EKS-GOG-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	458.7	7.4E-138	4	289	286

Status

Unreviewed

Ensembl Protein

ENSGGOP00000021873

UniProt Accession

G3S1C8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000015619	ENSGGOP00000015238	ENSGGOT00000015673
ENSGGOG00000015619	ENSGGOP00000021873	ENSGGOT00000034517

Organism

Gorilla gorilla

Functional Description

Protein Length

573

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR EIKLLKAIRR 60

NTMIRLLSLF KFKVLAYSLF LSCVSHYPLE DLELFPNGLD YQVVQKYLFQ IINNGIGFCH 120

SHDIIHRDIK PENILVSQSG VVKLCDFGFA RTLAAPGEVY TDYVATRWYR APELLVGDVK 180

YGKAVDVWAI GCLVTEMFMG EPLFPGDSDI DQLYHIMMCL GNLIPRHQEL FYKNPVFAGV 240

RLPEIKEREP LERRYPKLSE VVIDLAKKCL HIDPDKRPFC AELLHHDFFQ MDGFAESRFS 300

QELQLKVQKD ARNVSLSKKS QNRKKEKEKD DSLVEERKTL VVQDTNADPK IKDCKLFKIK 360

GSKIDGEKAE KGNRASNASC LHDSRTNHNK IVPSTSLKDC SNVSGDHTRN PSVAIPPLTH 420

NLSAVAPGIN SGMGTATIPI QGYRVDEKTK KCSIPFVKLN RHSPSGIYNI NVTTLVSSEK 480

NLFWASKKRR EYSRTDVRLP ELNCNHLPEL RALEGIARNS RLTKKGSKIL SESRIPSLAA 540

IDLHTPSIIL HQVSGPPLSD DSGADLPQVE HQH 573

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAAAACCT GGGTTTGGTT GGAGAGGGGA GTTATGGAAT GGTGATGAAG 60

TGTAGGAATA AAGATACTGG AAGAATTGTG GCCATAAAGA AGTTCTTAGA AAGTGACGAT 120

GACAAAATGG TTAAAAAGAT TGCAATGCGA GAAATCAAGT TACTAAAGGC AATAAGAAGA 180

AATACAATGA TTAGATTATT ATCATTGTTT AAGTTCAAAG TTCTTGCTTA TAGTCTCTTT 240

TTATCTTGTG TTTCTCATTA TCCTTTAGAA GACTTGGAGC TCTTTCCAAA TGGACTAGAC 300

TACCAAGTAG TTCAAAAGTA CTTGTTTCAG ATTATTAATA ATGGAATTGG ATTTTGTCAC 360

AGTCACGATA TCATACACAG AGATATAAAG CCAGAGAATA TATTAGTCTC CCAGTCTGGC 420

GTTGTGAAGC TATGCGATTT TGGATTTGCG CGAACATTGG CAGCTCCTGG GGAGGTTTAT 480

ACTGATTATG TGGCAACCCG ATGGTACAGA GCTCCAGAAC TACTGGTTGG TGATGTCAAG 540

TATGGCAAGG CTGTTGATGT GTGGGCCATT GGTTGTCTGG TAACTGAAAT GTTCATGGGG 600

GAACCCCTAT TTCCTGGAGA TTCTGATATT GATCAGCTAT ATCATATTAT GATGTGTTTA 660

GGTAATCTAA TTCCAAGGCA TCAGGAGCTT TTTTATAAAA ATCCTGTGTT TGCTGGAGTA 720

AGGTTGCCTG AAATCAAGGA AAGAGAACCT CTTGAAAGAC GCTATCCTAA GCTCTCTGAA 780

GTGGTGATAG ATTTAGCAAA GAAATGCTTA CATATTGACC CCGACAAAAG ACCCTTCTGT 840

GCTGAGCTCC TACACCATGA TTTCTTTCAA ATGGATGGAT TTGCTGAGAG TAGGTTTTCC 900

CAAGAACTAC AGTTAAAAGT ACAGAAAGAT GCCAGAAATG TTTCTTTATC TAAAAAATCC 960

CAAAACAGAA AGAAGGAAAA AGAAAAAGAT GATTCCTTAG TTGAAGAAAG AAAAACACTT 1020

GTGGTACAGG ATACCAATGC TGATCCCAAA ATTAAGGATT GTAAACTATT TAAAATAAAA 1080

GGCTCAAAAA TTGATGGAGA AAAAGCTGAA AAAGGCAATA GAGCTTCAAA TGCCAGCTGT 1140

