EKS-GOG-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	463.5	1.8E-139	675	930	256

Status

Unreviewed

Ensembl Protein

ENSGGOP00000016071

UniProt Accession

G3RK16;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA5

Gene Synonyms/Alias

EPHA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000016463	ENSGGOP00000016071	ENSGGOT00000016529

Organism

Gorilla gorilla

Functional Description

Protein Length

1035

Protein Sequence
(FASTA)

MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL RTLLASPSNE 60

VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ VCKVMEQNQN NWLLTSWISN 120

EGASRIFIEL KFTLRDCNSL PGGLGTCKET FNMYYFESDD QNGRNIKENQ YIKIDTIAAD 180

ESFTELDLGD RVMKLNTEVR DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL 240

AVFPDTITGA DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG 300

TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP TMACTRPPSA 360

PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS HARVCEECGG HVRYLPRQSG 420

LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL SPGARQYVSV NVTTNQAAPS PVTNVKKGKI 480

AKNSISLSWQ EPDRPNGIIL EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI 540

RARTAAGYGV FSRRFEFETT PVFAASSDQS QIPIIAVSVT VGVILLAVVI GVLLSGSCCE 600

CGCGRASSLC AVAHPSLIWR CGYSKAKQDP EEEKMHFHNG HIKLPGVRTY IDPHTYEDPN 660

QAVHEFAKEI EASCITIERV IGAGEFGEVC SGRLKLPGKR ELPVAIKTLK VGYTEKQRRD 720

FLGEASIMGQ FDHPNIIHLE GVVTKSKYDG KLYMSTNIST LSLQKNDGQF TVIQLVGMLR 780

GISAGMKYLS DMGYVHRDLA ARNILINSNL VCKVSDFGLS RVLEDDPEAA YTTRGGKIPI 840

RWTAPEAIAF RKFTSASDVW SYGIVMWEVV SYGERPYWEM TNQDVIKAVE EGYRLPSPMD 900

CPAALYQLML DCWQKDRNSR PKFDEIVNML DKLIRNPSSL KTLVNASCRV SNLLAEHSPL 960

GSGAYRSVGE WLEAIKMGRY TEIFMENGYS SMDAVAQVTL EDLRRLGVTL VGHQKKIMNS 1020

LQEMKVQLVN GMVPL 1035

Nucleotide Sequence
(FASTA)

