EKS-GOG-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	241.1	1.5E-71	999	1258	260

Status

Unreviewed

Ensembl Protein

ENSGGOP00000012483

UniProt Accession

G3RAL0;

Protein Name

Protein Synonyms/Alias

Gene Name

PASK

Gene Synonyms/Alias

PASK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000012790	ENSGGOP00000012483	ENSGGOT00000012844

Organism

Gorilla gorilla

Functional Description

Protein Length

1330

Protein Sequence
(FASTA)

MEDGGLTAFE EDQRCLSQSL PLPVSAEGPA AQTTAEPSRS FSSAHRHLSR RNGLSRLCQS 60

RTALSEDRWS SYCLSSLAAQ NICTSKLHCP AAPEHTDPSE PRGSVSCCSL LQGLSSGWSS 120

PLLPAPVCNP NKAIFTVDAK TTEILVANDK ACRLLGYSSQ DLIGQKLTQF FLRSDSDVVE 180

ALSEEHMEAD GHAAVVCGTV VDIISRSGEK IPVSVWMKRM RQEHRLCCVV VLEPVERVST 240

WVAFQSDGTV TSCDSLFAHL HGYVSGEDVA GQHITDLIPS VQLPPSGQHI PKTLKIQRSV 300

GRARDGTTFP LSLKLKSQPS SEEATTGEAA PVRGYRASVW VFCTISGLIT LLPDGTIHGI 360

NHSFALTLFG YGKTELLGKN ITFLIPGFYS YMDLAYNSSL QLPDLASCLD VGDESGCGER 420

TLDPWQGQDP AEGAQDPRIN VVLAGGHIVP RDETRKLMES QDIFTGTQTE LGAGGQFLSC 480

LSPQPAPGVD SVPEGSLPVH GEQALPEDQQ ITALGREEPV AIESPGQDLL GESSSERVDV 540

KPFASCEDSE APVPAEDGGS DAGMCGLCQK AQLERMGVSG PSSSDLWAGA AVAEPQAKGQ 600

LAGGSLLMHC PCYGSEWGLR WRSQELVPSP SGMAGLSFGT PTPDEPWLGV ENDREELQTC 660

LIKEQLSQLS LAGALDVPHA ELVPTECPAV TAPVSSCDLG GRDLYGGCTG SSSACYALAT 720

DLPGGLEAVE AQEVDVNSFS WNLKELFFSD QTDQTSSNCS CATSELREAP SSLAAGSDPD 780

VGSLQEQGSC VLDDRELLLL TGTCVDLGQG RRFRESCVGH DPTEPLEVCL VSSEHYAASD 840

RESPGRVPSM LDAGPEDTCP SAEEPRLNVQ VTSTPVIVMR GAAGLQREIQ EGAYSGSCYH 900

RDGLRLSIQF EVRRVELQGP TPLFCCWLVK DLLHSQRDSA SRTRLLLASL PGSTHSTAAE 960

LTGPSLVEVL RARPWFEEPH KAVELEGLAA CEGEYSQKYS TLSPLGSGAF GFVWTAVDKE 1020

KNKEVVVKFI KKEKVLEDCW IEDPKLGKVT LEIAILSRVE HANIIKVLDV FENQGFFQLV 1080

MEKHGSGLDL FAFIDRHPRL DEPLASYIFR QVRAGQSRLV SAVGYLRLKD IIHRDIKDEN 1140

IVIAEDFTIK LIDFGSAAYL ERGKLFYTFC GTIEYCAPEV LMGNPYRGPE LEMWSLGVTL 1200

YTLVFEENPF CELEETVEAA IHPPYLVSKE LMSLVSGLLQ PVPEKRTTLE KLVTDPWVTQ 1260

PVNLADYTWE EVCPVNKPES GVLSTASLEM GNRSLSDVAQ AQELCGGPIP GEAPNGQGCL 1320

HPGDPRLLTS 1330

Nucleotide Sequence
(FASTA)

