EKS-GOG-00236

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00236

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	386.9	4.7E-116	53	304	252

Status

Unreviewed

Ensembl Protein

ENSGGOP00000016685

UniProt Accession

G3RLN0;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000017093	ENSGGOP00000016685	ENSGGOT00000017154

Organism

Gorilla gorilla

Functional Description

Protein Length

779

Protein Sequence
(FASTA)

MSSARTHLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG 60

KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE 120

TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN 180

LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL 240

YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK 300

DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL 360

LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAAGPAIPTS 420

NSYSKKTQSN NAENKRPEED RESGRKASST AKVPASPLPG LERKKTTPTP STNSVLSTST 480

NRSRNSPLLE RASLGQASIQ NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP 540

NKASGLPPTE SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG 600

QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLNEP ESKDRVETLR 660

PHVVGSGGND KEKEEFREAK PRSLRFTWSM KTTSSMEPNE MMREIRKVLD ANSCQSELHE 720

KYMLLCMHGT PGHEDFVQWE MEVCKLPRLS LNGVRFKRIS GTSMAFKNIA SKIANELKL 779

Nucleotide Sequence
(FASTA)

ATGTCCAGCG CTCGGACCCA CCTACCCACG CTGAACGAGA GGGACACGGA GCAGCCCACC 60

TTGGGACACC TTGACTCCAA GCCCAGCAGT AAGTCCAACA TGATTCGGGG CCGCAACTCA 120

GCCACCTCTG CTGATGAGCA GCCCCACATT GGAAACTACC GGCTCCTCAA GACCATTGGC 180

AAGGGTAATT TTGCCAAGGT GAAGTTGGCC CGACACATCC TGACTGGGAA AGAGGTAGCT 240

GTGAAGATCA TTGACAAGAC TCAACTGAAC TCCTCCAGCC TCCAGAAACT ATTCCGCGAA 300

GTAAGAATAA TGAAGGTTTT GAATCATCCC AACATAGTTA AATTATTTGA AGTGATTGAG 360

ACTGAGAAAA CGCTCTACCT TGTCATGGAG TACGCTAGTG GCGGAGAGGT ATTTGATTAC 420

CTAGTGGCTC ATGGCAGGAT GAAAGAAAAA GAGGCTCGAG CCAAATTCCG CCAGATAGTG 480

TCTGCTGTGC AGTACTGTCA CCAGAAGTTT ATTGTTCATA GAGACTTAAA GGCAGAAAAC 540

CTGCTCTTGG ATGCTGATAT GAACATCAAG ATTGCAGACT TTGGCTTCAG CAATGAATTC 600

ACCTTTGGGA ACAAGCTGGA CACCTTCTGT GGCAGTCCCC CTTATGCTGC TCCAGAACTC 660

TTCCAGGGCA AAAAATATGA TGGACCCGAG GTGGATGTGT GGAGCCTAGG AGTTATCCTC 720

TATACACTGG TCAGCGGATC CCTGCCTTTT GATGGACAGA ACCTCAAGGA GCTGCGGGAA 780

CGGGTACTGA GGGGAAAATA CCGTATTCCA TTCTACATGT CCACGGACTG TGAAAACCTG 840

CTTAAGAAAT TTCTCATTCT TAATCCCAGC AAGAGAGGCA CTTTAGAGCA AATCATGAAA 900

GATCGATGGA TGAATGTGGG TCACGAAGAT GATGAACTAA AGCCTTATGT GGAGCCACTC 960

CCTGACTACA AGGACCCCCG GCGGACAGAG CTGATGGTGT CCATGGGTTA TACACGGGAA 1020

GAGATCCAGG ACTCGCTGGT GGGCCAGAGA TACAACGAGG TGATGGCCAC CTATCTGCTC 1080

CTGGGCTACA AGAGCTCCGA GCTGGAAGGC GACACCATCA CCCTGAAACC CCGGCCTTCA 1140

GCTGATCTGA CCAATAGCAG CGCCCCATCC CCATCCCACA AGGTACAGCG CAGCGTGTCG 1200

GCCAATCCCA AGCAGCGGCG CTTCAGCGAC CAGGCAGCTG GTCCTGCCAT TCCCACCTCT 1260

AATTCTTACT CTAAGAAGAC TCAGAGTAAC AACGCAGAAA ATAAGCGGCC TGAGGAGGAC 1320

CGGGAGTCAG GGCGGAAAGC CAGCAGCACA GCCAAGGTGC CTGCCAGCCC CCTGCCCGGT 1380

CTGGAGAGGA AGAAGACCAC CCCAACCCCC TCCACGAACA GCGTCCTCTC CACCAGCACA 1440

AATCGAAGCA GGAATTCCCC ACTTTTGGAG CGGGCCAGCC TCGGCCAGGC CTCCATCCAG 1500

AATGGTAAAG ACAGCCTAAC CATGCCAGGG TCCCGGGCCT CCACGGCTTC TGCTTCTGCC 1560

GCAGTCTCTG CGGCCCGGCC CCGCCAGCAC CAGAAATCCA TGTCGGCCTC CGTGCACCCC 1620

AACAAGGCCT CTGGGCTGCC CCCCACGGAG AGTAACTGTG AGGTGCCGCG GCCCAGCACA 1680

GCCCCCCAGC GTGTCCCTGT TGCCTCCCCA TCCGCCCACA ACATCAGCAG CAGTGGTGGA 1740

GCCCCAGACC GAACTAATTT CCCCCGGGGT GTGTCCAGCC GAAGCACCTT CCATGCTGGG 1800

CAGCTCCGAC AGGTGCGGGA CCAGCAGAAT TTGCCCTACG GTGTGACCCC AGCCTCTCCC 1860

TCTGGCCACA GCCAGGGCCG GCGGGGGGCC TCTGGGAGCA TCTTCAGCAA GTTCACCTCC 1920

AAGTTTGTAC GCAGGAACCT GAATGAACCT GAAAGCAAAG ACCGAGTGGA GACGCTCAGA 1980

CCTCACGTGG TGGGCAGTGG CGGCAACGAC AAAGAAAAGG AAGAATTTCG GGAGGCCAAG 2040

CCTCGCTCCC TCCGCTTCAC GTGGAGTATG AAGACCACGA GCTCCATGGA GCCCAACGAG 2100

ATGATGCGGG AGATCCGCAA GGTGCTGGAC GCGAACAGCT GCCAGAGCGA GCTGCATGAG 2160

AAGTACATGC TGCTGTGCAT GCACGGCACG CCGGGCCACG AGGACTTCGT GCAGTGGGAG 2220

ATGGAGGTGT GCAAACTGCC GCGGCTCTCT CTCAACGGGG TTCGATTTAA GCGGATATCG 2280

GGCACCTCCA TGGCCTTCAA AAACATTGCC TCCAAAATAG CCAACGAGCT GAAGCTTTAA 2340

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 53    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  112

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 113   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  172

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 173   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  232

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 233   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  292

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 293   GTLEQIMKDRWM  304

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013