CTCCATGACA GTAGGACAAA CCACAACAAA ATAGTGCCTT CAACAAGCCT CAAAGACTGC 1200

AGCAATGTCA GCGGGGACCA CACAAGGAAT CCAAGCGTGG CAATTCCCCC ACTTACACAC 1260

AATCTTTCTG CAGTTGCTCC CGGCATTAAT TCTGGAATGG GGACTGCGAC TATACCAATT 1320

CAGGGTTACA GAGTGGATGA GAAAACTAAG AAGTGTTCTA TTCCATTTGT TAAACTGAAC 1380

AGACATTCCC CATCAGGCAT TTATAACATT AATGTGACCA CATTAGTCTC TAGTGAAAAA 1440

AACCTCTTTT GGGCAAGTAA GAAAAGAAGA GAATACTCCA GGACAGATGT CCGTTTGCCT 1500

GAACTAAACT GTAATCATCT CCCTGAACTA AGAGCACTGG AAGGCATAGC TCGAAATTCC 1560

AGGCTAACAA AGAAAGGGAG CAAAATTCTT TCAGAATCTC GAATTCCTTC TCTGGCTGCT 1620

ATTGACCTGC ACACCCCCAG TATTATATTA CATCAGGTAT CAGGACCTCC CCTGTCAGAT 1680

GATTCAGGGG CTGATTTGCC TCAAGTGGAA CACCAGCACT GA 1722

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkdtg+ivaikkfles+ddk+vkkia+reikllk ++++ +

Q: 4     YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKAIRRNTM  63

         9***********************************************************

S: 61    vnllevfrrkkklylvf.eyvdktvldelerypnGveeelvkkilyqilk.aiefchknn  118

         + ll  f+ k   y +f   v +  l++le +pnG+++++v+k+l+qi++ +i fch+++

Q: 64    IRLLSLFKFKVLAYSLFlSCVSHYPLEDLELFPNGLDYQVVQKYLFQIINnGIGFCHSHD  123

         ********999888666277899*************************9648********

S: 119   iihrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGk  178

         iihrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk

Q: 124   IIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGK  183

         ************************************************************

S: 179   svdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklp  238

         +vdvwaiGcl++e+++Geplfpg+sd+dqly+i+++lG+liprhq++f+kn+vfaGv+lp

Q: 184   AVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFYKNPVFAGVRLP  243

         ************************************************************

S: 239   evedleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         e++++e+le++ypkl+ev++dl+kkcl++dp++r +c+ell+h++f

Q: 244   EIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF  289

         ********************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDTGRIVAIK KFLESDDDKM VKKIAMREIK LLKAIRRNTM 60

IRLLSLFKFK VLAYSLFLSC VSHYPLEDLE LFPNGLDYQV VQKYLFQIIN NGIGFCHSHD 120

IIHRDIKPEN ILVSQSGVVK LCDFGFARTL AAPGEVYTDY VATRWYRAPE LLVGDVKYGK 180

AVDVWAIGCL VTEMFMGEPL FPGDSDIDQL YHIMMCLGNL IPRHQELFYK NPVFAGVRLP 240

EIKEREPLER RYPKLSEVVI DLAKKCLHID PDKRPFCAEL LHHDFF 286

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013