ATGGAGGACG GGGGCTTAAC AGCCTTTGAA GAGGACCAGA GATGCCTTTC CCAGAGCCTT 60

CCCTTGCCAG TGTCAGCAGA GGGCCCAGCT GCACAGACCA CTGCTGAGCC CAGCAGGTCG 120

TTTTCCTCAG CCCACAGACA CCTGAGCAGA AGGAATGGGC TTTCCAGACT CTGCCAGAGC 180

AGGACGGCGC TCTCTGAAGA CAGATGGAGC TCCTATTGTC TATCATCACT GGCTGCCCAG 240

AATATTTGTA CAAGTAAACT GCACTGCCCT GCTGCCCCCG AGCACACGGA CCCGTCCGAG 300

CCCCGGGGCA GTGTGTCCTG CTGCTCCCTG CTGCAGGGAC TGTCCTCAGG GTGGTCCTCA 360

CCTCTGCTTC CGGCCCCTGT GTGCAACCCT AACAAGGCCA TCTTCACGGT GGATGCCAAG 420

ACCACAGAGA TCCTGGTTGC TAATGACAAA GCTTGCAGGC TCCTGGGGTA CAGCAGCCAG 480

GACCTGATTG GCCAGAAGCT CACGCAGTTC TTTCTGAGGT CAGATTCTGA TGTGGTGGAG 540

GCCCTCAGCG AGGAGCACAT GGAGGCCGAC GGCCACGCTG CGGTGGTGTG CGGCACGGTG 600

GTGGACATCA TCAGCCGTAG TGGGGAGAAG ATTCCAGTGT CTGTGTGGAT GAAGAGGATG 660

CGGCAGGAGC ATCGCCTATG CTGCGTGGTG GTCCTGGAGC CCGTGGAGAG GGTCTCGACC 720

TGGGTCGCTT TCCAGAGCGA TGGCACCGTC ACGTCATGCG ACAGTCTCTT TGCTCATCTT 780

CACGGGTACG TGTCTGGGGA GGACGTGGCT GGGCAGCATA TCACAGACCT GATCCCTTCT 840

GTGCAGCTCC CTCCTTCTGG CCAGCACATC CCAAAGACTC TCAAGATTCA GAGGTCTGTT 900

GGAAGAGCCA GGGACGGTAC CACCTTCCCT CTGAGCTTAA AGCTGAAATC CCAACCCAGC 960

AGCGAGGAGG CGACCACCGG TGAGGCAGCC CCTGTGAGGG GCTACCGGGC ATCTGTCTGG 1020

GTGTTCTGCA CCATTAGCGG CCTCATCACC CTCCTGCCGG ATGGGACCAT CCACGGCATC 1080

AACCACAGCT TCGCGCTGAC ACTGTTTGGT TACGGAAAGA CGGAGCTCCT GGGCAAGAAT 1140

ATCACTTTCC TGATTCCTGG TTTCTACAGC TACATGGACC TTGCGTACAA CAGCTCATTA 1200

CAGCTCCCAG ACCTGGCCAG CTGCCTGGAT GTTGGCGATG AGAGTGGGTG TGGGGAGAGA 1260

ACCTTGGACC CGTGGCAGGG CCAGGACCCA GCTGAGGGGG CCCAGGATCC AAGGATTAAT 1320

GTCGTGCTTG CTGGTGGCCA CATCGTGCCC CGAGATGAGA CCCGGAAGCT GATGGAAAGC 1380

CAAGACATCT TCACTGGGAC TCAGACTGAG CTGGGAGCTG GAGGCCAGTT CCTTTCCTGC 1440

CTCTCACCTC AGCCTGCTCC AGGGGTGGAC AGTGTCCCAG AAGGAAGCCT GCCAGTGCAC 1500

GGTGAACAGG CGCTGCCCGA GGACCAGCAA ATCACTGCCT TGGGGAGAGA GGAACCTGTG 1560

GCAATAGAGA GCCCCGGACA GGATCTTCTG GGAGAAAGCA GTTCTGAACG AGTGGATGTG 1620

AAGCCATTTG CTTCCTGCGA AGATTCTGAA GCTCCAGTCC CAGCTGAGGA TGGGGGCAGT 1680

GACGCTGGCA TGTGTGGCCT GTGTCAGAAG GCCCAGCTAG AGCGGATGGG AGTCAGTGGT 1740

CCCAGCAGTT CCGACCTTTG GGCTGGGGCT GCCGTGGCCG AGCCCCAGGC CAAGGGTCAG 1800

CTGGCGGGGG GCAGCCTCCT GATGCACTGC CCTTGCTACG GGAGTGAATG GGGCTTGCGG 1860

