EKS-GOG-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.2	4.8E-97	1095	1359	265

Status

Unreviewed

Ensembl Protein

ENSGGOP00000014248

UniProt Accession

G3RF89;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000014603	ENSGGOP00000014248	ENSGGOT00000014658

Organism

Gorilla gorilla

Functional Description

Protein Length

1364

Protein Sequence
(FASTA)

EKRAPASEYR PTVQHFSREM ENKETLKGLH KMDDRPEERM IREKLKATCM PAWKHEWLER 60

RNRRGPVVVK PIPVKGDGSE MNHLAAESPG EAQASAASPA SKGRRSPSPG NSPSGRTVKS 120

ESPGVRRKRV SPVPFQSGRI TPPRRAPSPD GFSPYSPEET NRRVNKVMRA RLYLLQQIGP 180

NSFLIGGDSP DNKYRVFIGP QNCSCARGTF CIHLLFVMLR VFQLEPSDPM LWRKTLKNFE 240

VESLFQKYHS RRSSRIKAPS RNTIQKFVSR MSNSHTLSSS STSTSSSENS IKDEEEQMCP 300

ICLLGMLDEE SLTVCEDGCR NKLHHHCMSI WAEECRRNRE PLICPLCRSK WRSHDFYSHE 360

LSSPVDSPSS LRAAQQQTIQ QQPLAGSQRR NQESNFNLTH YGTQQIPPAY KDLAEPWIQV 420

FGMELVGCLF SRNWNVREMA LRRLSHDVSG ALLLANGEST GNSGGSSGSS PSGGATSGSS 480

QTSISGDVVE ACCSVLSMVC ADPVYKVYVA ALKTLRAMLV YTPCHSLAER IKLQRLLQPV 540

VDTILVKCAD ANSRTSQLSI STLLELCKGQ AGELAIGREI LKAGSIGIGG VDYVLNCILG 600

NQTESNNWQE LLGRLCLIDR LLLEFPAEFY PHIVSTDVSQ AEPVEIRYKK LLSLLTFALQ 660

SIDNSHSMVG KLSRRIYLSS ARMVTTVPHV FSKLLEMLSV SSSTHFTRMR RRLMAIADEV 720

EIAEAIQLGV EDTLDGQQDS FLQASIPNNY LETTENSTPE CTIHLEKTGK GLCATKLSAS 780

SEDISERLAS ISVGPSSSTT TEQPKPMVQT KGRPHSQCLN SSPLSHHSQL MFPALSTPSS 840

STPSVPAGTA TDVSKHRLQG FIPCRIPSAS PQTQRKFSLQ FHRNCPENKD SDKLSPVFTQ 900

SRPLPSSNIH RPKPSRPTPG NTSKQGDPSK NSMTLDLNSS SKCDDSFGCS SNSSNAVIPS 960

DETVFTPVEE KCRLDVNTEL NSSIEDLLEA SMPSSDTTVT FKSEVAVLSP EKAENDDTYK 1020

DDVNHNQKCK EKMEAEEEEA LAIAMAMSAS QDALPIVPQL QVENGEDIII IQQDTPETLP 1080

GHTKAKQPYR EDTEWLKGQQ IGLGAFSSCY QAQDVGTGTL MAVKQVTYVR NTSSEQEEVV 1140

EALREEIRMM SHLNHPNIIR MLGATCEKSN YNLFIEWMAG GSVAHLLSKY GAFKESVVIN 1200

YTEQLLRGLS YLHENQIIHR DVKGANLLID STGQRLRIAD FGAAARLASK GTGAGEFQGQ 1260

LLGTIAFMAP EVLRGQQYGR SCDVWSVGCA IIEMACAKPP WNAEKHSNHL ALIFKIASAT 1320

TAPSIPSHLS PGLRDVALRC LELQPQDRPP SRELLKHPVF RTTW 1364

Nucleotide Sequence
(FASTA)

