EKS-GOG-00019
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00019
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR535.82.1E-1618701137268
StatusUnreviewed
Ensembl ProteinENSGGOP00000013375
UniProt AccessionG3RQJ8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSR
Gene Synonyms/Alias INSR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000013703ENSGGOP00000018071ENSGGOT00000034031
ENSGGOG00000013703ENSGGOP00000013375ENSGGOT00000013761
OrganismGorilla gorilla
Functional Description
Protein Length1229
Protein Sequence
(FASTA)
CPGMDIRNNL TRLHELENCS VIEGHLQILL MFKTRPEDFR DLSFPKLIMI TDYLLLFRVY 60
GLESLKDLFP NLTVIRGSRL FFNYALVIFE MVHLKELGLY NLMNITRGSV RIEKNNELCY 120
LATIDWSRIL DSVEDNYIVL NKDDNEECGD ICPGTAKGKT NCPATVINGQ FVERCWTHSH 180
CQKVCPTICK SHGCTAEGLC CHSECLGNCS QPDDPTKCVA CRNFYLDGRC VETCPPPYYH 240
FQDWRCVNFS FCQDLHHKCK NSRRQGCHQY VIHNNKCIPE CPSGYTMNSS NLAAELEANL 300
GLIEEISGYL KIRRSYALVS LSFFRKLRLI RGETLEIGNY SFYALDNQNL RQLWDWSKHN 360
LTITQGKLFF HYNPKLCLSE IHKMEEVSGT KGRQERNDIA LKTNGDQASC ENELLKFSYI 420
RTSFDKILLR WEPYWPPDFR DLLGFMLFYK EAPYQNVTEF DGQDACGSNS WTVVDIDPPL 480
RSNDPKSQNH PGWLMRGLKP WTQYAIFVKT LVTFSDERRT YGAKSDIIYV QTDATNPSVP 540
LDPISVSNSS SQIILKWKPP SDPNGNITHY LVFWERQAED SELFELDYCL KKTSSGTGAE 600
DPRPSRKRRS LGDVGNVTVA VPTVAAFPNT SSTSVPTSPE EHRPFEKVVN KESLVISGLR 660
HFTGYRIELQ ACNQDTPEER CSVAAYVSAR TMPEAKADDI VGPVTHEIFE NNVVHLMWQE 720
PKEPNGLIVL YEVSYRRYGD EELHLCVSRK HFALERGCRL RGLSPGNYSV RVRATSLAGN 780
GSWTEPTYFY VTDYLDVPSN IAKIIIGPLI FVFLFSVVIG SIYLFLRKRQ PDGPLGPLYA 840
SSNPEYLSAS DVFPCSVYVP DEWEVPREKI TLLRELGQGS FGMVYEGNAR DIIKGEAETR 900
VAVKTVNESA SLRERIEFLN EASVMKGFTC HHVVRLLGVV SKGQPTLVVM ELMAHGDLKS 960
YLRSLRPEAE NNPGRPPPTL QEMIQMAAEI ADGMAYLNAK KFVHRDLAAR NCMVAHDFTV 1020
KIGDFGMTRD IYETDYYRKG GKGLLPVRWM APESLKDGVF TTSSDMWSFG VVLWEITSLA 1080
EQPYQGLSNE QVLKFVMDGG YLDQPDNCPE RVTDLMRMCW QFNPKMRPTF LEIVNLLKDD 1140
LHPSFPEVSF FHSEENKAPE SEELEMEFED MENVPLDRSS HCQREEAGGR DGGSSLGFKR 1200
SYEEHIPYTH MNGGKKNGRI LTLPRSNPS 1229
Nucleotide Sequence
(FASTA)
TGTCCCGGCA TGGATATCCG GAACAACCTC ACTAGGTTGC ATGAGCTGGA GAATTGCTCT 60
GTCATCGAAG GACACTTGCA GATACTCTTG ATGTTCAAAA CGAGGCCCGA AGATTTCCGA 120
GACCTCAGTT TCCCCAAACT CATAATGATC ACTGATTACT TGCTGCTCTT CCGGGTCTAT 180
GGGCTCGAGA GCCTGAAGGA CCTGTTCCCC AACCTCACGG TCATCCGGGG ATCACGACTG 240
TTCTTTAACT ACGCGCTGGT CATCTTCGAG ATGGTTCACC TCAAGGAACT CGGCCTCTAC 300
AACCTGATGA ACATCACCCG GGGTTCTGTC CGCATCGAGA AGAACAATGA GCTCTGTTAC 360
TTGGCCACTA TCGACTGGTC CCGTATCCTG GATTCCGTGG AGGATAATTA CATCGTGTTG 420
AACAAAGATG ACAACGAGGA GTGTGGAGAC ATCTGTCCGG GTACCGCGAA GGGCAAGACC 480
AACTGCCCCG CCACCGTCAT CAATGGGCAG TTTGTCGAAC GGTGTTGGAC TCATAGTCAC 540
