EKS-GOG-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.9E-167	473	749	277

Status

Unreviewed

Ensembl Protein

ENSGGOP00000012768

UniProt Accession

G3RBC6;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000013080	ENSGGOP00000012768	ENSGGOT00000013135

Organism

Gorilla gorilla

Functional Description

Protein Length

817

Protein Sequence
(FASTA)

AWGFSLLHFC LWELLFSLGS AAIGLVMPEV AAAQPWGAPV EVESFLVHPG DLLQLRCRLR 60

DDVQSINWLR DGVQLAESNR TRITGEEVEV QDSVPADSGL YACVTSSPSG SDTTYFSVNV 120

SDALPSSDSS SEEKETDNTK PNRMPVAPYW TSPEKMEKKL HAVPAAKTVK FKCPSSGTPN 180

PTLRWLKNGK EFKPDHRIGG YKVRYATWSI IMDSVVPSDK GNYTCIVENE YGSINHTYQL 240

DVVERSPHRP ILQAGLPANK TVALGSNVEF MCKVYSDPQP HIQWLKHIEV NGSKIGPDNL 300

PYVQILKTAG VNTTDKEMEV LHLRNVSFED AGEYTCLAGN SIGLSHHSAW LTVLEALEER 360

PAVMTSPLYL EIIIYCTGAF LISCMVGSVI VYKMKSGTKK SDFHSQMAVH KLAKSIPLRR 420

QVTVSADSSA SMNSGVLLVR PSRLSSSGTP MLAGVSEYEL PEDPRWELPR DRLVLGKPLG 480

EGCFGQVVLA EAIGLDKDKP NRVTKVAVKM LKSDATEKDL SDLISEMEMM KMIGKHKNII 540

NLLGACTQDG PLYVIVEYAS KGNLREYLQA RRPPGLEYCY NPSHNPEEQL SSKDLVSCAY 600

QVARGMEYLA SKKCIHRDLA ARNVLVTEDN VMKIADFGLA RDIHHIDYYK KTTNGRLPVK 660

WMAPEALFDR IYTHQSDVWS FGVLLWEIFT LGGSPYPGVP VEELFKLLKE GHRMDKPSNC 720

TNELYMMMRD CWHAVPSQRP TFKQLVEDLD RIVALTSNQE YLDLSMPLDQ YSPSFPDTRS 780

STCSSGEDSV FSHEPLPEEP CLPRHPAQLA NGGLKRR 817

Nucleotide Sequence
(FASTA)

