EKS-GOG-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	314.4	7.8E-94	36	283	248

Status

Unreviewed

Ensembl Protein

ENSGGOP00000020634

UniProt Accession

G3RXU7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K7

Gene Synonyms/Alias

MAP3K7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000024243	ENSGGOP00000020634	ENSGGOT00000031588

Organism

Gorilla gorilla

Functional Description

Protein Length

606

Protein Sequence
(FASTA)

MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60

AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120

PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180

DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240

WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300

PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 360

SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN 420

ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP 480

WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI 540

ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ 600

KRQGTS 606

Nucleotide Sequence
(FASTA)

ATGTCTACAG CCTCTGCCGC CTCCTCCTCC TCCTCGTCTT CGGCCGGTGA GATGATCGAA 60

GCCCCTTCTC AGGTCCTCAA CTTTGAAGAG ATCGACTACA AGGAGATCGA GGTGGAAGAG 120

GTTGTTGGAA GAGGAGCCTT TGGAGTTGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 180

GCTATTAAAC AAATAGAAAG TGAATCTGAG AGGAAAGCAT TTATTGTAGA GCTTCGGCAG 240

TTATCCCGTG TGAACCATCC TAATATTGTA AAGCTTTATG GAGCCTGCTT GAATCCAGTG 300

TGTCTTGTGA TGGAATATGC TGAAGGGGGC TCTTTATATA ATGTGCTGCA TGGTGCTGAA 360

CCATTGCCAT ATTATACTGC TGCCCACGCA ATGAGTTGGT GTTTACAATG TTCCCAAGGA 420

GTGGCTTATC TTCACAGCAT GCAACCCAAA GCGCTAATTC ACAGGGACCT GAAACCACCA 480

AACTTACTGC TGGTTGCAGG GGGGACAGTT CTAAAAATTT GTGATTTTGG TACAGCCTGT 540

GACATTCAGA CACACATGAC CAATAACAAG GGGAGTGCTG CTTGGATGGC ACCTGAAGTT 600

TTTGAAGGTA GTAATTACAG TGAAAAATGT GACGTCTTCA GCTGGGGTAT TATTCTTTGG 660

GAAGTGATAA CGCGTCGGAA ACCCTTTGAT GAGATTGGTG GCCCAGCTTT CCGAATCATG 720

TGGGCTGTTC ATAATGGTAC TCGACCACCA CTGATCAAAA ATTTACCTAA GCCCATTGAG 780

AGCCTGATGA CTCGTTGTTG GTCTAAAGAT CCTTCCCAGC GCCCTTCAAT GGAGGAAATT 840

GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CAGATGAGCC ATTACAGTAT 900

CCTTGTCAGT ATTCAGATGA AGGACAGAGC AACTCTGCCA CCAGTACAGG CTCATTCATG 960

GACATTGCTT CTACAAATAC GAGTAACAAA AGTGACACTA ATATGGAACA AGTTCCTGCC 1020

ACAAATGATA CTATTAAGCG CTTAGAATCA AAATTGTTGA AAAATCAGGC AAAGCAACAG 1080

AGTGAATCTG GACGTTTAAG CTTGGGAGCC TCCCGTGGGA GCAGTGTGGA GAGCTTGCCC 1140

CCAACCTCTG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC TAGGATCGCT 1200

GCAACCACAG CCTATTCCAA GCCTAAACGG GGCCACCGTA AAACCGCTTC ATTTGGCAAC 1260

ATTCTGGATG TCCCTGAGAT CGTCATATCA GGCAACGGAC AGCCAAGACG TAGATCCATC 1320

CAAGACTTGA CTGTAACTGG AACAGAACCT GGTCAGGTGA GCAGTAGGTC ATCCAGTCCC 1380

AGTGTCAGAA TGATTACTAC CTCAGGACCA ACCTCAGAAA AGCCAACTCG AAGTCATCCA 1440

TGGACCCCTG ATGATTCCAC AGATACCAAT GGATCAGATA ACTCCATCCC AATGGCTTAT 1500

CTTACACTGG ATCACCAACT ACAGCCTCTA GCACCGTGCC CAAACTCCAA AGAATCTATG 1560

GCAGTGTTTG AACAGCATTG TAAAATGGCA CAAGAATATA TGAAAGTTCA AACAGAAATT 1620

GCATTGTTAT TACAGAGAAA GCAAGAACTA GTTGCAGAAC TGGACCAGGA TGAAAAGGAC 1680

CAGCAAAATA CATCTCGCCT GGTACAGGAA CATAAAAAGC TTTTAGATGA AAACAAAAGC 1740

CTTTCTACTT ACTACCAGCA ATGCAAAAAA CAACTAGAGG TCATCAGAAG TCAGCAGCAG 1800

AAACGACAAG GCACTTCATG A 1821

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 36    IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  91

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++p

Q: 92    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP  149

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 150   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  208

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 209   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  267

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 268   SKDPSQRPSMEEIVKI  283

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW RAKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCSQGVAYLH SMQPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPSQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013