EKS-GOG-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	438.0	1.5E-131	221	487	267

Status

Unreviewed

Ensembl Protein

ENSGGOP00000017218

UniProt Accession

G3RN52;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK2

Gene Synonyms/Alias

CHEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000023242	ENSGGOP00000017218	ENSGGOT00000033113

Organism

Gorilla gorilla

Functional Description

Protein Length

488

Protein Sequence
(FASTA)

VMSRESDVEA QQSHGSSACS QPHGSVTQSQ GSSSQSQGIS SSSTSTMPNS SQSSHSSSGT 60

LSSLETVSTQ ELYSIPEDQE PEDQEPEEPT PAPWARLWAL QDGFANLECV NDNYWFGRDK 120

SCEYCFDEPL LKRTDKYRTY SKKHFRIFRE VGPKNSYIAY IEDHSGNGTF VNTELVGKGK 180

RRPLNNNSEI ALSLSRNKVF VFFDLTVDDQ SVYPKALRDE YIMSKTLGSG ACGEVKLAFE 240

RKTCKKVAIK IISKRKFAIG SAREADPALN VETEIEILKK LNHPCIIKIK NFFDAEDYYI 300

VLELMEGGEL FDKVVGNKRL KEATCKLYFY QMLLAVQYLH ENGIIHRDLK PENVLLSSQE 360

EDCLIKITDF GHSKILGETS LMRTLCGTPT YLAPEVLVSV GTAGYNRAVD CWSLGVILFI 420

CLSGYPPFSE HRTQVSLKDQ ITSGKYNFIP EVWAEVSEKA LDLVKKLLVV DPKARFTTEE 480

ALRHPWLQ 488

Nucleotide Sequence
(FASTA)

GTGATGTCTC GGGAGTCGGA TGTTGAGGCT CAGCAGTCTC ATGGCAGCAG TGCCTGTTCA 60

CAGCCCCATG GCAGCGTTAC CCAGTCCCAA GGCTCCTCCT CACAGTCCCA GGGCATATCC 120

AGCTCCTCTA CCAGCACGAT GCCAAACTCC AGCCAGTCCT CTCACTCCAG CTCTGGGACA 180

CTGAGCTCCT TAGAGACAGT GTCCACTCAG GAACTCTATT CTATTCCTGA GGACCAAGAA 240

CCTGAGGACC AAGAACCTGA GGAGCCTACC CCTGCCCCCT GGGCTCGATT ATGGGCCCTT 300

CAGGATGGAT TTGCCAATCT TGAATGTGTG AATGACAACT ACTGGTTTGG GAGGGACAAA 360

AGCTGTGAAT ATTGCTTTGA TGAACCACTG CTGAAAAGAA CAGATAAATA CCGAACATAC 420

AGCAAGAAAC ACTTTCGGAT TTTCAGGGAA GTGGGTCCTA AAAACTCTTA CATTGCATAC 480

ATAGAAGATC ACAGTGGCAA TGGAACCTTT GTAAATACAG AGCTTGTAGG GAAAGGAAAA 540

CGCCGTCCTT TGAATAACAA TTCTGAAATT GCACTGTCAC TAAGCAGAAA TAAAGTTTTT 600

GTCTTTTTTG ATCTGACTGT AGATGATCAG TCAGTTTATC CTAAGGCATT AAGAGATGAA 660

TACATCATGT CAAAAACTCT TGGAAGTGGT GCCTGTGGAG AGGTAAAGCT GGCTTTCGAG 720

AGGAAAACAT GTAAGAAAGT AGCCATAAAG ATCATCAGCA AAAGGAAGTT TGCTATTGGT 780

TCAGCAAGAG AGGCAGACCC AGCTCTCAAT GTTGAAACAG AAATAGAAAT TTTGAAAAAG 840

CTAAATCATC CTTGCATCAT CAAGATTAAA AACTTTTTTG ATGCAGAAGA TTATTATATT 900

GTTTTGGAAT TGATGGAAGG GGGAGAGCTG TTTGACAAAG TGGTGGGGAA TAAACGCCTG 960

AAAGAAGCTA CCTGCAAGCT CTATTTTTAC CAGATGCTCT TGGCTGTGCA GTACCTTCAT 1020

GAAAACGGTA TTATACACCG TGACTTAAAG CCAGAGAATG TTCTATTGTC ATCTCAAGAA 1080

GAGGACTGTC TTATAAAGAT TACTGATTTT GGGCACTCCA AGATTTTGGG AGAGACCTCT 1140

CTCATGAGAA CCTTATGTGG AACCCCCACC TACTTGGCGC CTGAAGTTCT TGTTTCTGTT 1200

GGGACTGCTG GGTATAACCG TGCTGTGGAC TGCTGGAGTT TAGGAGTTAT TCTTTTTATC 1260

TGCCTTAGTG GGTATCCACC TTTCTCTGAG CATAGGACTC AAGTGTCACT GAAGGATCAG 1320

ATCACCAGTG GAAAATACAA CTTCATTCCT GAAGTCTGGG CAGAAGTCTC AGAGAAAGCT 1380

CTGGACCTTG TCAAGAAGTT GTTGGTAGTG GATCCAAAGG CACGTTTTAC GACAGAAGAA 1440

GCCTTAAGAC ACCCGTGGCT TCAG 1464

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59

         yi+sk+lG+Ga+g+vkla+e+kt+kkva+ki+skrk +i+s+re++ a +ve+e+eilkk

Q: 221   YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKfAIGSAREADPALNVETEIEILKK  280

         89*********************************999**********************

S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119

         l+hP+i+k+k++f++e++ y+vlel+egGel+dkvv +k+lke+++kl+f+q+l av+yl

Q: 281   LNHPCIIKIKNFFDAEDY-YIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYL  339

         *****************9.*****************************************

S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179

         he+giihrDlkPen+Lls++eed+l+kitDfG++k+lge+slm+tlCGtp+y+aPevlv+

Q: 340   HENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVS  399

         ************************************************************

S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239

          g+a+y+++vD+WslGv+lf++lsGypPfse++tqvslk+qi++gky+fi+e+w+++se+

Q: 400   VGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEK  459

         ************************************************************

S: 240   akdlikklLvvdPeerlsieealnhpWl  267

         a+dl+kklLvvdP++r+++eeal+hpWl

Q: 460   ALDLVKKLLVVDPKARFTTEEALRHPWL  487

         ***************************8

Domain Sequence
(FASTA)

YIMSKTLGSG ACGEVKLAFE RKTCKKVAIK IISKRKFAIG SAREADPALN VETEIEILKK 60

LNHPCIIKIK NFFDAEDYYI VLELMEGGEL FDKVVGNKRL KEATCKLYFY QMLLAVQYLH 120

ENGIIHRDLK PENVLLSSQE EDCLIKITDF GHSKILGETS LMRTLCGTPT YLAPEVLVSV 180

GTAGYNRAVD CWSLGVILFI CLSGYPPFSE HRTQVSLKDQ ITSGKYNFIP EVWAEVSEKA 240

LDLVKKLLVV DPKARFTTEE ALRHPWL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013