TGGCGAAGCC AGGAGTTGGT CCCCAGCCCC TCTGGGATGG CAGGCCTCTC GTTTGGGACA 1920

CCTACTCCAG ATGAGCCGTG GCTGGGAGTG GAAAACGACC GAGAAGAGCT GCAGACCTGC 1980

TTGATTAAGG AGCAGCTGTC CCAGTTGAGC CTTGCGGGAG CCCTGGATGT CCCCCACGCC 2040

GAACTCGTTC CAACAGAGTG CCCGGCTGTC ACCGCTCCTG TGTCGTCCTG TGATCTGGGA 2100

GGCAGAGACC TGTACGGTGG CTGCACGGGC AGCTCCTCAG CCTGCTATGC CTTGGCCACG 2160

GACCTCCCTG GGGGCCTGGA AGCAGTGGAG GCCCAGGAGG TTGATGTGAA TTCGTTTTCC 2220

TGGAACCTCA AGGAACTCTT TTTCAGTGAC CAGACAGACC AAACGTCATC AAATTGTTCC 2280

TGTGCTACGT CTGAACTCAG AGAGGCACCC TCTTCCTTGG CAGCGGGCTC CGATCCAGAT 2340

GTAGGCAGTC TCCAGGAACA GGGGTCGTGT GTCCTGGATG ACAGGGAGCT GTTACTACTG 2400

ACCGGCACCT GTGTTGACCT TGGCCAAGGC CGACGGTTCC GGGAGAGCTG TGTGGGACAT 2460

GATCCAACAG AACCGCTTGA GGTTTGTTTG GTGTCCTCTG AGCATTATGC AGCAAGCGAC 2520

AGAGAAAGCC CAGGACGCGT TCCTTCCATG TTGGATGCTG GCCCTGAGGA CACGTGCCCA 2580

TCAGCAGAGG AGCCAAGGCT GAACGTCCAG GTCACCTCCA CGCCCGTGAT CGTGATGCGC 2640

GGGGCTGCTG GCCTGCAGCG GGAGATCCAG GAGGGTGCCT ACTCCGGGAG CTGCTATCAT 2700

CGAGACGGCT TACGGCTGAG TATACAGTTT GAGGTGAGGC GGGTGGAGCT CCAGGGCCCC 2760

ACACCTCTGT TCTGCTGCTG GCTGGTGAAA GACCTCCTCC ACAGCCAACG CGACTCAGCC 2820

TCCAGGACCC GCCTGCTCCT TGCCAGCCTG CCCGGCTCCA CCCACTCTAC TGCTGCTGAG 2880

CTCACCGGAC CCAGCCTGGT GGAAGTGCTC AGAGCCAGAC CCTGGTTTGA GGAGCCCCAC 2940

AAGGCTGTGG AACTGGAGGG GTTGGCGGCC TGTGAGGGCG AGTACTCCCA AAAGTACAGT 3000

ACCCTGAGCC CGCTGGGCAG TGGGGCCTTC GGCTTCGTGT GGACTGCTGT GGACAAGGAA 3060

AAAAACAAGG AGGTGGTGGT GAAGTTTATT AAGAAGGAGA AGGTCTTGGA GGATTGTTGG 3120

ATTGAGGATC CCAAACTTGG GAAAGTTACT TTAGAGATCG CAATTCTATC CAGGGTGGAG 3180

CACGCCAATA TCATCAAGGT ATTGGATGTA TTTGAAAACC AAGGGTTCTT CCAGCTCGTG 3240

ATGGAGAAGC ACGGCTCCGG CCTAGATCTC TTCGCTTTCA TCGACCGCCA CCCCAGGCTG 3300

GATGAGCCCC TGGCGAGCTA CATCTTCCGA CAAGTGAGAG CAGGCCAGAG CCGTCTAGTG 3360

TCAGCAGTGG GATACCTGCG CTTGAAGGAC ATCATCCACC GTGACATCAA GGATGAGAAC 3420

ATCGTGATCG CCGAGGACTT CACAATCAAG CTCATAGACT TTGGCTCGGC CGCCTACTTG 3480

GAAAGGGGAA AATTATTTTA TACTTTTTGT GGGACCATCG AGTACTGTGC ACCGGAAGTT 3540

CTCATGGGGA ATCCCTACAG AGGGCCGGAG CTGGAGATGT GGTCTCTGGG AGTCACTCTG 3600

TACACGCTGG TCTTTGAGGA GAACCCCTTC TGTGAGCTGG AGGAGACCGT GGAGGCTGCC 3660

ATACACCCGC CATACCTGGT GTCCAAAGAA CTCATGAGCC TTGTGTCTGG GCTGCTGCAG 3720

