EKS-GOG-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	416.8	4.5E-125	48	300	253

Status

Unreviewed

Ensembl Protein

ENSGGOP00000014921

UniProt Accession

G3RWF2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK3

Gene Synonyms/Alias

PLK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000015294	ENSGGOP00000014921	ENSGGOT00000015347
ENSGGOG00000015294	ENSGGOP00000020135	ENSGGOT00000034224

Organism

Gorilla gorilla

Functional Description

Protein Length

633

Protein Sequence
(FASTA)

MEPAAGFLSP RPFQPPSALP GPELEMLAGL PTSDPGRLIT DPRSGRTYLK GRLLGKGGFA 60

RCYEATDTET GSAYAVKVIP QSRVAKPHQR EKILNEIELH RDLQHRHIVR FSHHFEDADN 120

IYIFLELCSR KSLAHIWKAR HTLLEPEVRY YLRQILSGLK YLHQRGILHR DLKLGNFFIT 180

ENMELKVGDF GLAARLEPPE QRKKTICGTP NYVAPEVLLR QGHGPEADVW SLGCVMYTLL 240

CGSPPFETAD LKETYRCIKQ VHYTLPASLS LPARQLLAAI LRASPRDRPS IDQILRHDFF 300

TKGYTPDRLP ISSCVTVPDL TPPNPARTLF AKVTKSLFGR KKKKSKNHAQ ERDEVSGLVS 360

GLMRTSVGHQ DARPEAPAAS GPAPVSLVET APEDSSPRGT LASSGDGFEE GLTVATVVES 420

ALCALRNCVA FMPPAEQNPA PLAQPEPLVW VSKWVDYSNK FGFGYQLSSR RVAVLFNDGT 480

HMALSANRKT VHYNPTSTKH FSFSVGAVPR ALQPQLGILR YFASYMEQHL MKGGDLPSVE 540

EVEVPAPPLL LQWVKTDQAL LMLFSDGTVQ VNFYGDHTKL ILSGWEPLLV TFVARNRSAC 600

TYLASHLRQL GCSPDLRQRL RYALRLLRDR SPA 633

Nucleotide Sequence
(FASTA)

