EKS-GOG-00064
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00064
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK371.53.3E-1117271020294
StatusUnreviewed
Ensembl ProteinENSGGOP00000014469
UniProt AccessionG3RFU0;
Protein Name
Protein Synonyms/Alias
Gene NameCDK12
Gene Synonyms/Alias CDK12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000014828ENSGGOP00000018001ENSGGOT00000026639
ENSGGOG00000014828ENSGGOP00000014469ENSGGOT00000014882
OrganismGorilla gorilla
Functional Description
Protein Length1490
Protein Sequence
(FASTA)
MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 60
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR 120
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVVKSS SRESRSSKLH 180
KEKTRKEREL KSAHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA 240
SYGQDYDLSP PRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR 300
SVSPYSRRRS SSYERSGSYS GRSPSPYVRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP 360
AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES 420
KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK 480
VKLDESSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP 540
TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN 600
SQPPIQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ 660
RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG 720
KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ 780
LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM 840
KQLMEGLDYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW 900
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW 960
PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL 1020
KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK 1080
NSSPAPPQPT PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI 1140
HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS 1200
STPADMQSIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL 1260
PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH 1320
QALRPMEYST RPHPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSV 1380
SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY 1440
GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY 1490
Nucleotide Sequence
(FASTA)
ATGCCCAATT CAGAGAGACA TGGGGGCAAG AAGGACGGGA GTGGAGGAGC TTCTGGAACT 60
TTGCAGCCGT CATCGGGAGG CGGCAGCTCT AACAGCAGAG AGCGTCACCG CTTGGTATCG 120
AAGCACAAGC GGCATAAGTC CAAACACTCC AAAGACATGG GGTTGGTGAC CCCCGAAGCA 180
GCATCCCTGG GCACAGTTAT CAAACCTTTG GTGGAGTATG ATGATATCAG CTCTGATTCC 240
GACACCTTCT CTGATGACAT GGCCTTCAAA CTAGACCGAA GGGAGAACGA CGAACGTCGT 300
GGATCAGATC GGAGCGACCG CCTGCACAAA CATCGTCACC ACCAGCACAG GCGTTCCCGG 360
GACTTACTAA AAGCTAAACA GACCGAAAAA GAAAAAAGCC AAGAAGTCTC CAGCAAGTCG 420
GGATCGATGA AGGACCGGAT ATCGGGAAGT TCAAAGCGTT CGAATGAGGA GACTGATGAC 480
TATGGAAAGG CGCAGGTAGT CAAAAGCAGC AGCAGGGAAT CCAGGTCATC CAAGCTCCAC 540
AAGGAGAAGA CCAGGAAAGA ACGGGAGCTG AAGTCTGCTC ACAAAGACCG GAGTAAAAGT 600
CATCGAAAAA GGGAAACACC CAAAAGTTAC AAAACAGTGG ACAGCCCAAA ACGGAGATCC 660
AGGAGCCCCC ACAGGAAGTG GTCTGACAGC TCCAAACAAG ATGATAGCCC CTCGGGAGCT 720
TCTTATGGCC AAGATTATGA CCTTAGTCCC CCACGATCTC ATACCTCGAG CAATTATGAC 780
TCCTACAAGA AAAGTCCTGG AAGTACCTCG AGAAGGCAGT CGGTCAGTCC CCCTTACAAG 840
GAGCCTTCGG CCTACCAGTC CAGCACCCGG TCACCGAGCC CCTACAGTAG GCGACAGAGA 900
