EKS-GOG-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR543.69.1E-164413680268
StatusUnreviewed
Ensembl ProteinENSGGOP00000026820
UniProt AccessionG3RAQ4;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameIGF1R
Gene Synonyms/Alias IGF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000012828ENSGGOP00000012531ENSGGOT00000012893
ENSGGOG00000012828ENSGGOP00000026820ENSGGOT00000029787
OrganismGorilla gorilla
Functional Description
Protein Length781
Protein Sequence
(FASTA)
MVENDHIRGA KSEILYIRTN ASVPSIPLDV LSASNSSSQL IVKWNPPSLP NGNLSYYIVR 60
WQRQPQDGYL YRHNYCSKED KIPIRKYADG TIDIEEVTEN PKTEVCGGEK GPCCACPKTE 120
AEKQAEKEEA EYRKVFENFL HNSIFVPRPE RKRRDVMQVA NTTMSSRSRN TTAADTYNIT 180
DPEELETEYP FFESRVDNKE RTVISNLRPF TLYRIDIHSC NHEAEKLGCS ASNFVFARTM 240
PAEGADDIPG PVTWEPRPEN SIFLKWPEPE NPNGLILMYE IKYGSQAEDQ RECVSRQEYR 300
KYGGAKLNRL NPGNYTARIQ ATSLSGNGSW TDPVFFYVQA KTGYENFIHL IIALPVAVLL 360
IVGGLVIMLY VFHRKRNNSR LGNGVLYASV NPEYFSAADV YVPDEWEVAR EKITMSRELG 420
QGSFGMVYEG VAKGVVKDEP ETRVAIKTVN EAASMRERIE FLNEASVMKE FNCHHVVRLL 480
GVVSQGQPTL VIMELMTRGD LKSYLRSLRP EMENNPVLAP PSLSKMIQMA GEIADGMAYL 540
NANKFVHRDL AARNCMVAED FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMSPESLKD 600
GVFTTYSDVW SFGVVLWEIA TLAEQPYQGL SNEQVLRFVM EGGLLDKPDN CPDMLFELMR 660
MCWQYNPKMR PSFLEIISSI KEEMEPGFRE VSFYYSEENK LPEPEELDLE PENMESVPLD 720
PSASSSSLPL PDRHSGHKAE NGPGPGVLVL RASFDERQPY AHMNGGRKNE RALPLPQSST 780
C 781
Nucleotide Sequence
(FASTA)
ATGGTGGAGA ACGACCATAT CCGTGGGGCC AAGAGTGAGA TCTTGTACAT TCGCACCAAT 60
GCTTCAGTTC CTTCCATTCC CTTGGACGTT CTTTCAGCAT CGAACTCCTC TTCTCAGTTA 120
ATCGTGAAGT GGAACCCTCC CTCTCTGCCC AACGGCAACC TGAGTTACTA CATTGTGCGC 180
TGGCAGCGGC AGCCTCAGGA CGGCTACCTT TACCGGCACA ATTACTGCTC CAAAGAAGAC 240
AAAATCCCCA TCAGGAAGTA TGCCGACGGC ACCATCGACA TTGAGGAGGT CACAGAGAAC 300
CCCAAGACTG AGGTGTGTGG TGGGGAGAAA GGGCCTTGCT GCGCCTGCCC CAAAACTGAA 360
GCCGAGAAGC AGGCCGAGAA GGAGGAGGCT GAATACCGCA AAGTCTTTGA GAATTTCCTG 420
CACAACTCCA TCTTCGTGCC CAGACCTGAA AGGAAGCGGA GAGATGTCAT GCAAGTGGCC 480
AACACCACCA TGTCCAGCCG AAGCAGGAAC ACCACGGCCG CAGACACCTA CAACATCACC 540
GACCCGGAAG AGCTGGAGAC AGAGTACCCT TTCTTTGAGA GCAGAGTGGA TAACAAGGAG 600
AGAACTGTCA TTTCTAACCT TCGGCCTTTC ACATTGTACC GCATCGATAT CCACAGCTGC 660
AACCACGAGG CTGAGAAGCT GGGCTGCAGC GCCTCCAACT TCGTCTTTGC AAGGACTATG 720
CCCGCAGAAG GAGCAGATGA CATTCCTGGG CCAGTGACCT GGGAGCCAAG GCCTGAAAAC 780
TCCATCTTTT TAAAGTGGCC GGAACCTGAG AATCCCAATG GATTGATTCT AATGTATGAA 840
ATAAAATACG GATCACAAGC TGAGGATCAG CGAGAATGTG TGTCCAGACA GGAATACAGG 900
AAGTATGGAG GGGCCAAGCT AAACCGGCTA AACCCGGGGA ACTACACAGC CCGGATTCAG 960
GCCACATCTC TCTCTGGGAA TGGGTCGTGG ACAGATCCTG TGTTCTTCTA TGTCCAGGCC 1020
AAAACAGGAT ATGAAAACTT CATCCATCTG ATCATCGCTC TGCCCGTCGC TGTCCTGTTG 1080
ATCGTGGGAG GGTTGGTGAT TATGCTGTAC GTCTTCCATA GAAAGAGAAA CAACAGCAGG 1140
CTGGGGAATG GAGTGCTGTA TGCCTCTGTG AACCCGGAGT ACTTCAGCGC TGCAGATGTG 1200