CCAGTGCCTG AGAAGCGCAC CACCTTGGAG AAGCTGGTGA CAGACCCGTG GGTAACACAG 3780

CCTGTGAATC TTGCTGACTA TACATGGGAA GAGGTGTGTC CAGTAAACAA GCCAGAAAGC 3840

GGAGTTCTGT CCACTGCGAG CCTGGAGATG GGGAACAGGA GCCTGAGTGA TGTGGCCCAG 3900

GCTCAGGAGC TTTGTGGGGG CCCCATTCCA GGTGAGGCTC CTAATGGCCA AGGCTGTTTG 3960

CATCCCGGGG ATCCCCGTCT GCTGACCAGC TAA 3993

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkk  54

         y++l+ lG+g+fg V +a++ke++++v+vK+ikk+k+      ++ +l k++ Ei+il++

Q: 999   YSTLSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVledcwiEDPKLGKVTLEIAILSR  1058

         88999*******************************99999998899*************

S: 55    lkhpniikllevietkkklylvle.yasggeLfdyieekgrlkekearklfkq.......  106

         ++h niik+l+v+e++ +++lv+e + sg +Lf  i ++ rl+e  a+ +f+q

Q: 1059  VEHANIIKVLDVFENQGFFQLVMEkHGSGLDLFAFIDRHPRLDEPLASYIFRQvragqsr  1118

         ************************888899******************************

S: 107   lvsavkYlhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaP  166

         lvsav Yl+ k+i+HrD+K eN+++ ++ +ik++DFG a+++++gkl+ tfcG+++Y+aP

Q: 1119  LVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAP  1178

         ************************************************************

S: 167   ellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskele  226

         e+l+g++Y+gp++++WslGv+Ly+lv+++ Pf e       e++ +  ++ p+ +skel+

Q: 1179  EVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCEL------EETVEAAIHPPYLVSKELM  1232

         ********************************998......788899999**********

S: 227   sLlrklLvvdpekRatieeilkhewl  252

         sL++ lL+  pekR+t+e++++++w+

Q: 1233  SLVSGLLQPVPEKRTTLEKLVTDPWV  1258

         *************************7

Domain Sequence
(FASTA)

YSTLSPLGSG AFGFVWTAVD KEKNKEVVVK FIKKEKVLED CWIEDPKLGK VTLEIAILSR 60

VEHANIIKVL DVFENQGFFQ LVMEKHGSGL DLFAFIDRHP RLDEPLASYI FRQVRAGQSR 120

LVSAVGYLRL KDIIHRDIKD ENIVIAEDFT IKLIDFGSAA YLERGKLFYT FCGTIEYCAP 180

EVLMGNPYRG PELEMWSLGV TLYTLVFEEN PFCELEETVE AAIHPPYLVS KELMSLVSGL 240

LQPVPEKRTT LEKLVTDPWV 260

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091	; PAS; 2.
SM00220	; S_TKc; 1.

Prosites

PS50112	; PAS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013