EKS-GOG-00150
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00150
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR519.12.8E-156461729269
StatusUnreviewed
Ensembl ProteinENSGGOP00000002871
UniProt AccessionG3RGH8;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000015081ENSGGOP00000002871ENSGGOT00000002936
ENSGGOG00000015081ENSGGOP00000014728ENSGGOT00000015144
OrganismGorilla gorilla
Functional Description
Protein Length797
Protein Sequence
(FASTA)
NGAGFGGACL MVAHLAHRSP GPRAGQQEQL VFSSGDAVEL SCPPPGGGPM GPTVWVKDGA 60
GLVPLERVLV GPQWLQVLNA SHEDSGAYSC RQQLTQRVLC HFSVRVTDAP SSGDDEDGDD 120
EAEDTGVDTG GSRVQGSGAP YWTRPERMDK KLLAVPAANT VRFRCPAAGN PTPSISWLKN 180
GREFRGEHRI GGIKLRHQQW SLVMESVVPS DRGNYTCVVE NKFGSIRQTY TLDVLERSRH 240
RPILQAGLPA NQTAVLGSDV EFHCKVYSDA QPHIQWLKHV EVNGSKVGPD GTPYVTVLKT 300
AGANTTDKEL EVLSLHNVTF EDAGEYTCLA GNSIGFSHHS AWLVVLPAEE ELVEPDEAGS 360
VYACILSYGV GFFLFILVVA AVTLCRLRSP PKKGLGSPTV HKISRFPLKR QVSLESSASM 420
SSNTSLVRIA RLSSGEGPTL ASVSELELPA DPKWELSRAR LTLGKPLGEG CFGQVVMAEA 480
IGIDKDRAAK PVTVAVKMLK DDATDEDLSD LVSEMEMMKM IGKHKNVINL LGACTQGGPL 540
YVLVEYAAKG NLREFLDYSF NTCRPPEERL TFKDLVSFAY QVAQGMEYLA SQKCIHRDLA 600
ARNVLVTEDN VMKIADFGLA RDVHNLDYYK KTTNGRLPVK WMAPEALFDQ VYTHQSDVWS 660
FGVLLWEIFT LGGSPYPGIP VEELFKLLKE GHRMDKPANC THDLYMIMRD CWQAAPSQRP 720
TFKQLVEDLD RVLTVTSADE YLDLSAPFEQ YSPGGQDTPS SSSSSSGRLR VCPRPAAPGP 780
TQQWGLADVK GHWSPTM 797
Nucleotide Sequence
(FASTA)
AATGGTGCCG GGTTTGGGGG TGCCTGCCTC ATGGTCGCCC ATCTTGCCCA CAGAAGTCCC 60
GGGCCCAGAG CCGGCCAGCA GGAGCAGTTG GTCTTCAGCA GCGGGGATGC TGTGGAGCTG 120
AGCTGTCCCC CGCCCGGGGG TGGTCCCATG GGGCCCACTG TCTGGGTCAA GGATGGCGCA 180
GGGCTGGTGC CCTTGGAGCG TGTCCTGGTG GGGCCCCAGT GGCTGCAGGT GCTGAATGCC 240
TCCCACGAGG ACTCCGGGGC CTACAGCTGC CGGCAGCAGC TCACGCAGCG TGTACTGTGC 300
CACTTCAGTG TGCGGGTGAC AGACGCTCCA TCCTCGGGGG ATGACGAAGA CGGGGACGAC 360
GAGGCTGAGG ACACAGGTGT GGACACAGGT GGCAGCAGGG TCCAGGGTTC AGGGGCCCCT 420
TACTGGACAC GGCCCGAGCG GATGGACAAG AAGCTGCTGG CCGTGCCGGC CGCCAACACG 480
GTCCGCTTCC GCTGCCCGGC CGCCGGCAAC CCCACTCCCT CCATCTCCTG GCTGAAGAAC 540
GGCAGGGAGT TCCGCGGCGA GCACCGCATC GGAGGCATCA AGCTGCGGCA TCAGCAGTGG 600
AGCCTGGTCA TGGAAAGCGT GGTGCCCTCG GACCGCGGCA ACTACACCTG CGTCGTGGAG 660
AACAAGTTTG GCAGCATCCG GCAGACGTAC ACGCTGGACG TGCTGGAGCG CTCCCGGCAC 720
CGGCCCATCC TGCAGGCGGG GCTGCCGGCC AACCAGACGG CGGTGCTGGG CAGTGACGTG 780
GAGTTCCACT GCAAGGTGTA CAGTGACGCA CAGCCCCACA TCCAGTGGCT CAAGCACGTG 840
GAGGTGAACG GCAGCAAGGT GGGCCCGGAC GGCACACCCT ACGTTACCGT GCTCAAGACG 900
GCGGGCGCTA ACACCACCGA CAAGGAGCTA GAGGTTCTCT CCTTGCACAA CGTCACCTTT 960
GAGGACGCCG GGGAGTACAC CTGTCTGGCG GGCAATTCTA TTGGGTTTTC TCATCACTCT 1020
GCGTGGCTGG TGGTGCTGCC AGCCGAGGAG GAGCTGGTGG AGCCTGACGA GGCGGGCAGT 1080
GTGTATGCAT GCATCCTCAG CTACGGGGTG GGCTTCTTCC TGTTCATCCT GGTGGTGGCG 1140
GCTGTGACGC TCTGCCGCCT GCGCAGCCCC CCCAAGAAAG GCCTGGGCTC CCCCACCGTG 1200
CACAAGATCT CCCGCTTCCC GCTCAAGCGA CAGGTGTCCC TGGAGTCCAG CGCGTCCATG 1260
AGCTCCAACA CATCACTGGT GCGCATCGCA AGGCTGTCCT CAGGGGAGGG CCCCACGCTG 1320
