EPS-GOG-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GOG-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	288.9	5.6E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSGGOP00000014035

UniProt Accession

G3REP4;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000014395	ENSGGOP00000014035	ENSGGOT00000014440

Organism

Gorilla gorilla

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT TNEDFRAAGK SGSALELSVE NVKNGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PKHIYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFSNAPK 300

VSDEAVKKDS ELDKHLESRV EEIMEKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NVIEAVYSRL NPHRESDGAS DEAEESGSQG KLVEALRQMR INHRGNYRQL LEEMLTSYRL 420

AKVEGEESPA EPAATATSSN SDAGNPVTMQ ESHTESESGL AELDSSNEDA GTKMSGEKI 479

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAAAAACATA ATGCTCATGG TGCTGGGAAT 60

GGTTTACGTT ATGGCCTGAG CAGCATGCAA GGATGGAGAG TGGAAATGGA AGATGCACAC 120

ACAGCTGTTG TAGGTATTCC TCACGGCTTG GAAGACTGGT CATTTTTTGC AGTTTATGAT 180

GGTCATGCTG GATCCCGAGT GGCAAATTAC TGCTCAACAC ATTTGTTAGA ACACATCACT 240

ACTAACGAAG ACTTTAGGGC AGCTGGAAAA TCAGGATCTG CTCTTGAGCT TTCAGTGGAA 300

AATGTTAAGA ATGGTATCAG AACTGGATTT TTGAAAATTG ATGAATACAT GCGTAACTTT 360

TCAGACCTCA GAAACGGGAT GGACAGGAGT GGTTCAACTG CAGTGGGAGT TATGATTTCA 420

CCTAAGCATA TCTACTTTAT CAACTGTGGT GATTCACGTG CTGTTCTGTA TAGAAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGCAATC CAAGGGAAAA GGAGCGAATC 540

CAAAATGCAG GAGGCAGCGT GATGATACAA CGTGTTAATG GTTCATTAGC AGTATCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCAACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAAATTTTA AGAGCAGAAG AGGATGAATT TATCATCTTG 720

GCTTGTGATG GGATCTGGGA TGTTATGAGT AATGAGGAGC TCTGTGAATT TGTTAAATCT 780

AGGCTTGAGG TATCTGATGA CCTGGAAAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CACAAGGGAA GTCGAGATAA CATGAGTATT GTACTAGTTT GCTTTTCAAA TGCTCCCAAG 900

GTCTCAGATG AAGCAGTGAA AAAAGATTCA GAGTTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAGATTA TGGAGAAGTC TGGCGAGGAA GGAATGCCTG ATCTTGCCCA TGTCATGCGC 1020

ATCTTGTCTG CAGAAAATAT CCCAAATTTG CCTCCTGGGG GAGGTCTTGC TGGCAAGCGT 1080

AATGTTATTG AAGCTGTTTA TAGTAGACTG AATCCACATA GAGAAAGTGA TGGGGCCTCC 1140

GATGAAGCAG AGGAAAGTGG ATCACAGGGA AAATTGGTGG AAGCTCTCAG GCAAATGAGA 1200

ATTAATCATA GGGGAAACTA CCGACAACTT CTGGAGGAGA TGCTGACTAG TTACAGGCTA 1260

GCTAAAGTAG AGGGAGAAGA AAGCCCTGCT GAACCAGCTG CCACAGCTAC TTCTTCGAAC 1320

AGTGATGCTG GAAACCCAGT GACAATGCAG GAAAGCCATA CTGAATCAGA AAGTGGTCTT 1380

GCTGAATTAG ACAGCTCTAA TGAAGATGCA GGGACAAAGA TGAGTGGTGA AAAAATATGA 1440

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e + ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TTNEDfraagksgsALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99********99999******************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITTN 60

EDFRAAGKSG SALELSVENV KNGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPK 120

HIYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013