EKS-GOG-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	339.5	2.1E-101	1061	1324	264

Status

Unreviewed

Ensembl Protein

ENSGGOP00000014200

UniProt Accession

G3RF43;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000014556	ENSGGOP00000014200	ENSGGOT00000014610

Organism

Gorilla gorilla

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV 60

NEEEDPSGGR QDWQPRREGV EITVTFPRDV SPPQEMSQED LKEKNQINSS HQEWAQAHAV 120

SHPNEIEKVE LRTKKLTMRP LVLQKEESSR ELCDVNLGFL LPRSCLELNI SKSVTREDAP 180

HFLKEQQRKS EEFSTSHMKY SGRSIEFLLP PLSLLPTRSC VLTIPQNHKF PKEKERNIPS 240

LTSFVPKLSV SVRQSDELSP SNKPLEALVK LLMDPTLRSS DGFIGSRNMC SFPKTNHHRQ 300

CLEMEENWKS KEIEECNKIE ITDFEKGQSL VSFENLKEGN IPADREEDID CHGSKTRKPE 360

EENFQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS EITPSQDEEM RNNKAASKRA 420

SLHKNEAMEP NNILEECTVL KSLSSVVFDD PIDKLPEGCS SMETNLKISI AERAKPEMSR 480

MVPLIHITFP VDGSPKEPVI AKPSLQKRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS 540

KIKTSKKTPQ NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK 600

QSTHRTQKPK KQSFPCICKN PGIQKSYVPL SVQPTEPRLN YLDLKYSDMF KEINSTANGP 660

GIYEMFGTPV YCHLRETERD ENKYYREICS APSGRSITNK CRSSHSERKS NIRTRLSQKK 720

THMKPPKTSF GIKQEHKVLI SKEKSSKAVH SNLHDIENGD GISEPDWQIK SSGNEFLSSK 780

DEIHPMNLAQ TPEQSMKQNE FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL 840

EELHHQIPFI PSENSWAVPN EKNSNKCVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS 900

KTLTNFSFQE KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN SISQEIMDSV 960

NNEELTDELL GCLAAELLAL DEKDNNSCQK MASETDPDNL NLVLRWRGST PKEMGRETTK 1020

VKIQRHSSGL RIYDREEKFL ISNEKKIFSE NSLKSEEPIL WTKGEILGKG AYGTVYCGLT 1080

SQGQLIAVKQ VALDTSNKLA TEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM 1140

EFIPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII 1200

KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI WSIGCTVFEM 1260

ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF VRMCLTRDQH ERPSALQLLK 1320

HSFLERSH 1328

Nucleotide Sequence
(FASTA)

