EKS-GOG-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GOG-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	507.2	8.6E-153	354	653	300

Status

Unreviewed

Ensembl Protein

ENSGGOP00000028731

UniProt Accession

G3SKT8;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA6

Gene Synonyms/Alias

EPHA6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGGOG00000034920	ENSGGOP00000028731	ENSGGOT00000041098

Organism

Gorilla gorilla

Functional Description

Protein Length

759

Protein Sequence
(FASTA)

ACRPGFYKAF AGNTKCSKCP PHSLTYMEAT SVCQCEKGYF RAEKDPPSMA CTRPPSAPRN 60

VVFNINETAL ILEWSPPSDT GGRKDLTYSV ICKKCGLDTS QCEDCGGGLR FIPRHTGLIN 120

NSVIVLDFVS HVNYTFEIEA MNGVSELSFS PKPFTAVTVT TDQDAPSLIG VVRKDWASQN 180

SIALSWQAPA FSNGAILDYE IKYYEKEHEQ LTYSSTRSKA PSVIITGLKP ATKYVFHIRV 240

RTATGYSGYS QKFEFETGDE TSDMAAEQGQ ILVIATAAVG GFTLLVILTL FFLITGRCQW 300

YIKAKMKSEE KRRNHLQNGH LRFPGIKTYI DPDTYEDPSL AVHEFAKEID PSRIRIERVI 360

GAGEFGEVCS GRLKTPGKRE IPVAIKTLKG GHMDRQRRDF LREASIMGQF DHPNIIRLEG 420

VVTKRSFPAI GVEAFCPSFL RAGFLNSIQA PHPVPGGGSL PPRIPAGRPV MIVVEYMENG 480

SLDSFLRKHD GHFTVIQLVG MLRGIASGMK YLSDMGYVHR DLAARNILVN SNLVCKVSDF 540

GLSRVLEDDP EAAYTTTGGK IPIRWTAPEA IAYRKFSSAS DAWSYGIVMW EVMSYGERPY 600

WEMSNQDVIL SIEEGYRLPA PMGCPASLHQ LMLHCWQKER NHRPKFTDIV SFLDKLIRNP 660

SALHTLVEDI LVMPESPGEV PEYPLFVTVG DWLDSIKMGQ YKNNFVAAGF TTFDLISRMS 720

IDDIRRIGVI LIGHQRRIVS SIQTLRLHMM HIQEKGFHV 759

Nucleotide Sequence
(FASTA)