TCTGTCAGTC CCTATAGCAG GAGACGGTCG TCCAGCTACG AAAGGAGTGG CTCTTACAGC 960
GGGCGATCGC CCAGTCCCTA TGTTCGAAGG CGGTCCAGCA GCCCTTTCCT GAGCAAGCGG 1020
TCTCTGAGTC GGAGTCCACT CCCCAGTAGG AAATCCATGA AGTCCAGAAG TAGAAGTCCT 1080
GCATATTCAA GACATTCATC TTCTCATAGT AAAAAGAAGA GATCCAGTTC ACGCAGTCGT 1140
CATTCCAGTA TCTCACCTGT CAGGCTTCCA CTTAATTCCA GTCTGGGAGC TGAACTCAGT 1200
AGGAAAAAGA AGGAAAGAGC AGCTGCTGCT GCTGCAGCAA AGATGGATGG AAAGGAGTCC 1260
AAGGGTTCAC CTGTATTTTT GCCTAGAAAA GAGAACAGTT CAGTAGAGGC TAAGGATTCA 1320
GGTTTGGAGT CTAAAAAGTT ACCCAGAAGT GTAAAATTGG AAAAATCTGC CCCAGATACT 1380
GAACTGGTGA ATGTAACACA TCTAAACACA GAGGTAAAAA ATTCTTCAGA TACAGGGAAA 1440
GTAAAGTTGG ATGAGAGCTC CGAGAAGCAT CTTGTTAAAG ATTTGAAAGC ACAGGGAACA 1500
AGAGACTCTA AACCCATAGC ACTGAAAGAG GAGATTGTTA CTCCAAAGGA GACAGAAACA 1560
TCAGAAAAGG AGACCCCTCC ACCTCTTCCC ACAATTGCTT CTCCCCCACC CCCTCTACCA 1620
ACTACTACCC CTCCACCTCA GACACCCCCT TTGCCACCTT TGCCTCCAAT ACCAGCTCTT 1680
CCACAGCAAC CACCTCTGCC TCCTTCTCAG CCAGCATTTA GTCAGGTTCC TGCTTCCAGT 1740
ACTTCAACTT TGCCCCCTTC TACTCACTCA AAGACATCTG CTGTGTCCTC TCAGGCAAAT 1800
TCTCAGCCCC CTATACAGGT TTCTGTGAAG ACTCAAGTAT CTGTAACAGC TGCTATTCCA 1860
CACCTGAAAA CTTCAACGTT GCCTCCTTTG CCCCTCCCAC CCTTATTACC TGGAGATGAT 1920
GACATGGATA GTCCAAAAGA AACTCTTCCT TCAAAACCTG TGAAGAAAGA GAAGGAACAG 1980
AGGACACGTC ACTTACTCAC AGACCTTCCT CTCCCTCCAG AGCTCCCTGG TGGAGATCTG 2040
TCTCCCCCAG ACTCTCCAGA ACCAAAGGCA ATCACACCAC CTCAGCAACC ATATAAAAAG 2100
AGACCAAAAA TTTGTTGTCC TCGTTATGGA GAAAGAAGAC AAACGGAAAG CGACTGGGGG 2160
AAACGCTGTG TGGACAAGTT TGACATTATT GGGATTATTG GAGAAGGAAC CTATGGCCAA 2220
GTATATAAAG CCAAGGACAA AGACACAGGA GAACTAGTGG CTCTGAAGAA GGTGAGACTA 2280
GACAATGAGA AAGAGGGCTT CCCAATCACA GCCATTCGTG AAATCAAAAT CCTTCGTCAG 2340
TTAATCCACC GAAGTGTTGT TAACATGAAG GAAATTGTCA CAGATAAACA AGATGCACTG 2400
GATTTCAAGA AGGACAAAGG TGCCTTTTAC CTTGTATTTG AGTATATGGA CCATGACTTA 2460
ATGGGACTGC TAGAATCTGG TTTGGTGCAC TTTTCTGAGG ACCATATCAA GTCGTTCATG 2520
AAACAGCTAA TGGAAGGATT GGATTACTGT CACAAAAAGA ATTTCCTGCA TCGGGATATT 2580
AAGTGTTCTA ACATTTTGCT GAATAACAGT GGGCAAATCA AACTAGCAGA TTTTGGACTT 2640
GCTCGGCTCT ATAACTCTGA AGAGAGTCGC CCTTACACAA ACAAAGTCAT TACTTTGTGG 2700
TACCGACCTC CAGAACTACT GCTAGGAGAG GAACGTTACA CACCAGCCAT AGATGTTTGG 2760
AGCTGTGGAT GTATTCTTGG GGAACTGTTC ACAAAGAAGC CTATTTTTCA AGCCAATCTG 2820
GAACTGGCTC AGCTAGAACT GATCAGCCGA CTTTGTGGTA GCCCTTGTCC AGCTGTGTGG 2880
CCTGATGTTA TCAAACTGCC CTACTTCAAC ACCATGAAAC CGAAGAAGCA ATATCGAAGG 2940
CGTCTACGAG AAGAATTCTC TTTCATTCCT TCTGCAGCAC TTGATTTATT GGACCACATG 3000
CTGACACTAG ATCCTAGTAA GCGGTGCACA GCTGAACAGA CCCTACAGAG TGACTTCCTT 3060
AAAGATGTCG AACTCAGCAA AATGGCTCCT CCAGACCTCC CCCACTGGCA GGATTGCCAT 3120
GAGTTGTGGA GTAAGAAACG GCGACGTCAG CGACAAAGTG GTGTTGTAGT CGAAGAGCCA 3180
CCTCCATCCA AAACTTCTCG AAAAGAAACT ACCTCAGGGA CAAGTACTGA GCCTGTGAAG 3240
AACAGCAGCC CAGCACCACC TCAGCCTACT CCTGGCAAGG TGGAGTCTGG GGCTGGGGAT 3300
GCAATAGGCC TTGCTGACAT CACACAACAG CTGAATCAAA GTGAATTGGC AGTGTTATTA 3360
AACCTGCTGC AGAGCCAAAC CGACCTGAGC ATTCCTCAAA TGGCACAGCT GCTTAACATC 3420
CACTCCAACC CAGAGATGCA GCAGCAGCTG GAAGCCCTGA ACCAATCCAT CAGTGCCCTG 3480
ACGGAAGCTA CTTCCCAGCA GCAGGACTCA GAGACCATGG CCCCAGAGGA GTCTTTGAAG 3540
GAAGCACCCT CTGCCCCAGT GATCCTGCCT TCAGCAGAAC AGACGACCCT TGAAGCTTCA 3600