GAGAAGAGGG CTCCTGCCAG TGAATACAGA CCAACAGTAC AGCATTTTAG TCGTGAGATG 60

GAGAATAAAG AAACTCTCAA AGGGTTGCAC AAGATGGATG ATCGTCCAGA GGAACGAATG 120

ATCAGGGAGA AACTGAAGGC AACCTGTATG CCAGCCTGGA AGCACGAATG GTTGGAAAGG 180

AGAAATAGGC GAGGGCCTGT GGTGGTAAAA CCAATCCCAG TTAAAGGAGA TGGATCTGAA 240

ATGAATCACT TAGCAGCTGA GTCTCCAGGA GAGGCCCAGG CAAGTGCGGC TTCACCAGCT 300

TCCAAAGGCC GACGCAGTCC TTCTCCTGGC AACTCCCCAT CAGGTCGCAC AGTGAAATCA 360

GAATCTCCAG GAGTAAGGAG AAAAAGAGTT TCCCCAGTGC CTTTTCAGAG TGGCAGAATC 420

ACACCACCCC GAAGAGCCCC TTCACCAGAT GGCTTCTCAC CATATAGCCC TGAGGAAACA 480

AATCGCCGTG TTAACAAAGT GATGCGGGCC AGACTATACT TACTGCAGCA GATAGGGCCT 540

AACTCTTTCC TGATTGGAGG AGACAGCCCA GACAATAAAT ACCGGGTGTT TATTGGGCCT 600

CAGAACTGCA GCTGTGCACG TGGAACATTC TGTATTCATC TGCTATTTGT GATGCTCCGG 660

GTGTTTCAAC TAGAACCTTC AGACCCAATG TTATGGAGAA AAACTTTAAA GAATTTTGAG 720

GTTGAGAGTT TGTTCCAGAA ATATCACAGT AGGCGTAGCT CAAGGATCAA AGCTCCATCT 780

CGTAACACCA TCCAGAAGTT TGTTTCACGC ATGTCAAATT CTCATACATT GTCATCATCT 840

AGTACTTCTA CATCTAGTTC AGAAAACAGC ATAAAGGATG AAGAGGAACA GATGTGTCCT 900

ATTTGCTTGT TGGGCATGCT TGATGAAGAA AGTCTTACAG TTTGTGAAGA CGGCTGCAGG 960

AACAAGCTGC ACCACCACTG CATGTCAATT TGGGCAGAAG AGTGTAGAAG AAATAGAGAA 1020

CCTTTAATAT GTCCCCTTTG TAGATCTAAG TGGAGATCTC ATGATTTCTA CAGCCACGAG 1080

TTGTCCAGTC CTGTGGATTC CCCTTCTTCC CTCAGAGCTG CACAGCAGCA AACCATACAG 1140

CAGCAGCCTT TGGCTGGATC ACAAAGAAGG AATCAAGAGA GCAATTTTAA CCTTACTCAT 1200

TATGGAACTC AGCAAATCCC TCCTGCTTAC AAAGATTTAG CTGAGCCATG GATTCAGGTG 1260

TTTGGAATGG AACTCGTTGG CTGCTTATTT TCTAGAAACT GGAATGTGAG AGAGATGGCC 1320

CTCAGGCGTC TTTCCCATGA TGTCAGTGGG GCCCTGCTGT TGGCAAATGG GGAGAGCACT 1380

GGAAATTCTG GGGGCAGCAG TGGAAGCAGC CCGAGTGGGG GAGCCACCAG TGGGTCTTCC 1440

CAGACCAGTA TCTCAGGAGA TGTGGTGGAG GCATGCTGCA GCGTTCTGTC AATGGTCTGT 1500

GCTGACCCTG TCTACAAAGT GTACGTTGCT GCTTTAAAAA CATTGAGAGC CATGCTGGTA 1560

TATACTCCTT GCCACAGTTT AGCGGAAAGA ATCAAACTTC AGAGACTTCT GCAGCCAGTT 1620

GTAGACACCA TCCTAGTCAA ATGTGCAGAT GCCAATAGCC GCACAAGTCA GCTGTCCATA 1680

TCAACACTGT TGGAACTGTG CAAAGGCCAA GCAGGAGAGT TGGCAATTGG CAGAGAAATA 1740

CTAAAAGCTG GATCCATTGG TATTGGTGGT GTTGATTATG TCTTAAATTG TATTCTTGGA 1800

AACCAAACTG AATCAAACAA TTGGCAAGAA CTTCTTGGCC GCCTTTGTCT TATAGATAGA 1860

CTGTTGTTGG AATTTCCTGC TGAATTTTAT CCTCATATTG TCAGTACTGA TGTTTCACAA 1920

GCTGAGCCTG TTGAAATCAG GTATAAGAAG CTGCTGTCCC TCTTAACCTT TGCTTTGCAG 1980

TCCATTGATA ATTCCCACTC AATGGTTGGC AAACTTTCCA GAAGGATCTA CTTGAGTTCT 2040

GCAAGAATGG TTACTACAGT ACCCCATGTG TTTTCAAAAC TGTTAGAAAT GCTGAGTGTT 2100

TCCAGTTCCA CTCACTTCAC CAGGATGCGT CGCCGTTTGA TGGCTATTGC AGATGAGGTG 2160

GAAATTGCCG AAGCCATCCA GTTGGGCGTA GAAGACACTT TGGATGGTCA ACAGGACAGC 2220

TTCTTGCAGG CATCTATTCC CAACAACTAT CTGGAAACCA CAGAGAACAG TACCCCTGAG 2280

TGCACAATCC ATTTAGAGAA AACTGGAAAA GGATTATGTG CTACAAAATT GAGTGCCAGT 2340

