168   evleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklk  216

         ev+e+++++a++ydk+CDlWslGv+lyi+l+GypPf++++g           r +++kl+

Q: 221   EVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGadcgwdrgevcRVCQNKLF  280

         ****************************************99******************

S: 217   eriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         e+iqegkyefP+++W+++s+eakdli+klL+rd+k+rl++++vl+hpwv

Q: 281   ESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV  329

         ************************************************8

Domain Sequence
(FASTA)

KLTSELLGEG AYAKVQGAVS LQNGKEYAVK IIEKQAGHSR SRVFREVETL YQCQGNKNIL 60

ELIEFFEDDT RFYLVFEKLQ GGSILAHIQK QKHFNEREAS RVVRDVAAAL DFLHTKGIAH 120

RDLKPENILC ESPEKVSPVK ICDFDLGSGM KLNNSCTPIT TPELTTPCGS AEYMAPEVVE 180

VFTDQATFYD KRCDLWSLGV VLYIMLSGYP PFVGHCGADC GWDRGEVCRV CQNKLFESIQ 240

EGKYEFPDKD WAHISSEAKD LISKLLVRDA KQRLSAAQVL QHPWV 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013