ATGGAGCCTG CCGCCGGTTT CCTGTCTCCG CGCCCCTTCC AGCCTCCGAG TGCCTTGCCC 60

GGACCTGAGC TGGAGATGCT GGCCGGGCTA CCGACGTCAG ACCCCGGGCG CCTCATCACG 120

GACCCGCGCA GCGGCCGCAC CTACCTCAAA GGCCGCTTGT TGGGCAAGGG GGGCTTCGCC 180

CGCTGCTACG AGGCCACTGA CACAGAGACT GGCAGCGCCT ACGCTGTCAA AGTCATCCCG 240

CAGAGCCGCG TCGCCAAGCC GCATCAGCGC GAGAAGATCC TAAATGAGAT TGAGCTGCAC 300

CGAGACCTGC AGCACCGCCA CATCGTGCGT TTTTCGCACC ACTTTGAGGA CGCTGACAAC 360

ATCTACATTT TCTTGGAGCT CTGCAGCCGA AAGTCCCTGG CCCACATCTG GAAGGCCCGG 420

CACACCCTGT TGGAGCCAGA AGTGCGCTAC TACCTGCGGC AGATCCTTTC TGGCCTCAAG 480

TACTTGCACC AGCGCGGCAT CTTGCACCGG GACCTCAAGT TGGGAAATTT TTTCATCACT 540

GAGAACATGG AACTGAAGGT GGGGGATTTT GGGCTGGCAG CCCGGTTGGA GCCTCCAGAG 600

CAGAGGAAGA AGACCATCTG TGGCACCCCC AACTATGTGG CTCCAGAAGT GCTGCTGAGA 660

CAGGGCCACG GCCCTGAGGC GGATGTATGG TCACTGGGCT GTGTCATGTA CACGCTGCTC 720

TGCGGGAGCC CTCCCTTTGA GACGGCTGAC CTGAAGGAGA CGTACCGCTG CATCAAGCAG 780

GTTCACTACA CGCTGCCTGC CAGCCTCTCA CTGCCTGCCC GGCAGCTCCT GGCCGCCATC 840

CTTCGGGCCT CACCCCGAGA CCGCCCCTCT ATTGACCAGA TCCTGCGCCA TGACTTCTTT 900

ACCAAGGGCT ACACTCCCGA TCGACTCCCT ATCAGCAGCT GCGTGACAGT CCCAGACCTG 960

ACACCCCCCA ACCCAGCTAG GACTCTGTTT GCCAAAGTTA CCAAGAGCCT CTTTGGCAGA 1020

AAGAAGAAGA AGAGTAAGAA TCATGCCCAG GAGAGGGACG AGGTCTCCGG TTTGGTGAGC 1080

GGCCTCATGC GCACATCCGT TGGCCATCAG GATGCCAGGC CAGAGGCTCC AGCAGCTTCT 1140

GGCCCAGCCC CTGTCAGCCT GGTAGAGACA GCACCTGAAG ACAGCTCACC CCGTGGGACA 1200

CTGGCAAGCA GTGGAGATGG ATTTGAAGAA GGTCTGACTG TGGCCACAGT AGTGGAGTCA 1260

GCCCTTTGTG CTCTGAGAAA CTGTGTAGCC TTCATGCCCC CAGCGGAACA GAACCCGGCC 1320

CCCCTGGCCC AGCCAGAGCC TCTGGTGTGG GTCAGCAAGT GGGTTGACTA CTCCAATAAG 1380

TTCGGCTTTG GGTATCAACT GTCCAGCCGC CGTGTGGCTG TGCTCTTCAA CGATGGCACA 1440

CATATGGCCC TGTCGGCCAA CAGAAAGACT GTGCACTACA ATCCCACCAG CACAAAGCAC 1500

TTCTCCTTCT CCGTGGGTGC TGTGCCCCGG GCCCTGCAGC CTCAGCTGGG TATCCTGCGG 1560

TACTTCGCCT CCTACATGGA GCAGCACCTC ATGAAGGGTG GAGATCTGCC CAGTGTGGAA 1620

GAGGTAGAGG TACCTGCTCC GCCCTTGCTG CTGCAGTGGG TCAAGACGGA TCAGGCTCTC 1680

CTCATGCTGT TTAGTGATGG CACTGTCCAG GTGAACTTCT ACGGGGACCA CACCAAGCTG 1740

ATTCTCAGTG GCTGGGAGCC CCTCCTTGTG ACTTTTGTGG CCCGAAATCG TAGTGCTTGT 1800

ACTTACCTCG CTTCCCACCT TCGGCAGCTG GGCTGCTCTC CAGACCTGCG GCAGCGACTC 1860

CGCTATGCTC TGCGCCTGCT CCGGGACCGC AGCCCAGCCT AG 1902

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y +g+llGkGgfa+cye++d+et++++avkv+p+s++ak++qrek+ +eie+hr+l+h++

Q: 48    YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH  107

         889*********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i

Q: 108   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI  167

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f++e++e+k+gdfGla+rle++e+rkkt+cGtPny+aPevl ++gh+ e+

Q: 168   LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA  227

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGc++ytll+G+PPfet++lkety++ik+ +y+lP+sls +a++l+a++l+++P++

Q: 228   DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD  287

         ************************************************************

S: 241   rpsleevlkdefl  253

         rps++++l+++f+

Q: 288   RPSIDQILRHDFF  300

         ************8

Domain Sequence
(FASTA)

YLKGRLLGKG GFARCYEATD TETGSAYAVK VIPQSRVAKP HQREKILNEI ELHRDLQHRH 60

IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQRGI 120

LHRDLKLGNF FITENMELKV GDFGLAARLE PPEQRKKTIC GTPNYVAPEV LLRQGHGPEA 180

DVWSLGCVMY TLLCGSPPFE TADLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPRD 240

RPSIDQILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020658	; Ser/Thr_kinase_Plk3.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013