EKS-GOG-00187

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00187

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	421.9	1.2E-126	36	290	255

Status

Unreviewed

Ensembl Protein

ENSGGOP00000027239

UniProt Accession

G3RLS9;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK1

Gene Synonyms/Alias

TESK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000017152	ENSGGOP00000027239	ENSGGOT00000026580
ENSGGOG00000017152	ENSGGOP00000016739	ENSGGOT00000017210

Organism

Gorilla gorilla

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

MAGERPPLRG PGPGPGESSY RALRSAVSSL ARVDDFHCAE KIGAGFFSEV YKVRHRQSGQ 60

VMVLKMNKLP SNRGNTLREV QLMNRLRHPN ILRFMGVCVH QGQLHALTEY MNGGTLEQLL 120

SSPEPLSWPV RLHLALDIAR GLRYLHSKGV FHRDLTSKNC LVRREDRGFT AVVGDFGLAE 180

KIPVYREGAR KEPLAVVGSP YWMAPEVLRG ELYDEKADVF AFGIVLCELI ARVPADPDYL 240

PRTEDFGLDV PAFRTLVGDD CPLPFLLLAI HCCSLEPSTR APFTEITQHL EWILEQLPEP 300

APLTRTALTH NQGSVARGGP SATLPRPDPR LSRSRSDLFL PPSPESPPNW GDNLTRVNPF 360

SLREDLRGGK IKLLDTPSKP VLPLVPPSPF PSTQLPLVTT PETLVQPGTP ARRCRSLPSS 420

PELPRRMETA LPGPGPPPVG PSAEEKMECE GSSPEPEPPG PAPQLPLAVA TDNFISTCSS 480

ASQPWSPRSG PVLNNNPPAV VVNSPQGWAG EPWNRAQHSL PRAAALERTE PSPPPSAPRE 540

PDEGLPCPGC CLGPFSFGFL SMCPRPTPAV ARYRNLNCEA GSLLCHRGHH AKPPTPSLQL 600

PGARS 605

Nucleotide Sequence
(FASTA)