TGCCAGAAAG TTTGCCCGAC CATCTGTAAG TCACACGGCT GCACCGCCGA AGGCCTCTGT 600
TGCCACAGCG AGTGCCTGGG CAACTGTTCT CAGCCCGACG ACCCCACCAA GTGCGTGGCC 660
TGCCGCAACT TCTACCTGGA CGGCAGGTGT GTGGAGACCT GCCCGCCCCC GTACTACCAC 720
TTCCAGGACT GGCGCTGTGT GAACTTCAGC TTCTGCCAGG ACCTGCACCA CAAATGCAAG 780
AACTCGCGGA GGCAGGGCTG CCACCAGTAC GTCATTCACA ACAACAAGTG CATCCCTGAG 840
TGTCCCTCCG GGTACACGAT GAATTCCAGC AATCTGGCAG CTGAGCTAGA AGCCAACCTC 900
GGCCTCATTG AAGAAATTTC AGGGTATCTA AAAATCCGCC GATCCTACGC TCTGGTGTCA 960
CTTTCCTTCT TCCGGAAGTT ACGTCTGATT CGAGGAGAGA CCTTGGAAAT CGGGAACTAC 1020
TCCTTCTATG CCTTGGACAA CCAGAACCTA AGGCAGCTCT GGGATTGGAG CAAACACAAC 1080
CTCACCATCA CTCAGGGGAA ACTCTTCTTC CACTATAACC CCAAACTCTG CTTGTCAGAA 1140
ATCCACAAGA TGGAAGAAGT TTCAGGAACC AAGGGGCGCC AGGAGAGAAA CGACATTGCC 1200
CTGAAGACCA ATGGCGACCA GGCATCCTGT GAAAATGAGT TACTTAAATT TTCTTACATT 1260
CGGACATCTT TTGACAAGAT CTTGCTGAGA TGGGAGCCGT ACTGGCCCCC AGACTTCCGA 1320
GACCTCTTGG GGTTCATGCT GTTCTACAAA GAGGCCCCTT ATCAGAATGT GACGGAGTTC 1380
GACGGGCAGG ATGCATGTGG TTCCAACAGT TGGACGGTGG TAGACATTGA CCCACCCCTG 1440
AGATCCAATG ACCCCAAATC ACAGAACCAC CCAGGGTGGC TGATGCGGGG TCTCAAGCCC 1500
TGGACCCAGT ATGCCATCTT CGTGAAGACC CTGGTCACCT TTTCGGATGA ACGCCGGACC 1560
TATGGGGCCA AGAGTGACAT CATTTATGTC CAGACAGATG CCACCAACCC CTCCGTGCCC 1620
CTGGATCCAA TCTCAGTGTC TAACTCATCA TCCCAGATTA TTTTGAAGTG GAAACCCCCC 1680
TCCGACCCCA ATGGCAACAT CACCCACTAC CTGGTTTTCT GGGAGAGGCA GGCGGAAGAC 1740
AGTGAGCTGT TCGAGCTGGA TTATTGCCTC AAAAAAACCT CTTCAGGCAC TGGTGCCGAG 1800
GACCCTAGGC CATCTCGGAA ACGCAGGTCC CTTGGCGATG TTGGGAATGT GACGGTGGCC 1860
GTGCCCACGG TGGCAGCTTT CCCCAACACT TCCTCAACCA GCGTGCCCAC GAGTCCAGAG 1920
GAGCACAGGC CTTTTGAGAA GGTGGTGAAC AAGGAGTCGC TGGTCATCTC CGGCTTGCGA 1980
CACTTCACGG GCTATCGCAT CGAGCTGCAG GCTTGCAACC AGGACACCCC TGAGGAACGG 2040
TGCAGTGTGG CAGCCTACGT CAGTGCCAGG ACCATGCCTG AAGCCAAGGC TGATGACATT 2100
GTCGGCCCTG TGACGCATGA AATCTTTGAG AACAACGTCG TCCACTTGAT GTGGCAGGAG 2160
CCGAAGGAGC CCAATGGTCT GATCGTGCTG TATGAAGTGA GTTATCGGCG ATATGGTGAT 2220
GAGGAGCTGC ATCTCTGCGT CTCCCGCAAG CACTTCGCTC TGGAACGGGG CTGCAGGCTG 2280
CGTGGACTGT CACCGGGGAA CTACAGCGTG CGAGTCCGGG CCACCTCCCT TGCGGGCAAC 2340
GGCTCTTGGA CGGAACCCAC CTATTTCTAC GTGACAGACT ATTTAGATGT CCCGTCAAAT 2400
ATTGCAAAAA TTATCATTGG CCCCCTCATC TTTGTCTTTC TCTTCAGTGT TGTGATTGGA 2460
AGTATTTATC TATTCCTGAG AAAGAGGCAG CCAGATGGGC CGCTGGGACC GCTTTATGCT 2520
TCTTCAAACC CTGAGTATCT CAGTGCCAGT GATGTGTTTC CATGCTCTGT GTACGTGCCG 2580
GACGAGTGGG AGGTGCCTCG AGAGAAGATC ACCCTCCTTC GAGAGCTGGG GCAGGGATCC 2640
TTCGGCATGG TGTATGAGGG CAATGCCAGG GACATCATCA AGGGTGAGGC AGAGACCCGC 2700
GTGGCGGTGA AGACGGTCAA CGAGTCAGCC AGTCTCCGAG AGCGGATTGA GTTCCTCAAT 2760
GAGGCCTCGG TCATGAAGGG CTTCACCTGC CATCACGTGG TGCGCCTCCT GGGAGTGGTG 2820