GCTTGCAGAC CAGGATTCTA TAAAGCTTTT GCTGGGAACA CAAAATGTTC TAAATGTCCT 60

CCACACAGTT TAACATACAT GGAAGCAACT TCTGTCTGTC AGTGTGAAAA GGGTTATTTC 120

CGAGCTGAAA AAGACCCACC TTCTATGGCA TGTACCAGGC CACCTTCAGC TCCTAGGAAT 180

GTGGTTTTTA ACATCAATGA AACAGCCCTT ATTTTGGAAT GGAGCCCACC AAGTGACACA 240

GGAGGGAGAA AAGATCTCAC ATACAGTGTA ATCTGTAAGA AATGTGGCTT AGACACCAGC 300

CAGTGTGAGG ACTGTGGTGG AGGACTCCGC TTCATCCCAA GACATACAGG CCTGATCAAC 360

AATTCCGTGA TAGTACTTGA CTTTGTGTCT CACGTGAATT ACACCTTTGA AATAGAAGCA 420

ATGAATGGAG TTTCTGAGTT GAGTTTTTCT CCCAAGCCAT TCACAGCTGT TACAGTGACC 480

ACGGATCAAG ATGCACCTTC CCTGATAGGT GTGGTAAGGA AGGACTGGGC ATCCCAAAAT 540

AGCATTGCCC TATCATGGCA AGCACCTGCT TTTTCCAATG GAGCCATTCT GGACTACGAG 600

ATCAAGTACT ATGAGAAAGA ACATGAGCAG CTGACCTACT CTTCCACAAG GTCCAAGGCC 660

CCCAGTGTCA TCATCACAGG TCTCAAGCCA GCCACCAAGT ATGTATTTCA CATCCGAGTG 720

AGAACTGCGA CAGGATACAG TGGCTACAGT CAGAAATTTG AATTTGAAAC AGGAGATGAA 780

ACTTCTGACA TGGCAGCAGA ACAAGGACAG ATTCTCGTGA TAGCCACCGC CGCTGTTGGC 840

GGATTCACTC TCCTCGTCAT CCTCACTTTA TTCTTCTTGA TCACTGGAAG ATGTCAGTGG 900

TACATAAAAG CCAAGATGAA GTCAGAAGAG AAGAGAAGAA ACCACTTACA GAATGGGCAT 960

TTGCGCTTCC CAGGAATTAA AACTTACATT GATCCAGATA CATATGAAGA CCCATCCCTA 1020

GCAGTCCATG AATTTGCAAA GGAGATTGAT CCCTCAAGAA TTCGTATTGA GAGAGTCATT 1080

GGGGCAGGTG AATTTGGAGA AGTCTGTAGT GGACGTTTGA AGACACCAGG GAAAAGAGAG 1140

ATCCCAGTTG CCATTAAAAC TTTGAAAGGT GGCCACATGG ATCGGCAAAG AAGAGATTTT 1200

CTAAGAGAAG CTAGTATCAT GGGCCAGTTT GACCATCCAA ACATCATTCG CCTAGAAGGT 1260

GTTGTCACCA AAAGATCCTT CCCGGCCATT GGGGTGGAGG CGTTTTGCCC CAGCTTCCTG 1320

AGGGCAGGGT TTTTAAATAG CATCCAGGCC CCGCATCCAG TGCCAGGGGG AGGATCTTTG 1380

CCCCCCAGGA TTCCTGCTGG CAGACCAGTA ATGATTGTGG TGGAATATAT GGAGAATGGA 1440

TCCCTAGACT CCTTTTTGCG GAAGCATGAT GGCCACTTCA CAGTCATCCA GTTGGTCGGA 1500

ATGCTCCGAG GCATTGCATC AGGCATGAAG TATCTTTCTG ATATGGGTTA TGTTCATCGA 1560

GACCTAGCGG CTCGGAATAT ACTGGTCAAT AGCAACTTAG TATGCAAAGT TTCTGATTTT 1620

GGTCTCTCCA GAGTGCTAGA AGATGATCCA GAAGCTGCTT ATACGACAAC TGGTGGAAAA 1680

ATCCCCATAA GGTGGACAGC CCCAGAAGCC ATCGCCTACA GAAAATTCTC CTCAGCAAGT 1740

GATGCATGGA GCTATGGCAT TGTCATGTGG GAGGTCATGT CCTATGGAGA GAGACCTTAT 1800

TGGGAAATGT CTAACCAAGA TGTCATTCTG TCCATTGAAG AAGGGTACAG ACTTCCAGCT 1860

CCCATGGGCT GTCCAGCATC TCTACACCAA CTGATGCTCC ATTGCTGGCA GAAGGAGAGA 1920

AATCATAGAC CAAAATTTAC TGACATTGTC AGCTTCCTTG ACAAACTGAT CCGAAATCCC 1980

AGTGCCCTTC ACACCCTGGT GGAGGACATC CTTGTAATGC CAGAGTCCCC TGGTGAAGTT 2040

CCGGAATATC CTTTGTTTGT CACAGTTGGT GACTGGCTAG ATTCTATAAA GATGGGGCAA 2100

TACAAGAATA ATTTCGTGGC AGCAGGGTTT ACAACATTTG ACCTGATTTC AAGAATGAGC 2160

ATTGATGACA TTAGAAGAAT TGGAGTCATA CTTATTGGAC ACCAGAGACG AATAGTCAGC 2220

AGCATACAGA CTTTACGTTT ACACATGATG CACATACAGG AGAAGGGATT TCATGTA 2277

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         ++ie+viGaGefGevcsGrlk+pgkrei+vaiktlk+g++++qrrdfl+easi+Gqfdhp

Q: 354   IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHP  413

         78**********************************************************

S: 61    niirleGvvtk..........................................skpvmiv  78

         niirleGvvtk                                          ++pvmiv

Q: 414   NIIRLEGVVTKrsfpaigveafcpsflragflnsiqaphpvpgggslppripaGRPVMIV  473

         ************************************************************

S: 79    teymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmgyvhrdlaarnilvnsnl  138

         +eymeng+ldsflrk+dg+ftviqlvgmlrGiasgmkylsdmgyvhrdlaarnilvnsnl

Q: 474   VEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNL  533

         ************************************************************

S: 139   vckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkftsasdvwsyGivlwevl  198

         vckvsdfGlsrvledd+eaaytt+ggkipirwtapeaiayrkf+sasd+wsyGiv+wev+

Q: 534   VCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVM  593

         ************************************************************

S: 199   syGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcwqkdraerpkfeqivsil  258

         syGerpyw+msnqdvi +ieegyrlp+pm+cpa+l+qlml+cwqk+r++rpkf++ivs+l

Q: 594   SYGERPYWEMSNQDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFL  653

         *********************************************************975

Domain Sequence
(FASTA)

IRIERVIGAG EFGEVCSGRL KTPGKREIPV AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP 60

NIIRLEGVVT KRSFPAIGVE AFCPSFLRAG FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV 120

VEYMENGSLD SFLRKHDGHF TVIQLVGMLR GIASGMKYLS DMGYVHRDLA ARNILVNSNL 180

VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI RWTAPEAIAY RKFSSASDAW SYGIVMWEVM 240

SYGERPYWEM SNQDVILSIE EGYRLPAPMG CPASLHQLML HCWQKERNHR PKFTDIVSFL 300

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 2.
PF00536	; SAM_1; 1.

SMARTs

SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013