TCAGAGGACA TTTCTGAGAG ACTGGCCAGC ATTTCAGTAG GACCTTCTAG TTCAACAACA 2400

ACAGAGCAAC CAAAGCCAAT GGTTCAAACA AAAGGCAGAC CCCACAGTCA GTGTTTGAAC 2460

TCCTCTCCTT TATCTCATCA TTCCCAATTA ATGTTTCCAG CCTTGTCAAC CCCTTCTTCT 2520

TCGACCCCAT CTGTACCAGC TGGCACTGCA ACAGATGTCT CTAAGCATAG ACTTCAGGGA 2580

TTCATTCCCT GCAGAATACC TTCTGCATCT CCTCAAACAC AGCGCAAGTT TTCTCTACAA 2640

TTCCACAGAA ACTGTCCTGA AAACAAAGAC TCAGATAAAC TTTCCCCAGT CTTTACTCAG 2700

TCAAGACCCT TGCCCTCCAG TAACATACAC AGGCCAAAGC CATCTCGACC TACCCCAGGT 2760

AATACAAGTA AACAGGGAGA TCCCTCAAAA AATAGCATGA CACTTGATCT GAACAGTAGT 2820

TCCAAATGTG ATGACAGCTT TGGCTGTAGC AGCAATAGTA GTAATGCTGT TATACCCAGT 2880

GACGAGACAG TGTTCACCCC AGTGGAGGAG AAATGCAGAT TAGATGTCAA TACAGAGCTC 2940

AACTCCAGTA TTGAGGACCT TCTTGAAGCA TCTATGCCTT CAAGTGATAC AACAGTAACT 3000

TTTAAGTCAG AAGTTGCTGT CCTGTCTCCT GAAAAGGCTG AAAATGATGA TACCTACAAA 3060

GATGATGTGA ATCATAATCA AAAGTGCAAA GAGAAGATGG AAGCTGAAGA AGAAGAAGCT 3120

TTAGCAATTG CCATGGCAAT GTCAGCGTCT CAGGATGCCC TCCCCATAGT TCCTCAGCTG 3180

CAGGTTGAAA ATGGAGAAGA TATCATCATT ATTCAACAGG ATACACCAGA GACTCTACCA 3240

GGACATACCA AAGCAAAACA ACCGTATAGA GAAGACACTG AATGGCTGAA AGGTCAACAG 3300

ATAGGCCTTG GAGCATTTTC TTCTTGTTAT CAGGCTCAAG ATGTGGGAAC TGGAACTTTA 3360

ATGGCTGTTA AACAGGTGAC TTATGTCAGA AACACATCTT CTGAGCAAGA AGAAGTAGTA 3420

GAAGCACTAA GAGAAGAGAT AAGAATGATG AGCCATCTGA ATCATCCAAA CATCATTAGG 3480

ATGTTGGGAG CCACGTGTGA GAAGAGCAAT TACAATCTCT TCATTGAATG GATGGCAGGG 3540

GGATCGGTGG CTCATTTGCT GAGTAAATAT GGAGCCTTCA AAGAATCAGT AGTTATTAAC 3600

TACACTGAAC AGTTACTCCG TGGCCTTTCG TATCTCCATG AAAACCAAAT CATTCACAGA 3660

GATGTCAAAG GTGCCAATTT GCTAATTGAC AGCACTGGTC AGAGACTAAG AATTGCAGAT 3720

TTTGGAGCTG CAGCCAGGTT GGCATCAAAA GGAACTGGTG CAGGAGAGTT TCAGGGACAA 3780

TTACTGGGGA CAATTGCATT TATGGCACCT GAGGTACTAA GAGGTCAACA GTATGGAAGG 3840

AGCTGTGATG TATGGAGTGT TGGCTGTGCT ATTATAGAAA TGGCTTGTGC AAAACCACCA 3900

TGGAATGCAG AAAAACACTC CAATCATCTT GCTTTGATAT TTAAGATTGC TAGTGCAACT 3960

ACTGCTCCAT CGATCCCTTC ACATTTGTCT CCTGGTTTAC GAGATGTGGC TCTTCGTTGT 4020

TTAGAACTTC AACCTCAGGA CAGACCTCCA TCAAGAGAGC TACTGAAGCA TCCAGTCTTT 4080

CGTACTACAT GGTAG 4095

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1095  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1154

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1155  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1214

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1215  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1274

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1275  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1332

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1333  LRDVALRCLELQPQDRPPSRELLKHPV  1359

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013