EKS-GOG-00066

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00066

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	361.4	4.2E-108	19	302	284

Status

Unreviewed

Ensembl Protein

ENSGGOP00000013021

UniProt Accession

G3RC03;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000013349	ENSGGOP00000013021	ENSGGOT00000013397

Organism

Gorilla gorilla

Functional Description

Protein Length

353

Protein Sequence
(FASTA)

SRALRRRMAL DVKSRAKRYE KLDFLGEGQF ATVYKARDKN TNQIVAIKKI KLGHRSEAKD 60

GINRTALREI KLLQELSHPN IIGLLDAFGH KSNISLVFDF METDLEVIIK DNSLVLTPSH 120

IKAYMLMTLQ GLEYLHQHWI LHRDLKPNNL LLDENGVLKL ADFGLAKSFG SPNRAYTHQV 180

VTRWYRAPEL LFGARMYGVG VDMWAVGCIL AELLLRVPFL PGDSDLDQLT RIFETLGTPT 240

EEQWPDMCSL PDYVTFKSFP GIPLHHIFSA AGDDLLDLIQ GLFLFNPCAR ITATQALKMK 300

YFSNRPGPTP GCQLPRPNCP VETLKEQSNP ALAIKRKRTE ALEQGGLPKK LIF 353

Nucleotide Sequence
(FASTA)

AGTCGGGCTT TACGGCGCCG GATGGCTCTG GACGTGAAGT CTCGGGCAAA GCGTTATGAG 60

AAGCTGGACT TCCTTGGGGA GGGACAGTTT GCCACCGTTT ACAAGGCCAG AGATAAGAAT 120

ACCAACCAAA TTGTCGCCAT TAAGAAAATC AAACTTGGAC ATAGATCAGA AGCTAAAGAT 180

GGTATAAATA GAACCGCCTT AAGAGAGATA AAATTATTAC AGGAGCTAAG TCATCCAAAT 240

ATAATTGGTC TCCTTGATGC TTTTGGACAT AAATCTAATA TTAGCCTTGT CTTTGATTTT 300

ATGGAAACTG ATCTGGAGGT TATAATAAAG GATAATAGTC TTGTGCTGAC ACCATCACAC 360

ATCAAAGCCT ACATGTTGAT GACTCTTCAA GGATTAGAAT ATTTACATCA ACATTGGATC 420

CTACATAGGG ATCTGAAACC AAACAACTTG TTGCTAGATG AAAATGGAGT TCTAAAACTG 480

GCAGATTTTG GCCTGGCCAA ATCTTTTGGG AGCCCCAATA GAGCTTATAC ACATCAGGTT 540

GTAACCAGGT GGTATCGGGC CCCTGAGTTA CTATTTGGAG CTAGGATGTA TGGTGTAGGT 600

GTGGACATGT GGGCTGTTGG CTGCATATTA GCAGAGTTAC TTCTAAGGGT TCCTTTTTTG 660

CCAGGAGATT CAGACCTTGA TCAGCTAACA AGAATATTTG AAACTTTGGG CACACCAACT 720

GAGGAACAGT GGCCGGACAT GTGTAGTCTT CCAGATTATG TGACATTTAA GAGTTTCCCT 780

GGAATCCCGT TGCATCACAT CTTCAGTGCA GCAGGAGACG ACTTACTAGA TCTCATACAA 840

GGCTTATTCT TATTTAATCC ATGTGCTCGA ATTACGGCCA CACAGGCACT GAAAATGAAG 900

TATTTCAGTA ATCGGCCAGG GCCAACACCT GGATGTCAGC TGCCAAGACC AAACTGTCCA 960

GTGGAAACCT TAAAGGAGCA ATCAAATCCA GCTTTGGCAA TAAAAAGGAA AAGAACAGAG 1020

GCCTTAGAAC AAGGAGGATT GCCCAAGAAA CTAATTTTTT AA 1062

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 19    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  78

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 79    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  136

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 137   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  196

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp+y  +

Q: 197   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-T  255

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ ++++ ++ ldl++ l+ ++p  Ri+a++al+ kyf

Q: 256   FKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF  302

         9999999******9999*****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDYVTFKS 240

FPGIPLHHIF SAAGDDLLDL IQGLFLFNPC ARITATQALK MKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013