EKS-GOG-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	8.1E-126	187	473	287

Status

Unreviewed

Ensembl Protein

ENSGGOP00000015331

UniProt Accession

G3RI43;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000015713	ENSGGOP00000015331	ENSGGOT00000015769

Organism

Gorilla gorilla

Functional Description

Protein Length

508

Protein Sequence
(FASTA)

QLMWLYCCFY SLIGAILGRS ETQECLFFNA NWEKDRTNQT GVEPCYGDKD KRRHCFATWK 60

NISGSIEIVK QGCWLDDINC YDRTDCVEKK DSPEVYFCCC EGNMCNEKFS YFPEMEVTQP 120

TSNPVTPKPP YYNILLYSLV PLMLIAGIVI CAFWVYRHHK MAYPPVLVPT QDPGPPPPSP 180

LLGLKPLQLL EVKARGRFGC VWKAQLLNEY VAVKIFPIQD KQSWQNEYEV YSLPGMKHEN 240

ILQFIGAEKR GTSVDVDLWL ITAFHEKGSL SDFLKANVVS WNELCHIAET MARGLAYLHE 300

DIPGLKDGHK PAISHRDIKS KNVLLKNNLT ACIADFGLAL KFEAGKSAGD THGQVGTRRY 360

MAPEVLEGAI NFQRDAFLRI DMYAMGLVLW ELASRCTAAD GPVDEYMLPF EEEIGQHPSL 420

EDMQEVVVHK KKRPVLRDYW QKHAGMAMLC ETIEECWDHD AEARLSAGCV GERITQMQRL 480

TNIITTEDIV TVVTMVTNVD FPPKESSL 508

Nucleotide Sequence
(FASTA)

CAGCTAATGT GGTTATATTG TTGTTTTTAT TCTCTTATAG GTGCTATACT TGGTAGATCA 60

GAAACTCAGG AGTGTCTTTT CTTTAATGCT AATTGGGAAA AAGACAGAAC CAATCAAACT 120

GGTGTTGAAC CGTGTTATGG TGACAAAGAT AAACGGCGGC ATTGTTTTGC TACCTGGAAG 180

AATATTTCTG GTTCCATTGA AATAGTGAAA CAAGGTTGTT GGCTGGATGA TATCAACTGC 240

TATGACAGGA CTGATTGTGT AGAAAAAAAA GACAGCCCTG AAGTATATTT TTGTTGCTGT 300

GAGGGCAATA TGTGTAATGA AAAGTTTTCT TATTTTCCGG AGATGGAAGT CACACAGCCC 360

ACTTCAAATC CAGTTACACC TAAGCCACCC TATTACAACA TCCTGCTCTA TTCCTTGGTG 420

CCACTTATGT TAATTGCGGG GATTGTCATT TGTGCATTTT GGGTGTACAG GCATCACAAG 480

ATGGCCTACC CTCCTGTACT TGTTCCAACT CAAGACCCAG GACCACCCCC ACCTTCTCCA 540

TTACTAGGTT TGAAACCATT GCAGCTATTA GAAGTGAAAG CAAGGGGAAG ATTTGGTTGT 600

GTCTGGAAAG CCCAGTTGCT TAACGAATAT GTGGCTGTCA AAATATTTCC AATACAGGAC 660

AAACAGTCAT GGCAAAATGA ATACGAAGTC TACAGTTTGC CTGGAATGAA GCATGAGAAC 720

ATATTACAGT TCATTGGTGC AGAAAAACGA GGCACCAGTG TTGATGTGGA TCTTTGGCTG 780

ATCACAGCAT TTCATGAAAA GGGTTCACTA TCAGACTTTC TTAAGGCTAA TGTGGTCTCT 840

TGGAATGAAC TGTGTCATAT TGCAGAAACC ATGGCTAGAG GATTGGCATA TTTACATGAG 900

GATATACCTG GCCTAAAAGA TGGCCACAAA CCTGCCATAT CTCACAGGGA CATCAAAAGT 960

AAAAATGTGC TGTTGAAAAA CAACCTGACA GCTTGCATTG CTGACTTTGG GTTGGCCTTA 1020

AAATTTGAGG CTGGCAAGTC TGCAGGCGAT ACCCATGGAC AGGTTGGTAC CCGGAGGTAC 1080

ATGGCTCCAG AGGTATTAGA GGGTGCTATA AACTTCCAAA GGGATGCATT TTTGAGGATA 1140

GATATGTACG CCATGGGATT AGTCCTATGG GAACTGGCTT CTCGCTGTAC TGCTGCAGAT 1200

GGACCTGTAG ATGAATACAT GTTGCCATTT GAGGAGGAAA TTGGCCAGCA TCCATCTCTT 1260

GAAGACATGC AGGAAGTTGT TGTGCATAAA AAAAAGAGGC CTGTTTTAAG AGATTATTGG 1320

CAGAAACATG CTGGAATGGC AATGCTCTGT GAAACCATTG AAGAATGTTG GGATCACGAC 1380

GCAGAAGCCA GGTTATCAGC TGGATGTGTA GGTGAAAGAA TTACCCAGAT GCAGAGACTA 1440

ACAAATATTA TTACCACAGA GGACATTGTA ACAGTGGTCA CAATGGTGAC AAATGTTGAC 1500

TTTCCTCCCA AAGAATCTAG TCTATGA 1527

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 187   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  246

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 247   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  306

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 307   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  364

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 365   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  423

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 424   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  473

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013