EKS-GOG-00294

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00294

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	501.7	5.0E-151	511	768	258

Status

Unreviewed

Ensembl Protein

ENSGGOP00000013968

UniProt Accession

G3REI1;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB4

Gene Synonyms/Alias

ERBB4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000014309	ENSGGOP00000013968	ENSGGOT00000014371

Organism

Gorilla gorilla

Functional Description

Protein Length

1085

Protein Sequence
(FASTA)

VTRTVCAEQC DGRCYGPYVS DCCHRECAGG CSGPKDTDCF VCLSYDIDTI CVQHCIKYYI 60

SSLLSFQSHY NNRRGRNVKG FHSNAFPNNF VVDSSSCVRA CPSSKMEVEE NGIKMCKPCT 120

DICPKACDGI GTGSLMSAQT VDSSNIDKFI NCTKINGNLI FLVTGIHGDP YNAIEAIDPE 180

KLNVFRTVRE ITGFLNIQSW PPNMTDFSVF SNLVTIGGRV LYSGLSLLIL KQQGITSLQF 240

QSLKEISAGN IYITDNSNLC YYHTINWTTL FSTINQRIVI RDNRKAENCT AEGMVCNHLC 300

SSDGCWGPGP DQCLSCRRFS RGRICIESCN LYDGEFREFE NGSICVECDP QCEKMEDGLL 360

TCHGPGPDNC TKCSHFKDGP NCVEKCPDGL QGANSFIFKY ADPDRECHPC HPNCTQGCNG 420

PTSHDCIYYP WTGHSTLPQH ARTPLIAAGV IGGLFILVIV GLTFAVYVRR KSIKKKRALR 480

RFLETELVEP LTPSGTAPNQ AQLRILKETE LKRVKVLGSG AFGTVYKGIW VPEGETVKIP 540

VAIKILNETT GPKANVEFMD EALIMASMDH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY 600

VHEHKDNIGS QLLLNWCVQI AKGMMYLEER RLVHRDLAAR NVLVKSPNHV KITDFGLARL 660

LEGDEKEYNA DGGKMPIKWM ALECIHYRKF THQSDVWSYG VTIWELMTFG GKPYDGIPTR 720

EIPDLLEKGE RLPQPPICTI DVYMVMVKCW MIDADSRPKF KELAAEFSRM ARDPQRYLVI 780

QGDDRMKLPS PNDSKFFQNL LDEEDLEDMM DAEEYLVPQA FNIPPPIYTS RARIDSNRNQ 840

FVYRDGGFAA EQGVSVPYRA PTSTIPEAPV AQGATAEIFD DSCCNGTLRK PVVPHVQEDS 900

STQRYSADPT VFAPERSPRG ELDEEGYMTP MRDKPKQEYL NPVEENPFVS RRKNGDLQAL 960

DNPEYHNASN GPPKAEDEYV NEPLYLNTFA NTLGKAEYLK NNILSMPEKA KKAFDNPDYW 1020

NHSLPPRSTL QHPDYLQEYS TKYFYKQNGR IRPIVAENPE YLSEFSLKPG TVLPPPPYRH 1080

RNTVV 1085

Nucleotide Sequence
(FASTA)

