EKS-GOG-00290

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00290

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	385.8	1.1E-115	788	1053	266

Status

Unreviewed

Ensembl Protein

ENSGGOP00000023542

UniProt Accession

G3S635;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000024276	ENSGGOP00000025845	ENSGGOT00000031532
ENSGGOG00000024276	ENSGGOP00000023542	ENSGGOT00000023126

Organism

Gorilla gorilla

Functional Description

Protein Length

1085

Protein Sequence
(FASTA)

MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK 60

KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQRASA 120

VLQRGIQNQA EPRECLQQQY RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN 180

NMACISKNQG SELSGVISSA CDKESNMEQR VIMISKSEYS VHSSLASKVD VEQVVMYCKE 240

KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL 300

HQVVETSHED LPASQERSEV NPARMGPSVG SQQELRAPCL PVTYQQTPAN MEKNPREAPP 360

VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK STHEFKPQSG 420

AEIKEGCETH KVANVSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL 480

PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL 540

PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF 600

TSAAQLASTP FHKLPAESVH ILEDKENVVA RQCTQGTSDS CEENMVVPSR DGKFSPIQEK 660

SPEQAFSSHM YSASLLHLSQ PAAGGVLTCE AELGVEACRL TDTDAAIAED PPDAIAGFQA 720

EWMQMSSLGT VDAPNFIVGN PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF 780

QLGSKLVYVH HLLGEGAFAQ VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER 840

LKPSMQHMFM KFYSAHLFQN GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR 900

MLYMIEQVHD CEIIHGDIKP DNFILGNGFL EQDDEEDLSA GLALIDLGQS IDMKLFPKGT 960

IFTAKCETSG FQCVEMLSNK PWNYQIDYFG VAATVYCMLF GTYMKVKNEG GECKPEGLFR 1020

RLPHLDMWNE FFHVMLNIPD CHHLPSLDLL RQKLKKVFQQ HYTNKIRALR KRLIVLLLEC 1080

KRSRK 1085

Nucleotide Sequence
(FASTA)