ATGAGTTCTA TGCCAAAACC AGAAAGACAT GCTGAGTCAT TGCTTGACAT CTGTCATGAT 60

ACAAACTCTT CTCCAACTGA TTTGATGACA GTTACCAAAA ATCAAAACAT CATCTTGCAA 120

AGCATCAGCA GAAGTGAGGA GTTCGACCAA GATGGTGACT GCAGTCATTC CACACTGGTT 180

AATGAAGAAG AAGATCCCAG TGGTGGTAGA CAGGACTGGC AACCCAGGAG AGAAGGTGTT 240

GAGATCACTG TAACTTTTCC AAGAGATGTC AGTCCTCCCC AAGAAATGAG CCAAGAAGAC 300

TTAAAAGAAA AGAATCAGAT AAACTCATCG CATCAAGAAT GGGCACAAGC ACATGCAGTT 360

TCTCATCCAA ATGAAATAGA AAAGGTGGAG CTCAGGACAA AGAAGCTGAC CATGCGGCCC 420

TTAGTTTTGC AAAAAGAGGA AAGTTCCAGG GAGCTCTGCG ATGTGAACTT GGGCTTTTTG 480

CTGCCAAGAT CTTGTTTAGA ACTAAACATT TCCAAGTCTG TAACCAGAGA AGATGCTCCT 540

CATTTTCTGA AGGAGCAGCA AAGAAAATCT GAAGAGTTTT CGACCTCTCA TATGAAGTAC 600

AGTGGCCGAA GCATCGAGTT CCTTCTGCCA CCACTGTCAC TCTTGCCCAC GCGATCTTGT 660

GTCCTTACTA TCCCCCAAAA TCACAAGTTT CCAAAAGAAA AAGAAAGAAA CATTCCAAGC 720

CTCACATCTT TTGTGCCTAA GCTCTCAGTG TCTGTTCGTC AATCTGATGA GCTCAGCCCA 780

TCAAACAAGC CTCTGGAAGC CCTAGTTAAG TTGTTGATGG ATCCGACTCT CAGGTCCTCT 840

GATGGCTTCA TTGGGTCAAG AAACATGTGC TCTTTTCCTA AGACTAACCA TCACAGACAA 900

TGCCTGGAGA TGGAGGAAAA CTGGAAATCC AAGGAAATAG AAGAATGTAA CAAAATTGAA 960

ATCACTGACT TCGAAAAAGG GCAGTCTTTG GTGTCTTTTG AGAATTTGAA GGAAGGCAAT 1020

ATTCCTGCAG ATAGGGAAGA GGATATTGAC TGCCATGGTA GTAAAACGCG AAAACCTGAA 1080

GAAGAGAACT TTCAATATCT TTCATCAAGA AAGAATGAGA GTTCAGTAGC CAAAAACTAT 1140

GAACAAGATC CAGAAATAGT ATGTACCATT CCAAGCAAGT TCCAAGAAAC CCAGCATTCA 1200

GAAATAACTC CAAGCCAGGA TGAAGAGATG AGAAATAATA AAGCTGCTTC AAAAAGAGCT 1260

TCATTACATA AAAATGAAGC AATGGAACCA AACAATATTT TAGAAGAGTG TACTGTACTT 1320

AAAAGCTTAT CCAGTGTAGT CTTTGATGAC CCCATTGATA AACTCCCAGA AGGTTGTAGC 1380

AGCATGGAGA CAAACTTAAA AATATCAATA GCAGAAAGAG CCAAACCAGA AATGAGTAGG 1440

ATGGTGCCTC TTATCCACAT CACCTTCCCT GTGGATGGAA GCCCCAAGGA ACCAGTGATA 1500

GCCAAACCAA GCCTCCAAAA AAGAAAGGGA ACCATTCATA ACAACCATAG TGTCAACATA 1560

CCTGTACACC AAGAAAATGA CAAGCATAAG ATGAATTCCC ATAGGAGTAA GTTGGATTCA 1620

AAGATCAAGA CAAGTAAGAA GACACCTCAG AATTTCGTGA TTTCTACCGA AGGTCCCATT 1680

AAGCCTACCA TGCATAAAAC CAGCATAAAA ACACAAATTT TCCCGGCTTT GGGACTTGTT 1740

GACCCCAGGC CTTGGCAATT GCCCAGGTTT CAAAAGAAAA TGCCACAGAT AGCAAAGAAG 1800

CAATCAACTC ACCGGACTCA GAAACCTAAA AAGCAATCAT TTCCTTGCAT CTGTAAAAAT 1860

CCAGGAATAC AAAAGTCATA TGTTCCTCTC TCTGTTCAGC CGACAGAGCC AAGACTAAAT 1920

TACCTAGATC TTAAGTATAG TGATATGTTC AAAGAAATCA ATTCAACTGC TAATGGACCT 1980

GGAATCTATG AAATGTTTGG GACCCCTGTT TATTGTCATT TGCGAGAGAC TGAAAGGGAT 2040

GAAAACAAGT ATTACCGTGA GATATGTTCG GCTCCATCAG GCAGAAGTAT CACCAATAAA 2100

TGTCGATCTT CACACAGTGA GAGGAAGAGC AATATCAGAA CAAGACTTTC TCAGAAAAAA 2160

ACACATATGA AACCCCCAAA GACTTCATTT GGCATTAAAC AAGAGCACAA AGTCTTAATT 2220

TCTAAAGAAA AGAGTTCCAA GGCTGTACAT AGCAACCTAC ATGACATTGA AAATGGTGAT 2280

GGTATTTCAG AACCAGACTG GCAGATAAAG TCTTCAGGAA ATGAGTTTCT ATCTTCCAAA 2340

GATGAAATTC ATCCCATGAA CTTGGCTCAG ACACCTGAGC AGTCCATGAA ACAGAATGAA 2400

TTCCCTCCTG TCTCAGATTT ATCCATTGTT GAAGAAGTTT CTATGGAAGA GTCTACTGGT 2460