TCCAAGGGCC AGCCCACGCT GGTGGTGATG GAGCTGATGG CTCACGGAGA CCTGAAGAGC 2880
TACCTCCGTT CTCTGCGGCC AGAGGCTGAG AATAATCCCG GCCGCCCTCC CCCTACCCTT 2940
CAAGAGATGA TTCAGATGGC GGCAGAGATT GCTGACGGGA TGGCCTACCT GAACGCCAAG 3000
AAGTTTGTGC ATCGGGACCT GGCAGCGAGA AACTGCATGG TCGCCCATGA TTTTACTGTC 3060
AAAATTGGAG ACTTTGGAAT GACCAGAGAC ATCTATGAAA CGGATTACTA CCGGAAAGGG 3120
GGCAAGGGTC TGCTCCCTGT ACGGTGGATG GCGCCGGAGT CCCTGAAGGA TGGGGTCTTC 3180
ACCACTTCTT CTGACATGTG GTCCTTTGGC GTGGTCCTTT GGGAAATCAC CAGCTTGGCA 3240
GAACAGCCTT ACCAAGGCCT GTCTAATGAA CAGGTGTTGA AATTTGTCAT GGATGGAGGG 3300
TATCTGGATC AACCCGACAA CTGTCCAGAG AGAGTCACTG ACCTCATGCG CATGTGCTGG 3360
CAATTCAACC CCAAGATGAG GCCAACCTTC CTGGAGATTG TCAACCTGCT CAAGGACGAC 3420
CTGCACCCCA GCTTTCCAGA GGTGTCGTTC TTCCACAGCG AGGAGAACAA GGCTCCCGAG 3480
AGTGAGGAGC TGGAGATGGA GTTTGAGGAC ATGGAGAATG TGCCCCTGGA CCGCTCCTCG 3540
CACTGTCAGA GGGAGGAGGC GGGGGGCCGG GATGGAGGGT CCTCGCTAGG TTTCAAGCGG 3600
AGCTACGAGG AACACATCCC TTACACACAC ATGAACGGAG GCAAGAAAAA CGGGCGGATT 3660
CTGACCTTGC CTCGGTCCAA TCCTTCCTAA 3690
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+llrelGqGsfGmvyeG+a+d++kge+etrva+ktvne+as reriefl+easvmk f+
Q: 870   ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFT  929
         789*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrpe+en+++++pp+l+++iqmaae
Q: 930   CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAE  989
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 990   IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1049
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l++p+ncp
Q: 1050  MAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  1109
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         e++t+lmr+cwq+npk+rp+fleiv+ll
Q: 1110  ERVTDLMRMCWQFNPKMRPTFLEIVNLL  1137
         *************************976
Domain Sequence
(FASTA)
ITLLRELGQG SFGMVYEGNA RDIIKGEAET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60
CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPEA ENNPGRPPPT LQEMIQMAAE 120
IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MAPESLKDGV FTTSSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240
ERVTDLMRMC WQFNPKMRPT FLEIVNLL 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00014
EKS-BOT-00015
EKS-CAE-00002
EKS-CAF-00017
EKS-CAP-00016
EKS-CII-00007
EKS-CIS-00008
EKS-DAR-00019
EKS-FEC-00016
EKS-GAG-00016
EKS-HOS-00018
EKS-ICT-00017
EKS-LAC-00018
EKS-LOA-00015
EKS-MEG-00014
EKS-MUM-00015
EKS-MUP-00018
EKS-MYL-00018
EKS-NOL-00018
EKS-ORC-00014
EKS-OTG-00016
EKS-PES-00017
EKS-POA-00016
EKS-RAN-00017
EKS-TAR-00027
EKS-XET-00016
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013