ATGGACACCC CGGAAAATGT CCTTCAGATG CTTGAAGCCC ACATGCAGAG CTACAAGGGC 60

AATGACCCTC TTGGTGAATG GGAAAGATAC ATACAGTGGG TAGAAGAGAA TTTTCCTGAG 120

AATAAAGAAT ACTTGATAAC TTTACTAGAA CATTTAATGA AGGAATTTTT AGATAAGAAG 180

AAATACCACA ATGACCCAAG ATTCATCAGT TATTGTTTAA AATTTGCTGA GTACAACAGT 240

GACCTCCATC AATTTTTTGA GTTTCTGTAC AACCATGGGA TTGGAACCCT GTCATCCCCT 300

CTGTACATTG CGTGGGCAGG GCATCTGGAA GCCCAAGGAG AGCTGCAGCG TGCCAGTGCT 360

GTCCTTCAGA GAGGAATTCA AAACCAGGCT GAACCCAGAG AGTGCCTGCA ACAACAATAC 420

AGGTTATTTC AGACACGCCT CACTGAAACC CATTTGCCAG CTCAAGCTAG AACCTCAGAA 480

CCTCTGCATA ATGTTCAGGT TTTAAATCAA ATGATAACAT CAAAATCAAA TCCAGGAAAT 540

AACATGGCCT GCATTTCTAA GAATCAGGGT TCAGAGCTTT CTGGAGTGAT ATCTTCAGCT 600

TGTGATAAAG AGTCAAATAT GGAACAAAGA GTGATCATGA TTTCTAAATC AGAATATTCT 660

GTGCACTCAT CTTTGGCATC CAAAGTTGAT GTTGAGCAGG TTGTTATGTA TTGCAAGGAG 720

AAGCTTATTC GTGGGGAATC AGAATTTTCC TTTGAAGAAT TGAGAGCCCA GAAATACAAT 780

CAACGGAGAA AGCATGAGCA ATGGGTAAAT GAAGACAGAC ATTATATGAA AAGGAAAGAA 840

GCAAATGCTT TTGAAGAACA GCTATTAAAA CAGAAAATGG ATGAACTTCA TAAGAAGTTG 900

CATCAGGTGG TGGAGACATC CCATGAGGAT CTGCCCGCTT CCCAGGAAAG GTCCGAGGTT 960

AATCCAGCAC GTATGGGGCC AAGTGTAGGC TCCCAGCAGG AACTGAGAGC GCCATGTCTT 1020

CCAGTCACCT ATCAGCAGAC ACCAGCGAAC ATGGAAAAGA ACCCAAGAGA GGCACCTCCT 1080

GTTGTTCCTC CTTTGGCAAA TGCTATTTCT GCAGCTTTGG TGTCCCCAGC CACCAGCCAG 1140

AGCATTGCTC CTCCTGTTCC TTTGAAAGCC CAGACAGTAA CAGACTCCAT GTTTGCAGTG 1200

GCCAGCAAAG ATGCTGGATG TGTGAATAAG AGTACTCATG AATTCAAGCC ACAGAGTGGA 1260

GCAGAGATCA AAGAAGGGTG TGAAACACAT AAGGTTGCCA ACGTAAGTTC TTTTCACACA 1320

ACTCCAAACA CATCACTGGG AATGGTTCAG GCAACACCAT CCAAAGTGCA GCCATCACCC 1380

ACCGTGCACA CAAAAGAAGC ATTAGGTTTC ATCATGAATA TGTTTCAGGC TCCTACACTT 1440

CCTGATATTT CTGATGACAA AGATGAATGG CAATCTCTAG ATCAAAATGA AGATGCATTT 1500

GAAGCCCAGT TTCAAAAAAA TGTAAGGTCA TCTGGGGCTT GGGGAGTCAA TAAGATCATC 1560

TCTTCTTTGT CATCTGCTTT TCATGTGTTT GAAGATGGAA ACAAAGAAAA TTATGGATTA 1620

CCACAGCCTA AAAATAAACC CACAGGAGCC AGGACCTTTG GAGAACGCTC TGTCAGCAGA 1680

CTTCCTTCAA AACCAAAGGA GGAAGTGCCT CATGCTGAAG AGTTTTTGGA TGACTCAACT 1740

GTATGGGGTA TTCGCTGCAA CAAAACCCTG GCACCCAGTC CTAAGAGCCC AGGAGACTTC 1800

ACATCTGCTG CACAACTTGC GTCTACACCA TTCCACAAGC TTCCAGCGGA GTCAGTGCAC 1860

ATTTTAGAAG ATAAAGAAAA TGTGGTAGCA AGACAGTGTA CCCAGGGGAC TTCGGATTCC 1920

TGTGAAGAAA ACATGGTGGT GCCTTCAAGG GATGGAAAAT TCAGTCCAAT TCAAGAGAAA 1980

AGCCCAGAAC AGGCCTTCTC GTCTCACATG TATTCAGCAT CCTTACTTCA TCTGAGCCAG 2040

CCTGCTGCAG GTGGGGTACT TACCTGTGAG GCAGAGTTGG GCGTTGAGGC TTGCAGACTC 2100

ACAGACACTG ACGCTGCCAT TGCAGAAGAT CCACCAGATG CTATTGCTGG GTTCCAAGCA 2160

GAATGGATGC AGATGAGTTC ACTTGGGACT GTTGATGCTC CAAACTTCAT TGTTGGGAAC 2220

CCATGGGATG ATAAGCTGAT TTTCAAACTT TTATCTGGGC TTTCTAAACC AGTGAGTTCC 2280

