EKS-GOG-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.1	1.0E-135	234	521	288

Status

Unreviewed

Ensembl Protein

ENSGGOP00000011797

UniProt Accession

G3R8S9;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000012093	ENSGGOP00000011797	ENSGGOT00000012138

Organism

Gorilla gorilla

Functional Description

Protein Length

532

Protein Sequence
(FASTA)

MGWLEELNWQ LHIFLLILLS MHTRANFLDN MLLRSAGKLN VGTKKEDGES TAPTPRPKVL 60

RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR 120

RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHKALLI SVTVCSLLLF LIILFCYFRY 180

KRQETRPRYS IGLEQDETYI PPGESLRDLI EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDY LKSTTLDTKS MLKLAYSSVS GLCHLHTEIF STQGKPAIAH 360

RDLKSKNILV KKNGTCCIAD LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN 420

HFQSYIMADM YSFGLILWEV ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCIKKLR 480

PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI KL 532

Nucleotide Sequence
(FASTA)

ATGGGTTGGC TGGAAGAACT AAACTGGCAG CTTCACATTT TCTTGCTCAT TCTTCTCTCT 60

ATGCACACAA GGGCAAACTT CCTTGATAAC ATGCTTTTGC GAAGTGCAGG AAAATTAAAT 120

GTGGGCACCA AGAAAGAGGA TGGTGAGAGT ACAGCCCCCA CCCCCCGTCC AAAGGTCTTG 180

CGTTGTAAAT GCCACCACCA TTGTCCAGAA GACTCAGTCA ACAATATTTG CAGCACAGAC 240

GGATATTGTT TCACGATGAT AGAAGAGGAT GACTCTGGGA TGCCTGTGGT CACTTCTGGA 300

TGCCTAGGAC TAGAAGGCTC AGATTTTCAG TGTCGGGACA CTCCCATTCC TCATCAAAGA 360

AGATCAATTG AATGCTGCAC AGAAAGGAAC GAATGTAATA AAGACCTACA CCCTACACTG 420

CCTCCATTGA AAAACAGAGA TTTTGTTGAT GGACCTATAC ACCACAAGGC TTTACTTATA 480

TCTGTGACTG TCTGTAGTTT GCTCTTGTTC CTTATCATAT TATTTTGTTA CTTCCGGTAT 540

AAAAGACAAG AAACCAGACC TCGATACAGC ATTGGGTTAG AACAGGATGA AACTTACATT 600

CCTCCTGGAG AATCCCTGAG AGACTTAATT GAGCAGTCTC AGAGCTCAGG AAGTGGATCA 660

GGCCTCCCTC TGCTGGTCCA AAGGACTATA GCTAAGCAGA TTCAGATGGT GAAACAGATT 720

GGAAAAGGTC GCTATGGGGA AGTTTGGATG GGAAAGTGGC GTGGCGAAAA GGTAGCTGTG 780

AAAGTGTTCT TCACCACAGA GGAAGCCAGC TGGTTCAGAG AGACAGAAAT ATATCAGACA 840

GTGTTGATGA GGCATGAAAA CATTTTGGGT TTCATTGCTG CAGATATCAA AGGGACAGGG 900

TCCTGGACCC AGTTGTACCT AATCACAGAC TATCATGAAA ATGGTTCCCT TTATGATTAT 960

CTGAAGTCCA CCACCCTAGA CACTAAATCA ATGCTGAAGT TAGCCTACTC TTCTGTCAGT 1020

GGCTTATGTC ATTTACACAC AGAAATCTTT AGTACTCAAG GCAAACCAGC AATTGCCCAT 1080

CGAGATCTGA AAAGTAAAAA CATTCTGGTG AAGAAAAATG GAACTTGCTG TATTGCTGAC 1140

CTGGGCCTGG CTGTTAAATT TATTAGTGAT ACAAATGAAG TTGACATACC ACCTAACACT 1200

CGAGTTGGCA CCAAACGCTA TATGCCTCCA GAAGTGTTGG ACGAGAGCTT GAACAGAAAT 1260

CACTTCCAGT CTTACATCAT GGCTGACATG TATAGTTTTG GCCTCATCCT TTGGGAGGTT 1320

GCTAGGAGAT GTGTATCAGG AGGTATAGTG GAAGAATACC AGCTTCCTTA TCATGACCTA 1380

GTGCCCAGTG ACCCCTCTTA TGAGGACATG AGGGAGATTG TGTGCATCAA GAAGTTACGC 1440

CCCTCATTCC CAAACCGGTG GAGCAGTGAT GAGTGTCTAA GGCAGATGGG GAAACTCATG 1500

ACAGAATGCT GGGCTCACAA TCCTGCATCA AGGCTGACAG CCCTGCGGGT TAAGAAAACA 1560

CTTGCCAAAA TGTCAGAGTC CCAGGACATT AAACTCTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 354   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 412   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 471   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013