GCCAGTGTCT CCGAGCTCGA GCTGCCTGCT GACCCCAAAT GGGAGCTGTC TCGGGCCCGG 1380
CTGACCCTGG GCAAGCCCCT TGGGGAGGGC TGCTTCGGCC AGGTGGTCAT GGCGGAGGCC 1440
ATCGGCATTG ACAAGGACCG GGCCGCCAAG CCTGTCACCG TAGCCGTGAA GATGCTGAAA 1500
GACGATGCCA CTGACGAGGA CCTGTCGGAC CTGGTGTCTG AGATGGAGAT GATGAAGATG 1560
ATCGGGAAAC ACAAAAACGT CATCAACCTG CTGGGCGCCT GCACGCAGGG CGGGCCCCTG 1620
TACGTGCTGG TGGAGTACGC GGCCAAGGGT AACCTGCGGG AGTTCCTGGA CTACTCCTTC 1680
AACACCTGCA GGCCGCCCGA GGAGCGGCTC ACCTTCAAGG ACCTGGTGTC CTTTGCCTAC 1740
CAGGTGGCCC AGGGCATGGA GTACCTGGCC TCCCAGAAGT GCATCCACAG GGACCTGGCT 1800
GCCCGCAATG TGCTGGTGAC CGAGGACAAC GTGATGAAGA TCGCAGACTT CGGGCTGGCC 1860
CGGGACGTGC ACAACCTCGA CTACTACAAG AAGACAACCA ATGGCCGGCT GCCCGTGAAG 1920
TGGATGGCGC CTGAGGCCTT GTTTGACCAA GTCTACACTC ACCAGAGTGA CGTCTGGTCC 1980
TTTGGGGTCC TGCTCTGGGA GATCTTCACG CTGGGGGGCT CCCCGTACCC CGGCATCCCT 2040
GTGGAGGAGC TCTTCAAGCT GCTGAAGGAG GGCCACCGCA TGGACAAGCC CGCCAACTGC 2100
ACACACGACC TGTACATGAT CATGCGGGAC TGCTGGCAAG CCGCGCCCTC GCAGAGGCCC 2160
ACCTTCAAGC AGCTGGTGGA GGACCTGGAC CGTGTCCTTA CCGTGACGTC CGCCGACGAG 2220
TACCTGGACC TGTCGGCGCC TTTCGAGCAG TACTCCCCGG GTGGCCAGGA CACCCCCAGC 2280
TCCAGCTCCA GCTCCTCGGG ACGACTCCGT GTTTGCCCAC GGCCTGCTGC CCCCGGCCCC 2340
ACCCAGCAGT GGGGGCTCGC GGACGTGAAG GGCCACTGGT CCCCAACAAT GTGA 2394
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datd+dl+dlvseme++k+
Q: 461   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDEDLSDLVSEMEMMKM  520
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkn+inllGactq+Gplyv+veyaakGnlrefl        ++s ++++ +ee+lt+
Q: 521   IGKHKNVINLLGACTQGGPLYVLVEYAAKGNLREFL--------DYSFNTCRPPEERLTF  572
         ***********************************9........7999************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvsfayqva+Gmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt
Q: 573   KDLVSFAYQVAQGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  632
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfd+vyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 633   TNGRLPVKWMAPEALFDQVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  692
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mr+cw+a++s+rptfkqlvedl
Q: 693   RMDKPANCTHDLYMIMRDCWQAAPSQRPTFKQLVEDL  729
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDEDLSD LVSEMEMMKM 60
IGKHKNVINL LGACTQGGPL YVLVEYAAKG NLREFLDYSF NTCRPPEERL TFKDLVSFAY 120
QVAQGMEYLA SQKCIHRDLA ARNVLVTEDN VMKIADFGLA RDVHNLDYYK KTTNGRLPVK 180
WMAPEALFDQ VYTHQSDVWS FGVLLWEIFT LGGSPYPGIP VEELFKLLKE GHRMDKPANC 240
THDLYMIMRD CWQAAPSQRP TFKQLVEDL 269
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gallus gallus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00142
EKS-CAF-00155
EKS-CAP-00149
EKS-EQC-00146
EKS-GAG-00124
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-ORA-00127
EKS-ORL-00169
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-PTV-00141
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013