TATCCAAATA CTTTTGAATG GCAATGTAAA CTTCCAGCCA TCAAGCCCAA GACTGAATTT 2340

CAATTGGGTT CTAAGCTGGT CTATGTCCAT CACCTTCTTG GAGAAGGAGC CTTTGCCCAG 2400

GTGTACGAAG CTACCCAGGG AGATCTGAAT GATGCTAAAA ATAAACAGAA ATTTGTTTTA 2460

AAGGTCCAAA AGCCTGCCAA CCCCTGGGAA TTCTACATTG GGACCCAGTT GATGGAAAGA 2520

CTAAAGCCAT CTATGCAGCA CATGTTTATG AAGTTCTATT CTGCCCACTT ATTCCAGAAT 2580

GGCAGTGTAT TAGTAGGAGA GCTCTACAGC TATGGAACAT TATTAAATGC CATTAACCTC 2640

TATAAAAATA CCCCTGAAAA AGTGATGCCT CAAGGTCTCG TCATCTCTTT TGCTATGAGA 2700

ATGCTTTACA TGATTGAGCA AGTGCATGAC TGTGAAATCA TTCATGGAGA CATTAAACCA 2760

GACAATTTCA TACTTGGAAA CGGATTTTTG GAACAGGATG ATGAAGAAGA TTTATCTGCT 2820

GGCTTGGCAC TGATTGACCT GGGTCAGAGT ATAGATATGA AACTTTTTCC AAAAGGAACT 2880

ATATTCACAG CAAAGTGTGA AACATCTGGT TTTCAGTGTG TTGAGATGCT CAGCAACAAA 2940

CCATGGAACT ACCAGATCGA TTACTTTGGG GTTGCTGCAA CAGTATATTG CATGCTCTTT 3000

GGCACTTACA TGAAAGTGAA AAATGAAGGA GGAGAGTGTA AGCCTGAAGG TCTTTTTAGA 3060

AGGCTTCCTC ATTTGGATAT GTGGAATGAA TTTTTTCATG TTATGTTGAA TATTCCAGAT 3120

TGTCATCATC TTCCATCTTT GGATTTGTTA AGGCAAAAGC TGAAGAAAGT ATTTCAACAA 3180

CACTATACTA ACAAGATTAG GGCCCTACGT AAAAGGCTAA TTGTACTGCT CTTAGAATGT 3240

AAGCGTTCAC GAAAATAA 3258

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+a++    d+k++++++lKv+kpan+WefYI +ql+eRlk ++++

Q: 788   YVHHLLGEGAFAQVYEATQgdlnDAKNKQKFVLKVQKPANPWEFYIGTQLMERLK-PSMQ  846

         79******************9999*******************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++++++sa+lfq++s+lv e++sygtll++in++k++ +kvm++ lv+++++++l+++e

Q: 847   HMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIE  906

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgka  177

         ++H++eIiHgD+kPdnf+lgn + ++ d+++ ++gl+liD+g+siDmkl+p+gt f++k+

Q: 907   QVHDCEIIHGDIKPDNFILGNGFLEQDDEEDLSAGLALIDLGQSIDMKLFPKGTIFTAKC  966

         ************************************************************

S: 178   ktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkke  237

         +t++f+c+eml++k+w+Yq+D+fg+aa+++++lfg+y++v++egg++k++  ++rl++ +

Q: 967   ETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLD  1026

         ************************************************************

S: 238   lwekiferlLNisdastlpsleelveek  265

         +w+++f+++LNi+d+++lpsl+ l++ k

Q: 1027  MWNEFFHVMLNIPDCHHLPSLDLLRQ-K  1053

         ************************95.4

Domain Sequence
(FASTA)

YVHHLLGEGA FAQVYEATQG DLNDAKNKQK FVLKVQKPAN PWEFYIGTQL MERLKPSMQH 60

MFMKFYSAHL FQNGSVLVGE LYSYGTLLNA INLYKNTPEK VMPQGLVISF AMRMLYMIEQ 120

VHDCEIIHGD IKPDNFILGN GFLEQDDEED LSAGLALIDL GQSIDMKLFP KGTIFTAKCE 180

TSGFQCVEML SNKPWNYQID YFGVAATVYC MLFGTYMKVK NEGGECKPEG LFRRLPHLDM 240

WNEFFHVMLN IPDCHHLPSL DLLRQK 266

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013