EKS-GOG-00123

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00123

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	465.4	6.8E-140	1084	1342	259

Status

Unreviewed

Ensembl Protein

ENSGGOP00000011976

UniProt Accession

G3R996;

Protein Name

Protein Synonyms/Alias

Gene Name

MST1R

Gene Synonyms/Alias

MST1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000012260	ENSGGOP00000011976	ENSGGOT00000012320

Organism

Gorilla gorilla

Functional Description

Protein Length

1401

Protein Sequence
(FASTA)

MELLPPLPQS FLLLLLLPAK LAAGEDWQCP RTPYAASRDF DMKYVVPSFS AGGLVQAMVT 60

YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 120

KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS 180

PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK 240

HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLNC 300

RFAPKRRRRG APEGGQSYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV 360

GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQLPSFCPNP PGLEALSPNT 420

SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELARSL 480

NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIRGPGCRHF LTCGRCLSAW 540

RFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG 600

LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT 660

NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN 720

GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG 780

YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRQCERQLP EQQLCRLPEY VVRDPQGWVA 840

GNLSARGDGA AGFTLPGFRF LPPPHPPSAN LVPLKPEEHA IKFEYIGLGA VADCVGINVT 900

VGGESCQHEF RGDMVVCPLP PSLQLGQDGA PLQVCVDGEC HILGRVVRPG PDGVPQSTLL 960

GILLPLLLLV AALATALVFS YWWRRKQLVL PLNLNDLASL DQTAGAIPLP ILYSGSDYRS 1020

GLALPAIDGL DSTTCVHGAS FSDSKDESCV PLLRKESIQL RDLDSALLVE VKDVLIPHER 1080

VVTHSDRVIG KGHFGVVYHG EYIDQAQNRI QCAIKSLSRI TEMQQVEAFL REGLLMRGLN 1140

HPNVLALIGI MLPPEGLPHV LLPYMCHGDL LQFIRSPQRN PTVKDLISFG LQVARGMEYL 1200

AEQKFVHRDL AARNCMLDES FTVKVADFGL ARDILDKEYY SVRQHRHARL PVKWMALESL 1260

QTYRFTTKSD VWSFGVLLWE LLTRGAPPYR HIDPFDLTHF LAQGRRLPQP EYCPDSLYQV 1320

MQQCWEADPA VRPTFGVLVG EVEQIVSALL GDHYVQLPAT YMNLGPSTSH EMNVRPEQPQ 1380

SSPMPGNVRR PRPLSEPPRP T 1401

Nucleotide Sequence
(FASTA)

