EKS-GOG-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	353.3	1.1E-105	270	521	252

Status

Unreviewed

Ensembl Protein

ENSGGOP00000018282

UniProt Accession

G3RFN9;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK3

Gene Synonyms/Alias

PAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000014763	ENSGGOP00000014411	ENSGGOT00000014823
ENSGGOG00000014763	ENSGGOP00000018282	ENSGGOT00000034686

Organism

Gorilla gorilla

Functional Description

Protein Length

546

Protein Sequence
(FASTA)

MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN 60

KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS 120

NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SKSTKTASEP 180

PLAPPVNEPP PVIAPRPEHT KSIYTRSVVE SIASPAVPNK EVTPPSAENA NSSTLYRNTD 240

RQRKKSKMTD EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTALDI ATGQEVAIKQ 300

MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG SLTDVVTETC 360

MDEGQIAAVC RECLQALDFL HSNQVIHRDI KSDNILLGMD GSVKLTDFGF CAQITPEQSK 420

RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL GIMAIEMVEG EPPYLNENPL RALYLIATNG 480

TPELQNPERL SAVFRDFLNR CLEMDVDRRG SAKELLQHPF LKLAKPLSSL TPLIIAAKEA 540

IKNSSR 546

Nucleotide Sequence
(FASTA)

ATGTCTGACG GTCTGGATAA TGAAGAGAAA CCCCCAGCTC CTCCACTGAG GATGAATAGT 60

AACAACCGGG ATTCTTCAGC ACTCAACCAC AGCTCCAAAC CACTTCCCAT GGCCCCTGAA 120

GAGAAGAATA AGAAAGCCAG GCTTCGCTCT ATCTTCCCAG GAGGAGGGGA TAAAACCAAT 180

AAGAAGAAGG AGAAAGAGCG CCCAGAGATC TCTCTTCCTT CAGACTTTGA GCATACGATT 240

CATGTGGGGT TTGATGCAGT CACCGGGGAA TTCACTCCAG ATCTCTATGG CTCACAGATG 300

TGCCCAGGGA AGCTCCCAGA GGGAATTCCA GAGCAATGGG CACGATTACT CCAAACCTCC 360

AACATAACAA AATTGGAACA GAAGAAGAAC CCACAAGCTG TTCTAGATGT TCTCAAATTC 420

TATGATTCCA AAGAAACAGT CAACAACCAG AAATACATGA GCTTTACATC AGGAGATAAA 480

AGTGCACATG GATACATAGC AGCCCATCCT TCGAAGAGTA CAAAAACAGC ATCTGAGCCT 540

CCATTGGCCC CTCCTGTGAA TGAGCCACCA CCAGTTATCG CACCAAGACC AGAGCATACA 600

AAATCAATCT ACACTCGTTC TGTGGTTGAA TCCATTGCTT CACCAGCAGT ACCAAATAAA 660

GAGGTCACAC CACCCTCTGC TGAAAATGCC AATTCCAGTA CTTTGTACAG GAACACAGAT 720

CGGCAAAGAA AAAAATCCAA GATGACAGAT GAGGAGATCT TAGAGAAGCT AAGAAGCATT 780

GTGAGTGTTG GGGACCCAAA GAAAAAATAC ACAAGATTTG AAAAAATTGG TCAAGGGGCA 840

TCAGGTACTG TTTATACAGC ACTAGACATT GCAACAGGAC AAGAGGTGGC CATAAAGCAG 900

ATGAACCTTC AACAGCAACC CAAGAAGGAA TTAATTATTA ATGAAATTCT GGTCATGAGG 960

GAAAATAAGA ACCCTAATAT TGTTAATTAT TTAGATAGCT ACTTGGTGGG TGATGAACTA 1020

TGGGTAGTCA TGGAATACTT GGCTGGTGGC TCTCTGACTG ATGTGGTCAC CGAGACCTGT 1080

ATGGATGAAG GACAGATAGC AGCTGTCTGC AGAGAGTGCC TGCAAGCTTT GGATTTCCTG 1140

CACTCAAACC AGGTGATCCA TAGAGATATA AAGAGTGACA ATATTCTTCT CGGGATGGAT 1200

GGCTCTGTTA AATTGACTGA CTTTGGGTTC TGTGCCCAGA TCACTCCTGA GCAAAGTAAA 1260

CGAAGCACTA TGGTGGGAAC CCCATATTGG ATGGCACCTG AGGTGGTGAC TCGAAAAGCT 1320

TATGGTCCGA AAGTTGATAT CTGGTCTCTT GGAATTATGG CAATTGAAAT GGTGGAAGGT 1380

GAACCCCCTT ACCTTAATGA AAATCCACTC AGGGCATTGT ATCTGATAGC CACTAATGGA 1440

ACCCCAGAGC TCCAGAATCC TGAGAGACTG TCAGCTGTAT TCCGTGACTT TTTAAATCGC 1500

TGTCTTGAGA TGGATGTGGA TAGGCGAGGA TCTGCCAAGG AGCTTTTGCA GCATCCATTT 1560

TTAAAATTAG CCAAGCCTCT CTCCAGCCTG ACTCCTCTGA TTATCGCTGC AAAGGAAGCG 1620

ATTAAGAACA GCAGCCGCTA A 1641

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 270   YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  329

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lHs++vi

Q: 330   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  386

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 387   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  444

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s  f++f+++cl+

Q: 445   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM  504

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++++R sa+ell+h+Fl

Q: 505   DVDRRGSAKELLQHPFL  521

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTALD IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSAVFRDFLN RCLEMDVDRR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013