EKS-GOG-00173
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00173
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC439.08.5E-132252518267
StatusUnreviewed
Ensembl ProteinENSGGOP00000012708
UniProt AccessionG3RB70;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000013021ENSGGOP00000012708ENSGGOT00000013074
OrganismGorilla gorilla
Functional Description
Protein Length592
Protein Sequence
(FASTA)
MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL HQQHPLTLKW 60
VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP EQPGLPCPGE DKSIYRRGAR 120
RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHGLVPLTC 180
RKHMDSVMPS QEPPVDDKNE DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG 240
IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE 300
KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI 360
CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP 420
EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF 480
LSVKASHVLK GFLNKDPKER LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT 540
DDYGLDNFDT QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV 592
Nucleotide Sequence
(FASTA)
ATGCCCAGCA GGACCGGCCC CAAGATGGAA GGGAGCGGCG GCCGCGTCCG CCTCAAGGCG 60
CATTACGGGG GGGACATCTT CATCACCAGC GTGGACGCCG CCACGACCTT CGAGGAGCTC 120
TGCGAGGAAG TGAGAGACAT GTGTCGTCTG CACCAGCAGC ACCCGCTCAC CCTCAAGTGG 180
GTGGACAGCG AAGGTGACCC TTGCACGGTG TCCTCCCAGA TGGAGCTGGA AGAGGCTTTC 240
CGCCTGGCCC GTCAGTGCAG GGACGAAGGC CTCATCATTC ATGTTTTCCC GAGCACCCCT 300
GAGCAGCCTG GCCTGCCGTG TCCGGGAGAA GACAAATCTA TCTACCGCCG GGGAGCCAGA 360
AGATGGAGGA AGCTGTACCG TGCCAACGGC CATCTCTTCC AAGCCAAGCG CTTTAACAGG 420
AGAGCGTACT GCGGTCAGTG CAGCGAGAGG ATATGGGGCC TCGCGAGGCA AGGCTACAGG 480
TGCATCAACT GCAAACTGCT GGTCCATAAG CGCTGCCACG GCCTCGTCCC GCTGACCTGC 540
AGGAAGCATA TGGATTCTGT CATGCCTTCC CAAGAGCCTC CAGTAGACGA CAAGAACGAG 600
GACGCCGACC TTCCTTCCGA GGAGACAGAT GGAATTGCTT ACATTTCCTC ATCCCGGAAG 660
CATGACAGCA TTAAAGACGA CTCCGAGGAC CTTAAGCCAG TTATCGATGG GATGGATGGA 720
ATCAAAATCT CTCAGGGGCT TGGGCTGCAG GACTTCGACC TAATCAGAGT CATCGGGCGC 780
GGGAGCTACG CCAAGGTTCT CCTGGTGCGG TTGAAGAAGA ATGACCAAAT TTACGCCATG 840
AAAGTGGTGA AGAAAGAGCT GGTGCATGAT GACGAGGATA TTGACTGGGT ACAGACAGAG 900
AAGCACGTGT TTGAGCAGGC ATCCAGCAAC CCCTTCCTGG TCGGATTACA CTCCTGCTTC 960
CAGACGACAA GTCGGCTGTT CCTGGTCATT GAGTACGTCA ACGGTGGGGA CCTGATGTTC 1020
CACATGCAGA GGCAGAGGAA GCTCCCTGAG GAGCACGCCA GGTTCTACGC GGCCGAGATC 1080
TGCATCGCCC TCAACTTCCT GCACGAGAGG GGGATCATCT ACAGGGACCT GAAGCTGGAC 1140
AACGTCCTCC TGGATGCGGA CGGGCACATC AAGCTCACAG ACTACGGCAT GTGCAAGGAA 1200
GGCCTGGGCC CTGGTGACAC AACGAGCACT TTCTGCGGAA CCCCGAATTA CATCGCCCCC 1260
GAAATCCTGC GGGGAGAGGA GTACGGGTTC AGCGTGGACT GGTGGGCGCT GGGAGTCCTC 1320
ATGTTTGAGA TGATGGCCGG GCGCTCCCCG TTCGACATCA TCACCGACAA CCCGGACATG 1380
AACACAGAGG ACTACCTTTT CCAAGTGATC CTGGAGAAGC CCATCCGGAT CCCCCGGTTC 1440
CTGTCCGTCA AAGCCTCCCA TGTTTTAAAA GGATTTTTAA ATAAGGACCC CAAAGAGAGG 1500
CTCGGCTGCC GGCCACAGAC TGGATTTTCT GACATCAAGT CCCACGCGTT CTTCCGCAGC 1560
ATAGACTGGG ACTTGCTGGA GAAGAAGCAG GCACTCCCTC CATTCCAGCC ACAGATCACG 1620
GACGACTACG GTCTGGACAA CTTTGACACA CAGTTCACCA GCGAGCCCGT GCAGCTGACC 1680
CCAGACGATG AGGATGCCAT AAAGAGGATC GACCAGTCAG AGTTCGAAGG CTTCGAGTAT 1740
ATCAACCCAT TATTGCTGTC CACCGAGGAG TCAGTGTGA 1779
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 252   FDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  311
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g
Q: 312   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  371
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvllda+Ghikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+s
Q: 372   IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS  431
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233
         vdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++lkg
Q: 432   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG  491
         **************************999*******************************
S: 234   lltkdpekrlGvk.eegeedikehaff  259
         +l+kdp++rlG++ ++g +dik+haff
Q: 492   FLNKDPKERLGCRpQTGFSDIKSHAFF  518
         ************889***********9
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNDQIYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60
FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120
IIYRDLKLDN VLLDADGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE ILRGEEYGFS 180
VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL SVKASHVLKG 240
FLNKDPKERL GCRPQTGFSD IKSHAFF 267
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-BOT-00174
EKS-CAE-00132
EKS-CAF-00181
EKS-CII-00115
EKS-CIS-00206
EKS-DAR-00466
EKS-DIO-00088
EKS-DRM-00085
EKS-EQC-00172
EKS-FEC-00166
EKS-GAG-00149
EKS-GAA-00210
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-MAM-00174
EKS-MEG-00138
EKS-MOD-00171
EKS-MUP-00178
EKS-OCP-00108
EKS-ORL-00205
EKS-OTG-00179
EKS-PES-00153
EKS-POA-00172
EKS-RAN-00170
EKS-SAH-00165
EKS-TEN-00219
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013