ATGCGGGGCT CGGGGCCCCG GGGTGCGGGA CGCCGGCGGC CCCCAAGCGG CGGCGGCGAC 60

ACCCCAATCA CCCCAGCGTC CCTGGCCGGC TGCTACTCTG CACCTCGACG GGCTCCCCTC 120

TGGACGTGCC TTCTCCTGTG CGCCGCACTC CGGACCCTCC TGGCCAGCCC CAGCAACGAA 180

GTGAATTTAT TGGATTCACG CACTGTCATG GGGGACCTGG GATGGATTGC TTTTCCAAAA 240

AATGGGTGGG AAGAGATTGG TGAAGTGGAT GAAAATTATG CCCCTATCCA CACATACCAA 300

GTATGCAAAG TGATGGAACA GAATCAGAAT AACTGGCTTT TGACCAGTTG GATCTCCAAT 360

GAAGGTGCTT CCAGAATCTT CATAGAACTC AAATTTACCC TGCGGGACTG CAACAGCCTT 420

CCTGGAGGAC TGGGGACCTG TAAGGAAACC TTTAATATGT ATTACTTTGA GTCAGATGAT 480

CAGAATGGGA GAAACATCAA GGAAAACCAA TACATCAAAA TTGATACCAT TGCTGCCGAT 540

GAAAGCTTTA CAGAACTTGA TCTTGGTGAC CGTGTTATGA AACTGAATAC AGAGGTCAGA 600

GATGTAGGAC CTCTAAGCAA AAAGGGATTT TATCTTGCTT TTCAAGATGT TGGTGCTTGC 660

ATTGCTCTGG TTTCTGTGCG TGTATACTAT AAAAAATGCC CTTCTGTGGT ACGACACTTG 720

GCTGTCTTCC CTGACACCAT CACTGGAGCT GATTCTTCCC AGTTGCTCGA AGTGTCAGGC 780

TCCTGTGTCA ACCATTCTGT GACCGATGAA CCTCCCAAAA TGCACTGCAG CGCCGAAGGG 840

GAGTGGCTGG TGCCCATCGG GAAATGCATG TGCAAGGCAG GATATGAAGA GAAAAATGGC 900

ACCTGTCAAG TGTGCAGACC TGGGTTCTTC AAAGCCTCAC CTCACATCCA GAGCTGCGGC 960

AAATGTCCAC CTCACAGTTA TACCCATGAG GAAGCTTCAA CCTCTTGTGT CTGTGAAAAG 1020

GATTATTTCA GGAGAGAGTC TGATCCACCC ACAATGGCAT GCACAAGACC CCCCTCTGCT 1080

CCTCGGAATG CCATCTCAAA TGTTAATGAA ACTAGTGTTT TTCTGGAATG GATTCCGCCT 1140

GCTGACACTG GTGGAAGGAA AGACGTGTCA TATTATATTG CATGCAAGAA GTGCAACTCC 1200

CATGCACGTG TGTGTGAGGA GTGTGGCGGT CATGTCAGGT ACCTTCCCCG GCAAAGCGGC 1260

CTGAAAAACA CCTCTGTCAT GATGGTGGAT CTACTCGCTC ACACAAACTA TACCTTTGAG 1320

ATTGAGGCAG TGAATGGAGT GTCCGACTTG AGCCCAGGAG CCCGGCAGTA TGTGTCTGTA 1380

AATGTAACCA CAAATCAAGC AGCTCCATCT CCAGTCACCA ATGTGAAAAA AGGGAAAATT 1440

GCAAAAAACA GCATCTCTTT GTCTTGGCAA GAGCCAGATC GCCCCAATGG AATCATCCTG 1500

GAGTATGAAA TCAAGTATTT TGAAAAGGAC CAAGAGACCA GCTACACGAT TATCAAATCT 1560

AAAGAGACAA CTATTACTGC AGAGGGCTTG AAACCAGCTT CAGTTTATGT CTTCCAAATT 1620

CGAGCACGTA CAGCAGCAGG CTATGGTGTC TTCAGTCGAA GATTTGAGTT TGAAACCACC 1680

CCAGTGTTTG CAGCATCCAG CGATCAAAGC CAGATTCCTA TAATTGCTGT GTCTGTGACA 1740

GTGGGAGTCA TTTTGTTGGC AGTGGTTATC GGCGTCCTCC TCAGTGGAAG TTGCTGCGAA 1800

TGTGGCTGTG GGAGGGCTTC TTCCCTGTGC GCTGTTGCCC ATCCAAGCCT AATATGGCGG 1860

TGTGGCTACA GCAAAGCAAA ACAAGATCCA GAAGAGGAAA AGATGCATTT TCATAATGGG 1920

CACATTAAAC TGCCAGGAGT AAGAACTTAC ATTGATCCAC ATACCTATGA GGATCCCAAT 1980

CAAGCTGTCC ACGAATTTGC CAAGGAGATA GAAGCATCAT GTATCACCAT TGAGAGAGTT 2040

ATTGGAGCAG GTGAATTTGG TGAAGTTTGT AGTGGACGTT TGAAACTACC AGGAAAAAGA 2100

GAATTACCAG TGGCTATCAA AACCCTTAAA GTAGGCTATA CTGAAAAGCA ACGCAGAGAT 2160

TTCCTAGGTG AAGCAAGTAT CATGGGACAG TTTGATCACC CTAACATCAT CCATTTAGAA 2220

GGTGTGGTGA CCAAAAGTAA GTATGATGGC AAATTGTACA TGAGTACTAA TATTTCTACA 2280

TTGTCTTTAC AGAAAAACGA TGGGCAGTTC ACTGTGATTC AGCTTGTTGG CATGCTGAGA 2340

GGTATCTCTG CAGGAATGAA GTACCTTTCT GACATGGGCT ATGTGCATAG AGACCTTGCT 2400

GCTAGAAACA TCTTAATCAA CAGTAACCTT GTGTGCAAAG TGTCTGACTT TGGACTTTCC 2460

CGGGTACTGG AAGATGATCC CGAGGCAGCC TACACCACAA GGGGAGGAAA AATTCCAATC 2520

AGATGGACTG CCCCAGAAGC AATAGCTTTC CGAAAGTTTA CTTCTGCCAG TGATGTCTGG 2580

AGTTATGGAA TAGTAATGTG GGAAGTTGTG TCTTATGGAG AGAGGCCCTA CTGGGAGATG 2640

ACCAATCAAG ATGTGATTAA AGCAGTAGAG GAAGGCTATC GTCTGCCAAG CCCCATGGAT 2700

TGTCCTGCTG CTCTCTATCA GTTAATGCTG GATTGCTGGC AGAAAGACCG AAATAGCAGG 2760

CCCAAGTTTG ATGAAATAGT CAACATGTTG GACAAGCTGA TACGTAACCC AAGTAGTCTG 2820

AAGACGCTGG TTAATGCATC CTGCAGAGTA TCTAATTTAT TGGCAGAACA TAGCCCACTA 2880

GGATCTGGGG CCTACAGATC AGTAGGTGAA TGGCTAGAGG CAATCAAGAT GGGCCGGTAT 2940

ACAGAGATTT TCATGGAAAA TGGATACAGT TCAATGGACG CTGTGGCTCA GGTGACCTTG 3000

GAGGATTTGA GACGGCTTGG AGTGACTCTT GTCGGTCACC AGAAGAAGAT CATGAACAGC 3060

CTTCAAGAAA TGAAGGTGCA GCTGGTAAAC GGAATGGTGC CATTG 3105

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         ++ie+viGaGefGevcsGrlklpgkre++vaiktlk g+tekqrrdfl easi+Gqfdhp

Q: 675   ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  734

         78**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         nii+leGvvtksk    +  ym+       l+k+dgqftviqlvgmlrGi++gmkylsdm

Q: 735   NIIHLEGVVTKSKYDGKL--YMSTNISTLSLQKNDGQFTVIQLVGMLRGISAGMKYLSDM  792

         ************987654..8888888888******************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+rk

Q: 793   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK  852

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpyw+m+nqdvika+eegyrlp+pmdcpaalyqlmldc

Q: 853   FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC  912

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqkdr++rpkf++iv++l

Q: 913   WQKDRNSRPKFDEIVNML  930

         ***************985

Domain Sequence
(FASTA)

ITIERVIGAG EFGEVCSGRL KLPGKRELPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60

NIIHLEGVVT KSKYDGKLYM STNISTLSLQ KNDGQFTVIQ LVGMLRGISA GMKYLSDMGY 120

VHRDLAARNI LINSNLVCKV SDFGLSRVLE DDPEAAYTTR GGKIPIRWTA PEAIAFRKFT 180

SASDVWSYGI VMWEVVSYGE RPYWEMTNQD VIKAVEEGYR LPSPMDCPAA LYQLMLDCWQ 240

KDRNSRPKFD EIVNML 256

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013