GCCTGGGGGT TCTCTTTGCT ACATTTTTGT CTTTGGGAGC TGCTTTTTTC TCTGGGATCG 60

GCTGCAATAG GCCTTGTGAT GCCAGAGGTG GCTGCAGCCC AGCCCTGGGG AGCCCCTGTG 120

GAAGTGGAGT CCTTCCTGGT CCACCCCGGT GACCTGCTGC AGCTTCGCTG TCGGCTGCGG 180

GACGATGTGC AGAGCATCAA CTGGCTGCGG GACGGGGTGC AGCTGGCGGA AAGCAACCGC 240

ACCCGCATCA CAGGGGAGGA GGTGGAGGTG CAGGACTCCG TGCCCGCAGA CTCCGGCCTC 300

TATGCTTGCG TAACCAGCAG CCCCTCGGGC AGTGACACCA CCTACTTCTC CGTCAATGTT 360

TCAGATGCTC TCCCCTCCTC GGACTCCTCT TCAGAGGAGA AAGAAACAGA TAACACCAAA 420

CCAAACCGTA TGCCCGTAGC TCCATATTGG ACATCCCCGG AAAAGATGGA AAAGAAATTG 480

CATGCAGTGC CGGCTGCCAA GACAGTGAAG TTCAAATGCC CTTCCAGTGG GACCCCAAAC 540

CCCACACTGC GCTGGTTGAA AAATGGCAAA GAATTCAAAC CTGACCACAG AATTGGAGGC 600

TACAAGGTCC GTTATGCCAC CTGGAGCATC ATAATGGACT CCGTGGTGCC CTCTGACAAG 660

GGCAACTACA CCTGCATTGT GGAGAATGAG TACGGCAGCA TCAACCACAC ATACCAGCTG 720

GATGTCGTGG AGCGGTCCCC TCACCGGCCC ATCCTGCAAG CAGGGTTGCC TGCCAACAAG 780

ACAGTCGCCC TGGGTAGCAA CGTGGAGTTC ATGTGTAAGG TGTACAGTGA CCCGCAGCCG 840

CATATCCAGT GGCTAAAGCA CATCGAGGTG AACGGGAGCA AGATTGGTCC AGACAACCTG 900

CCTTATGTCC AGATCTTGAA GACTGCTGGA GTTAATACCA CCGACAAAGA GATGGAGGTG 960

CTTCACTTAA GAAATGTCTC CTTTGAGGAT GCAGGGGAGT ATACGTGCTT GGCGGGTAAC 1020

TCTATCGGAC TCTCCCATCA CTCTGCATGG TTGACCGTTC TGGAAGCCCT GGAAGAGAGG 1080

CCGGCAGTGA TGACCTCGCC CCTGTACCTG GAGATCATCA TCTATTGCAC AGGGGCCTTC 1140

CTCATCTCCT GCATGGTGGG GTCGGTCATC GTCTACAAGA TGAAGAGTGG TACCAAGAAG 1200

AGCGACTTCC ACAGCCAGAT GGCTGTGCAC AAGCTGGCCA AGAGCATCCC TCTGCGCAGA 1260

CAGGTAACAG TGTCTGCTGA CTCCAGTGCA TCCATGAACT CTGGGGTTCT TCTGGTTCGG 1320

CCGTCACGGC TCTCCTCCAG TGGGACTCCC ATGCTAGCAG GGGTCTCTGA GTATGAGCTT 1380

CCCGAAGACC CTCGCTGGGA GCTGCCTCGG GACAGACTGG TCTTAGGCAA ACCCCTGGGA 1440

GAGGGCTGCT TTGGGCAGGT GGTGTTGGCA GAGGCTATCG GGCTGGACAA GGACAAACCC 1500

AACCGTGTGA CCAAAGTGGC TGTGAAGATG TTGAAGTCGG ACGCAACAGA GAAAGACTTG 1560

TCAGACCTGA TCTCGGAAAT GGAGATGATG AAGATGATCG GGAAGCATAA GAATATCATC 1620

AACCTGCTGG GGGCCTGCAC GCAGGATGGT CCCTTGTATG TCATCGTGGA GTATGCCTCC 1680

AAGGGCAACC TGCGGGAGTA CCTGCAGGCC CGGAGGCCCC CAGGGCTGGA ATACTGCTAC 1740

AACCCCAGCC ACAACCCAGA GGAGCAGCTC TCCTCCAAGG ACCTGGTGTC CTGTGCCTAC 1800

CAGGTGGCCC GAGGCATGGA GTATCTGGCC TCCAAGAAGT GCATACACCG AGACCTGGCA 1860

GCCAGGAATG TCCTGGTGAC AGAGGACAAT GTGATGAAGA TAGCAGACTT TGGCCTCGCA 1920

CGGGACATTC ACCACATCGA CTACTATAAA AAGACAACCA ACGGCCGACT GCCTGTGAAG 1980

TGGATGGCGC CCGAGGCATT ATTTGACCGG ATCTACACCC ACCAGAGTGA TGTGTGGTCT 2040

TTCGGGGTGC TCCTGTGGGA GATCTTCACT CTGGGCGGCT CCCCATACCC CGGTGTGCCT 2100

GTGGAGGAGC TTTTCAAGCT GCTGAAGGAG GGTCACCGCA TGGACAAGCC CAGTAACTGC 2160

ACCAACGAGC TGTACATGAT GATGCGGGAC TGCTGGCATG CAGTGCCCTC ACAGAGACCC 2220

ACCTTCAAGC AGCTGGTGGA AGACCTGGAC CGCATCGTGG CCTTGACCTC CAACCAGGAG 2280

TACCTGGACC TGTCCATGCC CCTGGACCAG TACTCCCCCA GCTTTCCCGA CACCCGGAGC 2340

TCTACGTGCT CCTCAGGGGA GGATTCCGTC TTCTCTCATG AGCCGCTGCC CGAGGAGCCC 2400

TGCCTGCCCC GACACCCAGC CCAGCTTGCC AATGGCGGAC TCAAACGCCG CTGA 2454

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 473   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  532

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 533   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  592

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 593   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  652

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 653   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  712

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 713   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  749

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013