AGCACACCAG CTGACATGCA GAGTATATTG GCAGTTCTCT TGAGTCAGCT GATGAAAACC 3660
CAAGAGCCAG CAGGCAGTCT GGAGGAAAAC AACAGTGACA AGAACAGTGG GCCACAGGGG 3720
CCCCGAAGAA CTCCCACAAT GCCACAGGAG GAGGCAGCAG CATGTCCTCC TCACATTCTT 3780
CCACCAGAGA AGAGGCCCCC TGAGCCCCCC GGACCTCCAC CGCCGCCACC TCCACCCCCT 3840
CTGGTTGAAG GCGATCTTTC CAGCGCCCCC CAGGAGTTGA ACCCAGCCGT GACAGCCGCC 3900
TTGCTGCAAC TTTTATCCCA GCCTGAAGCA GAGCCTCCTG GCCACCTGCC ACATGAGCAC 3960
CAGGCCTTGA GACCAATGGA GTACTCCACC CGACCCCATC CAAACAGGAC TTATGGAAAC 4020
ACTGATGGGC CTGAAACAGG GTTCAGTGCC ATTGACACTG ATGAACGAAA CTCTGGTCCA 4080
GCCTTGACAG AATCCTTGGT CCAGACCCTG GTGAAGAACA GGACCTTCTC AGGCTCTGTG 4140
AGCCACCTTG GGGAGTCCAG CAGTTACCAG GGCACAGGGT CAGTGCAGTT TCCAGGGGAC 4200
CAGGACCTCC GTTTTGCCAG GGTCCCCTTA GCGTTACACC CGGTGGTCGG GCAACCATTC 4260
CTGAAGGCTG AGGGAAGCAG CAATTCTGTG GTACATGCAG AGACCAAATT GCAAAACTAT 4320
GGGGAGCTGG GGCCAGGAAC CACTGGGGCC AGCAGCTCAG GAGCAGGCCT TCACTGGGGG 4380
GGCCCAACTC AGTCTTCTGC TTATGGAAAA CTCTATCGGG GGCCTACAAG AGTCCCACCA 4440
AGAGGGGGAA GAGGGAGAGG AGTTCCTTAC 4470
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60
         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +
Q: 727   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  786
         667889******************************************************
S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111
         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e
Q: 787   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  845
         ****************8899********************999.****************
S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170
         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe
Q: 846   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  905
         ***************************************7766527**************
S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230
         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k
Q: 906   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  965
         ************************************************************
S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp+kR++a+++lq++++
Q: 966   LPYFNTMKPKKQYRrRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFL  1020
         *****7777777777******9999**************************9985
Domain Sequence
(FASTA)
FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60
VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120
LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180
LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240
PYFNTMKPKK QYRRRLREEF SFIPSAALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00061
EKS-ANC-00062
EKS-BOT-00067
EKS-CAE-00042
EKS-CAJ-00060
EKS-CAF-00064
EKS-CAP-00063
EKS-CII-00024
EKS-CIS-00070
EKS-DAR-00080
EKS-EQC-00064
EKS-FEC-00063
EKS-GAM-00035
EKS-GAG-00051
EKS-HOS-00066
EKS-LAC-00067
EKS-LOA-00063
EKS-MAM-00063
EKS-MOD-00061
EKS-MUM-00065
EKS-MUP-00067
EKS-MYL-00064
EKS-NOL-00058
EKS-ORN-00085
EKS-ORA-00051
EKS-ORC-00061
EKS-ORL-00076
EKS-OTG-00068
EKS-PAT-00067
EKS-PES-00056
EKS-PEM-00035
EKS-POA-00060
EKS-RAN-00061
EKS-SAH-00058
EKS-SUS-00057
EKS-TEN-00089
EKS-TUT-00059
EKS-VIP-00026
EKS-XET-00059
EKS-XIM-00084
EKS-SAC-00066
EKS-SCP-00060
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013