ATGGAGCTCC TCCCGCCGCT GCCTCAGTCC TTCCTGTTGC TGCTGCTGTT GCCTGCCAAG 60

CTCGCGGCGG GCGAGGACTG GCAGTGCCCG CGCACCCCCT ACGCGGCCTC TCGCGACTTT 120

GACATGAAGT ACGTGGTGCC CAGCTTCTCC GCCGGAGGCC TGGTGCAGGC CATGGTGACC 180

TACGAGGGCG ACAGAAATGA GAGTGCTGTG TTTGTAGCCA TACGCAATCG CCTGCATGTG 240

CTTGGGCCTG ACCTGAAGTC TGTCCAGAGC CTGGCCACGG GCCCTGCTGG AGACCCTGGC 300

TGCCAGACGT GTGCAGCCTG TGGCCCAGGA CCCCACGGCC CTCCCGGTGA CACAGACACA 360

AAGGTGCTGG TGCTGGATCC CGCGCTGCCT GCGCTGGTCA GTTGTGGCTC CAGCCTGCAG 420

GGCCGCTGCT TCCTGCATGA CCTAGAGCCC CAAGGGACAG CCGTGCATCT GGCAGCGCCA 480

GCCTGCCTCT TCTCAGCCCA CCATAACCGG CCCGATGACT GCCCCGACTG TGTGGCCAGC 540

CCATTGGGCA CCCGTGTAAC TGTGGTTGAG CAAGGCCAGG CCTCCTATTT CTACGTGGCA 600

TCCTCACTGG ACGCAGCCGT GGCTGCCAGC TTCAGCCCAC GCTCAGTGTC TATCAGGCGT 660

CTCAAGGCCG ACGCCTCGGG ATTCGCACCG GGCTTTGTGG CGTTGTCAGT GCTGCCCAAG 720

CATCTTGTCT CCTACAGTAT TGAATACGTG CACAGCTTCC ACACGGGAGC CTTCGTATAC 780

TTCCTGACTG TACAGCCGGC CAGCGTGACA GATGATCCTA GTGCCCTGCA CACACGCCTG 840

GCACGGCTTA GCGCCACTGA GCCAGAGTTG GGTGACTATC GGGAGCTGGT CCTCAACTGC 900

AGATTTGCTC CAAAACGCAG GCGCCGGGGG GCCCCAGAAG GCGGACAGTC CTACCCTGTG 960

CTGCGGGTGG CCCACTCCGC TCCAGTGGGT GCCCAACTTG CCACTGAGCT GAGCATCGCT 1020

GAGGGCCAGG AAGTGCTATT TGGGGTCTTT GTGACTGGCA AGGATGGTGG TCCTGGCGTG 1080

GGCCCCAACT CTGTCGTCTG TGCCTTCCCC ATTGACCTGC TGGACACACT AATTGATGAG 1140

GGTGTGGAGC GCTGTTGTGA ATCCCCAGTC CATCCAGGCC TCCGGCGAGG CCTCGACTTC 1200

TTCCAGTTGC CCAGTTTTTG CCCCAACCCG CCTGGCCTGG AAGCCCTCAG CCCCAACACC 1260

AGCTGCCGCC ACTTCCCTCT GCTGGTCAGT AGCAGCTTCT CACGTGTGGA CCTATTCAAT 1320

GGGCTGTTGG GACCAGTACA GGTCACTGCA TTGTATGTGA CACGCCTTGA CAACGTCACA 1380

GTGGCGCACA TGGGCACAAT GGATGGGCGT ATCCTGCAGG TGGAGCTGGC CAGGTCACTA 1440

AACTACTTGC TGTATGTGTC CAACTTCTCA CTGGGTGACA GTGGGCAGCC CGTGCAGCGG 1500

GATGTCAGTC GTCTTGGGGA CCACCTACTC TTCGCCTCTG GGGACCAGGT TTTCCAGGTA 1560

CCTATCCGAG GCCCTGGCTG CCGCCACTTC CTGACCTGTG GGCGTTGCCT AAGTGCATGG 1620

CGTTTCATGG GCTGTGGCTG GTGTGGGAAC ATGTGCGGCC AGCAGAAGGA GTGTCCTGGC 1680

TCCTGGCAAC AGGACCACTG CCCACCTAAG CTTACTGAGT TCCACCCCCA CAGTGGACCT 1740

CTAAGGGGCA GTACAAGGCT GACCCTGTGT GGCTCCAACT TCTACCTGCA CCCTTCTGGT 1800

CTGGTGCCTG AGGGAACCCA TCAGGTCACT GTGGGCCAAA GTCCCTGCCG GCCACTGCCC 1860

AAGGACAGCT CAAAACTCAG ACCAGTGCCC CGGAAAGACT TTGTAGAGGA GTTTGAGTGT 1920

GAACTGGAGC CCTTGGGCAC CCAGGCAGTG GGGCCTACCA ACGTCAGCCT CACCGTGACT 1980

AACATGCCAC CGGGCAAGCA CTTCCGGGTA GACGGCACCT CCGTGCTGAG AGGCTTCTCT 2040

TTTATGGAGC CAGTGCTGAT AGCAGTGCAA CCCCTCTTTG GCCCACGGGC AGGAGGCACC 2100

TGTCTCACTC TTGAAGGCCA GAGTCTGTCT GTAGGCACCA GCCGGGCTGT GCTGGTCAAT 2160

GGGACTGAGT GTCTGCTAGC ACGGGTCAGT GAGGGGCAGC TTTTATGTGC CACACCCCCT 2220

GGGGCCACGG TGGCCAGTGT CCCCCTTAGC CTGCAGGTGG GGGGTGCCCA GGTACCTGGT 2280

TCCTGGACCT TCCAGTACAG AGAAGACCCT GTCGTGCTAA GCATCAGCCC CAACTGTGGC 2340

TACATCAACT CCCACATCAC CATCTGTGGC CAGCATCTAA CTTCAGCATG GCACTTAGTG 2400

CTGTCATTCC ATGACGGGCT TAGGGCAGTG GAAAGCAGGC AGTGTGAGAG GCAGCTTCCA 2460

GAGCAGCAGC TGTGCCGCCT TCCTGAATAT GTGGTCCGAG ACCCCCAGGG ATGGGTGGCA 2520

GGGAATCTGA GTGCCCGGGG GGATGGAGCT GCTGGCTTTA CACTGCCTGG CTTTCGCTTC 2580

CTACCCCCAC CCCATCCACC CAGTGCCAAC CTAGTTCCAC TGAAGCCTGA GGAGCATGCC 2640

ATTAAGTTTG AGTATATTGG GCTGGGCGCT GTGGCTGACT GTGTGGGTAT CAACGTGACC 2700

