EKS-GOG-00362

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00362

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	423.5	3.3E-127	234	487	254

Status

Unreviewed

Ensembl Protein

ENSGGOP00000028655

UniProt Accession

G3SKL2;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000034876	ENSGGOP00000028655	ENSGGOT00000041135

Organism

Gorilla gorilla

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MSNICQRLWE YLEPYLPCLS TEADKSTVIE NPGAHCSPQS QRHGHYFVAL FDYQARTAED 60

LSFRAGDKLQ VLDTLHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA 120

IGRSDAEKQL LYSENKTGSF LIRESESQKG EFSLSVLDGG VVKHYRIKRL DEGGFFLTRR 180

RIFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL 240

GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PNDFLREAQI MKNLRHPKLI QLYAVCTLED 300

PIYIITELMR HGSLQEYLQN DTGSKIHLTQ QVDMAAQVAS GMAYLESRNY IHRDLAARNV 360

LVGEHNIYKV ADFGLARVFK VDNEDIYESR HEIKLPVKWT APEAIRSNKF SIKSDVWSFG 420

ILLYEIITYG KMPYSGMTGA QVIQMLAQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF 480

ETLHWKLEDY FETDSSYSDA NNCIR 505

Nucleotide Sequence
(FASTA)

ATGAGCAACA TCTGTCAGAG GCTCTGGGAG TACCTAGAAC CCTATCTCCC CTGTTTGTCC 60

ACGGAGGCAG ACAAGTCAAC CGTGATTGAA AATCCAGGGG CCCATTGCTC TCCCCAGTCA 120

CAGAGGCATG GCCACTACTT TGTGGCTTTG TTTGATTACC AGGCTCGGAC TGCTGAGGAC 180

TTGAGCTTCC GGGCAGGTGA CAAACTTCAA GTTCTGGACA CTTTGCATGA GGGCTGGTGG 240

TTTGCCAGAC ACTTGGAGAA AAGACGAGAT GGCTCCAGTC AGCAACTACA AGGCTATATT 300

CCTTCTAACT ACGTGGCTGA GGACAGAAGC CTACAGGCAG AGCCGTGGTT CTTTGGAGCA 360

ATCGGAAGAT CAGATGCAGA GAAACAACTA TTATATTCAG AAAACAAGAC GGGTTCCTTT 420

CTAATCAGAG AAAGTGAAAG CCAAAAAGGA GAATTCTCTC TTTCAGTTTT AGATGGAGGA 480

GTTGTAAAAC ACTACAGAAT TAAAAGACTG GATGAAGGGG GATTTTTTCT CACGCGAAGA 540

AGAATCTTTT CAACACTGAA CGAATTTGTG AGCCACTACA CCAAGACAAG TGACGGCCTG 600

TGTGTCAAGC TGGGGAAACC ATGCTTAAAG ATCCAGGTCC CAGCTCCATT TGATTTGTCG 660

TATAAAACCG TGGACCAATG GGAGATAGAC CGCAACTCCA TACAGCTTCT GAAGCGATTG 720

GGATCTGGTC AGTTTGGCGA AGTATGGGAA GGTCTGTGGA ACAATACCAC TCCAGTAGCA 780

GTGAAAACAT TAAAACCAGG TTCAATGGAT CCAAATGACT TCCTGAGGGA GGCACAGATA 840

ATGAAGAACC TAAGACATCC AAAGCTTATC CAGCTTTATG CTGTTTGCAC TTTAGAAGAT 900

CCAATTTATA TTATTACAGA GTTGATGAGA CATGGAAGTC TGCAAGAATA TCTCCAAAAT 960

GACACTGGAT CAAAAATCCA TCTGACTCAG CAGGTAGACA TGGCAGCACA GGTTGCCTCT 1020

GGAATGGCCT ATCTGGAGTC TCGGAACTAC ATTCATAGAG ATCTGGCTGC CAGAAATGTC 1080

CTTGTTGGTG AACATAATAT CTACAAAGTA GCAGATTTTG GACTTGCCAG AGTTTTTAAG 1140

GTAGATAATG AAGACATCTA TGAATCTAGA CACGAAATAA AGCTGCCGGT GAAGTGGACT 1200

GCGCCCGAAG CCATTCGTAG TAATAAATTC AGCATTAAGT CCGATGTATG GTCATTTGGA 1260

ATCCTTCTTT ATGAAATCAT TACTTATGGC AAAATGCCTT ACAGTGGTAT GACAGGTGCC 1320

CAGGTAATCC AGATGTTGGC TCAAAACTAT AGACTTCCGC AACCATCCAA CTGTCCACAG 1380

CAATTTTACA ACATCATGTT GGAGTGCTGG AATGCAGAGC CTAAGGAACG ACCTACATTT 1440

GAGACACTGC ATTGGAAACT TGAAGACTAT TTTGAAACAG ACTCTTCATA TTCAGATGCA 1500

AATAACTGCA TAAGATGA 1518

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 234   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  293

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l++++g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 294   AVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHR  353

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y+++++ klP+kWtaPeai+ +kf+ik

Q: 354   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESRHEIKLPVKWTAPEAIRSNKFSIK  413

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp+++y+++lecw+++

Q: 414   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAE  473

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 474   PKERPTFETLHWKL  487

         **********9986

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDTG SKIHLTQQVD MAAQVASGMA YLESRNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESRHEI KLPVKWTAPE AIRSNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLAQNYRLP QPSNCPQQFY NIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013