GATAGAGACA TTTCTAACAA TCAAATACTC ACCACAAGCC TCAGAGATCT GCAAGAACTT 2520

GAAGAGCTAC ATCACCAGAT CCCATTTATC CCTTCAGAAA ACAGCTGGGC AGTGCCCAAT 2580

GAGAAGAATT CTAACAAGTG TGTACAGCAA GAAAAGCAGA ATACAGCATC TCTTAGTAAA 2640

GTAAATGCCA GCCGAATTTT AACTAATGAT CTAGAGTTTG ATAGCGTTTC AGATCACTCT 2700

AAAACACTTA CAAATTTCTC TTTCCAAGAA AAACAAGAAA GTGCATCTTC CCAGACATAT 2760

CAATATTGGG TACATTATTT GGATCATGAT AGTTTAGCAA ATAAGTCAAT CACATATCAA 2820

ATGTTTGGAA AAACCTTAAG TGGCACAAAT TCAATTTCCC AAGAAATTAT GGACTCTGTA 2880

AATAATGAAG AATTGACAGA TGAACTATTA GGTTGTCTAG CTGCAGAATT ATTAGCTCTT 2940

GATGAGAAAG ATAACAACTC TTGCCAAAAA ATGGCAAGTG AAACAGATCC TGACAACCTA 3000

AATCTTGTCC TCAGATGGAG AGGAAGTACC CCAAAAGAAA TGGGCAGAGA GACAACAAAA 3060

GTCAAAATAC AGAGGCATAG TAGTGGGCTC AGGATATATG ACAGGGAGGA GAAATTTCTC 3120

ATCTCAAATG AAAAGAAGAT ATTTTCTGAA AATAGTTTAA AGTCTGAAGA ACCTATCCTA 3180

TGGACCAAGG GTGAGATTCT TGGAAAGGGA GCCTACGGCA CAGTATACTG TGGTCTCACT 3240

AGTCAAGGGC AGCTAATAGC TGTAAAACAG GTGGCTTTGG ATACCTCTAA TAAATTAGCT 3300

ACTGAAAAGG AATACCGGAA ACTACAGGAA GAAGTAGATT TGCTCAAAGC ACTGAAACAT 3360

GTCAACATTG TGGCCTATTT GGGGACATGC TTGCAAGAGA ACACTGTGAG CATTTTCATG 3420

GAGTTTATTC CTGGTGGCTC AATCTCTAGT ATTATAAACC GTTTTGGGCC ATTGCCTGAG 3480

ATGGTGTTCT GTAAATATAC GAAACAAATT CTTCAAGGTG TTGCTTATCT CCATGAGAAC 3540

TGCGTGGTAC ATCGCGATAT CAAAGGAAAT AATGTTATGC TCATGCCAAC TGGAATAATA 3600

AAGCTGATTG ACTTTGGCTG TGCCAGGCGT TTGGCCTGGG CAGGTTTAAA TGGCACCCAC 3660

AGTGACATGC TTAAGTCCAT GCATGGGACT CCATATTGGA TGGCCCCAGA AGTCATCAAT 3720

GAGTCTGGCT ATGGACGGAA ATCAGATATC TGGAGCATTG GTTGTACTGT GTTTGAGATG 3780

GCTACAGGGA AGCCTCCACT GGCTTCCATG GACAGGATGG CCGCAATGTT TTACATCGGA 3840

GCACACCGAG GGCTGATGCC TCCTTTACCA GACCACTTCT CAGAAAATGC AGCAGACTTT 3900

GTGCGCATGT GCCTGACCAG GGACCAGCAT GAGCGACCTT CTGCTCTCCA GCTCCTGAAG 3960

CACTCCTTCT TGGAGAGAAG TCACTGA 3987

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekk.sekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 1061  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSNKlATEKEYRKLQEEVDLLKALK  1119

         89*****************8.89***********8765516677****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ +e++++if+E+++gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 1120  HVNIVAYLGTCLQENTVSIFMEFIPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE  1179

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG+++rla++  + ++   l+s++Gt+++maPEvi

Q: 1180  NCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1239

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p+++se+

Q: 1240  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPDHFSEN  1296

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1297  AADFVRMCLTRDQHERPSALQLLKHSFL  1324

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA TEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LQENTVSIFM EFIPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF 240

VRMCLTRDQH ERPSALQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013