GTGGGTGGTG AGAGCTGCCA GCACGAGTTC CGGGGGGACA TGGTTGTCTG CCCCCTGCCC 2760

CCATCCCTGC AGCTTGGCCA GGATGGTGCC CCATTGCAGG TCTGCGTAGA TGGTGAATGT 2820

CATATCCTGG GTAGAGTGGT GCGGCCAGGG CCAGACGGGG TCCCACAGAG CACGCTCCTT 2880

GGTATCCTGC TGCCTTTGCT GCTGCTTGTG GCTGCACTGG CGACTGCACT GGTCTTCAGC 2940

TACTGGTGGC GGAGGAAGCA GCTAGTTCTT CCTCTCAACC TGAATGACCT GGCATCCCTG 3000

GACCAGACTG CTGGAGCCAT ACCCCTGCCT ATTCTGTACT CGGGCTCTGA CTACAGAAGT 3060

GGCCTTGCAC TCCCTGCCAT TGATGGTCTG GATTCCACCA CTTGTGTCCA TGGAGCATCC 3120

TTCTCCGATA GTAAAGATGA ATCCTGTGTG CCACTGCTGC GGAAAGAGTC CATCCAGCTA 3180

AGGGACCTGG ACTCTGCGCT CTTGGTTGAG GTCAAGGATG TGCTGATTCC CCATGAGCGG 3240

GTGGTCACCC ACAGTGACCG AGTCATTGGC AAAGGCCACT TTGGAGTTGT CTACCACGGA 3300

GAATACATAG ACCAGGCCCA GAATCGAATC CAATGTGCCA TCAAGTCACT AAGTCGCATC 3360

ACAGAGATGC AGCAGGTGGA GGCCTTCCTG CGAGAGGGGC TGCTCATGCG TGGCCTGAAC 3420

CACCCGAATG TGCTGGCTCT CATTGGTATC ATGTTGCCAC CTGAGGGCCT GCCCCATGTG 3480

CTGCTGCCCT ATATGTGCCA CGGTGACCTG CTCCAGTTCA TCCGCTCACC TCAGCGGAAC 3540

CCCACCGTGA AGGACCTCAT CAGCTTTGGC CTGCAGGTAG CCCGCGGCAT GGAGTACCTG 3600

GCAGAGCAGA AGTTTGTGCA CAGGGACCTG GCTGCGCGGA ACTGCATGCT GGACGAGTCA 3660

TTCACAGTCA AGGTGGCTGA CTTTGGTTTG GCCCGCGACA TCCTGGACAA GGAGTACTAT 3720

AGTGTTCGAC AGCATCGCCA CGCTCGCCTA CCTGTGAAGT GGATGGCGCT GGAGAGCCTG 3780

CAGACCTATA GATTTACCAC CAAGTCTGAT GTGTGGTCAT TTGGTGTGCT GCTGTGGGAA 3840

CTGCTGACAC GGGGTGCCCC ACCATACCGC CACATTGACC CTTTTGACCT TACCCACTTC 3900

CTGGCCCAGG GTCGGCGCCT GCCCCAGCCT GAGTATTGCC CTGATTCTCT GTACCAAGTG 3960

ATGCAGCAAT GCTGGGAGGC AGACCCAGCA GTGCGACCCA CCTTCGGAGT ACTAGTGGGG 4020

GAGGTGGAGC AGATAGTGTC TGCACTGCTT GGGGACCATT ATGTGCAGCT GCCAGCAACC 4080

TACATGAACT TGGGCCCCAG CACCTCTCAT GAGATGAATG TGCGTCCAGA ACAGCCACAG 4140

TCCTCACCCA TGCCAGGGAA TGTACGCCGG CCCCGGCCAC TCTCAGAGCC TCCTCGGCCC 4200

ACTTGA 4206

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++++viGkGhfGvvy+ge++d+a+++i++a+ksl+rit++++ve+flregl+m++l+hpn

Q: 1084  HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPN  1143

         7899********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vl+l+Gi+l++eglp+v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla++

Q: 1144  VLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ  1203

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfGlard+ldke+y+v+++r+arlpvkw+aleslqt+

Q: 1204  KFVHRDLAARNCMLDESFTVKVADFGLARDILDKEYYSVRQHRHARLPVKWMALESLQTY  1263

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         + fttksdvwsfGvllwelltrga+py+++++fdlt++l++grrl++peycpd+ly+vm+

Q: 1264  R-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQ  1322

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsii  261

         +cw+a+pa rp+f  lv  +

Q: 1323  QCWEADPAVRPTFGVLVGEV  1342

         *************9998765

Domain Sequence
(FASTA)

HSDRVIGKGH FGVVYHGEYI DQAQNRIQCA IKSLSRITEM QQVEAFLREG LLMRGLNHPN 60

VLALIGIMLP PEGLPHVLLP YMCHGDLLQF IRSPQRNPTV KDLISFGLQV ARGMEYLAEQ 120

KFVHRDLAAR NCMLDESFTV KVADFGLARD ILDKEYYSVR QHRHARLPVK WMALESLQTY 180

RFTTKSDVWS FGVLLWELLT RGAPPYRHID PFDLTHFLAQ GRRLPQPEYC PDSLYQVMQQ 240

CWEADPAVRP TFGVLVGEV 259

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275	; P:multicellular organismal development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013