GTGACAAGGA CGGTGTGTGC AGAACAATGT GACGGCAGAT GCTACGGACC TTACGTCAGT 60

GACTGCTGCC ATCGAGAATG TGCTGGAGGC TGCTCAGGAC CTAAGGACAC AGACTGCTTT 120

GTATGTCTCT CTTATGATAT AGACACAATC TGTGTACAGC ACTGCATAAA ATATTATATA 180

TCTTCCCTCC TTTCTTTCCA GAGCCATTAT AACAATCGAA GAGGCAGAAA TGTGAAAGGG 240

TTTCATAGTA ACGCATTTCC CAATAACTTT GTGGTAGATT CCAGTTCTTG TGTGCGTGCC 300

TGCCCTAGTT CCAAGATGGA AGTAGAAGAA AATGGGATTA AAATGTGTAA ACCTTGCACT 360

GACATTTGCC CAAAAGCTTG TGATGGCATT GGCACAGGAT CATTGATGTC AGCTCAGACT 420

GTGGATTCCA GTAACATTGA CAAATTCATA AACTGTACCA AGATCAATGG GAATTTGATC 480

TTTCTAGTCA CTGGTATTCA TGGGGACCCT TACAATGCAA TTGAAGCCAT AGACCCAGAG 540

AAACTGAATG TCTTTCGGAC AGTCAGAGAG ATAACAGGTT TCCTGAACAT ACAGTCATGG 600

CCACCAAACA TGACTGACTT CAGTGTTTTT TCTAACCTGG TGACCATTGG TGGAAGAGTA 660

CTCTATAGCG GCCTGTCCTT GCTTATCCTC AAGCAACAGG GCATCACCTC TCTGCAGTTC 720

CAGTCCCTGA AGGAAATCAG CGCAGGAAAC ATCTATATTA CTGACAACAG CAACCTGTGT 780

TATTATCATA CCATTAACTG GACAACACTC TTCAGCACAA TCAACCAAAG AATAGTAATC 840

CGGGATAATA GAAAAGCTGA AAATTGTACT GCTGAAGGAA TGGTGTGCAA CCATCTGTGT 900

TCCAGTGATG GCTGTTGGGG ACCTGGGCCA GACCAATGTC TGTCGTGTCG CCGCTTCAGT 960

AGAGGAAGGA TCTGCATAGA GTCTTGTAAC CTCTATGATG GTGAATTTCG GGAGTTTGAG 1020

AATGGCTCCA TCTGTGTGGA GTGTGACCCC CAGTGTGAGA AGATGGAAGA TGGCCTCCTC 1080

ACATGCCATG GACCGGGTCC TGACAACTGT ACGAAGTGCT CTCATTTTAA AGATGGCCCA 1140

AACTGTGTGG AAAAATGTCC AGATGGCTTA CAGGGGGCAA ACAGTTTCAT TTTCAAGTAT 1200

GCTGATCCAG ATCGGGAGTG CCACCCATGC CATCCAAACT GCACCCAAGG GTGTAACGGT 1260

CCCACTAGTC ATGACTGCAT TTACTACCCA TGGACGGGCC ATTCCACTTT ACCACAACAT 1320

GCTAGAACTC CCCTGATTGC AGCTGGAGTA ATTGGTGGGC TCTTCATTCT GGTCATTGTG 1380

GGTCTGACAT TTGCTGTTTA TGTTAGAAGG AAGAGCATCA AAAAGAAAAG AGCCTTGAGA 1440

AGATTCTTGG AAACAGAGTT GGTGGAACCA TTAACTCCCA GTGGCACAGC ACCCAATCAA 1500

GCTCAACTTC GTATTTTGAA AGAAACTGAG CTGAAGAGGG TGAAAGTCCT TGGCTCAGGT 1560

GCTTTTGGAA CGGTTTATAA AGGTATTTGG GTACCTGAAG GAGAAACTGT GAAGATTCCT 1620

GTGGCTATTA AGATTCTTAA TGAGACAACT GGTCCCAAGG CAAATGTGGA GTTCATGGAT 1680

GAAGCTCTGA TCATGGCAAG TATGGATCAT CCACACCTAG TCAGGTTGCT GGGTGTGTGT 1740

CTGAGCCCAA CCATCCAGCT GGTTACTCAA CTTATGCCCC ATGGCTGCCT GTTGGAGTAT 1800

GTCCACGAGC ACAAGGATAA CATTGGATCA CAACTGCTGC TTAACTGGTG TGTCCAGATA 1860

GCTAAGGGAA TGATGTACCT GGAAGAAAGA CGACTCGTTC ATCGGGATTT GGCAGCCCGT 1920

AATGTCTTAG TGAAATCTCC AAACCATGTG AAAATCACAG ATTTTGGGCT AGCCAGACTC 1980

TTGGAAGGAG ATGAAAAAGA GTACAATGCT GATGGAGGAA AGATGCCAAT TAAATGGATG 2040

GCTCTGGAGT GTATACATTA CAGGAAATTC ACCCATCAGA GTGACGTTTG GAGCTATGGA 2100

GTTACTATAT GGGAACTGAT GACCTTTGGA GGAAAACCCT ATGATGGAAT TCCAACGCGA 2160

GAAATCCCTG ATTTATTAGA GAAAGGAGAA CGTTTGCCTC AGCCGCCCAT CTGCACTATT 2220

GACGTTTACA TGGTCATGGT CAAATGTTGG ATGATTGATG CTGACAGTAG ACCTAAATTT 2280

AAGGAACTGG CTGCTGAGTT TTCAAGGATG GCTCGAGACC CTCAAAGATA CCTAGTTATT 2340

CAGGGTGATG ATCGTATGAA GCTTCCCAGT CCAAATGACA GCAAGTTCTT TCAGAATCTC 2400

TTGGATGAAG AAGATTTGGA AGATATGATG GATGCTGAGG AGTACTTGGT CCCTCAGGCT 2460

TTCAACATCC CACCTCCCAT CTATACTTCC AGAGCAAGAA TTGACTCGAA TAGGAACCAG 2520

TTTGTATACC GAGACGGAGG TTTTGCTGCT GAACAAGGAG TGTCTGTGCC CTACAGAGCC 2580

CCAACTAGCA CAATTCCAGA AGCTCCTGTG GCACAGGGTG CTACTGCTGA GATTTTTGAT 2640

GACTCCTGCT GTAATGGCAC CCTACGCAAG CCAGTGGTAC CCCATGTCCA AGAGGACAGT 2700

AGCACCCAGA GGTACAGTGC TGACCCCACC GTGTTTGCCC CAGAACGGAG CCCACGAGGA 2760

GAGCTGGATG AGGAAGGTTA CATGACTCCT ATGCGAGACA AACCCAAACA AGAATACCTG 2820

AATCCAGTGG AGGAGAACCC TTTTGTTTCT CGGAGAAAAA ATGGAGACCT TCAAGCATTG 2880

GATAATCCCG AATATCACAA TGCATCCAAT GGTCCACCCA AGGCCGAGGA TGAGTATGTG 2940

AACGAGCCAC TGTACCTCAA CACCTTTGCC AACACCTTGG GAAAAGCTGA GTACCTGAAG 3000

AACAACATAC TGTCAATGCC AGAGAAGGCC AAGAAAGCGT TTGACAACCC TGACTACTGG 3060

AACCACAGCC TGCCACCTCG GAGCACCCTT CAGCACCCAG ACTACCTGCA GGAGTACAGC 3120

ACAAAATATT TTTATAAACA GAATGGGCGG ATCCGGCCTA TTGTGGCAGA GAATCCTGAA 3180

TACCTCTCTG AGTTCTCCCT GAAGCCAGGC ACTGTGCTGC CGCCTCCACC TTACAGACAC 3240

CGGAATACTG TGGTGTAA 3258

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 511   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  570

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gcll+yv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 571   PHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  630

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 631   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  690

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw

Q: 691   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  750

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 751   MIDADSRPKFKELAAEFS  768

         ****************96

Domain Sequence
(FASTA)

LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 1.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013