TACGTTCCTG ATGAGTGGGA GGTGGCTCGG GAGAAGATCA CCATGAGCCG GGAACTTGGG 1260
CAGGGGTCGT TTGGGATGGT CTATGAAGGA GTTGCCAAGG GTGTGGTGAA AGATGAACCT 1320
GAAACCAGAG TGGCCATTAA AACAGTGAAC GAGGCCGCAA GCATGCGTGA AAGGATTGAG 1380
TTTCTCAACG AAGCTTCTGT GATGAAGGAG TTCAATTGTC ACCATGTGGT GCGATTGCTG 1440
GGTGTGGTGT CCCAAGGCCA GCCAACACTG GTCATCATGG AACTGATGAC ACGGGGCGAT 1500
CTCAAAAGTT ATCTCCGGTC TCTGAGGCCA GAAATGGAGA ATAATCCAGT CCTAGCACCT 1560
CCAAGCCTGA GCAAGATGAT TCAGATGGCC GGAGAGATTG CAGACGGCAT GGCATACCTC 1620
AACGCCAATA AGTTCGTCCA CAGAGACCTT GCTGCCCGGA ATTGCATGGT AGCCGAAGAT 1680
TTCACAGTCA AAATCGGAGA TTTTGGTATG ACGCGAGATA TCTATGAGAC AGACTATTAC 1740
CGGAAAGGAG GGAAAGGGCT GCTGCCCGTG CGCTGGATGT CTCCCGAGTC CCTCAAGGAT 1800
GGAGTCTTCA CCACTTACTC GGACGTCTGG TCCTTCGGGG TCGTCCTCTG GGAGATCGCC 1860
ACACTGGCCG AGCAGCCCTA CCAGGGCTTG TCCAACGAGC AAGTCCTTCG CTTCGTCATG 1920
GAGGGTGGCC TTCTGGACAA GCCAGACAAC TGTCCTGACA TGCTGTTTGA ACTGATGCGC 1980
ATGTGCTGGC AGTATAACCC CAAGATGAGG CCTTCCTTCC TGGAGATCAT CAGCAGCATC 2040
AAGGAGGAGA TGGAGCCTGG CTTCCGGGAG GTCTCCTTCT ACTACAGCGA GGAGAACAAG 2100
CTGCCCGAGC CGGAGGAGCT GGACCTGGAG CCAGAGAACA TGGAGAGCGT CCCCCTGGAC 2160
CCCTCGGCCT CCTCGTCCTC CCTGCCACTG CCCGACAGAC ACTCAGGACA TAAGGCCGAG 2220
AACGGCCCCG GCCCTGGGGT GCTGGTCCTC CGCGCCAGCT TCGACGAGAG ACAGCCTTAC 2280
GCACACATGA ACGGGGGCCG CAAGAACGAG CGGGCCTTGC CGCTGCCCCA GTCTTCGACC 2340
TGCTGA 2346
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+
Q: 413   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  472
         799*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+en+++lapp+l+k+iqma+e
Q: 473   CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGE  532
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 533   IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  592
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         mspeslkdGvft+ sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+l+kp+ncp
Q: 593   MSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP  652
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         ++l+elmr+cwqynpk+rpsflei++++
Q: 653   DMLFELMRMCWQYNPKMRPSFLEIISSI  680
         *************************976
Domain Sequence
(FASTA)
ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPEM ENNPVLAPPS LSKMIQMAGE 120
IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MSPESLKDGV FTTYSDVWSF GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP 240
DMLFELMRMC WQYNPKMRPS FLEIISSI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Equus caballus"; ?>Felis catus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>
EKS-BOT-00014
EKS-CAJ-00017
EKS-EQC-00017
EKS-FEC-00015
EKS-LOA-00014
EKS-MAM-00016
EKS-MEG-00016
EKS-MUP-00017
EKS-MYL-00017
EKS-ORA-00015
EKS-OTG-00015
EKS-PAT-00016
EKS-PEM-00008
EKS-POA-00015
EKS-SAH-00013
EKS-TUT-00007
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013