EKS-GOG-00108
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GOG-00108
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec490.21.4E-147318568251
StatusUnreviewed
Ensembl ProteinENSGGOP00000025088
UniProt AccessionG3SKC9;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGGOG00000022176ENSGGOP00000025088ENSGGOT00000022818
ENSGGOG00000022176ENSGGOP00000028572ENSGGOT00000033756
OrganismGorilla gorilla
Functional Description
Protein Length575
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK 60
ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180
HRKTKKPLPP TPEEDQWYSK HMTRSQAEQL LKQEGKEGGF IVRDSSKAGK YTVSVFAKST 240
GDPQGVIRHY VVCSTPQSQY YLAEKHLFST IPELINYHQH NSAGLISRLK YPVSQQNKNA 300
PSTAGLGYGS WEIDPKDLTF LKELGTGQFG VVKYGKWRGQ YDVAIKMIKE GSMSEDEFIE 360
EAKVMMNLSH EKLVQLYGVC TKQRPIFIIT EYMANGCLLN YLREMRHRFQ TQQLLEMCKD 420
VCEAMEYLES KQFLHRDLAA RNCLVNDQGV VKVSDFGLSR YVLDDEYTSS VGSKFPVRWS 480
PPEVLMYSKF SSKSDIWAFG VLMWEIYSLG KMPYERFTNS ETAEHIAQGL RLYRPHLASE 540
KVYTIMYSCW HEKADERPTF KILLSNILDV MDEES 575
Nucleotide Sequence
(FASTA)
ATGGCCGCAG TGATTCTGGA GAGCATCTTT CTGAAGCGAT CCCAACAGAA AAAGAAAACA 60
TCACCTCTAA ACTTCAAGAA GCGCCTGTTT CTCTTGACCG TGCACAAACT CTCCTACTAT 120
GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180
ATCACTTGTG TTGAAACAGT GGTTCCTGAA AAAAATCCTC CTCCAGAAAG ACAGATTCCG 240
AGAAGAGGTG AAGAGTCCAG TGAAATGGAG CAAATTTCAA TCATTGAAAG GTTCCCTTAT 300
CCCTTCCAGG TTGTGTATGA TGAAGGGCCT CTCTACGTCT TCTCCCCAAC TGAAGAACTA 360
AGGAAGCGGT GGATTCACCA GCTCAAAAAC GTAATCCGGT ACAACAGTGA TCTGGTTCAG 420
AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480
AATGCTATGG GCTGCCAAAT TTTGGAGAAC AGGAATGGAA GCTTAAAACC TGGGAGTTCT 540
CACCGGAAGA CAAAAAAGCC TCTTCCCCCA ACGCCTGAGG AGGACCAGTG GTATTCCAAA 600
CACATGACTC GGAGTCAGGC TGAGCAACTG CTAAAGCAAG AGGGGAAAGA AGGAGGTTTC 660
ATTGTCAGAG ACTCCAGCAA AGCTGGCAAA TATACAGTGT CTGTGTTTGC TAAATCCACA 720
GGGGACCCTC AAGGGGTGAT ACGTCATTAT GTTGTGTGTT CCACACCTCA GAGTCAGTAT 780
TACCTGGCTG AGAAGCACCT TTTCAGCACC ATCCCTGAGC TCATTAACTA CCATCAGCAC 840
AACTCTGCAG GACTCATATC CAGGCTCAAA TATCCAGTGT CTCAACAAAA CAAGAATGCA 900
CCTTCCACTG CAGGCCTGGG ATACGGATCA TGGGAAATTG ATCCAAAGGA CCTGACCTTC 960
TTGAAGGAGC TGGGGACTGG ACAATTTGGG GTAGTGAAGT ATGGGAAATG GAGAGGCCAG 1020
TATGACGTGG CCATCAAGAT GATCAAAGAA GGCTCCATGT CTGAAGATGA ATTCATTGAA 1080
GAAGCCAAAG TCATGATGAA TCTTTCCCAT GAGAAGCTGG TGCAGTTGTA TGGCGTCTGC 1140
ACCAAGCAGC GCCCCATCTT CATCATCACT GAGTACATGG CCAATGGCTG CCTCCTGAAC 1200
TACCTGAGGG AGATGCGCCA CCGCTTCCAG ACTCAGCAGC TGCTAGAGAT GTGCAAGGAT 1260
GTCTGTGAAG CCATGGAATA CCTGGAGTCA AAGCAGTTCC TTCACCGAGA CCTGGCAGCT 1320
CGAAACTGTT TGGTAAACGA TCAAGGAGTT GTTAAAGTAT CTGATTTCGG CCTGTCCAGG 1380
TATGTCCTGG ATGATGAATA CACAAGCTCA GTAGGCTCCA AATTTCCAGT CCGGTGGTCC 1440
CCACCGGAAG TCCTGATGTA TAGCAAGTTC AGCAGCAAAT CTGACATTTG GGCTTTTGGG 1500
GTTTTGATGT GGGAAATTTA CTCCCTGGGG AAGATGCCAT ATGAGAGATT TACTAACAGT 1560
GAGACTGCTG AACACATTGC CCAAGGCCTA CGTCTCTACA GGCCTCATCT GGCTTCAGAG 1620
AAGGTATATA CCATCATGTA CAGTTGTTGG CATGAGAAAG CAGATGAGCG TCCCACTTTC 1680
AAAATTCTTC TGAGCAATAT TCTAGATGTC ATGGATGAAG AATCCTGA 1728
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly
Q: 318   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  377
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 378   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  437
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 438   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  497
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las+kvy++m+scw+ek++er
Q: 498   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADER  557
         ************************************************************
S: 241   ptfkellsale  251
         ptfk lls++ 
Q: 558   PTFKILLSNIL  568
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASEKVYTIMY SCWHEKADER 240
PTFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-EQC-00104
EKS-FEC-00102
EKS-GAG-00088
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORA-00087
EKS-ORC-00099
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAG-00139
EKS-TAR-00136
EKS-XET-00090
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013