EKS-GOG-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	554.2	5.7E-167	567	831	265

Status

Unreviewed

Ensembl Protein

ENSGGOP00000013475

UniProt Accession

G3RD78;

Protein Name

Protein Synonyms/Alias

Gene Name

MERTK

Gene Synonyms/Alias

MERTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000013806	ENSGGOP00000013475	ENSGGOT00000013863

Organism

Gorilla gorilla

Functional Description

Protein Length

979

Protein Sequence
(FASTA)

AITEAREEAK PYPLLLGPFP GSLQTDHTPL LSLPHASGYQ PALMFSPTQP GRPHTGNVAI 60

PQMTSVESKP LPPLAFKHTV GHIILSEHKG VKFNCSISVP NIYQDTTISW WKDGKELLGA 120

HHAITQFYPD DEVTAIIASF SITSVQRSDN GSYICKMKVN NEEIVSDPIY IEVQVSSTGT 180

RYHSPGQVAI GLLFGIFSCL AYADSETLEG EWFSSTGSTA QPETSFGHWY LSGLTEMAVF 240

SCEAHNDKGL TVSKGVQINI KAIPSPPTEV SIRNSTAHSI LISWVPGFDG YSPFRNCSIQ 300

VKEADPLSNG SVMIFNTSAS PHLYQIKQLQ ALANYSIGVS CMNEIGWSAV SPWILASTTE 360

GAPSVAPLNV TVFLNESSDN VDIRWMKPPT KQQDGELVGY RISHVWQSAG ISKELLEEVG 420

QNGSRARISV QVHNATCTVR IAAVTKGGVG PFSDPVKIFI PAHGWVDYAP SSTPAPGNAD 480

PVLIIFGCFC GFILIGLVLY ISLAIRKRVQ ETKFGNAFTE EDSELVVNYI AKKSFCRRAI 540

ELTLHSLGVS EELQNKLEDV VIDRNLLILG KILGEGEFGS VMEGNLKQED GTSLKVAVKT 600

MKLDNFSQRE IEEFLSEAAC MKDFSHPNVI RLLGVCIEMS SQGIPKPMVI LPFMKYGDLH 660

TYLLYSRLET GPKHIPLQTL LKFMVDIALG MEYLSNRNFL HRDLAARNCM LRDDMTVCVA 720

DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTSK SDVWAFGVTM WEIATRGMTP 780

YPGVQNHEMY DYLLHGHRLK QPEDCLDELY EIMYSCWRTD PLDRPTFSVL RLQLEKLLES 840

LPDVRNQADV IYVNTQLLES SEGLAQGSTL APLDLNIDPD SIIASCTPRA AISVVTAEIH 900

DSKPHEGRYI LNGGSEEWED LTSAPSAAVT AEKNSVLPGE RLVRNGVSWS HSSMLPLGSS 960

LPDELLFADD SSEGSEVLM 979

Nucleotide Sequence
(FASTA)

