EKS-GOG-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.2	1.5E-128	82	334	253

Status

Unreviewed

Ensembl Protein

ENSGGOP00000012402

UniProt Accession

G3RAD3;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000012710	ENSGGOP00000012402	ENSGGOT00000012761

Organism

Gorilla gorilla

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MELLRTITYQ PAASTKMCEQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAAPHHHH 60

HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 120

PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 180

EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 240

CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 300

SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA 360

KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEDIYKLRH DLKKTSITQQ PSKHRTDEEL 420

QPPTTTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 480

GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 540

KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDIRRPRL 600

YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 660

LMSGCSSELK NRMEYALNML LQRCN 685

Nucleotide Sequence
(FASTA)

ATGGAGCTTT TGCGGACTAT CACCTACCAG CCAGCCGCCA GCACCAAAAT GTGCGAGCAG 60

GCGCTGGGCA AGGGTTGCGG AGCGGACTCG AAGAAGAAGC GGCCGCCGCA GCCCCCCGAG 120

GAATCGCAGC CACCTCAGTC CCAGGCGCAA GTGCCCCCGG CGGCCCCTCA CCACCATCAC 180

CACCATTCGC ACTCGGGGCC GGAGATCTCG CGGATTATCG TCGACCCCAC GACGGGGAAG 240

CGCTACTGCC GGGGCAAAGT GCTGGGAAAG GGTGGCTTTG CAAAATGTTA CGAGATGACA 300

GATTTGACAA ATAACAAAGT CTACGCCGCA AAAATTATTC CTCACAGCAG AGTAGCTAAA 360

CCTCATCAAA GGGAAAAGAT TGACAAAGAA ATAGAGCTTC ACAGAATTCT TCATCATAAG 420

CATGTAGTAC AGTTTTACCA CTACTTCGAG GACAAAGAAA ACATTTACAT TCTCTTGGAA 480

TACTGCAGTA GAAGGTCAAT GGCTCATATT TTGAAAGCAA GAAAGGTGTT GACAGAGCCA 540

GAAGTTCGAT ACTACCTCAG GCAGATTGTG TCTGGACTGA AATACCTTCA TGAACAAGAA 600

ATCTTGCACA GAGATCTCAA ACTAGGGAAC TTTTTTATTA ATGAAGCCAT GGAACTAAAA 660

GTTGGGGACT TCGGTCTGGC AGCCAGGCTA GAACCCTTGG AACACAGAAG GAGAACGATA 720

TGTGGTACCC CAAATTATCT CTCTCCTGAA GTCCTCAACA AACAAGGACA TGGCTGTGAA 780

TCAGACATTT GGGCCCTGGG CTGTGTAATG TATACAATGT TACTAGGGAG GCCCCCATTT 840

GAAACTACAA ATCTCAAAGA AACTTATAGG TGCATAAGGG AAGCAAGGTA TACAATGCCG 900

TCCTCATTGC TGGCTCCTGC CAAGCACTTA ATTGCTAGTA TGTTGTCCAA AAACCCAGAG 960

GATCGTCCCA GTTTGGATGA CATCATTCGA CATGACTTTT TTTTGCAGGG CTTCACTCCG 1020

GACAGACTGT CTTCTAGCTG TTGTCATACA GTTCCAGATT TCCACTTATC AAGCCCAGCT 1080

AAGAATTTCT TTAAGAAAGC AGCTGCTGCT CTTTTTGGTG GCAAAAAAGA CAAAGCAAGA 1140

TATATTGACA CACATAATAG AGTGTCTAAA GAAGATGAAG ACATCTACAA GCTTAGGCAT 1200

GATTTGAAAA AGACTTCAAT AACTCAGCAA CCCAGCAAAC ACAGGACAGA TGAGGAGCTC 1260

CAGCCACCTA CCACCACAGT TGCCAGGTCT GGAACACCCG CAGTAGAAAA CAAGCAGCAG 1320

ATTGGGGATG CTATTCGGAT GATAGTCAGA GGGACTCTTG GCAGCTGTAG CAGCAGCAGT 1380

GAATGCCTTG AAGACAGTAC TATGGGAAGT GTTGCAGACA CAGTGGCAAG GGTTCTTCGG 1440

GGATGTCTGG AAAACATGCC GGAAGCTGAT TGCATTCCCA AAGAGCAGCT GAGCACATCA 1500

TTTCAGTGGG TCACCAAATG GGTTGATTAC TCTAACAAAT ATGGCTTCGG GTACCAGCTC 1560

TCAGACCACA CCGTCGGTGT CCTTTTCAAC AATGGTGCTC ACATGAGCCT CCTTCCAGAC 1620

AAAAAAACAG TTCACTATTA CGCAGAGCTT GGCCAATGCT CAGTTTTCCC AGCAACAGAT 1680

GCTCCTGAGC AATTTATTAG TCAAGTGACG GTGCTGAAAT ACTTTTCTCA TTACATGGAG 1740

GAGAACCTCA TGGATGGTGG AGATCTGCCT AGTGTTACTG ATATTCGAAG ACCTCGGCTC 1800

TACCTCCTTC AGTGGCTAAA ATCTGATAAG GCCCTAATGA TGCTCTTTAA TGATGGCACC 1860

TTTCAGGTGA ATTTCTACCA TGATCATACA AAAATAATCA TCTGTAGCCA AAATGAAGAA 1920

TATCTTCTCA CCTACATCAA TGAGGATAGG ATATCTACAA CTTTCAGGCT GACAACTCTG 1980

CTGATGTCTG GCTGTTCATC AGAATTAAAA AATCGAATGG AATATGCCCT GAACATGCTC 2040

TTACAAAGAT GTAACTGA 2058

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 82    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  141

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 142   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  201

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 202   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  261

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 262   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  321

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+++++++f+

Q: 322   RPSLDDIIRHDFF  334

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013