ATGGCCGGGG AACGGCCCCC ACTGCGGGGC CCTGGGCCCG GGCCTGGAGA GTCCTCCTAC 60

CGGGCTCTCC GCAGCGCCGT GTCTAGCCTG GCGCGTGTGG ACGATTTTCA CTGCGCGGAG 120

AAGATCGGGG CCGGCTTCTT CTCTGAGGTC TACAAGGTTC GGCACCGACA GTCAGGGCAA 180

GTCATGGTGC TGAAGATGAA CAAGCTCCCC AGTAACCGGG GCAACACACT ACGGGAAGTG 240

CAGCTGATGA ACCGGCTCAG GCACCCCAAC ATCCTAAGGT TCATGGGGGT CTGTGTGCAC 300

CAGGGACAGC TGCACGCTCT TACAGAGTAT ATGAATGGGG GGACATTGGA ACAGCTGCTC 360

AGCTCCCCTG AACCCCTATC CTGGCCGGTC AGGCTCCACC TGGCCCTGGA CATTGCCCGA 420

GGCCTGCGGT ACCTGCACTC CAAAGGTGTA TTTCACCGCG ACCTCACATC CAAGAACTGT 480

CTAGTCCGAC GGGAAGATCG AGGCTTCACC GCTGTCGTGG GTGACTTCGG GCTGGCTGAA 540

AAGATTCCTG TGTATAGGGA GGGGGCAAGG AAGGAGCCAT TGGCCGTGGT GGGCTCCCCA 600

TACTGGATGG CTCCAGAGGT GTTACGGGGT GAGCTGTATG ATGAGAAGGC TGATGTCTTT 660

GCCTTCGGGA TTGTCCTCTG TGAGCTCATC GCCCGAGTAC CTGCAGACCC TGACTACCTA 720

CCACGCACTG AGGACTTTGG CCTGGATGTG CCTGCTTTCC GAACTCTGGT GGGGGATGAC 780

TGCCCACTGC CTTTCTTGCT CCTGGCCATC CACTGCTGCA GCCTGGAACC CAGCACCCGT 840

GCCCCCTTCA CCGAAATTAC CCAGCACCTG GAATGGATCC TGGAGCAGCT GCCTGAGCCA 900

GCCCCACTCA CCAGGACTGC CCTGACACAC AATCAGGGCT CTGTTGCAAG AGGGGGTCCC 960

TCTGCCACGC TTCCCAGGCC AGATCCCCGG CTTTCCCGAA GCCGGTCAGA CCTCTTCCTG 1020

CCCCCATCAC CAGAATCACC CCCCAACTGG GGGGACAATC TGACTCGAGT CAACCCCTTC 1080

TCACTACGGG AAGACCTCAG GGGTGGCAAG ATCAAGCTCT TGGACACACC CAGCAAGCCA 1140

GTCCTGCCTC TTGTGCCACC ATCACCATTC CCATCCACTC AGCTGCCCTT AGTGACCACT 1200

CCGGAGACCC TGGTCCAGCC TGGGACACCT GCCCGCCGCT GCCGCTCACT ACCCTCATCC 1260

CCCGAGCTCC CCCGCCGTAT GGAGACAGCA CTGCCAGGTC CTGGCCCTCC CCCCGTGGGC 1320

CCCTCGGCTG AAGAGAAGAT GGAGTGCGAG GGCAGCAGCC CTGAGCCGGA ACCTCCAGGA 1380

CCAGCGCCCC AGCTGCCTCT GGCTGTGGCC ACAGACAACT TCATCAGCAC CTGTTCGTCG 1440

GCCTCCCAAC CCTGGTCCCC TAGATCAGGA CCCGTCCTCA ATAACAATCC CCCAGCTGTG 1500

GTGGTGAACT CCCCACAAGG CTGGGCTGGG GAGCCCTGGA ACCGGGCCCA GCATAGCCTG 1560

CCCCGGGCGG CAGCCCTGGA GCGGACAGAA CCCTCGCCAC CCCCTTCAGC TCCCCGGGAG 1620

CCCGATGAGG GGCTGCCCTG TCCTGGCTGC TGCCTCGGCC CCTTCAGCTT TGGCTTCCTG 1680

TCCATGTGCC CCCGCCCCAC ACCAGCTGTT GCCCGCTACC GCAACCTGAA CTGTGAGGCG 1740

GGCAGTCTCC TCTGCCACCG AGGGCACCAC GCCAAGCCAC CCACACCCAG CCTGCAGCTG 1800

CCTGGGGCAC GCTCTTAG 1818

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         ++++ek+G+Gffsev+kv+hr+sG+vmvlk  ++++ +nr n+l+ev+l+++l+hpn+l+

Q: 36    FHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNKLPSNRGNTLREVQLMNRLRHPNILR  93

         689***************************..****************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         f+Gv+v++++lh+ltey++gGtl++ll+s+e+l+w++r++la dia+Gl+ylhskg++hr

Q: 94    FMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHR  153

         ************************************************************

S: 121   dlnsknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywm  177

         dl+sknclvr+   ++++vv+dfGla          ek++++++++rk+ l+vvGsPywm

Q: 154   DLTSKNCLVRRedrGFTAVVGDFGLA----------EKIPVYREGARKEPLAVVGSPYWM  203

         **********988889**********..........9***********************

S: 178   aPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcP  237

         aPevl+g+ ydek+dvf+fGivlce+iarv adPdylPrtedfgldv afr+ lv++dcP

Q: 204   APEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRT-LVGDDCP  262

         ****************************************************.*******

S: 238   eaflklavvccdldpesrpsfeelekkl  265

          +fl la++cc+l+p++r++f+e++++l

Q: 263   LPFLLLAIHCCSLEPSTRAPFTEITQHL  290

         *************************987

Domain Sequence
(FASTA)

FHCAEKIGAG FFSEVYKVRH RQSGQVMVLK MNKLPSNRGN TLREVQLMNR LRHPNILRFM 60

GVCVHQGQLH ALTEYMNGGT LEQLLSSPEP LSWPVRLHLA LDIARGLRYL HSKGVFHRDL 120

TSKNCLVRRE DRGFTAVVGD FGLAEKIPVY REGARKEPLA VVGSPYWMAP EVLRGELYDE 180

KADVFAFGIV LCELIARVPA DPDYLPRTED FGLDVPAFRT LVGDDCPLPF LLLAIHCCSL 240

EPSTRAPFTE ITQHL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gadus morhua"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR015782	; Testis-specific_kinase_1.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013