GCTATCACTG AGGCAAGGGA AGAAGCCAAG CCTTACCCGC TACTCCTGGG ACCTTTTCCA 60

GGGAGCCTGC AAACTGACCA CACACCGCTG TTATCCCTTC CTCACGCCAG TGGGTACCAG 120

CCTGCCTTGA TGTTTTCACC AACCCAGCCT GGAAGACCAC ATACAGGAAA TGTAGCCATT 180

CCCCAGATGA CCTCTGTCGA ATCAAAGCCC CTACCGCCTC TTGCCTTCAA ACACACAGTT 240

GGACACATAA TACTTTCTGA ACATAAAGGT GTCAAATTTA ATTGCTCAAT CAGTGTACCT 300

AATATATACC AGGACACCAC AATTTCTTGG TGGAAAGATG GGAAGGAATT GCTTGGGGCA 360

CATCATGCAA TTACACAGTT TTATCCAGAT GATGAAGTTA CAGCAATAAT CGCTTCCTTC 420

AGCATAACCA GTGTGCAGCG TTCAGACAAT GGGTCGTATA TCTGTAAGAT GAAAGTAAAC 480

AATGAAGAGA TCGTGTCTGA TCCCATCTAC ATCGAAGTAC AAGTTTCCAG TACTGGTACC 540

AGATACCACT CACCTGGTCA AGTGGCTATT GGCTTATTAT TCGGCATCTT TTCCTGTCTT 600

GCCTATGCAG ACAGTGAAAC CCTGGAGGGT GAGTGGTTTT CCTCGACTGG CTCCACAGCT 660

CAGCCTGAGA CTTCTTTTGG GCACTGGTAT CTGTCAGGCC TGACGGAGAT GGCGGTCTTC 720

AGTTGTGAGG CCCACAATGA CAAAGGGCTG ACCGTGTCCA AGGGAGTGCA GATCAACATC 780

AAAGCAATTC CCTCCCCACC AACTGAAGTC AGCATCCGTA ACAGCACTGC ACACAGCATT 840

CTGATCTCCT GGGTTCCTGG TTTTGATGGA TACTCCCCGT TCAGGAATTG CAGCATTCAG 900

GTCAAGGAAG CTGATCCGCT GAGTAATGGC TCAGTCATGA TTTTTAACAC CTCTGCCTCA 960

CCACATCTGT ACCAAATCAA GCAGCTGCAA GCCCTGGCTA ATTACAGCAT TGGTGTTTCC 1020

TGCATGAATG AAATAGGCTG GTCTGCAGTG AGCCCTTGGA TTCTAGCCAG CACGACTGAA 1080

GGAGCCCCAT CAGTAGCACC TTTAAATGTC ACTGTGTTTC TGAATGAATC TAGTGATAAT 1140

GTGGACATCA GATGGATGAA GCCTCCGACT AAGCAGCAGG ATGGAGAACT GGTGGGCTAC 1200

CGGATATCCC ACGTGTGGCA GAGTGCAGGG ATTTCCAAAG AGCTCTTGGA GGAAGTTGGC 1260

CAGAATGGCA GCCGAGCTCG GATCTCTGTT CAAGTCCACA ATGCTACGTG CACAGTGAGG 1320

ATTGCAGCCG TCACCAAAGG GGGAGTTGGG CCCTTCAGTG ATCCAGTGAA AATATTTATC 1380

CCTGCACACG GTTGGGTAGA TTATGCCCCC TCTTCAACTC CGGCGCCTGG CAACGCAGAT 1440

CCTGTGCTTA TCATCTTTGG CTGCTTTTGT GGATTTATTT TGATTGGGTT GGTTTTATAC 1500

ATCTCCTTGG CCATCAGAAA AAGAGTCCAG GAGACAAAGT TTGGGAATGC ATTCACAGAG 1560

GAGGATTCTG AATTAGTGGT GAATTATATA GCAAAGAAAT CCTTCTGTCG GCGAGCCATT 1620

GAACTTACCT TACATAGCTT GGGAGTCAGT GAAGAACTAC AAAATAAACT AGAAGATGTT 1680

GTGATTGACA GGAATCTTCT AATTCTTGGA AAAATTCTGG GTGAAGGAGA GTTTGGGTCT 1740

GTAATGGAAG GAAATCTTAA GCAGGAAGAT GGGACCTCTC TGAAAGTGGC AGTGAAGACC 1800

ATGAAGTTGG ACAACTTTTC GCAGCGGGAG ATCGAGGAGT TTCTCAGTGA GGCAGCGTGC 1860

ATGAAAGACT TTAGCCACCC AAATGTCATT CGACTTCTAG GTGTGTGTAT AGAAATGAGC 1920

TCTCAAGGCA TCCCAAAGCC CATGGTAATT TTACCCTTCA TGAAATACGG GGACCTGCAT 1980

ACTTACTTAC TTTATTCCCG ATTGGAGACA GGACCAAAGC ATATTCCTCT GCAGACACTA 2040

TTGAAGTTCA TGGTGGATAT TGCCCTGGGA ATGGAGTATC TGAGCAACAG GAATTTTCTT 2100

CATCGAGATT TAGCTGCTCG AAACTGCATG TTGCGAGATG ACATGACTGT CTGTGTTGCG 2160

GACTTCGGCC TCTCTAAGAA GATTTACAGT GGCGATTATT ACCGGCAAGG CCGCATTGCT 2220

AAGATGCCTG TTAAATGGAT CGCCATAGAA AGTCTTGCAG ACCGAGTCTA CACAAGTAAA 2280

AGTGATGTGT GGGCATTTGG TGTGACCATG TGGGAAATAG CTACGCGGGG AATGACTCCC 2340

TATCCTGGGG TCCAGAACCA TGAGATGTAT GACTATCTTC TCCATGGCCA CAGGCTGAAG 2400

CAGCCCGAAG ACTGCCTGGA TGAACTGTAT GAAATAATGT ACTCTTGCTG GAGAACCGAT 2460

CCCTTAGACC GCCCCACCTT TTCAGTATTG AGGCTGCAGC TAGAAAAACT CTTAGAAAGT 2520

TTGCCTGACG TTCGGAACCA AGCAGACGTT ATTTACGTCA ATACACAGTT GCTGGAGAGC 2580

TCAGAGGGCC TGGCCCAGGG CTCCACCCTT GCTCCGCTGG ACTTGAACAT CGACCCTGAC 2640

TCTATAATTG CCTCCTGCAC TCCCCGCGCT GCCATCAGTG TGGTCACAGC AGAAATTCAT 2700

GACAGCAAAC CTCATGAAGG ACGGTACATC CTGAATGGGG GCAGTGAGGA ATGGGAAGAT 2760

CTGACTTCTG CCCCCTCTGC TGCAGTCACA GCTGAAAAGA ACAGTGTTTT ACCGGGGGAG 2820

AGACTTGTTA GGAATGGGGT CTCCTGGTCC CATTCGAGCA TGCTGCCCTT GGGAAGCTCA 2880

TTGCCCGATG AACTTTTGTT TGCTGACGAC TCCTCAGAAG GCTCAGAAGT CCTGATGTGA 2940

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lgk+lgegefgsvmeg+lkqedg++lkvavkt+kld+++++eieeflseaacmk+f+h

Q: 567   LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNFSQREIEEFLSEAACMKDFSH  626

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl+kfmv

Q: 627   PNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV  685

         ****************9.******************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk

Q: 686   DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  745

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc

Q: 746   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  805

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ldely++my+cw++dp drp+fsvlr

Q: 806   LDELYEIMYSCWRTDPLDRPTFSVLR  831

         *************************9

Domain Sequence
(FASTA)

LILGKILGEG EFGSVMEGNL KQEDGTSLKV AVKTMKLDNF SQREIEEFLS EAACMKDFSH 60

PNVIRLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD 120

IALGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180

IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240

DELYEIMYSC WRTDPLDRPT FSVLR 265

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013